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Stenotrophomonas Maltophilia


Presentation

  • Clinical data were analyzed as to predisposing factors, clinical presentation, antibiotic susceptibility, treatment selection, and clinical outcomes. RESULTS: Median age at presentation was 65 years (range, 16-98).[ncbi.nlm.nih.gov]
  • Both strains overexpressing smeVWX presented changes at the Gly266 position of SmeRv, the repressor of smeVWX.[ncbi.nlm.nih.gov]
  • So far, the present observation is the fourth similar case reported in the literature.[ncbi.nlm.nih.gov]
  • In addition to its classic association with pulmonary infections, S. maltophilia can cause skin and soft tissue infections with varying clinical presentations.[ncbi.nlm.nih.gov]
  • The patient rapidly presented respiratory insufficiency and death in the same day.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Based on these findings, we diagnosed the infant as having a complex UTI and started the intravenous administration of piperacillin/tazobactam. After 2 days, a urine culture showed Gram-negative bacilli (107 CFU/mL).[ncbi.nlm.nih.gov]
Rigor
  • Infection control measures should be rigorously adopted for the control of such nosocomial bacteria. KEYWORDS: Asia; bacterial infection; disease prevention[ncbi.nlm.nih.gov]
Chronic Diarrhea
  • We here report the complicated clinical course of a young patient with chronic diarrhea accompanied by severe, life-threatening malabsorption with extensive weight loss.[ncbi.nlm.nih.gov]
Purpura
  • We describe the case of a man in his 30s with B-cell acute lymphoblastic leukaemia who presented with a solitary patch of faint but tender purpura found to have rapidly progressive S. maltophilia infection diagnosed on skin biopsy.[ncbi.nlm.nih.gov]
  • […] thrombosis in a post-bone marrow transplantation child: implications in the fibrinolytic process. ( 17454909 ) Uckan D....AkyA1z C. 2007 30 Antimicrobial therapy for Stenotrophomonas maltophilia infections. ( 17334747 ) Nicodemo A.C....Paez J.I. 2007 31 Purpura[malacards.org]
Conjunctival Hyperemia
  • A 51-year-old white man presented with worsening light sensitivity, localized conjunctival hyperemia, and a painful scleral nodule in his right eye that developed over a period of 1 month after minor ocular trauma.[ncbi.nlm.nih.gov]
Corneal Infiltrate
  • The patient's corneal infiltrate was successfully cultured and a rare ocular organism identified. The patient's presentation and course and the response to empiric treatment are discussed.[ncbi.nlm.nih.gov]

Workup

  • S. maltophilia is resistance to most of routinely used antibiotic so this case highlights the importance of early detection and antibiotic sensitivity workup.[atmph.org]
  • Initial workup showed elevated troponin and procalcitonin. Chest X-ray findings were suggestive for left lower lobe pneumonia.[cureus.com]
Penicillium
  • Pulmonary infection caused by the opportunistic organisms Penicillium marneffei and Stenotrophomonas maltophilia in patients with Job's syndrome is rare and not well documented.[ncbi.nlm.nih.gov]
Corynebacterium Diphtheriae
  • Trends Microbiol 16 : 33 – 40. ( 1999 ) Cell surface hydrophobicity of sucrose fermenting and nonfermenting Corynebacterium diphtheriae strains evaluated by different methods.[academic.oup.com]
Liver Biopsy
  • After repeated negative blood cultures, histological examinations of liver biopsies suggested the possibility of chronic melioidosis, but the microbiological examination performed directly on the same specimen identified a Stenotrophomonas maltophilia[ncbi.nlm.nih.gov]

Treatment

  • At that time, TMP/SMX was discontinued and treatment was initiated with intravenous doxycycline and aerosolized colistin. The VAP episode was cured after 14 days of treatment with doxycycline/aerosolized colistin.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Treatment failure did not differ between patients receiving trimethoprim/sulfamethoxazole or minocycline monotherapy for treatment of S. maltophilia infections. The Author 2016.[ncbi.nlm.nih.gov]
  • Initial antibiotic treatment was intensive topical 0.3% ofloxacin and 5% cefuroxime, which was modified based on corneal scrape culture and sensitivity and clinical findings. One patient chose not to complete the treatment course.[ncbi.nlm.nih.gov]
  • Treatment is complicated because of its resistances to broad-spectrum antibiotics. TMP/SMX monotherapy can be considered an option of treatment for this type of keratitis.[ncbi.nlm.nih.gov]
  • The corneal lesion worsened suddenly after initial improvement with empirical antibiotic treatment. A culture revealed S. maltophilia. The keratitis rapidly progressed despite treatment with sensitivity-proven antibiotic agents.[ncbi.nlm.nih.gov]

Prognosis

  • These results suggest that more precise prediction and more appropriate treatment might improve the prognosis of patients with S. maltophilia bacteremia.[ncbi.nlm.nih.gov]
  • The review of clinical data indicated that a combination of SXT fluoroquinolone was not associated with improved prognosis compared with monotherapy.[ncbi.nlm.nih.gov]
  • More sophisticated antibiotic therapies introduced over the last decades have helped to improve the prognosis in cystic fibrosis, but then new multidrug-resistant pathogens emerged.[ncbi.nlm.nih.gov]
  • To report the clinical course, treatment response, and prognosis of Stenotrophomonas maltophilia endophthalmitis following cataract extraction.[ncbi.nlm.nih.gov]
  • Even though an early diagnosis and an adequate antibiotic prescription may improve Sm infection prognosis, S. maltophilia proves difficult to eradicate due to a high resistance rate in part intrinsic but also in part acquired.[ncbi.nlm.nih.gov]

Etiology

  • The purpose of the present case report was to highlight this highly resistant microbe as an infectious etiology.[ncbi.nlm.nih.gov]
  • A prompt complete resolution of lesions was observed following antibiotic treatment, with no recurrence of disease over the last 5 years, supporting an infectious rather than malignant etiology.[ncbi.nlm.nih.gov]
  • Causative etiology could be microbial contamination of the drug vial. S. maltophilia should be considered a pathogenic organism of postintravitreal endophthalmitis.[ncbi.nlm.nih.gov]
  • During the first year of renal replacement therapy, there were 3 episodes of peritonitis due to polymicrobial etiology, negative culture and Enterococcus faecalis , respectively.[revistanefrologia.com]

Epidemiology

  • The epidemiology of the organism is considered with particular reference to nosocomial outbreaks, several of which have been investigated by molecular typing techniques.[ncbi.nlm.nih.gov]
  • Molecular typing confirmed that the 3 cases were epidemiologically linked. Opportunistic pathogens such as S. maltophilia can lead to major problems in neonates.[ncbi.nlm.nih.gov]
  • Epidemiological study was done, and surveillance cultures grew the organism from the faucets from the room of 1 patient and also from some of the neighboring rooms in our ward but not from any other ward nor in the water reservoir of the building.[ncbi.nlm.nih.gov]
  • KEYWORDS: Antibiotic resistance; Molecular epidemiology; Stenotrophomonas maltophilia[ncbi.nlm.nih.gov]
  • Author information 1 Infection Control and Epidemiology Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • PATHOPHYSIOLOGY • S maltophilia has few pathogenic mechanisms and, for this reason, predominantly results in colonization rather than infection.[slideshare.net]
  • Otherwise, the pathophysiology of this nonfermentative aerobic gram-negative bacillus does not differ from other nonfermentative aerobic organisms. Epidemiology Frequency United States S maltophilia is a noninvasive organism that has low virulence.[emedicine.medscape.com]
  • TNF-α signaling contributes significantly to the pathophysiology of S. maltophilia pneumonia, as reflected by the minimal disease observed in the TNFR1 null mice.[doi.org]

Prevention

  • Removing the CVC and the combined antibiotics without preventing the neutrophil engraftment could avoid surgical drainage in pyomyositis due to S. maltophilia when detected in an early stage.[ncbi.nlm.nih.gov]
  • Early recognition of this unusual complication in a cancer patient undergoing chemotherapy can prevent further catastrophes.[ncbi.nlm.nih.gov]
  • S. maltophilia should be included as a pathogenic organism of NEC in severely immunocompromised patients to prevent a delayed diagnosis, which carries a high risk of inappropriate antimicrobial selection and fatal outcome.[ncbi.nlm.nih.gov]
  • The surveillance of CVCs, good adherence to the protocols and guidelines and "good practice" are the cornerstones for the prevention of nosocomial infections.[ncbi.nlm.nih.gov]
  • Molecular typing is helpful to improve effective control programs for preventing the spread of the infection.[ncbi.nlm.nih.gov]

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