Presentation
The precise etiology of this defect is at present not known, but receptors on the platelet surface may be involved. [ncbi.nlm.nih.gov]
Case: A gravid woman with two previous first-trimester miscarriages presented at 11 weeks of gestation with a deep venous thrombosis. [utsouthwestern.pure.elsevier.com]
The precise etiology of this defect is at present not known, but receptors on the platelet surface may be involved. Patients and methods: We examined fifty patients with otherwise unexplained arterial or venous thrombosis. [ashpublications.org]
MO...Rubin JR 20363102 2010 38 Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome. 38 Mears KA...Van Stavern GP 18662911 2009 39 Sticky platelet syndrome type II presenting with arterial microemboli in [malacards.org]
Entire Body System
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Rapidly Progressive Glomerulonephritis
Case 3 A 43‐year‐old female with ESRD due to rapidly progressive glomerulonephritis was admitted for deceased donor kidney transplantation. [onlinelibrary.wiley.com]
Gastrointestinal
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Rectal Bleeding
The patient was readmitted with massive rectal bleeding 1 month later. Colon biopsies showed ischemic colitis with histologic evidence of recurrent ischemia. [onlinelibrary.wiley.com]
Skin
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Sweating
Commentary: controversies in thrombosis and hemostasis part 1-hematidrosis: “Blood, Sweat and Fears” or A “Pigment of Fertile Imaginations?”. Semin Thromb Hemost 2018; 44 (03) 296-297 15 Salvagno GL, Pavan C, Lippi G. Rare thrombophilic conditions. [thieme-connect.com]
Psychiatrical
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Fear
Commentary: controversies in thrombosis and hemostasis part 1-hematidrosis: “Blood, Sweat and Fears” or A “Pigment of Fertile Imaginations?”. Semin Thromb Hemost 2018; 44 (03) 296-297 15 Salvagno GL, Pavan C, Lippi G. Rare thrombophilic conditions. [thieme-connect.com]
Neurologic
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Aphasia
Two months later she developed acute aphasia due to an infarction in the area of the left medial cerebral artery. A CT scan also disclosed two older lesions. [onlinelibrary.wiley.com]
Workup
Hypercoagulability workup, including protein S, protein C, ATIII, anti‐phospholipid antibodies, factor V Leiden and MTHFR mutations, were all within normal limits. [onlinelibrary.wiley.com]
Treatment
Low-dose aspirin treatment (80–100 mg) ameliorates the clinical symptoms and normalizes hyperaggregability. The precise etiology of this defect is at present not known, but receptors on the platelet surface may be involved. [ashpublications.org]
This review deals with the clinical aspects of thrombophilia, its etiopathogenesis, diagnosis as well as novel advances in the treatment and outlines the challenges for the further research. [tandfonline.com]
Low-dose aspirin treatment (80 to 100 mg) ameliorates the clinical symptoms and normalizes hyperaggregability. The precise etiology of this defect is at present not known, but receptors on the platelet surface may be involved. [ncbi.nlm.nih.gov]
Platelet Hyperaggregability is Highly Prevalent in Patients With Chronic Kidney Disease: An Underestimated Risk Indicator of Thromboembolic Events. 38 Yagmur E...Muhlfeld AS 23728835 2015 17 Primary thrombophilia in México X: a prospective study of the treatment [malacards.org]
Despite effective heparin treatment, the patient developed a segmental renal infarction on day 16 after renal transplantation. [onlinelibrary.wiley.com]
Prognosis
In the great majority of patients, the prognosis of TMD is good with complete resolution of the disease without any treatment; however, a few patients with TMD don’t show improvement and develop cancer in the blood or leukemia. [ndss.org]
Plasma exchange therapy, introduced 30 years ago, has dramatically improved the prognosis for patients with TTP. [emedicine.medscape.com]
Blood gases as an indicator of inhalation injury and prognosis in burn patients. Ann Burns Fire Disasters. 2008 Dec 31;21(4):192-8. [frag-den-professor.de]
Etiology
Conclusion: Sticky platelet syndrome causes arterial thromboses and may be an underappreciated etiology for adverse pregnancy outcomes. [utsouthwestern.pure.elsevier.com]
The precise etiology of this defect is at present not known, but receptors on the platelet surface may be involved. [ncbi.nlm.nih.gov]
The precise etiology of this defect is at present not known, but receptors on the platelet surface may be involved. Patients and methods: We examined fifty patients with otherwise unexplained arterial or venous thrombosis. [ashpublications.org]
End‐stage renal disease (ESRD) of unknown etiology had been diagnosed 3 months prior. Immunosuppression with prednisolon, mycophenolate mofetil and cyclosporin A was chosen. [onlinelibrary.wiley.com]
Epidemiology
Although recognized for more than 30 years, significant issues, namely the syndrome's etiology, inheritance, and epidemiology, remain unclear. [ncbi.nlm.nih.gov]
Epidemiology of Platelet Disorders Inherited hemostatic disorders are relatively rare. The prevalence of von Willebrand disease has been estimated at 1 case per 1000-5000 population. [emedicine.medscape.com]
Pathophysiology
The commonly proposed pathophysiological outcome includes thrombosis, namely venous thrombosis events, and pregnancy morbidity. [thieme-connect.com]
While we acknowledge the lack of biopsy‐confirmed evidence of intrapulmonary or intrarenal thrombosis in this case, a pathophysiological role of SPS appears likely, given the rapid and pronounced improvement of both lung and graft function following the [onlinelibrary.wiley.com]
Thus, the pathophysiology of this disease is similar to that of the hemolytic disease of newborns. Unlike hemolytic disease, however, thrombocytopenia occurs during the first pregnancy in 50% of cases. [emedicine.medscape.com]
Prevention
This concept is supported by evidence that arterial thrombi are more “enriched” in platelets, because the risk of arterial vascular events can theoretically be prevented by use of antiplatelet agents such as aspirin.[ 7 ] Conversely, there is a general [thieme-connect.com]
But doctors also hope to move beyond the ancient panacea of aspirin to more specific preventive therapies. One is a group of anti-clotting drugs that prevent a platelet plug from solidifying into a mature clot. [nytimes.com]
Some individuals may undergo preventative (prophylaxis) therapy to avoid blood clots from forming. For many individuals, daily treatment with aspirin (which thin the bloods and prevents blood clots) may be all that is needed. [rarediseases.org]
Lowering the risk of blood clots There are several drugs that can help prevent blood clots developing. [versusarthritis.org]
Some people with Hughes syndrome don’t present the symptoms of blood clots and won’t require any treatment beyond aspirin to prevent the risk of clots developing. [healthline.com]