CASE PRESENTATION: Here we describe two pediatric cases of S. pyogenes endocarditis with associated toxic shock. Case 1 was a previously well Caucasian 6-year-old female who presented with sepsis. [ncbi.nlm.nih.gov]

Table 1 Distribution of proteins among functional categories Regulation and Signaling The number of σ factors present in bacterial species varies considerably; for example, 18 σ factors are present in B. subtilis, whereas only 3 are present in the genome [doi.org]

Finally, we set out to define the macrophage phenotype present at the site of infection. [openarchive.ki.se]

• Streptococcal Infection

  In recent epidemiological studies, Streptococcus dysgalactiae subsp. equisimilis (SDSE) has been isolated from severe invasive streptococcal infection. [ncbi.nlm.nih.gov]

  Pathogenesis of group A streptococcal infections. Clin Microbiol Rev 2000;13:470-511 Holm SE et al. Aspects of serious group A streptococcal infections in Sweden, 1988-1989. J Infect Dis 1992;166:31-37 Kaufhold A, Ferrieri P. [nllplus.se]

  ^ "Streptococcal Infections: What is Group A Strepotococcus (GAS)". Retrieved 21 November 2012. ^ "Streptococcal Infections (Invasive Group A Strep)". New York City Department of Health and Mental Hygiene. [en.wikipedia.org]

  However, streptococcal TSS may also occur in association with other focal streptococcal infections, including pharyngeal infection. [emedicine.medscape.com]

• Asymptomatic

  KEYWORDS: Antibiotic prophylaxis; Asymptomatic diseases; Bacteraemia; Streptococcus pyogenes; Vaginitis [Indexed for MEDLINE] Free full text [ncbi.nlm.nih.gov]

  Conclusion: Finding the bacterium S. pyogenes among asymptomatic medical students is a warning sign of a potential infection. [scielo.org.co]

  Habitat Asymptomatic colonization of the upper respiratory tract in humans. [bio.libretexts.org]

• Severe Pain

  The symptoms may include fever, severe pain, dizziness, and red rash at wound site. These can lead to illnesses such as strep throat, impetigo, scarlet fever, glomerulonephritis, and necrotizing fasciitis. [microchemlab.com]

  pain, often in the arm or leg. [quiplabs.com]

  pain and swelling After a strep infection, people can develop problems including acute rheumatic fever and kidney problems, though these are rare. [healthdirect.gov.au]

  Early signs and symptoms of necrotizing fasciitis include fever, severe pain and swelling, and redness at the wound site. Early signs and symptoms of STSS may include fever, dizziness, confusion, low blood pressure, rash and abdominal pain. [health.ny.gov]

  They range from mild to severe, such as fever, severe pain, dizziness, and red rash at wound site. The symptoms at first might not seem severe, but in some cases the diseases have caused death to certain individuals. [microbewiki.kenyon.edu]

• Pharyngitis

  However, when recurrent pharyngitis takes place within 40 days after completing the treatment, alternative drugs should be considered for retreatment because the pharyngitis is likely to be due to reactivation. [ncbi.nlm.nih.gov]

  The incubation period of streptococcal pharyngitis usually is 1-3 days. How is streptococcal pharyngitis diagnosed? Streptococcal pharyngitis is usually diagnosed by culturing a swab of the throat. [web.archive.org]

  Suppurative disease spectrum Streptococcal pharyngitis S pyogenes causes up to 15-30% of cases of acute pharyngitis. [14] Frank disease occurs based on the degree of bacterial virulence after colonization of the upper respiratory tract. [emedicine.medscape.com]

• Dyspnea

  Case Presentation Case 1 An 83 year old man was seen in the Emergency Department (ED) with a 24‐hour history of worsening dyspnea. Review of systems (ROS) was positive for severe dyspnea, audible wheezing, and severe weakness. [remedypublications.com]

  She returned several days later with dyspnea and back pain. The ECG was significant for sinus tachycardia and S1Q3T3. Echocardiography demonstrated right ventricular strain and near to total occlusion of her pulmonary trunk. [onlinejacc.org]

  Twenty years later, the patient presents to the emergency department with dyspnea on exertion and CXR showed an enlarged cardiac silhouette and pulmonary edema. [step1.medbullets.com]

  Herein, we report the case of an immunocompetent 4-year-old boy who presented with cough, intermittent fever, and dyspnea attributed to penicillin-intermediate-resistant S. viridans-related community-acquired pneumonia. [indianpediatrics.net]

• Common Cold

  Most common colds are caused by a virus, while a bacterial infection causes strep throat. If you have a common cold, you usually have symptoms such as coughing, a runny nose, and hoarseness. [healthline.com]

  cold, acute rhinosinusitis, acute cough or bronchitis, acute pharyngitis (except those suggestive of streptococcal infection clinically) and many cases of acute otitis media do not require immediate antibiotic treatment,122 antibiotics are still very [tandfonline.com]

• Abdominal Pain

  Abstract We report the case of a 60-year-old female patient who presented to the emergency room for abdominal pain standing with impaired general status, fever of up to 38.7ºC, and somnolence. [ncbi.nlm.nih.gov]

  Young children may also have nausea, vomiting, and abdominal pain. Lab tests The “gold standard” is a throat culture. Rapid antigen detection tests are highly specific, but a negative result must be double-checked with a throat culture. [journals.lww.com]

  Occasionally it is also accompanied by nausea, vomiting, and abdominal pain. Strep throat can be diagnosed by a doctor through a throat culture or a rapid strep test. [pyogenesgonewild.com]

  Early signs and symptoms of necrotizing fasciitis include fever, severe pain and swelling, and redness at the wound site. Early signs and symptoms of STSS may include fever, dizziness, confusion, low blood pressure, rash and abdominal pain. [health.ny.gov]

  Dear Editor, We report the case of a 60-year-old female patient with a history of blood hypertension who presented to the emergency room for abdominal pain of increasing severity and 24 hours' standing with impaired general status, fever of up to 38.7 [scielo.isciii.es]

• Blood in Stool

  The classic presentation is a well-demarcated rash around the anus with itching, rectal pain, and, occasionally, blood-streaked stools. [mayomedicallaboratories.com]

• Skin Lesion

  Clinical significance The upper respiratory tract and skin lesions serve as primary focal sites of infections and principal reservoirs of transmission. [microbe-canvas.com]

  We swabbed throat and chronic skin lesions from residents and staff and examined these specimens for the presence of S. pyogenes. 61 specimens were taken from 18 of 19 residents and 39 of 39 staff. All results from swabbing were culture negative. [ncbi.nlm.nih.gov]

  A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER. [profiles.umassmed.edu]

  lesions (including children with chicken pox). [nanologix.com]

• Eruptions

  An-Initial-Step-of-GAS-Containing-Autophagosome-Like-Vacuoles-Formation-Requires-Rab7-ppat.1000670.s002.ogv 3,3 s, 748 × 166; 908 KB Riproduci file multimediale An-Initial-Step-of-GAS-Containing-Autophagosome-Like-Vacuoles-Formation-Requires-Rab7-ppat.1000670.s003.ogv 3,3 s, 640 × 243; 1,04 MB Bullous eruption [commons.wikimedia.org]

  Read More puerperal fever In puerperal fever …commonly producing this infection are Streptococcus pyogenes; staphylococci (inhabitants of the skin and of pimples, carbuncles, and many other pustular eruptions); the anaerobic streptococci, which flourish [britannica.com]

• Facial Pain

  Common symptoms include facial pain, headache, and fever following previous upper respiratory viral illness. [britannica.com]

• Cesarean Section

  Due to fetal distress, emergency Cesarean section was carried out and transferred to intensive care units. [ncbi.nlm.nih.gov]

• Confusion

  She was lethargic and confused. Blood cultures were positive for S pyogenes, and a swab of the right breast was negative for bacterial growth. [mdedge.com]

  Some microbiologists have forsaken the general "bacillus" term because of the confusion it can create. [en.wikipedia.org]

  Dizziness, fever, flu-like symptoms, confusion, and possible large rash Necrotizing fasciitis- intense pain near the site of trauma (break in the skin). [quiplabs.com]

  Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances No significant cautionary statements. [mayomedicallaboratories.com]

• Dizziness

  The symptoms may include fever, severe pain, dizziness, and red rash at wound site. These can lead to illnesses such as strep throat, impetigo, scarlet fever, glomerulonephritis, and necrotizing fasciitis. [microchemlab.com]

  Dizziness, fever, flu-like symptoms, confusion, and possible large rash Necrotizing fasciitis- intense pain near the site of trauma (break in the skin). [quiplabs.com]

  Symptoms include significant pain, swelling, and redness of infected area, fever, dizziness, difficulty breathing, dangerously low blood pressure, and a weak, rapid pulse. [9] Medical care is crucial as more than 50% of cases of streptococcal toxic shock [pyogenesgonewild.com]

  Physical symptoms headaches or dizziness muscle tension or pain stomach problems chest pain or a faster heartbeat sexual problems Mental symptoms difficulty concentrating struggling to make decisions feeling overwhelmed constantly worrying being forgetful [nhs.uk]

  Also, get emergency help immediately if you have chest pain, especially if you also have shortness of breath, jaw or back pain, pain radiating into your shoulder and arm, sweating, dizziness, or nausea. [mayoclinic.org]

• Difficulty Concentrating

  Physical symptoms headaches or dizziness muscle tension or pain stomach problems chest pain or a faster heartbeat sexual problems Mental symptoms difficulty concentrating struggling to make decisions feeling overwhelmed constantly worrying being forgetful [nhs.uk]

Eleven strains caused recurrent pharyngitis within 40 days after the last treatment, all of them showing the same PFGE-type as the primary strains. Eight of the strains caused recurrence more than 40 days after the treatment. [ncbi.nlm.nih.gov]

Learn more about the etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention of some of these infections below. [cdc.gov]

Learn more about the etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention of some of these infections below. [cdc.gov]

The pathogenesis of this invasive infection, as well as predictors of poor prognosis are discussed. [ncbi.nlm.nih.gov]

Although advances in antibiotic therapy and surgical techniques have improved the prognosis of endocarditis,1 the mortality rate in recent decades has held steady at 15% to 50%.2-11 Improving this prognosis will require identifying patients at higher [revespcardiol.org]

ARDS).[13] The incidence of toxic shock-like syndrome in bone marrow transplant recipients with S viridans bacteremia ranges from 8% to 33%, with a fatal outcome in 60% to 100% of patients.[4,5,10,11,15] ARDS and neurologic impairment carry an adverse prognosis [medscape.com]

Learn more about the etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention of some of these infections below. [cdc.gov]

BACKGROUND: Streptococcus pyogenes (group A Streptococcus) is the etiological agent of perineal infection in children, consisting of perianal infection, vulvovaginitis and balanitis. [ncbi.nlm.nih.gov]

The title is unfortunate, since it implies that infections produced by the usual etiologic agent in cases of subacute bacterial endocarditis can be controlled by sulfapyridine. [jamanetwork.com]

In recent epidemiological studies, Streptococcus dysgalactiae subsp. equisimilis (SDSE) has been isolated from severe invasive streptococcal infection. [ncbi.nlm.nih.gov]

Epidemiology of Streptococcus pyogenes. Streptococcus pyogenes: basic biology to clinical manifestations [Internet], [12] A. Filleron, E. Jeziorski, A.L. Michon, M. Rodière, H. Marchandin. [analesdepediatria.org]

We review 12 other cases reported in the literature, and discuss the pathophysiological mechanisms of this potentially life-threatening disease. [ncbi.nlm.nih.gov]

Taken together these findings highlight the complex pathophysiology of severe S. pyogenes infections, where on the one hand the bacteria and mediators present in the infected tissue potently activates neutrophils. [openarchive.ki.se]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Streptococcus pyogenes (group A streptococcus) is a common cause of pharyngitis and skin and soft tissue infection. [mayomedicallaboratories.com]

Learn more about the etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention of some of these infections below. [cdc.gov]

Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. [ncbi.nlm.nih.gov]

The global strategies for prevention of GAS on a larger scale remain complex (19). [isid.org]