CASE PRESENTATION: Here we describe two pediatric cases of S. pyogenes endocarditis with associated toxic shock. Case 1 was a previously well Caucasian 6-year-old female who presented with sepsis. [ncbi.nlm.nih.gov]

Table 1 Distribution of proteins among functional categories Regulation and Signaling The number of σ factors present in bacterial species varies considerably; for example, 18 σ factors are present in B. subtilis, whereas only 3 are present in the genome [doi.org]

• Ear Discharge

  • Patients with STSS when GAS is isolated from any sample (pharyngeal smear, wound, skin, ear discharge, etc.). [elsevier.es]

  Taking into account that culture of ear discharge specimens was only performed in cases of suppurative otitis media, it would be fair to assume that the incidence of streptococcal otitis media may be higher than reported in the literature (3–5%). 23 In [analesdepediatria.org]

Eleven strains caused recurrent pharyngitis within 40 days after the last treatment, all of them showing the same PFGE-type as the primary strains. Eight of the strains caused recurrence more than 40 days after the treatment. [ncbi.nlm.nih.gov]

Learn more about the etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention of some of these infections below. [cdc.gov]

Although advances in antibiotic therapy and surgical techniques have improved the prognosis of endocarditis,1 the mortality rate in recent decades has held steady at 15% to 50%.2-11 Improving this prognosis will require identifying patients at higher [revespcardiol.org]

ARDS).[13] The incidence of toxic shock-like syndrome in bone marrow transplant recipients with S viridans bacteremia ranges from 8% to 33%, with a fatal outcome in 60% to 100% of patients.[4,5,10,11,15] ARDS and neurologic impairment carry an adverse prognosis [medscape.com]

Prognosis Acute proliferative PSGN carries a good prognosis, as more than 95% of patients recover spontaneously within 3-4 weeks with no long-term sequelae. With appropriate treatment, pharyngitis and skin infections also have a good prognosis. [emedicine.medscape.com]

BACKGROUND: Streptococcus pyogenes (group A Streptococcus) is the etiological agent of perineal infection in children, consisting of perianal infection, vulvovaginitis and balanitis. [ncbi.nlm.nih.gov]

Learn more about the etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention of some of these infections below. [cdc.gov]

Etiology of community‐ acquired pneumonia in patients requiring hospitalization. Eur J Clin Microbiol. 1985;4(3):268-72. Dorff GJ, Rytel MW, Farmer SG, Scanlon G. Etiologies and characteristic features of pneumonias in a municipal hospital. [remedypublications.com]

In recent epidemiological studies, Streptococcus dysgalactiae subsp. equisimilis (SDSE) has been isolated from severe invasive streptococcal infection. [ncbi.nlm.nih.gov]

Epidemiology of Streptococcus pyogenes. Streptococcus pyogenes: basic biology to clinical manifestations [Internet], [12] A. Filleron, E. Jeziorski, A.L. Michon, M. Rodière, H. Marchandin. [analesdepediatria.org]

The Thomsen- Friedenreich antigen (T antigen) plays a role in the pathophysiology of pneumococcal HUS. We describe the case of a 3-year-old boy with GAS-associated HUS and show how T-antigen exposure was implicated in this case. [ncbi.nlm.nih.gov]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Streptococcus pyogenes (group A streptococcus) is a common cause of pharyngitis and skin and soft tissue infection. [mayomedicallaboratories.com]

Further studies are needed to determine whether ProT is the pathophysiological target zymogen of SfbX(1-312), to delineate the natural substrate of the SfbX(1-312)·ProT complex, and to elucidate the role of SfbX in the pathology of S. pyogenes infection [bloodjournal.org]

Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. [ncbi.nlm.nih.gov]

Add clindamycin to toxin-mediated disease in order to prevent protein production. [sharinginhealth.ca]

The global strategies for prevention of GAS on a larger scale remain complex (19). [isid.org]