Edit concept Question Editor Create issue ticket

Streptomycin


Presentation

  • Ototoxicity was present in 29% of adults and 25% of children.[ncbi.nlm.nih.gov]
  • At present we consider this treatment regimen our first choice of therapy in people with bilateral active Meniere's disease or in patients whose only hearing ear is actively fluctuating and in whom associated disabling vertigo is present.[ncbi.nlm.nih.gov]
  • In the present report we investigate the role of gidB gene mutations in streptomycin resistance.[ncbi.nlm.nih.gov]
  • These discrepancies were caused by some technical limitations; consequently, the present array should be considered as a first-step prior to a forthcoming optimized version of the array. 2013 Published by Elsevier Ltd.[ncbi.nlm.nih.gov]
  • Characterization of the metabolic products of the microbiota, the SCFAs, showed that formate was present in the ileum but low or not detectable in the cecum while butyrate was present in the cecum but not the ileum.[ncbi.nlm.nih.gov]
Loss of Hair
  • A loss of hair cells in the cristae and saccules was consistent with streptomycin ototoxicity.[ncbi.nlm.nih.gov]
Skin Lesion
  • Her general condition and skin lesions improved. A staged-fashion exposure test to the 4 anti-TB drugs allowed the incrimination of streptomycin as the offending agent.[ncbi.nlm.nih.gov]
Subcutaneous Nodule
  • It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli. Surrounding tissue is destroyed by the cytotoxic macrolide toxin mycolactone produced by microcolonies of M. ulcerans.[ncbi.nlm.nih.gov]
Hearing Problem
  • The risk of hearing problems may be higher if you have kidney problems or already have hearing problems, if you get high doses of streptomycin, or if you get streptomycin for a long time.[drugs.com]
  • Hearing loss Streptomycin is not recommended for use in patients with a hearing problem since it may increase the risk of deafness.[practo.com]
  • People with hearing problems. People with inner ear (vestibular) problems affecting balance. Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding.[netdoctor.co.uk]
  • Before using this medication , tell your doctor or pharmacist your medical history, especially of: kidney problems, hearing problems, severe loss of body water ( dehydration ), a certain muscle problem ( myasthenia gravis ), burns over a large area of[webmd.com]
Progressive Hearing Loss
  • A patient with bilateral Menière's disease who had progressive hearing loss and intractable vertigo was treated at ages 60 and 62 with parenteral streptomycin to ablate vestibular function, and at age 74 by a left endolymphatic shunt procedure.[ncbi.nlm.nih.gov]
Distractibility
  • His legal advisers had told him bluntly that it was a distraction. As one lawyer wrote, the missing page was “insignificant.” As for the professor’s story that Dr. Schatz’s uncle had carried off the key 1943 notebook, Dr.[nytimes.com]
Vertigo
  • The first reported use of streptomycin in the treatment of vertigo was in 1948. This was soon followed by its use for treating Menière's disease.[ncbi.nlm.nih.gov]
  • All 11 patients achieved relief of their disabling vertigo. One patient had recurrent vertigo 1 year after treatment and streptomycin perfusion of the labyrinth was performed subsequently.[ncbi.nlm.nih.gov]
  • Longer follow-up is required to judge the efficacy of LSI for controlling vertigo. We are currently studying these long-term results.[ncbi.nlm.nih.gov]
  • Perfusion of the perilymph with streptomycin through an opening in the bony lateral semicircular canal is the operation of choice for Meniere's disease, benign paroxysmal postural vertigo and other forms of vertigo.[ncbi.nlm.nih.gov]
  • Intramuscular dosages of streptomycin sulfate were titrated in eight patients with bilateral Meniere's disease in an attempt to alleviate disabling vertigo and hearing loss.[ncbi.nlm.nih.gov]
Dizziness
  • Stop using this medicine and check with your doctor right away if you or your child have sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears.[mayoclinic.org]
  • Possible side effects include injury to the kidneys and nerve damage that can result in dizziness and deafness. See study by P. Pringle (2012). The Columbia Electronic Encyclopedia, 6th ed. Copyright 2012, Columbia University Press.[infoplease.com]
  • . – Stop treatment in the event of dizziness, persistent giddiness, tinnitus or hearing defects (ototoxicity). – Drink sufficient liquid to limit the risk of renal toxicity. – Avoid or monitor combination with other ototoxic or nephrotoxic drugs (furosemide[medicalguidelines.msf.org]
  • You should let your doctor know if you experience any hearing loss, ringing sensations or other noise in the ears (tinnitus), dizziness or unsteadiness at any point during treatment.[netdoctor.co.uk]
  • An antibiotic, C 21 H 39 O 12 N 7, produced by the actinomycete Streptomyces griseus, used to treat tuberculosis and other bacterial infections. streptomycin Infectious disease An antibiotic used for TB Adverse effects N&V, dizziness, rash, fever, ototoxicity[medical-dictionary.thefreedictionary.com]
Oscillopsia
  • Although excellent control of vertigo was achieved significant post-treatment oscillopsia was experienced by these completely ablated patients.[ncbi.nlm.nih.gov]
  • It appears possible to eliminate the vertiginous episodes, preserve or improve hearing, and avoid ataxia and oscillopsia in most of these individuals.[ncbi.nlm.nih.gov]
  • None experienced oscillopsia in this series. In the entire group of 11 patients (22 ears), hearing was unchanged in 17 ears, improved in two and worse in three.[ncbi.nlm.nih.gov]

Treatment

  • A hearing threshold of 30 dB was found in two ears before and two after treatment; 30-60 dB was found in seven ears before and six after treatment; and 60 dB was found in 13 ears before and 14 after treatment.[ncbi.nlm.nih.gov]
  • […] in outcomes, which indicates that local preferences could dictate the treatment option.[ncbi.nlm.nih.gov]
  • The "dual" mode of treatment (surgery chemotherapy) reduced hospital admission period from 90 to 39.8 days, that's to 44.2%. This treatment for early stages could therefore replace surgery and in severe cases, is an indispensable aid before surgery.[ncbi.nlm.nih.gov]
  • Thirty-eight (76.0%) had previously used traditional treatment. Forty completed treatment and of these, 28 (70.0%) healed completely and 12 (30. 0%) improved by 80%-90%.[ncbi.nlm.nih.gov]
  • Soon after its discovery, streptomycin sulfate was found to be beneficial in the treatment of tuberculosis.[ncbi.nlm.nih.gov]

Prognosis

  • Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. Am J Gastroenterol 2010; 105: 2396-404.[livertox.nih.gov]
  • The MRC trial of streptomycin for pulmonary tuberculosis Given the uncertain prognosis of pulmonary tuberculosis and the limited supply of the drug, Bradford Hill proposed that it would be unethical not to assess what advantage streptomycin offered in[jameslindlibrary.org]
  • The prognosis of CF has improved, and thus side effects of treatments have become increasingly important.[doi.org]

Epidemiology

  • The presence of the C491T substitution in the rrs gene in streptomycin-susceptible and -resistant isolates demonstrates that this change is an epidemiological marker associated with LAM3 sublineage.[ncbi.nlm.nih.gov]
  • High-level gentamicin resistance in Enterococcus : microbiology, genetic basis, and epidemiology. Clin Infect Dis. 1990; 12:644-52. 31. Bhattacharya M, Warren JR.[drugs.com]
  • This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • This review of the current literature on side effects of aminoglycosides considers the pathophysiological mechanisms, epidemiology and risk factors, investigation of side effects and preventative strategies.[doi.org]

Prevention

  • […] antifungal agent used to prevent or treat fungal infections in humans or animals.[ebi.ac.uk]
  • To ensure adequate treatment of tuberculosis that is resistant to any single drug and to prevent emergence of multidrug-resistant tuberculosis, the American Thoracic Society and Centers for Disease Control and Prevention (CDC) recommend that most patients[web.archive.org]
  • Thus, our data highlighted that the combinations of specific components from essential oils and streptomycin were useful for the treatment of food-borne pathogens, which might help prevent the spread of antibiotic resistance through improving antibiotic[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!