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Streptozocin


Presentation

  • Eleven (44%) patients presented with a carcinoid syndrome. Nineteen (76%) patients presented with more than 10 liver nodules. One delayed case of ischemic cholecystitis was treated conservatively.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The present study necessitates further randomized clinical study of SO therapy in the treatment of ACC, mainly as adjuvant treatment immediately after curative intended surgery, and could be developed into a regular treatment regimen.[ncbi.nlm.nih.gov]
  • The aim of the present study was to determine the status of STZ usage in Japan and to evaluate the effectiveness and safety of STZ chemotherapy in Japanese NET patients. METHODS: A retrospective multi-center survey was conducted.[ncbi.nlm.nih.gov]
  • Hyperglycemia and hypoinsulinemia were evident 18 h after streptozocin injection, and significant hyperglucagonemia and acidosis were present at 36-48 h.[ncbi.nlm.nih.gov]
  • Abstract In the present study, we used streptozocin (STZ) to induce diabetes in rats and observed alterations in several physiologic functions and in monoamine content of different brain regions.[ncbi.nlm.nih.gov]
Abdominal Lymphadenopathy
  • Seven patients presented with extrahepatic progression with abdominal lymphadenopathies or metastases to the brain, ovary, adrenal gland, or lung.[ncbi.nlm.nih.gov]
Epigastric Mass
  • Tumor regression was verified by the disappearance of the epigastric mass, improvement of liver function, and reduction of serum gastrin levels to one third of the pretreatment level.[ncbi.nlm.nih.gov]
Blister
  • If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment: pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected[nlm.nih.gov]
Withdrawn
  • Affected organisms Humans and other mammals Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Drug Interactions All Drugs Approved Vet approved Nutraceutical Illicit Withdrawn Investigational Experimental Drug Interaction Unlock Additional[drugbank.ca]

Workup

  • 1859 Infectious Agents and Cancer 549 1860 Cancer of the Skin 1863 Melanoma 1889 Diagnostic Studies and Pretreatment Staging 1001 1908 Principles of Isolation Perfusion 701 1923 Intraocular Melanomas 1951 Invasion and Metastasis 117 1952 Metastatic WorkUp[books.google.com]

Treatment

  • Nine patients (56%) had stable disease while receiving treatment (range of treatment, 2-17 months). Six patients (38%) had progression of disease as their best response while receiving treatment.[ncbi.nlm.nih.gov]
  • Treatment with the combination also yielded a survival advantage over treatment with streptozocin alone (medians, 26 and 16 1/2 months), but this difference is not statistically significant.[ncbi.nlm.nih.gov]
  • The third patient received postoperative treatment with no effect on metastatic disease in the lungs, she died 9 months after start of treatment.[ncbi.nlm.nih.gov]
  • This patient's malignant gastrinoma responded to treatment with streptozocin and fluorouracil.[ncbi.nlm.nih.gov]
  • The results indicate that interferon treatment is superior to the combination of streptozocin plus 5-fluorouracil.[ncbi.nlm.nih.gov]

Prognosis

  • Compared to the most common pancreatic cancer—adenocarcinoma ( aka exocrine tumors), PNETs have a longer disease course and better prognosis; the 5-year survival rate is 42% for PNETs, but only about 5% to 6% for adenocarcinomas.[cancercommons.org]

Etiology

  • Nair, Understanding Type 1 Diabetes: Etiology and Models, Canadian Journal of Diabetes, 37, 4, (269), (2013). Ann T. Hanna-Mitchell, Giovanni W. Ruiz, Firouz Daneshgari, Guiming Liu, Gerard Apodaca and Lori A.[doi.org]

Epidemiology

  • Carcinoma of the Vulva 1528 Cancer of the Uterine Body 1543 Chemoprevention 609 1545 Uterine Sarcomas 1557 Gestational Trophoblastic Diseases 1564 Colon Cancer 1232 1574 Epothilones 455 1586 Genetic Predisposition 1390 1595 Epidemiology 1232 1604 Malignant[books.google.ro]
  • Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB (2008) One hundred years after ‘carcinoid’: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • He has served on NIH review panels in the neuroscience and drug discovery areas, including as founding Chair of the Pathophysiological Basis of Mental Disorders and Addictions study section, and is Associate Editor for the Journal of Pharmacology and[books.google.es]
  • Madias, An animal model of diabetic peripheral neuropathy and the pathophysiology of takotsubo syndrome: A proposal of an experiment, International Journal of Cardiology, 222, (882), (2016).[doi.org]
  • Fig. 2 Chemical formulas of alloxan, dialuric acid, butylalloxan, streptozotocin and methylnitrosourea Glucokinase inhibition Selective inhibition of glucose-induced insulin secretion is the major pathophysiological effect of the thiol group reactivity[doi.org]

Prevention

  • The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.[ebi.ac.uk]
  • Generally, if the early signs of nephrotoxicity are recognized, discontinuing streptozocin prevents severe renal failure. We report a patient treated for Hodgkin's disease with a combination regimen including streptozocin.[annals.org]
  • Your doctor will give you anti-sickness drugs to help prevent or control sickness. Take the drugs exactly as your nurse or pharmacist tells you. It is easier to prevent sickness than to treat it after it has started.[macmillan.org.uk]

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