Presentation
In most patients, multiple lacunar infarcts are also present in the basal ganglia, thalami, and pons 3. [radiopaedia.org]
This newly-published abstract reviews the clinical presentation of frontal-subcortical dementias, lists them, and suggests how they relate to cortical dementias. The classic “cortical dementia” is Alzheimer’s Disease. [brainsupportnetwork.org]
The loss of several subcortical afferents to prefrontal cortex may be responsible for the frontal cortical hypometabolism present in PSP. x [scite.ai]
Breaking away from prevailing views of dementia that rely heavily on the role of the cerebral cortex, the new perspective put forth here highlights white matter-cognition relationships, presenting an expanded view of dementia and its neurobiological origins [books.google.ae]
Abstract In this report, we present the cases of two 63-year-old women who developed high altitude cerebral edema complicated by the occurrence of permanent neuropsychiatric sequelae. [liebertpub.com]
Entire Body System
- Swelling
The pathological correlates of these hyperintensities are diverse and range from complete infarcts to astrocytic swelling (clasmatodendrosis). 46 Thus, although we have tentatively labeled one of the factors “small vessel disease” there may be other underlying [ahajournals.org]
- Pallor
Specific signs may provide diagnostic clues (Cooper and Greene, 2005) (e.g. the Argyll–Robertson pupil of neurosyphilis, optic disc pallor in vitamin B 12 deficiency, or cranial nerve signs in neurosarcoidosis). [neupsykey.com]
Psychiatrical
- Anhedonia
Clinical features[edit] Clinically subcortical dementia usually is seen with features like slowness of mental processing, forgetfulness, impaired cognition, lack of initiative-apathy, depressive symptoms (such as anhedonia, negative thoughts, loss of [en.wikipedia.org]
Neurologic
- Forgetful
Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease ), changes in speech, unsteady gait, clumsiness or frequent falls, changes in personality or mood or urinary symptoms. [my.clevelandclinic.org]
Its symptoms resemble that of Alzheimer’s and include forgetfulness, depression and deterioration of mental processes. Glossary Index [braintest.com]
• Subcortical dementia is a clinical syndrome characterized by slowness of mental processing, forgetfulness, impaired cognition, apathy, and depression. [jamanetwork.com]
Abstract Subcortical dementia is a clinical syndrome characterized by slowness of mental processing, forgetfulness, impaired cognition, apathy, and depression. [ncbi.nlm.nih.gov]
White matter demyelination is associated with subcortical dementia, which is characterized by slowness of information processing, forgetfulness, apathy depression, and impaired cognition. [freethesaurus.com]
- Apathy
White matter demyelination is associated with subcortical dementia, which is characterized by slowness of information processing, forgetfulness, apathy depression, and impaired cognition. [freethesaurus.com]
• Subcortical dementia is a clinical syndrome characterized by slowness of mental processing, forgetfulness, impaired cognition, apathy, and depression. [jamanetwork.com]
These pathologic lesions are associated with cognitive changes that include bradyphrenia, personality change (apathy, depression, and irritability), memory impairment, and impaired manipulation of acquired knowledge (calculation, abstraction). [medigoo.com]
Abstract Subcortical dementia is a clinical syndrome characterized by slowness of mental processing, forgetfulness, impaired cognition, apathy, and depression. [ncbi.nlm.nih.gov]
The principal features of subcortical dementia include bradyphrenia, impairment of executive function, recall abnormalities, visuospatial disturbances, depression, and apathy. [annualreviews.org]
- Apraxia
Clinical reports suggest that subcortical syndromes (eg, Parkinson's disease) involve less severe intellectual and memory dysfunction and lack the aphasia, agnosia, and apraxia typical of the cortical dementias (eg, dementia of the Alzheimer type). [jamanetwork.com]
Aphasia, apraxia, and agnosia are commonly seen in the cortical dementias, but are absent in the subcortical dementias. [medigoo.com]
The clinical characteristics of subcortical dementia differ from those of dementia of Alzheimer's type where prominent cerebral cortical involvement produces aphasia, amnesia, agnosia, and apraxia. [ncbi.nlm.nih.gov]
Subcortical dementia differs from other dementia such as Alzheimer's where prominent cerebral cortical involvement produces aphasia, amnesia, agnosia, and apraxia. [youtube.com]
- Amnesia
The clinical characteristics of subcortical dementia differ from those of dementia of Alzheimer's type where prominent cerebral cortical involvement produces aphasia, amnesia, agnosia, and apraxia. [jamanetwork.com]
Table 13.5 Causes of amnesia Transient Transient global amnesia Transient epileptic amnesia Head injury Alcoholic blackouts Post-electroconvulsive therapy Post-traumatic stress disorder Psychogenic fugue Amnesia for criminal offence Persistent (amnestic [neupsykey.com]
Subcortical dementia differs from other dementia such as Alzheimer's where prominent cerebral cortical involvement produces aphasia, amnesia, agnosia, and apraxia. [youtube.com]
Retrograde amnesia in patients with Alzheimer’s disease or Huntington’s disease. Neurobiology of Aging, 9, 181–186. Blessed, G., Tomlinson, B. E., & Roth, M. (1968). [pubs.asha.org]
- Memory Impairment
Other symptoms to look into include: Memory Memory dysfunctions tend to occur in both groups of dementia. Studies, however, propose that the nature of memory impairment is different in subcortical and cortical dementia. [readementia.com]
Cortical dysfunction leads to aphasia, agnosia, amnesia, and acalculia; subcortical dysfunction slows information processing and adversely affects memory, cognition, mood, and motivation.[6] Memory impairment is characterised by a greater deficit of spontaneous [go.gale.com]
These pathologic lesions are associated with cognitive changes that include bradyphrenia, personality change (apathy, depression, and irritability), memory impairment, and impaired manipulation of acquired knowledge (calculation, abstraction). [medigoo.com]
Memory impairment 2, other cognitive impairment B. These impairments cause dysfunction in In social or occupational activities C. Course shows gradual onset and decline D. Deficits are not due to: 1. Other cns conditions 2. [slideshare.net]
Treatment
Based on detailed patient observations, extensive clinical research and an exhaustive literature review, this book discusses the novel concept of white matter dementia, offering hope for better understanding and treatment of dementing illness. [books.google.ae]
Attempting to control symptoms and keep patients as comfortable as possible is currently the best treatment method. [caregiverrelief.com]
Treatment: Although subcortical dementia is a progressive deterioration of the brain, a diagnosis must be made before treatment is given. The amount of damage this disease causes directly relates to the cause of the dementia. [medigoo.com]
NPH Treatment and Prognosis Unlike other forms of dementia, there are some effective treatments for NPH. [kindlycare.com]
Treatment and Management Treatments and management of dementia generally have focused most on Alzheimer's disease since it's the most common cause of dementia. [verywellhealth.com]
Prognosis
Prognosis The prognosis of cortical and subcortical dementias varies significantly. Several different types of dementia fall into these categories, and progression is affected by a multitude of factors. [verywellhealth.com]
Prognosis The prognosis of cortical and subcortical dementia also significantly varies. Because different types of dementias fall under these two categories, multiple factors commonly affect prognosis. [readementia.com]
NPH Treatment and Prognosis Unlike other forms of dementia, there are some effective treatments for NPH. [kindlycare.com]
Catching vascular dementia early and preventing further damage makes for a better prognosis. [explainingmedicine.com]
SLIDESHOW Dementia, Alzheimer's Disease, and Aging Brains See Slideshow What is the prognosis for Binswanger's disease? Binswanger's disease is a progressive disease; there is no cure. [medicinenet.com]
Etiology
Recent reports that the… Expand Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by a… Expand Vascular dementia (VAD) is common, and small vessel disease is one of the most frequent etiologies [semanticscholar.org]
Article / Publication Details First-Page Preview Abstract Vascular dementia (VAD) is common, and small vessel disease is one of the most frequent etiologies of the disorder. [karger.com]
Submit Your Research The journal publishes study results related to dementia and Alzheimer's Disease, with an emphasis on interdisciplinary investigations and integrative/translational articles related to: etiology, risk factors, early detection, disease [alz-journals.onlinelibrary.wiley.com]
Most importantly, the underlying etiologies are those of well-recognized vascular risk factors, and this is, therefore, a form of cognitive impairment that is amenable to prevention as well as symptomatic relief. [medlink.com]
ETIOLOGY NEURO- DEGENERATIVE Alzheimer's Ds; Dementia with Lewy Bodies; Fronto- temporal dementia; Parkinson’s Ds VASCULAR Infarction; Hemodynamic insufficiency NEUROLOGICAL Multiple Sclerosis; Normal Pressure Hydrocephalus ENDOCRINE Hypothyroidism NUTRITIONAL [slideshare.net]
Epidemiology
P 30046879 2018 4 Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance, Cortical Atrophy, and Network Measures in a Memory Clinic Population. 38 Banerjee G...Werring DJ 29843234 2018 5 HIV-1-associated neurocognitive disorder: epidemiology [malacards.org]
Epidemiological studies have shown that sVAD shares with cerebrovascular disease most of the common risk factors. The molecular basis of this pathology remains controversial. [dovepress.com]
Open Access Article 1 Department of Epidemiology. Fay W. [mdpi.com]
EPIDEMIOLOGY ~ 5 to 8 % at age 65 to 70 ~ 15 to 20 % at age 75 to 80 up to 40 to 50 % over age 85 • Alzheimer's disease is most common dementia 50-75% • Dementia with Lewy bodies 15 to 35 % • Vascular dementia 5 – 20 % 5. [slideshare.net]
Epidemiology of early-onset dementia: a review of the literature. Clinical practice and epidemiology in mental health: CP & EMH 2013;9:88. Ye BS, Seo SW, Kim GH, et al. [researchsquare.com]
Pathophysiology
However, in "subcortical" dementia these high-level behaviours are less affected.[4] Pathophysiology[edit] In most common types of dementias there is widespread degeneration in the cerebral cortex – such as the plaques and neuro fibrillary tangles which [en.wikipedia.org]
Parkinson’s disease: Pathophysiology. Lancet, 337, 1321–1324. Albert, M. L., Feldman, R. G., & Willis, A. L. (1974). The “subcortical dementia” of progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry, 37, 121–130. [pubs.asha.org]
Biomarkers of AD pathophysiology involve cerebrospinal fluid (CSF) Aβ 1−42 plaque deposition, tau accumulation and neurodegeneration 13, 14, which are collectively referred to as ATN. [researchsquare.com]
Neuropsychology, neuropsychiatry and pathophysiology. British Journal of Psychiatry, 149, 682 – 697. Cummings, J. L. ( 1995 ) Behavioural and psychiatric symptoms associated with Huntington's disease. [cambridge.org]
Perceptual disturbances Delusions Perplexity Thought disorder Behavioural and other symptoms Agitation Irritability Labile affect Word-finding difficulties Temporal course Rapid onset Fluctuation over 24-hour period Reversal of sleep–wake cycle The pathophysiological [neupsykey.com]
Prevention
The best thing you can do if you don't have the disease already is to do what you can to prevent it. Prevention For people who don't have dementia right now, there may be some things you can do to prevent it. [betterhelp.com]
Alzheimer's disease, the author reconsiders brain-behavior relationships and expands the concept of dementia, discussing implications for diagnosis, treatment (medical, surgical, rehabilitative, and psychiatric) and therapeutic innovations aimed at prevention [books.google.ae]
Preventing Dementia Although research has yet to discover why Parkinson’s and Huntington’s disease is triggered in certain individuals, belief that a genetic component may exist to explain the origin of the disease is a theory popular among neurologists [caregiverrelief.com]
Much of this research focuses on finding better ways to prevent, treat, and ultimately cure neurological disorders, such as Binswanger's disease. [medicinenet.com]
[…] journal publishes study results related to dementia and Alzheimer's Disease, with an emphasis on interdisciplinary investigations and integrative/translational articles related to: etiology, risk factors, early detection, disease modifying interventions, prevention [alz-journals.onlinelibrary.wiley.com]