It usually presents in neonates who have experienced perinatal difficulty such as asphyxia, peripheral hypoxemia, hypothermia, meconium aspiration or trauma. [ncbi.nlm.nih.gov]

[…] disorder of infants in good health with lesions on trunk, extremities, buttocks, cheeks Hypercalcemia has been reported in some cases; thrombocytopenia, hypoglycemia and hypertriglyceridemia may also develop Lactic acidosis and hyperferritinemia were each present [pathologyoutlines.com]

• Generalized Lymphadenopathy

  Subcutaneous fat necrosis of the newborn mimicking generalized lymphadenopathy. Indian J Dermatol Venereol Leprol 2007;73:357-8 How to cite this URL: Pai SA, Nagesh K, Radhakrishnan C N. [ijdvl.com]

• Subcutaneous Nodule

  Erythematous to violaceous, firm, subcutaneous nodules appear approximately 1 to 4 weeks after delivery, preceding the development of signs and symptoms of hypercalcemia. [utexas.influuent.utsystem.edu]

  We discuss four cases of SFN at term or post-term that developed painful subcutaneous nodules. [austinpublishinggroup.com]

  Indurated, well delimited and mobile subcutaneous nodules over the back at 23 days of life. B. [endopedonline.com.ar]

• Pyuria

  Pyuria (20- 25 WBC / HPF), hypercalcaemia (ca = 13.5mg/dl, P = 3.5mg/dl, Alk .ph = 326), hyperammonia (160mg/dl), hyperuricemia (7.2mg/dl), hypertriglyceridemia (415mg/dl) were detected as abnormal laboratory findings. [pjms.com.pk]

• Base Deficit

  The cord arterial pH was 6.85 and the base deficit 18.1 mmol/l. Blood cultures were drawn, and the infant received amoxicillin and gentamicin. A chest radiograph showed cardiac enlargement with clear lung fields. [fn.bmj.com]

Furthermore, the immediate postnatal period was complicated by pain resistant to treatment with opiates. [ncbi.nlm.nih.gov]

The deep nodules usually occur within 1 to 30 days after the cessation of high-dose steroid treatment. Traumatic fat necrosis has focal areas of necrosis and inflammation but lacks the crystals in the fat. [dermaamin.com]

Corticosteroid treatment was discontinued after one week, and the special milk formula and diuretics after one month. [fn.bmj.com]

SN is associated with a poor prognosis. [ncbi.nlm.nih.gov]

[…] usually good; hypercalcemia associated with poor prognosis severity correlates with mortality; many infants die in a few days Occasional patients may show a mixed pattern with features of both syndromes. [meducator3.net]

This review attempts to put into perspective their similarities and differences in light of historical, biochemical, pathologic, and etiologic considerations. Recent therapeutic modalities and the prognosis are discussed. [ncbi.nlm.nih.gov]

Etiology Different predisposing factors play an important role in the etiology of subcutaneous fat necrosis of the newborn. [drmhijazy.com]

The etiology of this disorder is probably ischemic injury to subcutaneous fat. Lesions often develop at sites of pressure. Figure 22-2 The infants develop single or multiple firm red-purple nodules or plaques that are asymptomatic. [accesspediatrics.mhmedical.com]

Clinical Features: Indurated erythematous or violaceous nodules of unknown etiology appearing in the first few weeks of life Affects full-term or post-term infants. [dermpedia.org]

Translated title: Fat necrosis of the newborn: report of two cases Author(s): 1, &, Anass Es Seddiki 1, Mounia Chaalal 2, Rim Amrani 1 Publication date (Electronic): 16 September 2015 Journal: The Pan African Medical Journal Publisher: The African Field Epidemiology [scienceopen.com]

There are no epidemiologic data available for SCFN. [humpath.com]

[…] maternal hypercoagulable state such as protein C deficiency and antiphospholipid syndrome. [23] Local pressure trauma during delivery from forceps, from prolonged labor, and from being large for gestational age (macrosomia) may play a role. [20, 21] Epidemiology [emedicine.com]

SCFN and BAT can be found at the same sites, suggesting a pathophysiological connection. [ncbi.nlm.nih.gov]

DISCUSSION SCFN is a rare, often painful condition of unknown pathophysiology. [fn.bmj.com]

The pathophysiology of hypercalcaemia is not known completely but calcium release from necrotic fat cells and production of 1, 25 (OH) 2 vit D from granulomatous cells (like macrophages) result to prostaglandin production which increases osteoclatsic [pjms.com.pk]

Subcutaneous fat necrosis of the newborn usually runs a self-limited course, but it may be complicated by hypercalcemia and other metabolic abnormalities. [1, 2] Pathophysiology The exact pathogenesis of subcutaneous fat necrosis of the newborn (SFNN) [emedicine.com]

Physicians caring for infants with subcutaneous fat necrosis of the newborn should be aware of the above associations in order to provide prompt and appropriate treatment to prevent associated, undesirable sequelae. [ncbi.nlm.nih.gov]

The early diagnosis and prompt treatment of hypercalcemia are essential to prevent severe complications. Keywords: Hypercalcemia; Fat Necrosis; Infant, Newborn; Nephrocalcinosis; Subcutaneous Fat. Refbacks There are currently no refbacks. [actamedicaportuguesa.com]

Elevated serum calcium may persist long after the withdrawal of cutaneous lesions, which is the reason for continuous monitoring of serum calcium and appropriate treatment in case of hypercalcemia in order to prevent metastatic calcifi cation. [paedcro.com]

In order to prevent other complications resulting from hypercalcemia, regular follow-up for calcium levels is recommended in these patients. [3], [4] Our patient had no hematologic or metabolic abnormality. [jcnonweb.com]

[…] caregiver's knowledge in the management of pediatric atopic dermatitis Pediatric Dermatology, 2019 Jan;36(1):105-109 2019年2月 新生児の皮膚ケア：新生児のバリア機能を維持するためのケアとおむつ皮膚炎の予防の発展 Neonatal skin care: Developments in care to maintain neonatal barrier function and prevention [maruho.co.jp]