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Subependymoma
Presentation
- By presenting our case report, we hope to draw attention to this rare but potentially life-threatening presentation of subependymoma.[ncbi.nlm.nih.gov]
- Clinical presentation, radiological, and pathological studies of this case of subependymoma are presented. The incidence of spinal subependymoma was also discussed in light of a literature review.[ncbi.nlm.nih.gov]
- They often present clinically with pain and neurologic symptoms, including motor, sensory, urinary, and sexual dysfunction.[ncbi.nlm.nih.gov]
- The tumor presented here is unique in that several atypical pathological features were found in an otherwise typical subependymoma.[ncbi.nlm.nih.gov]
- This 39-year-old man presented with a 6-month history of occipital headaches. Magnetic resonance imaging revealed an irregularly shaped fourth ventricle mass.[ncbi.nlm.nih.gov]
Hematological
Spontaneous Hemorrhage
- A spontaneous hemorrhagic event within an asymptomatic lateral ventricle subependymoma can result in a surgical emergence as a consequence of sudden obstruction of cerebrospinal fluid pathways.[ncbi.nlm.nih.gov]
Entire Body System
Asymptomatic
- Subependymoma is a rare low-grade glioma of the central nervous system that is often asymptomatic and discovered incidentally. If symptomatic, however, its clinical features vary widely.[ncbi.nlm.nih.gov]
- The patient's tumor was asymptomatic for many years. Imaging findings included asymmetry of the lateral ventricles.[ncbi.nlm.nih.gov]
- They usually occur in elderly men and often are asymptomatic and discovered incidentally. We report a case of a 6-year-old girl with a symptomatic subependymoma in the third ventricle with MR imaging.[ncbi.nlm.nih.gov]
- To the authors' knowledge, this is the first reported case of rapid, nonhemorrhagic expansion associated with necrosis in a previously asymptomatic subependymoma.[ncbi.nlm.nih.gov]
- Subependymomas are benign intraventricular tumors with an indolent growth pattern, which are usually asymptomatic, and most commonly occur in the fourth and lateral ventricles.[ncbi.nlm.nih.gov]
Swelling
- It filled his entire right lateral ventricle causing massive swelling.[chicagonow.com]
- Case: A 13 years old male patient applied to our outpatient clinic with a pain and swelling in sacrococcygeal area. He had these complaints about 18 months.In his physical examination a firm, well circumscribed immobile lesion (mass?)[bildirim.org]
Coronary Atherosclerosis
- Coronary atherosclerosis and mild cardiac hypertrophy were present as the only pathologic changes outside the central nervous system. The cause of death is discussed in light of earlier reports on brain tumours and sudden fatal incidents.[ncbi.nlm.nih.gov]
Gastrointestinal
Nausea
- She had a 2-month history of progressive headache, neck stiffness and nausea. Computed tomography revealed hydrocephalus for which a ventriculoperitoneal shunt was inserted.[ncbi.nlm.nih.gov]
- We report a case of a large, heterogeneously enhancing, pathologically proven, supratentorial subependymoma in a 31-year-old male patient presenting with headache, nausea and vomiting as well as gait disturbances.[ncbi.nlm.nih.gov]
- A 63-year-old man was admitted to our hospital because of loss of memory, disorientation, nausea, and urinary incontinence.[ncbi.nlm.nih.gov]
- For several years he had suffered with nausea and vomiting, and now presented signs of direct involvement of the posterior fossa.[ncbi.nlm.nih.gov]
- The most common clinical presentations included ataxia (n 4), dizziness/vertigo (n 3), nausea/vomiting (n 3), headaches (n 3), and incidental finding at autopsy (n 2).[ncbi.nlm.nih.gov]
Overeating
- Over half were entirely intraventricular, 6 extended into brain substance and 2 into subarachnoidal cisterns. Twelve were isodense, 15 showed diffuse but irregular enhancement, and 5 contained nodular calcification.[ncbi.nlm.nih.gov]
- A 37-year-old female presented with a rare spinal subependymoma manifesting as progressive weakness of her right lower extremity over an 8-month period. She had a 10-year history of back pain and urinary disturbance.[ncbi.nlm.nih.gov]
- Highlights of this edition include over 6,800 images of remarkable quality, more color images, and new information using advanced techniques, including perfusion and diffusion MRI and functional MRI.[books.google.com]
- The great majority of these neuroglial heterotopias were located over the brain stem and were topographically close to the subependymomas.[ncbi.nlm.nih.gov]
Eyes
Aniridia
- We observed an unusually large subependymoma in a female patient with congenital aniridia. To analyze the genetic mechanisms of tumorigenesis, we first examined the paired box 6 (PAX6) gene using both tumor tissue and peripheral lymphocytes.[ncbi.nlm.nih.gov]
- Maekawa M, Fujisawa H, Iwayama Y, Tamase A, Toyota T, Osumi N, Yoshikawa T Giant subependymoma developed in a patient with aniridia: analyses of PAX6 and tumor-relevant genes. Brain Pathol.20(6):1033-41.[path.upmc.edu]
Urogenital
Sexual Dysfunction
- They often present clinically with pain and neurologic symptoms, including motor, sensory, urinary, and sexual dysfunction.[ncbi.nlm.nih.gov]
- Two years later, with hormone replacement therapy (desmopressin, hydrocortisone, levothyroxine, testosterone undecanoate) there was no sexual dysfunction.[endocrine-abstracts.org]
Incontinence
- A 63-year-old man was admitted to our hospital because of loss of memory, disorientation, nausea, and urinary incontinence.[ncbi.nlm.nih.gov]
- Due to spinal cord compression from these tumors, patients usually present with neurological deficits such as paresis, dysesthesias, or incontinence.[sciforschenonline.org]
Neurologic
Headache
- She had a 2-month history of progressive headache, neck stiffness and nausea. Computed tomography revealed hydrocephalus for which a ventriculoperitoneal shunt was inserted.[ncbi.nlm.nih.gov]
- We report a case of a large, heterogeneously enhancing, pathologically proven, supratentorial subependymoma in a 31-year-old male patient presenting with headache, nausea and vomiting as well as gait disturbances.[ncbi.nlm.nih.gov]
- We describe a case of infratentorial, intraparenchymal subependymoma in a 28-year-old man with intermittent headache. Imaging revealed a well-demarcated cystic and solid cerebellar mass near the fourth ventricle.[ncbi.nlm.nih.gov]
- In this report, we describe a case of subependymoma of the lateral ventricle with headache in a young female patient. This is the first reported case subependymoma in Korea that was documented along with Magnetic resonance image.[ncbi.nlm.nih.gov]
- This 39-year-old man presented with a 6-month history of occipital headaches. Magnetic resonance imaging revealed an irregularly shaped fourth ventricle mass.[ncbi.nlm.nih.gov]
Myelopathy
- The patient experiencing myelopathy symptoms underwent a surgical resection of cervical spinal cord subependymoma that resulted in return to normal function.[ncbi.nlm.nih.gov]
- Most of the intraventricular subependymomas are subclinical and thus incidentally encountered at autopsy, whereas the spinal ones are inevitably accompanied by myelopathy and are often diagnosed clinically as ependymomas or astrocytomas.[ncbi.nlm.nih.gov]
- CONCLUSIONS: Subependymomas are indolent tumors that when symptomatic can present with cerebrospinal fluid (CSF) obstructive symptoms in the brain and myelopathy in the spinal cord. There is no one symptom diagnostic for subependymomas.[ncbi.nlm.nih.gov]
- Conclusions: Subependymomas are indolent tumors that when symptomatic can present with cerebrospinal fluid (CSF) obstructive symptoms in the brain and myelopathy in the spinal cord. There is no one symptom diagnostic for subependymomas.[jhu.pure.elsevier.com]
Meningism
- The autopsy showed brain and pulmonary edema, numerous small meningeal meningiomas, bilateral and symmetrical juxtaventricular meningiomas, and a well-demarcated gray tan tumor in the medulla oblongata and upper cervical spinal cord.[ncbi.nlm.nih.gov]
- A 76-year-old woman with a 2-year history of progressive weakness of the left arm and leg underwent a laminectomy for an intradural, extramedullary, pedunculated subependymoma involving the meninges and spinal nerve roots at C7-T1.[ncbi.nlm.nih.gov]
- Rubinstein considers that in some instances the lesions may be reactive in nature; he quotes one instance of chronic granular cryptococcal ependymitis and meningitis associated with subependymoma.[ependymomas.com]
Long Tract Signs
- Patients with intraspinal subependymomas initially presented with back pain and long-tract signs. The tumors were hyperintense on T2-weighted MR imaging, isointense on T1-weighted imaging, and noncontrast enhancing.[ncbi.nlm.nih.gov]
- Results Patients with intraspinal subependymomas initially presented with back pain and long-tract signs. The tumors were hyperintense on T2-weighted MR imaging, isointense on T1-weighted imaging, and noncontrast enhancing.[doi.org]
Altered Mental Status
- The patient developed sudden onset of headache and altered mental status followed by complete resolution, likely due to intermittent hydrocephalus.[ncbi.nlm.nih.gov]
Workup
- Conclusions: The case is an educative example about the necessity to keep possible intracranial lesions in mind when starting the workup of a patient presenting with erectile dysfunction.[endocrine-abstracts.org]
- 4th ventricle, symptoms are related to obstruction and subsequently increased intracranial pressure In spinal ependymomas, presentation is typically with sensory deficits (compared with astrocytomas, which tend to present with pain and motor symptoms) Workup[en.wikibooks.org]
HLA Type
HLA-DR2
- She was positive for HLA-DR2. At autopsy there was a tumour dorsal to the fourth ventricle which involved the midbrain tectum and rostral pons. Histologic examination of the tumour confirmed it to be a subependymoma.[ncbi.nlm.nih.gov]
Treatment
- Consequently, we explore the SEER database to evaluate prognostic and treatment factors associated with intracranial subependymoma.[ncbi.nlm.nih.gov]
- After a careful review of the literature, the optimal treatment of this spinal tumour is debated.[ncbi.nlm.nih.gov]
- The child may have had treatment to relieve signs or symptoms caused by the tumor. Subependymoma Treatment of newly diagnosed subependymoma (WHO ... 4 ...[familydiagnosis.com]
- Surgical extirpation is one of the treatment options to establish the correct diagnosis and to prevent symptoms.[ncbi.nlm.nih.gov]
- We document a successful case of radiosurgical treatment of a multiply recurrent subependymoma.[ncbi.nlm.nih.gov]
Prognosis
- The pathology, the clinical findings and the prognosis of this tumour are discussed.[ncbi.nlm.nih.gov]
- Although radical removal is considered the rational goal of treatment, larger experience is necessary to know both the rate of growth and prognosis of subependymomas when these tumors arise within the spinal cord.[ncbi.nlm.nih.gov]
- They are biologically benign with low proliferative index, hence postoperative prognosis is very good. We present a case of a 42-year-old male patient with an intramedullary Subependymoma located within the central canal of thoracic region cord.[ncbi.nlm.nih.gov]
- Recognition of subependymoma should prompt the surgeon to attempt radical tumor removal because it can be achieved without sacrificing contiguous tissue and carries a good prognosis.[ncbi.nlm.nih.gov]
- Tumors, attached to the floor of the fourth ventricle carry the worst prognosis, because of the location. A mixed ependymomasubependymoma carries a worse prognosis than a pure subependymoma.[ependymomas.com]
Etiology
- This case lends support to the notion that some subependymomas are reactive in etiology.[ncbi.nlm.nih.gov]
- Subependymomas have been described with features identical to this case, however, since these commonly present as non-enhancing intraventricular lesions [5,7], it was felt to be a less likely etiology.[sciforschenonline.org]
Epidemiology
- Epidemiology Subependymomas are often asymptomatic tumors discovered on autopsy. Autopsy series have estimated that subependymomas account for 8.3% of all ependymal tumors.[prod.wiki.cns.org]
- Accessed on January 12, 2016 6.0 6.1 Epidemiology of subependymoma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. . Accessed on January 12, 2016 7.0 7.1 Clinical presentation of subependymoma.[wikidoc.org]
- general Benign slowly growing neoplasm typically attached to a ventricular wall Cell of origin unknown but resembles subependymal tissue Slow growing; 50% have symptoms (associated with larger size or specific locations, J Neurosurg 1978;49:689 ) Epidemiology[pathologyoutlines.com]
- Jump to navigation Jump to search Epidemiology [ edit ] 5-10% of pediatric brain tumors Primarily in infants and children Approximately 200 pediatric cases per year in USA Location [ edit ] Glial tumors that arise from ependymal lining of the ventricular[en.wikibooks.org]
Sex distribution
Age distribution
Pathophysiology
- It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care.[books.google.com]
- Subependymal astrocytoma; Subependymal astrocytomas Overview Subependymoma is a type of brain tumor; specifically, it is a rare form of ependymal tumors. [1] Subependymoma is a benign ( WHO grade I ) tumor, which is slow growing and non-invasive. [2] Pathophysiology[wikidoc.org]
Prevention
- Surgical extirpation is one of the treatment options to establish the correct diagnosis and to prevent symptoms.[ncbi.nlm.nih.gov]
- Prompt and radical surgical removal of the mass, which allows a rapid resolution of hydrocephalus and prevents the risk of rebleeding, may constitute the safest management strategy.[ncbi.nlm.nih.gov]
- Establishing the correct preoperative diagnosis is important to prevent unnecessary surgical intervention.[ncbi.nlm.nih.gov]
- Prevention - Subependymoma Not supplied. Diagnosis - Subependymoma Not supplied. Prognosis - Subependymoma Subependymal tumors are slow growing tumors. Surgical resection alone often offers a cure.[checkorphan.org]