Suberosis presentation is similar to other hypersensitivity pneumonitis types. It may induce bronchial asthma or impaired gas exchange symptoms [1]. Patients have different complaints depending on the time of presentation. During the acute form, that occurs several hours after exposure, affected individuals have dyspnea, cough, chest tightness, malaise and flu-like symptoms, such as fever, chills, and headache that disappear in 12 hours up to several days after exposure has been discontinued, but may re-appear if exposed again to the etiologic factors. Clinical examination reveals tachypnea and basal bilateral fine crackles, as well as mild wheezing in certain cases. The subacute form develops in people that are still exposed to the causative agent. They complain about anorexia, weight loss, and persistent respiratory signs, like a productive cough and dyspnea. Clinical findings are similar but usually less severe. Fatigability sets in an insidious manner. In the chronic phase, the same findings are noted; the only difference is that they become progressively worse and have insidious onset [2]. Muscle wasting, digital clubbing, respiratory distress and inspiratory crackles are often noticed. If a chronic hypersensitivity pneumonitis patient develops a superimposed acute episode, the presentation may be dramatic, with severe respiratory distress and ventilation support may be needed.

• Exposure to Moldy Cork Dust

  Wikipedia Suberosis Suberosis, also known as corkhandler's disease or corkworker's lung, is a type of hypersensitivity pneumonitis usually caused by the fungus Penicillium glabrum (formerly called Penicillum frequentans) from exposure to moldy cork dust [findwords.info]

  […] to moldy cork dust. suberosis ( uncountable ) A type of hypersensitivity pneumonitis usually caused by the fungus Penicillium glabrum after exposure to moldy cork dust. pneumonoultramicroscopicsilicovolcanoconiosis abatis abiogenesis absis is gnosis [engyes.com]

  […] translation and definition "suberosis", Dictionary English-English online suberosis Definitions [noun] A type of hypersensitivity pneumonitis usually caused by the fungus Penicillium glabrum after exposure to moldy cork dust. [glosbe.com]

  Suberosis Suberosis also known as Corkhandler disease or Corkworker Lung is a type of hypersensitivity pneumonitis usually caused by the fungus Penicillium glabrum (formerly called Penicillum frequentans) from Exposure to moldy cork dust. [codelay.com]

  Suberosis Suberosis, also known as corkhandler`s disease or corkworker`s lung, is a type of hypersensitivity pneumonitis usually caused by the fungus Penicillium glabrum (formerly called Penicillum frequentans) from exposure to moldy cork dust. [encyclo.co.uk]

• Fever

  During the acute form, that occurs several hours after exposure, affected individuals have dyspnea, cough, chest tightness, malaise and flu-like symptoms, such as fever, chills, and headache that disappear in 12 hours up to several days after exposure [symptoma.com]

  Early symptoms include fever and flu-like symptoms. A few days later the skin begins to blister and peel forming painful raw areas. [najdi.si]

• Pain

  Does... [ Read More ] Hi there I am looking for feedback on where your surgeons document the post op pain management reassignment to anesthesiology when your anesthesiologists perform the post ... [ Read More ] In the state of Georgia are Anesthesia Assistant [coder.aapc.com]

  A few days later the skin begins to blister and peel forming painful raw areas. Mucous membranes, such as the mouth, are also typically involved. https://en.wikipedia.org/wiki/Toxic_epidermal_necrolysis [najdi.si]

• Cough

  Disease/Syndrome Suberosis Category Hypersensitivity Pneumonitis Synonyms Cork-handlers' lung Comments Acute presentation: flu-like illness with cough; Subacute: recurrent "pneumonia"; Chronic: exertional dyspnea, productive cough, and weight loss; The [haz-map.com]

  They complain about anorexia, weight loss, and persistent respiratory signs, like a productive cough and dyspnea. Clinical findings are similar but usually less severe. Fatigability sets in an insidious manner. [symptoma.com]

  Dyspnea and cough were the most frequent symptoms. Clinical and functional improvement occurred after antigen avoidance. CONCLUSIONS: In addition to P frequentans, A fumigatus and cork dust itself may contribute to the development of suberosis. [ncbi.nlm.nih.gov]

  Dyspnea and cough were the most frequent symptoms. Clinical and functional improvement occurred after antigen avoidance. Conclusions: In addition to P frequentans, A fumigatus and cork dust itself may contribute to the development of suberosis. [go.gale.com]

• Dyspnea

  They complain about anorexia, weight loss, and persistent respiratory signs, like a productive cough and dyspnea. Clinical findings are similar but usually less severe. Fatigability sets in an insidious manner. [symptoma.com]

  Dyspnea and cough were the most frequent symptoms. Clinical and functional improvement occurred after antigen avoidance. CONCLUSIONS: In addition to P frequentans, A fumigatus and cork dust itself may contribute to the development of suberosis. [ncbi.nlm.nih.gov]

  Disease/Syndrome Suberosis Category Hypersensitivity Pneumonitis Synonyms Cork-handlers' lung Comments Acute presentation: flu-like illness with cough; Subacute: recurrent "pneumonia"; Chronic: exertional dyspnea, productive cough, and weight loss; The [haz-map.com]

  Dyspnea and cough were the most frequent symptoms. Clinical and functional improvement occurred after antigen avoidance. Conclusions: In addition to P frequentans, A fumigatus and cork dust itself may contribute to the development of suberosis. [go.gale.com]

• Pneumonia

  ← Return Also described as suberosis There are 103 cases described in 7 citations Citation Antigens Cases 2019 Suberosis: Case report of acute hypersensitivity pneumonia Ferreira, C., et al. Revista Portuguesa de Imunoalergologia. [hplung.com]

  Disease/Syndrome Suberosis Category Hypersensitivity Pneumonitis Synonyms Cork-handlers' lung Comments Acute presentation: flu-like illness with cough; Subacute: recurrent "pneumonia"; Chronic: exertional dyspnea, productive cough, and weight loss; The [haz-map.com]

  […] effective 10/1/2017) : No change 2019 (effective 10/1/2018) : No change Corkhandler's disease or lung J67.3 Corkworker's disease or lung J67.3 Disease, diseased - see also Syndrome corkhandler's or corkworker's J67.3 Pneumonitis (acute) (primary) - see also Pneumonia [icd10data.com]

• Pulmonary Disorder

  Symptoms Asthma and feverish pulmonary disorders follow each other and are associated with unstable pulmonary infiltrates. Diagnostic methods Skin tests with moulds are possible in principle. [phadia.com]

• Dysphagia

  I found sites that say to use U1 or U2 but they are for phys... [ Read More ] if a pt is having an EGD w BX for dysphagia and a screening colonoscopy turned BX .... Would you code 00813 PT ? ... [ Read More ] Hello everyone! [coder.aapc.com]

• Denial

  We are receiving denials that this provider ... [ Read More ] Are there new CMS CCI edits for billing out 93312, 93320 & 93325 for anesthesiologists. We are getting denials from all insurance providers when we bill for these. [coder.aapc.com]

• Headache

  During the acute form, that occurs several hours after exposure, affected individuals have dyspnea, cough, chest tightness, malaise and flu-like symptoms, such as fever, chills, and headache that disappear in 12 hours up to several days after exposure [symptoma.com]

Blood workup in suberosis should include a complete cell blood count, that will demonstrate neutrophilia in many cases. Inflammatory markers, such as C-reactive protein and erythrocyte sedimentation rate, as well as serum immunoglobulins may be increased. More specific information is provided by the bronchoscopic alveolar lavage, that will demonstrate the presence and predominance of lymphocytes. The alveolar lavage fluid and the serum contain precipitate antibodies against the causative antigens, thus demonstrating sensitization, but not the disease itself. On the other hand, some victims that present with typical history and clinical signs, have no detectable antibodies. In these instances, the enzyme-linked immunosorbent assay testing for a wider panel of precipitins may shed light on the case.

The simple thoracic radiograph shows no pathognomonic findings. However, diffuse, reticulonodular or micronodular interstitial patterns are often described [3]. In the chronic phase, fibrotic scars and linear opacities are present and emphysema may be described. High-resolution computer tomography scans are valuable in appreciating the presence of ground-glass opacities, traction bronchiectasis and honeycombing [4].

When the diagnosis cannot be otherwise defined, a pulmonary biopsy is needed [5]. The histological analysis will highlight the existence of mononuclear cellular infiltrates, noncaseating granulomas and scar tissue [6] [7]. If granulomas prove difficult to find, staining with cathepsin K may help [8].

Acute and subacute cases are characterized by a restrictive ventilatory pattern, whereas in chronic suberosis patients a restrictive or mixed aspect is described by pulmonary function studies. Pulmonary function parameters correlate well with the duration of the exposure to the antigens [9].

• Penicillium

  […] with Penicillium notatum. [eurekamag.com]

  BACKGROUND: We characterized by immunoblotting the antigenicity of the most frequent fungi colonizing cork during its industrial processing, Penicillium glabrum and Chrysonilia sitophila. [ncbi.nlm.nih.gov]

  Background: We characterized by immunoblotting the antigenicity of the most frequent fungi colonizing cork during its industrial processing, Penicillium glabrum and Chrysonilia sitophila. [onlinelibrary.wiley.com]

  [Extrinsic allergic alveolitis caused by Penicillium frequentans. Review and presentation of a case]. [unboundmedicine.com]

The text also examines genetics, lung function, bronchoscopy, treatment and new findings in the field. [books.google.com]

(September 2017) Treatment This section is empty. You can help by adding to it. [wikiwand.com]

[1] Cause Cork is often harvested from the cork oak ( Quercus suber ) and stored in slabs in a hot and humid environment until covered in mold. [1] Cork workers may be exposed to organic dusts in this process, leading to this disease. [1] Diagnosis Treatment [readtiger.com]

Treatment depends on the type of exposure and the stage of the disease. It may involve medicines, oxygen therapy, or a lung transplant in severe cases. [icdlist.com]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Revista Portuguesa de Pneumologia. 81 2003 Suberosis: clinical study and new etiologic agents in a series of eight patients Morell, F., et al. Chest. [hplung.com]

"Suberosis *: clinical study and new etiologic agents in a series of eight patients." Chest, vol. 124, no. 3, Sept. 2003, p. 1145+. Accessed 9 Mar. 2020. Gale Document Number: GALE|A109844994 [go.gale.com]

The aims of the study were to assess the etiologic role of several fungi and cork itself in the genesis of suberosis, and to review the clinical characteristics of patients with this disease. METHODS: Eight patients with suberosis were studied. [ncbi.nlm.nih.gov]

Part of the Clinical Focus Series, Hypersensitivity Pneumonitis is a concise guide to the condition, discussing epidemiologic, immune-pathologic, physiologic, diagnostic and therapeutic developments. [books.google.com]

Epidemiologic study in a factory of cork products]. 61 Villar TG 4802814 1973 20 Some aspects of suberosis: respiratory disease in cork workers. 61 Avila R 4265665 1972 21 [On pneumoconiosis caused by cork (suberosis)]. 61 Lo Storto A...De Salvia F 5142905 [malacards.org]

Despite the importance of the Spanish cork industry, there are few epidemiologic (5) or sporadic studies (6,7) on this subject, particularly as compared to those published by Portuguese authors. (3) In early works, researchers (2-8) detected precipitins [go.gale.com]

Epidemiologic study in a factory of cork products]. [Journal Article] Arch Monaldi. 1973 Jul-Aug; 28(4):261-76.Villar TGAM Respiratory disease in cork workers ("suberosis"). [unboundmedicine.com]

In conclusion, Suberosis and bird fancier's disease are HP with different clinical and laboratory profiles, suggesting that despite their pathophysiological similarities, different antigenic exposures may cause different immune and inflammatory response [ncbi.nlm.nih.gov]

In conclusion, Suberosis and bird fancier's disease are EAA with different clinical and laboratory profiles, suggesting that despite their pathophysiological similarities, different antigenic exposures may cause different immune and inflammatory response [mendeley.com]

Their global dimension has been emphasized in several recent international publications, stressing that the most important means for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior [books.google.com]

You can prevent the information generated by the Google cookie about your use of our Sites from being collected and processed by Google in the future by downloading and installing Google Analytics Opt-out Browser Add-on for your current web browser. [mycobank.org]

Bioaerosols in the Workplace: Evaluation, Control and Prevention Guide. Montréal: Bibliothètec national du Québec; 2001. 25. Kromhout, H. Design of measurement strategies for workplace exposures. [content.sciendo.com]

1. Avila R, Villar T. Suberosis respiratory disease in cork workers. The Lancet. 1968;291(7543):620-1.
2. Wild L, Lopez M. Hypersensitivity Pneumonitis: a comprehensive review. J Invest Allergol Clin Immunol. 2001;11:3-15.
3. Silva C, Churg A, Müller N. Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings. AJR Am J Roentgenol. 2007;188(2):334-44.
4. Morell F, Roger A, Reyes L, et al. Bird fancier's lung: a series of 86 patients. Medicine. 2008;87(2):110-30.
5. Trahan S, Hanak V, Ryu JH, et al. Role of surgical lung biopsy in separating chronic hypersensitivity pneumonia from usual interstitial pneumonia/idiopathic pulmonary fibrosis: analysis of 31 biopsies from 15 patients. Chest. 2008;134(1):126-32.
6. Jacobsen G, Schlunssen V, Schaumburg I, et al. Increased incidence of respiratory symptoms among female woodworkers exposed to dry wood. Eur Respir J. 2009;33(6):1268-76.
7. Takemura T, Akashi T, Ohtani Y, et al. Pathology of hypersensitivity pneumonitis. Curr Opin Pulm Med. 2008;14(5):440-54.
8. Selman M, Pardo A, King TE Jr. Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med. 2012;186(4):314-24.
9. Alegre J, Morell F, Cobo E. Respiratory symptoms and pulmonary function of workers exposed to cork dust, toluene diisocyanate and conidia. Scand J Work Environ Health. 1990;16(3):175-81.