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Succinylcholine

Succinylcholine Injectable Solution


Presentation

  • Abstract We present the case of a woman who had two severe anaphylactic episodes with hypotension and bradycardia in relation to the administration of general anesthesia.[ncbi.nlm.nih.gov]
  • Innervated as well as denervated mouse muscle cells and human embryonic kidney (HEK293) cells expressing γ‑AChR and ε‑AChR were used in the present study.[ncbi.nlm.nih.gov]
  • The present study investigates the in vivo and in vitro degradation as well as elimination of both target analytes using authentic blood and urine samples from anesthetized patients.[ncbi.nlm.nih.gov]
  • CLINICAL FEATURES: A 39-yr-old female with primary hyperparathyroidism and a normal airway examination presented for elective parathyroidectomy.[ncbi.nlm.nih.gov]
  • RESULTS: The wild-type BCHE was present in 38 patients, and 21 were heterozygous for the K-variant.[ncbi.nlm.nih.gov]
Intravenous Administration
  • We hypothesized that intravenous administration of plant-derived recombinant BChE, which also prevents mortality in nerve agent poisoning, would rapidly reverse the effects of succinylcholine.[ncbi.nlm.nih.gov]
Plethora
  • Despite its potential to produce a short-acting, ultra-intense neuromuscular block rapidly in seconds, it is surrounded by a plethora of side effects and drug interactions.[ncbi.nlm.nih.gov]
Pneumonia
  • We report the case of a 34-year-old woman who received succinylcholine while undergoing laparoscopic Roux-en-Y gastric bypass and later developed succinylcholine myalgia leading to a prolonged hospital stay and subsequent pneumonia.[ncbi.nlm.nih.gov]
  • PATIENT: A 16-yr-old boy treated in the intensive care unit due to Klebsiella pneumoniae sepsis, which developed after chemotherapy for nonlymphoblastic leukemia.[ncbi.nlm.nih.gov]
  • Page 348 - Hospital-acquired pneumonia in adults: diagnosis, assessment of severity, initial antimicrobial therapy, and preventive strategies. ‎ Page 361 - Pepe PE, et al.[books.google.com]
Dyspnea
  • MEASUREMENTS AND MAIN RESULTS: A 37-yr-old female with recently diagnosed acute myelogenous leukemia was admitted to the ICU with mental status changes and progressive dyspnea requiring intubation and mechanical ventilation.[ncbi.nlm.nih.gov]
Refractory Shock
  • Author information 1 Département d'Anesthésie-Réanimation, Hôpital Central, Centre Hospitalier Universitaire, 29, avenue du Maréchal de Lattre de Tassigny, 54000 Nancy, France. [email protected] Abstract Refractory shock from anaphylaxis can occur[ncbi.nlm.nih.gov]
Hyperhidrosis
  • We report a case of palmar hyperhidrosis who underwent transthoracic endoscopic sympathetic ganglionectomy under general anesthesia with a facemask developed prolonged paralysis following the operation.[ncbi.nlm.nih.gov]
Severe Osteoporosis
  • Abstract Three cases are reported where pre-existing medical conditions (severe osteoporosis, amyotrophic lateral sclerosis, cardiac arrhythmias) made the administration of succinylcholine during ECT potentially dangerous.[ncbi.nlm.nih.gov]
Osteoporosis
  • Abstract Three cases are reported where pre-existing medical conditions (severe osteoporosis, amyotrophic lateral sclerosis, cardiac arrhythmias) made the administration of succinylcholine during ECT potentially dangerous.[ncbi.nlm.nih.gov]
Diplopia
  • Transient and tolerable diplopia and difficulty opening eyes emerged after pretreatment of 0.02 mg/kg cisatracurium.[ncbi.nlm.nih.gov]
Flaccid Paralysis
  • Flaccid paralysis of the extremities was noted throughout the procedure. A failed airway was declared and a surgical airway was deemed necessary. No additional anaesthetic medications were administered.[emj.bmj.com]

Workup

Potassium Increased
  • Our objectives in this study were to determine the factors associated with arterial potassium increase (ΔK) and to assess the occurrence of acute hyperkalemia 6.5 mmol/L after succinylcholine injection for intubation in the ICU.[ncbi.nlm.nih.gov]
  • Investigations Common Transient blood potassium increase. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.[medicines.org.uk]

Treatment

  • The patient received 7 electroconvulsive therapy treatments during a 2-week hospital stay. The anesthetic regimen included methohexital for induction and succinylcholine for neuromuscular relaxation.[ncbi.nlm.nih.gov]
  • The aim of our trial is to evaluate the rate of the LSR after intubation following treatment with succinylcholine, vecuronium, or no muscle relaxant.[ncbi.nlm.nih.gov]
  • Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck.[ebi.ac.uk]
  • RESULTS: Patients in the S group were less satisfied with the treatment than patients in RS group (72.7 vs. 93.7%, p   0.007).[ncbi.nlm.nih.gov]
  • From 167 patients enrolled, 150 received treatment. The all-subjects-treated population comprised 70 patients in the rocuronium-sugammadex group and 80 in the succinylcholine group.[ncbi.nlm.nih.gov]

Etiology

  • Critically ill patients could be at high risk of hyperkalemia after receiving succinylcholine because one or more etiologic factors of nicotinic receptor upregulation can be present, but there are few data on its real risk.[ncbi.nlm.nih.gov]
  • Read more (PubMed: 20068044) » Martyn JA & Richtsfeld M Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology 104 :158-69 (2006).[abcam.com]
  • Just to be thorough check out the abstract to Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology. 2006 Jan;104(1):158-69.[forums.studentdoctor.net]

Epidemiology

  • Until more epidemiologic data are collected and analyzed, having dantrolene available, where succinylcholine may be used, is reasonable, and this practice should be maintained.[ncbi.nlm.nih.gov]
  • Article metrics Cited by: Cited 0 times via Crossref Cited-by Linking Collapse Jeffrey J Perry Correspondence to: Clinical Epidemiology Programme, The Ottawa Hospital, Ottawa, Canada [email protected] Jacques S Lee Emergency Department, Sunnybrook and[cochranelibrary.com]
Sex distribution
Age distribution

Pathophysiology

  • PURPOSE: We present a case of spontaneous subluxation of the Temporo-mandibular joint (TMJ) induced by succinylcholine, to compare our experience with previous cases reported in the literature, and to review the pathophysiology, preoperative screening[ncbi.nlm.nih.gov]
  • Of most concern are pathophysiologic states that increase chemosensitivity of the muscle membrane because of development of receptor sites in extrajunctional areas.[journals.lww.com]
  • Pharmacotherapy: A Pathophysiologic Approach. 6th ed. McGraw-Hill, 2005:685. Pharmacology for Anaesthesia and Intensive Care. 2nd Edition. Peck, Hill & Williams Reimring, MJ; Morgan, SW; Bramwell, PF (1970).[en.wikipedia.org]

Prevention

  • CONCLUSIONS: Magnesium sulphate can prevent and reduce the degree of fasciculation after anaesthesia. Therefore it can be used to prevent fasciculation.[ncbi.nlm.nih.gov]
  • OBJECTIVE: The present study compared the efficacy of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia. DESIGN: Prospective, randomized, placebo controlled, double blinded study.[ncbi.nlm.nih.gov]
  • Challenge of mice with an LD100 of succinylcholine followed by BChE administration resulted in complete prevention of respiratory inhibition and concomitant mortality.[ncbi.nlm.nih.gov]
  • Abstract Two separate methods of preventing post-ECT emergence agitation are increasing the succinylcholine dose to about 1.1 mg/kg and adding a methohexital bolus of about 0.67 mg/kg immediately at seizure end.[ncbi.nlm.nih.gov]
  • In the precurarization group the rise in CK was prevented and the levels were significantly less as compared to the group which received succinylcholine alone.[ncbi.nlm.nih.gov]

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