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Sudden Death


Presentation

Coronary Atherosclerosis
  • The heart showed mild cardiomegaly with concentric left ventricular hypertrophy, and sub-occlusive coronary atherosclerosis. Toxicological testing was negative for common drugs, including cocaine and its metabolites.[ncbi.nlm.nih.gov]
  • The authors concluded that marathon running could not ensure absolute protection from coronary atherosclerosis.[sportsci.org]
  • Left ventricular hypertrophy associated with chronic stenosing coronary atherosclerosis. B. Hypertensive heart disease without significant coronary atherosclerosis (be especially careful to view heart weight in view of the body weight).[poptop.hypermart.net]
  • Sudden cardiac death not related to coronary atherosclerosis. Toxicol Pathol . 2006. 34(1):52-7. Latini R, Maggioni AP, Flather M. ACE inhibitor use in patients with myocardial infarction. Summary of evidence from clinical trials.[emedicine.medscape.com]
Weight Gain
  • Amongst patients with sudden death, 7 out of 10 (70%) were documented to have used illicit drugs prior to death, with a tendency to weight gain also noted. The mean time to myocarditis post clozapine commencement was 15 7days.[ncbi.nlm.nih.gov]
Arachnodactyly
Venous Insufficiency
  • Venous disease, including varicose veins and chronic venous insufficiency, is one of the most common chronic medical conditions. Haemorrhage from rupture of varicose veins in the legs is rare and can lead to sudden death.[ncbi.nlm.nih.gov]
Pigmented Tumor
  • Meningeal melanocytoma is a rare benign pigmented tumor. It develops from melanocytes normally present in the meninges of the posterior fossa and medulla. It is an extra-axial tumor that manifests because of compression of adjacent structures.[ncbi.nlm.nih.gov]
Motor Symptoms
  • Abstract Multiple system atrophy (MSA) manifests as a combination of dysautonomia and motor symptoms/signs.[ncbi.nlm.nih.gov]
Generalized Seizure
  • A 21-year-old man with a previous history of recurrent lipothymia was admitted to the emergency department because of generalized seizures. Death occurred despite resuscitation. A medico-legal autopsy was performed.[ncbi.nlm.nih.gov]
Dysautonomia
  • Abstract Multiple system atrophy (MSA) manifests as a combination of dysautonomia and motor symptoms/signs.[ncbi.nlm.nih.gov]

Workup

  • The focus is on exclusion of known phenotypes/genotypes or, alternatively, the blind workup of a relative of an undiagnosed cardiac arrest.[patient.info]
  • […] natriuretic peptide (BNP) Other tests to evaluate or predict risk of SCD Imaging studies: Chest radiography, echocardiography, nuclear scintigraphy Electrocardiography (ECG): Including, possibly, signal-averaged ECG Coronary angiography Electrophysiology See Workup[emedicine.medscape.com]
Mediastinal Mass
  • Therefore, forensic pathologists should include hemangioma as a differential diagnosis in children with anterior mediastinal masses.[ncbi.nlm.nih.gov]
First-Degree Atrioventricular Block
  • CASE REPORT: We present the case of a 46-year-old man, whose ECG showed bizarre voltage criteria for left ventricular hypertrophy and first-degree atrioventricular block, a dilated left ventricle with mildly impaired global systolic function and non-sustained[ncbi.nlm.nih.gov]

Treatment

  • The authors discuss different etiologies and treatment of arrhythmia in children, reviewing the pediatric algorithm for shockable rhythm.[ncbi.nlm.nih.gov]

Prognosis

  • This paper reviews different pathologies underlying sudden death with emphasis on the autonomic nervous system contribution, possibilities of early diagnosis and prognosis of sudden death using various clinical markers including autonomic markers (heart[ncbi.nlm.nih.gov]
  • Data from a large pathology registry.” during: The press conference “Preventing sudden death: diet or device” on 28 August at 15:00 to 16:00 The session “ Prognosis in cardiomyopathies ” on 30 August at 16:30 to 18:00 in Raphael – The Hub Notes to editor[escardio.org]
  • Factors influencing prognosis after myocrdial infarction. Curr Probl Cardiol. 1979;4:6-53. Medline 35 . Bigger JT, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM.[revespcardiol.org]

Etiology

  • The etiology remains unclear and its presentation depends on the affected arteries. With coronary artery involvement, manifestations range from chest pain and shortness of breath to sudden death.[ncbi.nlm.nih.gov]

Epidemiology

  • Some of the epidemiological and pathological studies have also suggested an association between the presence of fatty liver and sudden death. A 37-year-old man was found dead when he was asleep in the bed at home.[ncbi.nlm.nih.gov]
  • Science Science Home Blood Disorders and Blood Safety Sleep Science and Sleep Disorders Lung Diseases Health Disparities and Inequities Heart and Vascular Diseases Precision Medicine Activities Obesity, Nutrition, and Physical Activity Population and Epidemiology[nhlbi.nih.gov]
  • It is not fully understood what implications this may have for the epidemiology of the disease.[apsnet.org]
  • SCD may also be caused by non-cardiac conditions - eg, pulmonary embolism. [ 1 ] Epidemiology The incidence of SCD is approximately 1 in 1,000 per year. [ 2 ] The incidence of SCD parallels the incidence of coronary heart disease, with the peak incidence[patient.info]
  • Sudden death--definition and epidemiologic considerations. Prog Cardiovasc Dis . 1980 Jul-Aug. 23(1):1-12. [Medline] . Thompson RJ, McCullough PA, Kahn JK.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Unfortunately, the bulk of the guidelines have very little basis in the underlying pathophysiology responsible for sudden cardiac death (SCD) in patients with CHD.[ncbi.nlm.nih.gov]

Prevention

  • The SDY Case Registry is a collaborative effort between the National Institutes of Health, the Centers for Disease Control and Prevention, and the Michigan Public Health Institute.[ncbi.nlm.nih.gov]

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