Presentation
A 16-year-old African-American female presented with a surgical site infection 8 weeks after a motor vehicle accident with multiple traumas. [ncbi.nlm.nih.gov]
Entire Body System
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Intravenous Administration
The percent of dose excreted in urine over a 12-hour period following the intravenous administration of the first dose of 1200 mg of sulfamethoxazole and 240 mg of trimethoprim on day 1 ranged from 7% to 12.7% as free sulfamethoxazole and 17% to 42.4% [globalrph.com]
Intravenous Administration Rapid or direct IV injection must be avoided. Dilute 5 ml of the concentrate for injection in 125 ml of D5W. For fluid-restricted patients, 75 ml of D5W may be used. [pdr.net]
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Hypoxemia
The hypoxemia and ground-glass opacity increased on hospital day 3, and the administration of adjunctive steroid therapy resulted in an improvement in the patient's condition. [ncbi.nlm.nih.gov]
Musculoskeletal
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Muscle Twitch
Tell your doctor right away if you have any of the following symptoms while using this medicine: confusion, weakness, muscle twitching, an irregular heartbeat, numbness or tingling in the hands, feet, or lips, or trouble breathing. [goodrx.com]
Skin
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Alopecia
Transient alopecia was observed in one patient during therapy. We conclude that prophylactic treatment with sulfamethoxazole-trimethoprim is beneficial in patients with chronic granulomatous disease. [ncbi.nlm.nih.gov]
Neurologic
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Hyperreflexia
The clinical results were as follows; mild improvements of hyperreflexia of knee jerks and of rigospasticity of the legs during S-T treatment period. In addition, S-T significantly reduced the times of 8 motor activities on the timed tests. [ncbi.nlm.nih.gov]
Urogenital
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Vaginal Bleeding
Both patients presented a platelet count below 5,000/microL, extensive purpura, and significant vaginal bleeding. [ncbi.nlm.nih.gov]
Workup
Serum
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Neutrophil Count Increased
No significant influence of initial neutrophil count on response rate was noted, although patients in whom the neutrophil count increased during therapy had a higher response rate (84%) than patients in whom the neutrophil count decreased or remained [ncbi.nlm.nih.gov]
Treatment
Diagnosis and treatment were carried out by nurses, without medical supervision. [ncbi.nlm.nih.gov]
Etiology
TMP/SMX was identified as the likely etiology of pancreatitis by the medical team. Evaluation with the Naranjo algorithm indicated a "possible" adverse drug reaction. [ncbi.nlm.nih.gov]
In those cases in which an etiologic agent has been identified, viruses, in particular coxsackie B viruses, have been most frequently implicated ( 4 ). [wwwnc.cdc.gov]
Epidemiology
Department of Rheumatology, JA Toride Medical Center, 2-1-1 Hongo, Toride, Ibaraki, 302-0022, Japan. 20 Clinical Research Center, Medical Hospital of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo, 113-8549, Japan. 21 Division of Epidemiology [ncbi.nlm.nih.gov]
Infectious Disease Epidemiology Section. Louisiana Office of Public Health. 17 July 2011. Archived (PDF) from the original on 23 February 2014. Retrieved 12 February 2014. Harik, NS (1 July 2013). [en.wikipedia.org]
The study was performed in compliance with the ethical guidelines for epidemiological research in Japan and the Helsinki Declaration (revised in 2008). [arthritis-research.biomedcentral.com]
Molecular epidemiology and antimicrobial susceptibility profiles of methicillin-resistant Staphylococcus aureus blood culture isolates: results of the Quebec Provincial Surveillance Programme. Epidemiol Infect 2015 ; 143 : 1511 -8. [bmj.com]
Prevention
Therefore, the prophylactic administration of sulfamethoxazole-trimethoprim has potential to be effective in preventing P. pneumonia as well as eliminating airway colonization with P. jirovecii. [ncbi.nlm.nih.gov]