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Sulfhemoglobinemia


Presentation

  • Predisposing factors, such as chronic constipation, present in our patient, have been suggested as a source of hydrogen sulfide.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: There is a potential for the diagnosis of methemoglobin with some of the limitations of present co-oximeters. The laboratory diagnosis of sulfhemoglobinemia can be difficult to make.[ncbi.nlm.nih.gov]
  • Alana Flexman presented an unusual case in The Lancet. [2] A 42-year-old male patient was brought into Vancouver 's St.[en.wikipedia.org]
  • Although reduced enzyme activity within the erythrocytes has been referred to as the intrinsic mechanism for the onset of the present disease, there was no abnormality in the present case as far as examined.[jstage.jst.go.jp]
  • We present a unique case in which a patient on chronic metoclopramide therapy developed sulfhemoglobinemia that resolved with subsequent discontinuation of the drug.[ncbi.nlm.nih.gov]
Pathologist
  • Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.[books.google.com]
Candidiasis
  • الصفحة 20 - Candidiasis of bronchi, trachea, or lungs Candidiasis, esophageal Cervical cancer, invasive* Coccidioidomycosis, disseminated or extrapulmonary Cryptococcosis, extrapulmonary Cryptosporidiosis, chronic intestinal ( 1... ‏[books.google.com]
Dyspnea
  • Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion. She sought medical attention 10 d later, at which time initial laboratory tests revealed a methemoglobin level of 47%.[ncbi.nlm.nih.gov]
  • Early symptoms include: headache fatigue dyspnea lethargy cyanosis Symptoms at higher methemoglobin levels : respiratory depression altered consciousness shock seizures death (the final “symptom”) Acquired methemoglobinemia is life threatening when methemoglobin[dailyem.wordpress.com]
  • Presentation Most mild cases are asymptomatic but symptoms might include the following depending on severity: • Greenish discoloration of blood, mucous membranes, and skin • Oxygen desaturation • Tachcardia • dyspnea Diagnosis To establish a diagnosis[nursingworldnigeria.com]
  • Signs and symptoms include cyanosis, dyspnea, headache, fatigue, mental status changes, and loss of consciousness The presence of methemoglobin in the blood, resulting in cyanosis.[icd9data.com]
Cyanosis
  • After removing the suspected toxic agent the cyanosis decreased significantly. The findings underline the importance of routine SHb detection in cyanosis of unknown origin especially in emergency cases.[ncbi.nlm.nih.gov]
  • Abstract Phenacetin-induced sulfhemoglobinemia was diagnosed in a middle-aged woman with a 6-month history of cyanosis and a 10-year history of ingestion of analgesics.[ncbi.nlm.nih.gov]
  • Two doses of 1 mg methylene blue/kg i.v. were given without significant improvement in either her cyanosis or methemoglobin level.[ncbi.nlm.nih.gov]
  • It is a rare cause of cyanosis, which is usually drug induced.[ncbi.nlm.nih.gov]
  • It causes cyanosis even at low blood levels. It is a rare blood condition that occurs when a sulfur atom is incorporated into the hemoglobin molecule.[en.wikipedia.org]
Lip Cyanosis
  • Physical exam was normal except for lip cyanosis. A CT pulmonary angiogram was negative for pulmonary embolism.[casereports.bmj.com]
Dysuria
  • About 4 months prior to presenting to the emergency department, she had started taking phenazopyridine, an over-the-counter medication for symptoms of dysuria.[ncbi.nlm.nih.gov]

Workup

  • Henry Harold Friedman Lippincott Williams & Wilkins, ٠١‏/٠١‏/٢٠٠١ - 441 من الصفحات Now in its updated Seventh Edition, this popular Spiral(R) Manual is a step-by-step guide to the diagnostic workup of 75 of the most common clinical problems in internal[books.google.com]
Thrombocytosis
  • Essential thrombocytosis Hypercoagulability primary: Antithrombin III deficiency · Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden · Hyperprothrombinemia acquired: DIC ( Congenital afibrinogenemia , Purpura[dictionary.sensagent.com]
  • Essential thrombocytosis Hypercoagulability primary: Antithrombin III deficiency · Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden · Hyperprothrombinemia acquired: DIC ( Congenital afibrinogenemia, Purpura[dictionnaire.sensagent.leparisien.fr]
Chlamydia
  • The modifications at various positions in structure have resulted in a series of potent compounds having wide spectrum of activity which includes gram negative and gram positive organisms, mycobacterium, chlamydia etc.[ijp-online.com]
Treponema Pallidum
  • pallidum immobilization or fluorescent treponemal antibody absorption test An abnormal titer of antinuclear antibody by immunofluorescence or an equivalent assay at any point in time and in the absence of drugs known to be associated with "druginduced[books.google.com]

Treatment

  • Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections.[books.google.com]
  • The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy[books.google.ro]
  • Abstract A 43-y-old Caucasian female applied 4 ounces of dimethyl sulfoxide (DMSO) to her lower abdomen for treatment of interstitial cystitis. Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion.[ncbi.nlm.nih.gov]
  • […] of Interest: None The development of fluoroquinolones in early 1980s was a breakthrough in the treatment of infectious diseases.[ijp-online.com]

Prognosis

  • It can be caused by phenazopyridine. [1] Prognosis and treatment [ edit ] The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be necessary in extreme cases.[en.wikipedia.org]
  • It can be caused by phenazopyridine . [1] Prognosis and treatment The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be necessary in extreme cases.[popflock.com]
  • It can be caused by phenazopyridine. [1] Prognosis and treatment The condition generally resolves itself with erythrocyte (red blood cell) turnover, although blood transfusions can be necessary in extreme cases.[dictionnaire.sensagent.leparisien.fr]

Etiology

  • Methemoglobinemia: Etiology, pharmacology and clinical management . Ann Emerg Med 1999 ; 34: 646 – 56 . Google Scholar Crossref Medline ISI 9. Rausch-Madison, S, Mohsenifar, Z. Methodologic problems encountered with cooximetry in methemoglobinemia .[doi.org]
  • الصفحة 372 - Either (1) or (2): (1) Evidence from the history, physical examination, or laboratory tests of a specific organic factor (or factors) judged to be etiologically related to the disturbance. (2) In the absence of such evidence, an etiologic[books.google.com]
  • In a complex case of unknown etiology, flagging SulfHb alerts the clinician to the cause of the discoloration and the remote potential for tissue hypoxia.[clinchem.aaccjnls.org]

Epidemiology

  • Pagina 69 - Epidemiology is defined as the study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to control of health problems. ‎[books.google.ro]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis.[books.google.ro]
  • Useful For Suggests clinical disorders or settings where the test may be helpful Diagnosing methemoglobinemia and sulfhemoglobinemia Identifying cyanosis due to other causes, such as congenital heart disease Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]

Prevention

  • Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection.[books.google.com]
  • Outlook Sulfahemoglobinemia is a rare condition that mostly resolves on its own without being noticed, clinically identified cases normally require transfusion and supportive managements to prevent end organ damage Share this news with friends!!![nursingworldnigeria.com]
  • The Centers for Disease Control and Prevention is authorized by IACET to offer 0.3 IACET CEU's for this program.[atsdr.cdc.gov]
  • High amounts of this type of abnormal hemoglobin prevent the normal movement of oxygen by the blood. Sulfhemoglobin: A rare abnormal form of hemoglobin that can't carry oxygen.[nlm.nih.gov]
  • […] treatment with MB. don’t give meth blue to methb if g6pd, do exchange transfusion instead Dapsone is one of the few agents that can cause recurrent methemoglobinemia; one of the treatments is actually cimetidine, since it inhibits the P450 system and prevents[crashingpatient.com]

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