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Sulfonamide

Sulfa Drug


Presentation

  • AREAS COVERED IN THIS REVIEW: The article presents the main classes of sulfonamide inhibitors investigated between 2013 and present.[ncbi.nlm.nih.gov]
  • In the present study, a sampling strategy for a complete aquaculture period was conducted.[ncbi.nlm.nih.gov]
  • We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs.[ncbi.nlm.nih.gov]
  • In the present work, a highly effective synthetic procedure was proposed for this group of potent cancerostatic drugs and compared with previously used methods.[ncbi.nlm.nih.gov]
  • Our present findings indicate that the G1 arrest is associated with the induction of CDKN1A and CDKN1B proteins, and that this response is also present in melanoma cells containing TP53 mutated.[ncbi.nlm.nih.gov]
Impaired Balance
  • Type 2 diabetes mellitus (T2DM) is characterised not only by hyperglycaemia and insulin resistance but also an impaired balance between the processes of coagulation and fibrinolysis.[ncbi.nlm.nih.gov]
Urticaria
  • A narrow outcome was defined by the occurrence of reactions such as urticaria, anaphylactic shock, erythema multiforme, and drug allergy. A broad definition also included asthma, eczema, and unspecified adverse effects of a drug.[nejm.org]
  • […] extremities Fixed drug eruption Well-defined, round or oval patches of redness and swelling of the skin, sometimes surmounted by a blister Develops within 30 minutes to 8 hours of taking the drug Type I (immediate, IgE-mediated, true allergic response)* Urticaria[dermnetnz.org]
  • Cross-reactivity among para-amine group in sulfonamide-induced urticaria and fixed drug eruption [abstract]. J Allergy Clin Immunol 1991; 87(1 Pt 2): 230 CrossRef Google Scholar 40. Moseley V, Baroody N.[doi.org]
  • […] develop within one to three weeks after starting treatment, and resolve within one to two weeks after ceasing treatment. 8,10 Anaphylaxis typically occurs within thirty minutes of the first dose, but is more common with parenteral administration. 8 Urticaria[bpac.org.nz]

Workup

  • An efficient method for the copper-catalyzed arylation of sulfonamides in water under ligand-free conditions offers high yields, simple workup procedure, and elimination of toxic materials. M. Nasrollahzadeh, A. Ehsani, M.[organic-chemistry.org]

Treatment

  • To report the safe and successful use of the carbonic anhydrase inhibitor acetazolamide for treatment of patients with episodic ataxia and periodic paralysis who had been denied treatment because of a history of severe allergic reactions to antibiotic[ncbi.nlm.nih.gov]
  • PURPOSE: The conventional treatment of Nocardia keratitis is with topical sulfonamides. Recently, topical trimethoprim and sulfamethoxazole (Bactrim) has been suggested as treatment.[ncbi.nlm.nih.gov]
  • They are also used in the treatment of certain forms of malaria.[britannica.com]
  • In the past decade there has been a significant reduction in deaths due to malaria, in part due to the success of the gold standard antimalarial treatment - artemisinin combination therapies (ACTs).[ncbi.nlm.nih.gov]
  • Also, strong accumulation of CDKN1A and CDKN1B in cells nuclei was seen upon TSPC treatment in both cell lines.[ncbi.nlm.nih.gov]

Etiology

  • A new γ-carbonic anhydrase (CA, EC 4.1.1.1) was cloned and characterized kinetically in the genome of the bacterial pathogen Burkholderia pseudomallei, the etiological agent of melioidosis, an endemic disease of tropical and sub-tropical regions of the[ncbi.nlm.nih.gov]
  • Sulfamonomethoxine is used to combat hyperpyrexia of unknown etiology. Product Specifications Catalog ID S-630 CAS # 1220-83-3 MW 280.30 g/mol Grade MOLECULAR BIOLOGY GRADE Join our list to receive promos and articles. Join Now[goldbio.com]

Epidemiology

  • Biology and Epidemiology 3.2.1.1.2. Chemotherapy 3.2.1.2. American Trypanosomiasis 3.2.1.2.1. Biology and Epidemiology 3.2.1.2.2. Chemotherapy 3.2.1.3. Leishmaniasis 3.2.1.3.1. Biology and Epidemiology 3.2.1.3.2. Chemotherapy 3.2.2.[doi.org]
  • Epidemiology of allergic drug reactions. Monogr Allergy 1993 ;31: 147 - 170 23. Smith JW, Johnson JE, Cluff LE. Studies on the epidemiology of adverse drug reactions. II. An evaluation of penicillin allergy. N Engl J Med 1966 ;274: 998 - 1002 24.[nejm.org]
Sex distribution
Age distribution

Pathophysiology

  • To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a[ncbi.nlm.nih.gov]
  • During pathophysiological conditions, the over expression of AP and e5'NT lead to an increased production of adenosine that enhance tumor proliferation, invasiveness, neoangiogenesis and disrupts the body antitumor response.[ncbi.nlm.nih.gov]

Prevention

  • Sulfa drugs were the first chemical substances systematically used to treat and prevent bacterial infections in humans.[britannica.com]
  • Abstract As the most important fishery medicines, sulfonamides are widely used to prevent diseases caused by pathogens in aquaculture.[ncbi.nlm.nih.gov]
  • […] use, eyes Sulfadoxine - Long acting, absorbed rapidly and excreted slowly Mefenide - skin, burns, topical Trimethoprim-Sulfamethoxazole Pyrimethamine-sulfadoxine - Inhibits dihydrofolate reductase in protozoa (malaria) Added to a sulfa drug to help prevent[quizlet.com]
  • They also showed that penicillin could prevent the inhibiting action of paraaminobenzoic acid on the sulfonamide drugs.[jamanetwork.com]
  • […] sulfonamide ( British sulphonamide ) noun Medicine Any of a class of synthetic drugs, derived from sulfanilamide, which are able to prevent the multiplication of some pathogenic bacteria.[en.oxforddictionaries.com]

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