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Sulindac


Presentation

  • Interstitial nephritis was present on renal biopsy in all cases. The nephrotic syndrome and renal failure resolved in all cases after withdrawal of sulindac.[ncbi.nlm.nih.gov]
Fatigue
  • Update on Drugs that Can Cause High Blood Potassium [ hide all summaries ] (December 2008) This article lists 68 drugs that can cause high blood potassium (hyperkalemia) that can result in nausea, fatigue, muscle weakness or tingling sensations, as well[worstpills.org]
  • […] cracks in the skin dark urine decreased urine output diarrhea difficult or labored breathing difficult or painful urination difficulty with swallowing dilated neck veins discoloration of urine disturbed color perception dizziness double vision extreme fatigue[mayoclinic.org]
  • She recovered rapidly and was well during follow up until she inadvertently restarted sulindac and redeveloped symptoms of fatigue, fever and jaundice within 24 hours.[livertox.nih.gov]
  • Undesirable effects such as dizziness, drowsiness, fatigue and visual disturbances are possible after taking NSAIDs. If affected, patients should not drive or operate machinery.[medicines.org.uk]
  • Fatigue that interferes with your daily activities Lasting loss of appetite or rapid weight loss of five pounds in a week Excessive gas or pain in your abdomen that does not go away Pain along the digestive tract, especially if worse after eating Difficulty[upmc.com]
Painless Jaundice
  • Two patients who developed painless jaundice while taking sulindac are described. Rechallenge in one case confirmed the association of hepatic damage with sulindac administration.[ncbi.nlm.nih.gov]
Nausea
  • The patient was hospitalized with an acute onset of headache, nuchal rigidity, nausea, and blurred vision. Brain imaging was unremarkable and a lumbar puncture revealed a lymphocytic pleocytosis. No infectious source was identified.[ncbi.nlm.nih.gov]
  • Common side effects may include: nausea, vomiting, stomach pain, indigestion, loss of appetite; diarrhea, constipation, gas; headache, dizziness, nervousness; itching, rash; or ringing in your ears.[everydayhealth.com]
  • PubMed Citation (68 year old man with recurrent attacks of nausea, abdominal pain and fever who was taking sulindac intermittently; selective challenge let to rapid appearance of fever, pain, and nausea [amylase 1542 U/L, ALT 80 U/L, Alk P 400 U/L without[livertox.nih.gov]
Diarrhea
  • Diarrhea and a small bowel lesion similar to that reported in celiac sprue were observed in a patient who had been taking sulindac.[ncbi.nlm.nih.gov]
  • If you have diarrhea, eat low-fiber foods that are high in protein and calories and avoid foods that can irritate your digestive tracts or lead to cramping.[upmc.com]
  • Adverse Reactions: GI ulcer/bleeding/pain, dyspepsia, nausea, diarrhea, constipation, rash (discontinue if occurs), dizziness, headache, tinnitus, edema, nephritis, nephrotic syndrome, pancreatitis, jaundice, hepatitis.[empr.com]
Abdominal Pain
  • One patient was inadvertently treated two years later with sulindac with recurrence of abdominal pain, marked hyperamylasemia, and jaundice. Clinical resolution was rapid with each episode following discontinuation of sulindac.[ncbi.nlm.nih.gov]
  • Sometimes, ulceration of the stomach and bleeding can occur without any abdominal pain, and black tarry stools, weakness, and dizziness upon standing ( orthostatic hypotension ) may be the only signs of internal bleeding.[medicinenet.com]
  • pain Other: Chills Before Calling Emergency The following information is helpful for emergency assistance: The person's age, weight, and condition The name of product (as well as the ingredients and strength if known) The time it was swallowed The amount[ufhealth.org]
  • Possible side effects Side Effect Frequency Consult your doctor Common Rare Only if severe In all cases abdominal pain X X nausea/vomiting X X constipation X X heartburn X X headache X X drowsiness/dizziness X visual disturbances X X difficulty swallowing[health24.com]
Right Upper Quadrant Pain
  • Two months later, she presented with right upper quadrant pain. Diagnostic studies including ultrasonography (US), computed tomography (CT) and endoscopic retrograde cholangiography (ERC), led to the diagnosis of cholecystohepatolithiasis.[ncbi.nlm.nih.gov]
Hepatomegaly
  • The prompt reappearance of fever, chills, pruritus, rash, tender hepatomegaly, and abnormal liver tests after only two doses of Sulindac suggested a hypersensitivity reaction.[ncbi.nlm.nih.gov]
Retinal Pigmentation
  • KEYWORDS: age-related macular degeneration; oxidative stress; preconditioning; retinal pigmented epithelial cells; sulindac[ncbi.nlm.nih.gov]
Eczema
  • Use cautiously with a history of eczema. Avoid if pregnant or breastfeeding. Thyme : Thyme has been used medicinally for thousands of years.[thesourcenatural.com]
Headache
  • The patient was hospitalized with an acute onset of headache, nuchal rigidity, nausea, and blurred vision. Brain imaging was unremarkable and a lumbar puncture revealed a lymphocytic pleocytosis. No infectious source was identified.[ncbi.nlm.nih.gov]
  • Adverse Reactions: GI ulcer/bleeding/pain, dyspepsia, nausea, diarrhea, constipation, rash (discontinue if occurs), dizziness, headache, tinnitus, edema, nephritis, nephrotic syndrome, pancreatitis, jaundice, hepatitis.[empr.com]
Encephalopathy
  • We report a case of encephalopathy associated with the intake of sulindac.[ncbi.nlm.nih.gov]

Workup

Pulmonary Infiltrate
  • Pulmonary infiltrates, cough, dyspnea, and fever developed in a 62-year-old woman with chronic degenerative arthritis who had been receiving sulindac therapy for six months. Her pulmonary signs and symptoms resolved upon withholding the drug.[ncbi.nlm.nih.gov]
Liver Function Tests Abnormal
  • ., eosinophilia, rash) occur or if liver function test abnormalities persist or worsen. 100 Hematologic Effects Anemia reported rarely. 100 Determine hemoglobin concentration or hematocrit in patients receiving long-term therapy if signs or symptoms of[drugs.com]

Treatment

  • Cytotoxicity, pH, and SCFA content of fecal water showed no differences at all among the three treatment groups.[ncbi.nlm.nih.gov]
  • Columns, mean of three independent treatments; bars, SD.[dx.doi.org]

Prognosis

  • Relentless growth and recurrence carry a poor prognosis. Recently, nonsteroidal anti-inflammatory drugs have been used to halt the growth of these tumors, presumably by interfering with prostaglandin metabolism.[ncbi.nlm.nih.gov]
  • The prognosis of Sulindac Overdose is dependent on the amount of drug consumed, time between overdose and treatment, severity of the symptoms, as well as general health status of the patient In most cases, the individual can recover from the symptoms[dovemed.com]
  • Outlook (Prognosis) Recovery is likely, except in very large overdoses. Very large overdoses can be deadly. References Aronson JK. Sulindac. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:591-594. Hatten BW.[ufhealth.org]

Etiology

  • TEN has multiple etiologies, but the basic mechanism of injury is believed to be an immunological reaction directed at the basal cell layer.(ABSTRACT TRUNCATED AT 250 WORDS)[ncbi.nlm.nih.gov]
  • Etiologic factors contributing to the development of these defects are unknown. To investigate this we have reviewed reports of risk factors for each anomaly and report them here.[oadoi.org]

Epidemiology

  • Article navigation Department of Cancer Epidemiology, Research Institute, Osaka Medical Center for Cancer and Cardiovascular Diseases , Japan Correspondence to: Hideki Ishikawa, M.D., Department of Cancer Epidemiology, Research Institute, Osaka Medical[academic.oup.com]
  • […] humans. 1 Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX- 2 was discovered. 2 Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology[caymanchem.com]
  • Clinical trial and epidemiological data suggest that use of some NSAIDs (particularly at high doses and in long term treatment) may be associated with a small increased risk of arterial thrombotic events (for example myocardial infarction or stroke).[medicines.org.uk]
  • Husain T, Langlois PH, Sever LE, Gambello MJ (2008) Descriptive epidemiologic features shared by birth defects thought to be related to vascular disruption in Texas, 1996–2002.[oadoi.org]
Sex distribution
Age distribution

Pathophysiology

  • This hypersensitivity response cannot be explained pathophysiologically by any mechanism.[ncbi.nlm.nih.gov]
  • Parente L, Perretti M (2003) Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol 65:153–159 CrossRef PubMed Google Scholar 2.[oadoi.org]

Prevention

  • Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force.[ncbi.nlm.nih.gov]
  • These results have implications for future NSAID-based cancer prevention clinical trials.[cancerpreventionresearch.aacrjournals.org]

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