We describe a cohort of 7 patients (2 adults, 5 children) presenting with severe hypercalcemia who had homozygous or compound heterozygous mutations in CYP24A1. [ncbi.nlm.nih.gov]

• Malaise

  In addition, there may be one to two hours of chills, headache, nausea and malaise (a general sick feeling). In rare cases, PMLE may erupt as red plaques (flat, raised areas), small fluid-filled blisters or tiny areas of bleeding under the skin. [drugs.com]

• Knee Pain

  Knee radiographic osteoarthritis (OA) and knee pain were also assessed. RESULTS: The mean 25(OH)D serum level was 52.8 nmoles/liter at baseline (range 13-119 nmoles/liter). [ncbi.nlm.nih.gov]

  These associations were not significantly different in analyses stratified by gender, the presence of radiographic OA, or the presence of knee pain. [hopkinsarthritis.org]

• Corneal Deposit

  Follow-up of the 2 adult patients showed reduced glomerular filtration rate and extrarenal manifestations, including calcic corneal deposits and osteoporosis. [ncbi.nlm.nih.gov]

• Hearing Impairment

  CONCLUSIONS: The results support the hypothesis that chronic sun exposure is a risk factor of hearing impairment. [ncbi.nlm.nih.gov]

• Hyperpigmentation

  Facial wrinkle length and area of hyperpigmentation, which are considered to be associated with exposure to sun, were measured using imaging with computer-based image analysis. [ncbi.nlm.nih.gov]

  And it all adds up over time to cause skin aging, fine lines, wrinkles, sun spots, elastosis (the degradation of the elastic tissue of the skin), the breakdown of collagen, hyperpigmentation, and other more serious conditions including skin cancer. [sunsaferx.com]

• Cognitive Disorder

  Serotonin and melatonin have also been implicated in many mental and cognitive disorders, such as Alzheimer's disease, Parkinson's disease, and sleep disorders [ 25, 29 ]. Light has been shown to also affect brain blood flow. [ncbi.nlm.nih.gov]

• Uric Acid Increased

  Uric acid increased by two-fold, which may be the adaptive response against photo-oxidative stress because uric acid is a good scavenger of singlet oxygen and oxygen radicals. [ncbi.nlm.nih.gov]

• Colitis

  METHODS: This is a case-control study of 292 patients with IBD [132 with Crohn's disease (CD) and 160 with ulcerative colitis (UC)], 80 diseased and 540 healthy controls, conducted via a validated questionnaire to quantify sunlight exposure. [ncbi.nlm.nih.gov]

Twelve nightshift nurses received three treatments: Placebo (Pla), Melatonin (Mel), and Melatonin with Sunglasses (Mel-S). Each treatment procedure was administered for 2d of different 4d nightshifts in a repeated measures crossover design. [ncbi.nlm.nih.gov]

Unfortunately, some psoriasis sufferers are rather sensitive to sun light, and may not be improved with this treatment. It is usually best to apply a tar or dithranol preparation daily, to be followed later by ultra-violet light treatment. [diagnose-me.com]

BACKGROUND: The prognosis of primary glioblastoma (GBM) is poor. Approximately 2/3 of primary brain tumor diagnoses are GBM, of which 95% are primary lesions. [ncbi.nlm.nih.gov]

However, in cases of autoimmunity, the immune system’s overactivity is what underlies symptoms, and so the sun may prevent the onset and improve prognosis of these types of diseases. [healevate.com]

Patients with the highest blood levels of vitamin D have thinner melanoma and better survival prognosis than those with the lowest vitamin D levels Vitamin D Deficiency Common in Sick Kids Still, there's no getting around the fact that vitamin D, produced [articles.mercola.com]

Sunlight exposure and physical activity represent modifiable lifestyle factors that, if shown to be important in breast cancer etiology, could be adopted as appropriate by individuals to substantively affect their breast cancer risk. [mskcc.org]

Because most arsenic-induced skin cancers arise from these skin lesions, treatment and remediation plans should take into consideration these etiologic cofactors. [ncbi.nlm.nih.gov]

Author Affiliations From the Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, National Institutes of Health, Bethesda, Md.; and the Ocular Oncology Service, Wills Eye Hospital, Jefferson Medical College, Thomas [nejm.org]

It is an important etiological factor in the development of skin cancers and sun-related eye problems when exposure is high, or Vitamin D Deficiency (VDD) [ 1, 2 ]. [link.springer.com]

OBJECTIVES: To analyse comprehensively the epidemiological literature concerning the association between AMD and sunlight exposure. [ncbi.nlm.nih.gov]

Therefore, preventive measures, for example, wearing sunglasses to minimize sunlight exposure, should start early to prevent development of AMD later in life. [ncbi.nlm.nih.gov]

Many health issues can be prevented by getting an adequate amount of vitamin... [naturalnews.com]