Symptoma

Superficial Punctate Keratopathy Type Thygeson

RESULTS: At the time of presentation, the mean patient age was 28.7 years. The most common presenting symptoms included photophobia, blurred vision, and irritation. [ncbi.nlm.nih.gov]

Case presentation A 15-year-old boy presented with long-term ocular symptoms of foreign body sensation, burning, irritation, tearing, and transient photophobia. One year's treatment with steroidal agents had led to only partial improvement. [casesjournal.biomedcentral.com]

These changes were present under the intraepithelial lesions, and in other areas where lesions were not present. [eyewiki.aao.org]

Clinical features: Symptoms: Patients usually present with bilateral keratitis Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years. [columbiaeye.org]

We present 4 cases with TSPK who developed sight-altering scarring after a prolonged disease course. METHODS Retrospective chart review of cases seen at the Proctor Medical Group. RESULTS Patients age ranged from 31 to 68 years. [semanticscholar.org]

  • Inflammation

    You are here Home › Education › Digital Reference of Ophthalmology › Cornea & External Diseases › Non-Infectious › Uncommon, non-contagious, primary corneal inflammation of unknown etiology. [columbiaeye.org]

    Some differentiate between superficial keratopathy(epithelial defects) and superficial keratitis (which then describes focal swelling of the epithelium caused by inflammative diseases). [zeitzfrankozeitz.de]

    It is a type of inflammation of the cornea. Description This problem appears as fine, scattered areas of loss of epithelium from the cornea - the clear part of the surface of the eye. [healthcentral.com]

    Absence of conjunctival or corneal inflammation and/ or scarring was noted in all patients. In vivo confocal microscopy images showed in the superficial epithelium round and/or oval shaped zones of hyper-reflective and abnormal epithelial cells. [iovs.arvojournals.org]

    Azari, Wills Eye Hospital The typical TSPK is an elevated or flat round-oval shaped, gray-whitish lesion, occupying the central intraepithelial corneal area with no underlying stromal edema or inflammation. [eyewiki.aao.org]

  • Physician

    Definition Thygeson's disease is an eye condition named after Phillips Thygeson, an American physician born in 1903. It is now more commonly known as punctate epithelial keratitis or superficial punctate keratitis. [healthcentral.com]

    Chief Editor Additional Contributors Robert S Duszak, OD, FAAO Attending Physician, Philadelphia Veterans Affairs Medical Center; Consulting Staff, Nemours Health Clinic, Mayfair Eye Associates; Adjunct Clinical Faculty, Eye Institute of the Pennsylvania [emedicine.medscape.com]

  • Swelling

    Some differentiate between superficial keratopathy(epithelial defects) and superficial keratitis (which then describes focal swelling of the epithelium caused by inflammative diseases). [zeitzfrankozeitz.de]

  • Photophobia

    Clinical features: Symptoms: Patients usually present with bilateral keratitis Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years. [columbiaeye.org]

    CASE SUMMARY: A 37-years-old woman complained of redness, photophobia, and tearing in both eyes, which lasted for 6 years. [koreamed.org]

    The clinical picture was characterized by recurrent episodes of photophobia, tearing and burning and foreign body sensation in the eyes. [ncbi.nlm.nih.gov]

    Symptoms Typically, the patient is young, usually under 40 years of age, and complains of foreign body sensation, photophobia (aversion to light), and tearing. [healthcentral.com]

  • Foreign Body Sensation

    Clinical features: Symptoms: Patients usually present with bilateral keratitis Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years. [columbiaeye.org]

    The clinical picture was characterized by recurrent episodes of photophobia, tearing and burning and foreign body sensation in the eyes. [ncbi.nlm.nih.gov]

    Symptoms Typically, the patient is young, usually under 40 years of age, and complains of foreign body sensation, photophobia (aversion to light), and tearing. [healthcentral.com]

    “Characteristically, it produces symptoms of photophobia, tearing and foreign body sensation.” According to Dr. [reviewofoptometry.com]

  • Confusion

    Over the years this has proven not only confusing but unnecessary, since almost without exception the various types of epithelial keratitis have been definable either as etiologic or as clinical entities. [jamanetwork.com]

    Despite differences in frequency, causation, and infectivity, adenovirus epithelial keratitis and Thygeson's superficial punctate keratitis (TSPK) are often confused in clinical practice owing to the similarity between adenovirus epithelial infiltrates [lehmanns.de]

  • Burning Sensation

    sensations and watery eyes. [wikizero.com]

  • HLA-DR3

    Although TSPK has a genetic association with HLA-DR3, controversy exists regarding its exact etiology. [emedicine.medscape.com]

    Br J Ophthalmol. 2007;91(8):1038-41. 7.0 7.1 7.2 Darrell RW: Thygeson's superficial punctate keratitis: natural history and association with HLA-DR3, Trans Am Ophthalmol Soc 79:486, 1981. 8.0 8.1 8. [eyewiki.aao.org]

    Thygeson's superficial punctate keratitis: natural history and association with HLA-DR3. In: Darell, R.W., ed. Viral diseases of the eye. Philadelphia : Lea & Febiger 1985 : 312 – 34. Google Scholar 2. Thygeson, P.. Superficial punctate keratitis. [journals.sagepub.com]

Treatment There are a number of different treatments to deal with TSPK. Symptoms may disappear without treatment, but treatment may help increase time to and success of remission. [wikidoc.org]

Treatment [ edit ] There are a number of different treatments to deal with TSPK. Symptoms may disappear if untreated, but treatment may decrease both the healing time and the chances of remission. [wikizero.com]

Treatment There is no specific treatment for this disorder, but the use of topical corticosteroids can bring dramatic symptomatic relief. The lesions and symptoms may begin to clear after two to three days of treatment. [healthcentral.com]

PURPOSE: To evaluate the presentation, treatment, and disease course of Thygeson's superficial punctate keratitis. DESIGN: Observational case series. [ncbi.nlm.nih.gov]

Cases of TSPK in patients ranging in age from 2.5 years to 70 years have been reported, with a mean age of 29 years. [2] Prognosis Regardless of the treatment method selected, the visual prognosis in patients with TSPK is excellent. [2, 3, 4] Patient [emedicine.medscape.com]

Over the years this has proven not only confusing but unnecessary, since almost without exception the various types of epithelial keratitis have been definable either as etiologic or as clinical entities. [jamanetwork.com]

You are here Home › Education › Digital Reference of Ophthalmology › Cornea & External Diseases › Non-Infectious › Uncommon, non-contagious, primary corneal inflammation of unknown etiology. [columbiaeye.org]

The etiology remains unknown. [lup.lub.lu.se]

The etiology remains unknown. Publisher Full Text [Thygeson's keratitis--clinical characteristics and therapy]. [unboundmedicine.com]

Epidemiology Frequency United States The frequency of TSPK in the United States is currently unknown. International The worldwide frequency of TSPK is unknown. [emedicine.medscape.com]

Corneal lesions show a tendency for the central pupillary area distribution with mild or absent conjunctival inflammation and no association to systemic disease. [1] [2] There are no specific data on the epidemiology of the disease. [eyewiki.aao.org]

Pathophysiology A review of the literature suggests the pathophysiology of TSPK remains unclear, although viral and immunogenic components are both likely in the disease's formation. [emedicine.medscape.com]

The pathophysiology of TSPK remains unknown. Both, viral and immunologic mechanisms have been implicated. Adenovirus, herpes simplex virus, and varicella zoster virus, have all been implicated as a possible causes of the disease. [eyewiki.aao.org]

CONCLUSIONS: A supratarsal injection of triamcinolone may be an effective method to prevent recurrence of chronic, steroid-dependent Thygeson's superficial punctate keratitis. [koreamed.org]

The immunosuppressant properties of cyclosporine -- a drug most commonly used to prevent graft rejection and reduce the corneal bodies -- and the wetting action of the artificial tears relieve the mechanical trauma caused by the lid rubbing against the [healio.com]

Vision Section Optometric Education Section Public Health & Environmental Vision Section Special Interest Groups Academic Medical Center Optometrists (AMCO) SIG Fellows Doing Research SIG Neuro-ophthalmic Disorders in Optometry SIG Nutrition, Disease Prevention [aaopt.org]