You are here Home › Education › Digital Reference of Ophthalmology › Cornea & External Diseases › Non-Infectious › Uncommon, non-contagious, primary corneal inflammation of unknown etiology. [columbiaeye.org]

Some differentiate between superficial keratopathy(epithelial defects) and superficial keratitis (which then describes focal swelling of the epithelium caused by inflammative diseases). [zeitzfrankozeitz.de]

It is a type of inflammation of the cornea. Description This problem appears as fine, scattered areas of loss of epithelium from the cornea - the clear part of the surface of the eye. [healthcentral.com]

Absence of conjunctival or corneal inflammation and/ or scarring was noted in all patients. In vivo confocal microscopy images showed in the superficial epithelium round and/or oval shaped zones of hyper-reflective and abnormal epithelial cells. [iovs.arvojournals.org]

Azari, Wills Eye Hospital The typical TSPK is an elevated or flat round-oval shaped, gray-whitish lesion, occupying the central intraepithelial corneal area with no underlying stromal edema or inflammation. [eyewiki.aao.org]

Definition Thygeson's disease is an eye condition named after Phillips Thygeson, an American physician born in 1903. It is now more commonly known as punctate epithelial keratitis or superficial punctate keratitis. [healthcentral.com]

Chief Editor Additional Contributors Robert S Duszak, OD, FAAO Attending Physician, Philadelphia Veterans Affairs Medical Center; Consulting Staff, Nemours Health Clinic, Mayfair Eye Associates; Adjunct Clinical Faculty, Eye Institute of the Pennsylvania [emedicine.medscape.com]

Some differentiate between superficial keratopathy(epithelial defects) and superficial keratitis (which then describes focal swelling of the epithelium caused by inflammative diseases). [zeitzfrankozeitz.de]

Clinical features: Symptoms: Patients usually present with bilateral keratitis Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years. [columbiaeye.org]

CASE SUMMARY: A 37-years-old woman complained of redness, photophobia, and tearing in both eyes, which lasted for 6 years. [koreamed.org]

The clinical picture was characterized by recurrent episodes of photophobia, tearing and burning and foreign body sensation in the eyes. [ncbi.nlm.nih.gov]

Symptoms Typically, the patient is young, usually under 40 years of age, and complains of foreign body sensation, photophobia (aversion to light), and tearing. [healthcentral.com]

Clinical features: Symptoms: Patients usually present with bilateral keratitis Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years. [columbiaeye.org]

The clinical picture was characterized by recurrent episodes of photophobia, tearing and burning and foreign body sensation in the eyes. [ncbi.nlm.nih.gov]

Symptoms Typically, the patient is young, usually under 40 years of age, and complains of foreign body sensation, photophobia (aversion to light), and tearing. [healthcentral.com]

“Characteristically, it produces symptoms of photophobia, tearing and foreign body sensation.” According to Dr. [reviewofoptometry.com]

Over the years this has proven not only confusing but unnecessary, since almost without exception the various types of epithelial keratitis have been definable either as etiologic or as clinical entities. [jamanetwork.com]

Despite differences in frequency, causation, and infectivity, adenovirus epithelial keratitis and Thygeson's superficial punctate keratitis (TSPK) are often confused in clinical practice owing to the similarity between adenovirus epithelial infiltrates [lehmanns.de]

sensations and watery eyes. [wikizero.com]

Although TSPK has a genetic association with HLA-DR3, controversy exists regarding its exact etiology. [emedicine.medscape.com]

Br J Ophthalmol. 2007;91(8):1038-41. 7.0 7.1 7.2 Darrell RW: Thygeson's superficial punctate keratitis: natural history and association with HLA-DR3, Trans Am Ophthalmol Soc 79:486, 1981. 8.0 8.1 8. [eyewiki.aao.org]

Thygeson's superficial punctate keratitis: natural history and association with HLA-DR3. In: Darell, R.W., ed. Viral diseases of the eye. Philadelphia : Lea & Febiger 1985 : 312 – 34. Google Scholar 2. Thygeson, P.. Superficial punctate keratitis. [journals.sagepub.com]