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Suprasellar Tumor

Cns Suprasellar Tumor


Presentation

  • This unusual presentation is discussed and plausible hypotheses are given.[ncbi.nlm.nih.gov]
  • We present a case of a 10-year-old girl treated with therapeutic anticoagulation for previous cardiac valvular replacement, who presented with rapidly growing giant ( 4 cm) suprasellar germinoma.[ncbi.nlm.nih.gov]
  • A case report of ectopic pituitary gland in the suprasellar region of a normal 39-year-old woman with persistent headaches is presented.[ncbi.nlm.nih.gov]
  • We report the unusual presentation of a TRb in a 12-month-old boy with extensive bilateral Rb, a voluminous suprasellar tumor, pineal cyst, and leptomeningeal disease. The special features of this "quadrilateral" Rb are discussed.[ncbi.nlm.nih.gov]
  • Synopsis Our patient is a 60-year-old male who presented with hypogonadism and possible mild diabetes insipidus. MRI revealed an atypical suprasellar mass which was excised using an expanded endoscopic endonasal approach.[pituitary.ucla.edu]
Anosmia
  • Anosmia after anterior communicating artery aneurysm surgery: Comparison between the anterior interhemispheric and basal interhemispheric approaches. Neurosurgery 1996;38:325-8. [ PUBMED ] 4. Suzuki J, Katakura R, Mori T.[neurologyindia.com]
Dutch
  • However, we have identified a 16th-century autopsy report, written by the Dutch professor of anatomy Pieter Pauw (1564-1617), which describes an 18-year-old girl who developed marked polyuria and subsequently became totally blind from a cystic tumor compressing[ncbi.nlm.nih.gov]
Diplopia
  • Diplopia indicated a possible tumor mass involving the cavernous sinus.[kjim.org]
  • […] and choriocarcinomas (5%). [2] The parasellar extension and rapid growth can rarely mimic pituitary apoplexy. » Case Reports Case 1 A 13-year-old short-statured boy presented with polyuria, polydypsia and nocturia of six months' duration, headache and diplopia[neurologyindia.com]
  • Two-year-old male patient with diplopia and a decrease in left eye vision. A , Axial T2-weighted image (3200/84/1) shows a hyperintense suprasellar mass encasing the anterior portion of the circle of Willis.[ajnr.org]
  • Within months of surgery, the patient’s diplopia and movement of her right eye improved. She had no other neurologic complaints.[barrowneuro.org]
  • Visual symptoms and signs include vision loss, diplopia, and multiple cranial nerve palsies secondary to rapid expansion of the tumor into the adjacent cavernous sinuses, with cranial nerve III the most commonly affected.[webeye.ophth.uiowa.edu]
Headache
  • A case report of ectopic pituitary gland in the suprasellar region of a normal 39-year-old woman with persistent headaches is presented.[ncbi.nlm.nih.gov]
  • In 1942, when she was 47 years old, she displayed the first symptoms of a suprasellar brain tumor: headache and hemianopsia.[ncbi.nlm.nih.gov]
  • A 45-year-old man was seen for urgent evaluation of worsening headaches and loss of vision. He first noticed his symptoms 6 months before the onset of recurrent headaches with blurry and blank spots in his vision.[healio.com]
  • A 24-year-old male was presented to the neurosurgery department with a history of headache, diminution of vision of 4 months' duration.[ijem.in]
  • Clinical presentation: A 55-years-old man with a history of persistent headache in the right frontal area for a period of 10 years prior to the admission as well as visual disturbances and decreased libido for 1 year period prior to the admission.[endocrine-abstracts.org]
Bitemporal Hemianopsia
  • An examination of her visual fields revealed bitemporal hemianopsia. Her corrected visual acuity with eye glasses was insufficient.[semanticscholar.org]
  • Physical examinations were normal except bitemporal hemianopsia revealed by ophthalmic examination. Preoperative neuroendocrine examinations showed a mild hyperprolactinemia of 72.3ng/ml (normal range, 2.8 ng/ml-29.2 ng/ml).[path.upmc.edu]
  • His vision postoperatively showed a persistent bitemporal hemianopsia, but with significant improvement in visual acuity to 20/40 in the right eye and 20/20 in the left eye.[healio.com]
  • Case report A 68-year-old man was examined for bitemporal hemianopsia and falling episodes. Computed tomography (CT) revealed a 32 mm spontaneously hyperdense suprasellar mass (Fig. 1 ). No calcification was noted.[jbsr.be]
  • In four of the five known cases, bitemporal hemianopsia was the primary complaint (Table 1). Our patient’s only symptom was diplopia. Other symptoms reported to mimic pituitary adenomas are acromegaly, amenorrhea, and hypopituitarism (Table 1).[barrowneuro.org]

Workup

  • It is crucial to have a multidisciplinary team approach with baseline and follow up endocrine workup.[abstracts.eurospe.org]
  • It is important to note that while a sellar mass may present with bitemporal hemianopia, the combination of findings described above describing a junctional scotoma also localizes to the sellar area, and additional workup is indicated.[webeye.ophth.uiowa.edu]
  • Dynamic pituitary MRI has high sensitivity and specificity for the diagnosis of mild Cushing's syndrome and should be part of theinitial workup. Horm Metab Res. 2007;39(6):451-456. Simonetta AB. Imaging of suprasellar and parasellar tumors.[appliedradiology.com]
  • However, in many cases CT and MRI imaging data can be complementary and thus on a case-by-case basis both imaging studies may be indicated. [13] Cerebral angiography is not performed routinely in the workup of sellar mass lesions.[emedicine.medscape.com]

Treatment

  • Combination treatment with metformin and pioglitazone was markedly effective in improving glycemic control. Additionally, metformin treatment showed marked anorectic effects on the hyperphagia.[ncbi.nlm.nih.gov]
  • He responded to treatment with corticosteroid and cyclophosphamide. The intracranial lesions seemed to be rare, but important manifestations of the systemic disease, and were clearly visualized by magnetic resonance imaging.[ncbi.nlm.nih.gov]
  • To round out the clinician's understanding of the illness, a patient describes the experience of diagnosis, treatment, and follow-up.[books.google.ro]
  • Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography.[books.google.ro]
  • In her lifetime Haskil had three major disorders: juvenile scoliosis requiring treatment in her adolescence, a tumor of the sellar region requiring surgery at age 47 years, and a traumatic brain injury causing her death at the age of 65.[ncbi.nlm.nih.gov]

Prognosis

  • Although rare, pure suprasellar germinomas carry worse prognosis than other locations.[ncbi.nlm.nih.gov]
  • It addresses diagnosis, pathophysiology, management and prognosis and is written in a clear, concise style for quick, easy reference in the clinic.[books.google.es]
  • The role of liver biopsy in fatty liver disease is contentious, not least because liver biopsy carries a finite risk of death ( 6 ) and the prognosis of NAFLD acquired in childhood is not yet known.[journals.lww.com]
  • The prognosis for pediatric patients appears worse than for adults, with more aggressive tumors and surgical resection in the hypothalamic-suprasellar region being more difficult.[ajnr.org]

Etiology

  • In 183 short chapters, the book provides the essentials clinicians need on symptoms/signs, diagnostic tests, and neurologic disorders of all etiologies. For this edition, Timothy A.[books.google.es]
  • Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric[books.google.ro]
  • […] signs; (3) endocrine disturbances are highly frequent before surgery, while surgical intervention had little effect in increasing endocrine morbidity; (4) NEC, even though producing less endocrine dysfunctions than other tumor types, are an important etiology[karger.com]
  • Although more experiences based on sub-classified etiology for internal carotid artery stenosis are required, various types of operations including intracranial-extracranial vascular surgery might be justified based on this principle.[bmcresnotes.biomedcentral.com]
  • The etiology of fatty liver is poorly understood but is most commonly encountered in individuals with type 2 diabetes, truncal obesity and hyperlipidemia. Many of these patients demonstrate resistance to insulin ( 5 ).[journals.lww.com]

Epidemiology

  • Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric[books.google.ro]
  • Epidemiology As a general rule, brain tumours increase in frequency with age, with individual exceptions (e.g. pilocytic astrocytoma , the vast majority of which are found in young patients), and a number of uncommon tumours found in infancy (see brain[radiopaedia.org]
  • The epidemiology and long-term prognosis of fatty liver disease in children is not known. Hepatic steatosis occurs in many chronic liver diseases, some of which are amenable to treatment, such as Wilson’s disease and inherited metabolic diseases.[journals.lww.com]
  • Epidemiology of central nervous system tumors in childhood and adolescence based on the new WHO classification. Childs Nerv Syst. 2001; 17 (9): 503-11[ DOI ][ PubMed ] 2. Keene DL, Johnston DL. 2015; : 9-12[ DOI ] 3.[iranjradiol.com]
Sex distribution
Age distribution

Pathophysiology

  • It addresses diagnosis, pathophysiology, management and prognosis and is written in a clear, concise style for quick, easy reference in the clinic.[books.google.es]
  • Pathophysiology Hematogenous metastases to this region most frequently go to the pituitary gland, infundibulum, and tuber cinereum, because these structures lie outside the blood-brain barrier.[radiologykey.com]
  • The histologic characteristics of these lesions are discussed in Pathophysiology. At times, the differentiation of hyperplasia from adenoma may be difficult. Other nonpituitary mass lesions may be identified easily by pathologic examination.[emedicine.medscape.com]
  • Pathophysiology Nearly all pituitary adenomas are monoclonal and most appear to be sporadic.[endocrinologyadvisor.com]

Prevention

  • Extreme caution was taken to avoid spillage of tumor cyst fluid into subarachnoid spaces, in order to prevent chemical meningitis.[neurologyindia.com]
  • It failed to prevent the recurrence or progression of residual tumor in another 5 patients, occurring from 6 to 60 months after irradiation.[clinicalgate.com]
  • In an effort to prevent further weight gain, a low-fat diet was introduced, but compliance was poor because of hyperphagia.[journals.lww.com]
  • BMC Research Notes 2013 6 :499 Ogawa and Tominaga; licensee BioMed Central Ltd. 2013 Received: 25 June 2013 Accepted: 27 November 2013 Published: 1 December 2013 Abstract Background Treatment strategy to prevent perioperative cerebral infarction in patients[bmcresnotes.biomedcentral.com]

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