Presentation
Presently, the diagnosis of syphilis is dependent mainly on serological tests. [ncbi.nlm.nih.gov]
We present two cases of young pregnant women who were diagnosed syphilis during their antenatal visit. [ukm.pure.elsevier.com]
Presentation on theme: "Syphilis in Pregnancy Jillian E Peterson. [slideplayer.com]
Penicillin-allergic pregnant women present management dilemmas. Erythromycin failure occurs in 10% of nonpregnant women with early syphilis. [glowm.com]
Entire Body System
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Noncompliance
Several factors contributed to the increase in congenital syphilis, including increased incidence of maternal disease, failure to detect maternal disease, noncompliance with treatment recommendations, and fetal treatment failure. [journals.lww.com]
HIB is safe for infants with AIDS. 58) B - lack of symptoms, troublesome side effects of the medications, complex regimens result in noncompliance. There are effective medications for hypertension. [online-nursing-dot.com]
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Unsafe Sexual Practices
This has been attributed partly to unsafe sexual practices and decreasing use of condoms. [slideshare.net]
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Hunting
Reyes M, Hunt N, Ostrea E, et al. Maternal/congenital syphilis in a large tertiary-care urban hospital. Clin Infect Dis 1993 ; 17 : 1041 –6. Campos-Outcalt D, Ryan K. [sti.bmj.com]
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Developmental Disabilities
Such children are weak, lag behind in growth and body weight, developmentally disabled, both physically and mentally. [infobaby.org]
Gastrointestinal
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Chronic Diarrhea
Renal and ocular manifestations and, occasionally, syphilitic pneumonitis, chronic diarrhea, or myocarditis may occur in early congenital syphilis. [glowm.com]
Jaw & Teeth
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Notched Incisors
incisors), interstitial keratitis, and eighth nerve deafness. [glowm.com]
Musculoskeletal
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Myopathy
Features of syphilis in HIV include: generalized lymphadenopathy; splenomegaly; hepatitis; skin rashes, alopecia or both; oral manifestations; cognitive impairment; meningitis; cranial nerve palsies; myopathies; and uveitis. [academic.oup.com]
Neurologic
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Convulsions
Neurological manifestations of LCS include mental retardation, hydrocephalus, convulsive disorders, cranial nerve abnormalities (including blindness and deafness), and juvenile general paresis [ 2, 27 ]. [ncbi.nlm.nih.gov]
Heroin : Impaired respiratory functioning, tremors, convulsions, and neonatal irritability and withdrawal. [registerednursing.org]
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Flaccid Paralysis
paralysis of the upper limbs and knee. [pediatriconcall.com]
Workup
Colonoscopy
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Multiple Ulcerations
ulcerations can occur if coexisting HIV infection Can persist 3-6wks without treatment 4 Secondary Syphilis 25% of untreated patients will develop secondary syphilis Rash Most characteristic finding Diffuse symmetric maculopapular rash Includes trunk [slideplayer.com]
Treatment
Two of the six fetal treatment failures produced preterm stillborns. Only one maternal treatment failure occurred, in a human immunodeficiency virus-infected woman. [ncbi.nlm.nih.gov]
Etiology
However, we must also consider congenital syphilis as a risk factor for the concomitant occurrence of infections with distinct etiology in these newborns. [omicsonline.org]
Infection is thought to be a major etiologic factor in some preterm labors. When cervical, vaginal, or urinary tract infections are present, the risk of preterm birth is increased (Box 3). [intranet.tdmu.edu.ua]
[…] for ____ after hydostatic mole...therefore, _______ are suggested and highly important 1 year; oral contraceptives Persistent uncontrollable vomiting that begins in early weeks of pregnancy and may continue throughout pregnancy Hyperemesis Gravidarum Etiology [freezingblue.com]
Learning Objectives Learning Objectives : Upon completion of this educational activity the participant should be able to recognize sonographic features of ectopic pregnancy, describe physiologic changes and common etiologies for pelvic pain in the pregnant [sonoworld.com]
Section 5 - Management and Treatment of Specific Infections Syphilis Etiology Caused by Treponema pallidum subsp. pallidum. [canada.ca]
Epidemiology
Future analyses can be tailored to countries using local epidemiologic and programmatic data. [ncbi.nlm.nih.gov]
[…] can occur if infectious lesion on breast 11 Congenital Syphilis Transmission can occur any time in gestation Frequency of transmission increases as gestation advances Higher rate of transmission w/ primary & secondary infection 12 Congenital Syphilis Epidemiology [slideplayer.com]
Epidemiology (Sunnyvale) 6:269. doi:10.4172/2161-1165.1000269 Copyright: 2016 de Oliveiraa BCA. [omicsonline.org]
Pathophysiology
Berman SM (2004) Maternal syphilis: pathophysiology and treatment. Bull World Health Organ 82:433–488 PubMed Google Scholar 3. Mandelbrot L, Marcollet A (2004) Syphilis and pregnancy. Rev Prat 54:392–395 PubMed Google Scholar 4. [link.springer.com]
Maternal syphilis: pathophysiology and treatment. Bulletin of the World Health Organization. 2004; 82 (6):433–438. [ PMC free article ] [ PubMed ] [ Google Scholar ] 2. Ingall D, Sánchez PJ. Syphilis. In: Remington JS, Klein JO, editors. [ncbi.nlm.nih.gov]
Although congenital syphilis has been studied and described for many years, our understanding of the pathophysiology of maternal transmission of Treponema pallidum is still incomplete. [academic.oup.com]
Berman SM (2004) Maternal syphilis: pathophysiology and treatment. Bull World Health Organ 82: 433–438. View Article Google Scholar 28. [journals.plos.org]
While the gestational outcomes of syphilis have been well described, the specific pathophysiologic changes occurring in utero have not been clearly elucidated. [medicalreview.columbia.edu]
Prevention
OBJECTIVE: To evaluate prospectively the Centers for Disease Control and Prevention (CDC) recommended regimens for the treatment of antepartum syphilis and prevention of congenital syphilis. [ncbi.nlm.nih.gov]
Failure of recommended maternal therapy to prevent congenital syphilis. Sex Transm Dis 1991;18:102–6. 12. Centers for Disease Control and Prevention. Guidelines for the prevention of sexually transmitted diseases. [journals.lww.com]