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Syphilitic Alopecia
Syphilis with Alopecia

Presentation

Confluent small alopecic patches of the parietal area are present on an erythematous scalp (a). [derm101.com]

Patients often present with other mucocutaneous symptoms of secondary syphilis. [escholarship.org]

This presentation serves as a reminder to clinicians to be cognizant of alopecia as a presenting sign of syphilis. [ucdavis.pure.elsevier.com]

Entire Body System

  • Unsafe Sexual Practices

    Safer-sex messages should include reducing the number of sexual partners; knowing the health status and HIV infection status of partners; avoiding unsafe sexual practices, not just for HIV, but for all STDs; and using barrier protection methods such as [hivinsite.ucsf.edu]

Skin

  • Alopecia

    A case of syphilitic alopecia on the legs of young man is described. Both positive serologic tests and the clinical response to treatment with penicillin suggest that this alopecia was due to syphilis. [ncbi.nlm.nih.gov]

    The moth-eaten alopecia of secondary syphilis. A histopathological study of 12 patients. Am J Dermatopathol. 1995;17:158. PubMed 7. Lee JY, Hsu ML. Alopecia syphilitica, a simulator of alopecia areata: histopathology and differential diagnosis. [derm101.com]

    […] syphilitic alopecia alopecia syphilitica alopecia involving the eyebrows, beard, and scalp in secondary syphilis; it occurs in small, irregular scattered patches, resulting in a moth-eaten appearance. Called also moth-eaten a. [medicine.academic.ru]

    Syphilitic alopecia can closely resemble alopecia areata both clinically and histopathologically. [academic.oup.com]

  • Follicular Hyperkeratosis

    Moreover, we observed additional features, including tapering hairs, diffuse scaling and focal follicular hyperkeratosis. [derm101.com]

Treatment

Natural 500ML Herbal Hair Shampoo Black Rose Moisturizing Hair Treatment Cream HMG-18. [hieratic.eu]

Treatment The preparation, dosage, and duration of treatment vary, depending on the stage of syphilis, HIV status of the patient, and presence of neurosyphilis [23, 24, 25, 26]. [escholarship.org]

Both positive serologic tests and the clinical response to treatment with penicillin suggest that this alopecia was due to syphilis. [ncbi.nlm.nih.gov]

[…] of HIV in Industrialized and Middle Income CountriesŠAdults Adolescents and Pediatric 1310 Chapter 115 Guidelines for the Treatment of HIV and AIDS in ResourceLimited Countries 1328 Chapter 116 Guidelines for Prevention of Perinatal HIV Infection 1345 [books.google.com]

Prognosis

[…] favorable prognosis for patients diagnosed with either primary or secondary syphilis 20% of untreated patients with tertiary syphilis die of the disease prognosis for tertiary syphilis depends on the extent of scarring and tissue damage with adequate [medbullets.com]

Patient Education National Alopecia Areata Foundation: www.naaf.org Prognosis Androgenic alopecia : Prognosis depends on response to treatment. AA : often regrows within 1 year even without treatment. [unboundmedicine.com]

With penicillin administration, hair of the legs, scalp, and eyebrows started to grow; the hair was fully regrown within 6 months, which suggests good prognosis with treatment instigation for syphilitic alopecia of all areas. [mdedge.com]

The more profuse the eruption the better is the prognosis. The severe type (Oroya): The only skin manifestations are mild skin lesion due to insect bite at the site of inoculation. [drmhijazy.com]

[…] squaric acid ( Table 2 5 – 18 ). 7 Overall, 34 to 50 percent of patients with alopecia areata will recover within one year; this number is as high as 80 percent in patients with one or two patches. 6 The more severe the disease at onset, the worse the prognosis [aafp.org]

Etiology

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.com]

Treatments all focus on symptom management rather than etiology. [unboundmedicine.com]

Clinically, diffuse syphilitic alopecia, as a rule, does not differ from symptomatic hair loss of a different etiology, therefore, in all patients with a sudden diffuse alopecia of unknown etiology, it is recommended to investigate serological responses [en.medicine-guidebook.com]

Etiology Treponema bacteria (particularly during stages I/II) are highly contagious! Sexual contact with a partner who suffers from active syphilis will lead to infection in 30% of cases! [amboss.com]

Epidemiology

Venereal Diseases; Milica Marković ; City Institute for Skin and Venereal Diseases Džordža Vašingtona 17 11000 Belgrade Serbia Dubravka Salemović ; Institute for Infectious and Tropical Diseases, Clinical Centre of Serbia Sandra Šipetić ; Institute of Epidemiology [hrcak.srce.hr]

Epidemiology References: [1] [2] Epidemiological data refers to the US, unless otherwise specified. Etiology Treponema bacteria (particularly during stages I/II) are highly contagious! [amboss.com]

Reexamining syphilis: an update on epidemiology, clinical manifestations, and management. Annals of Pharmacotherapy 2008; 42: 226-236. [PubMed] 13. Jordaan HF, Louw M. [escholarship.org]

Epidemiology Epidemiologic studies demonstrate that history of an STD, including syphilis, is associated with an increased risk of HIV disease among both gay men (7,9) and heterosexuals (8) because sexual behaviors that increase the risk of acquiring [hivinsite.ucsf.edu]

Piraccini BM, Broccoli A, Starace M, Jasper V, D'Antuono A, Dika A, Patrizi A: Hair and scalp manifestations in secondary syphilis: epidemiology, clinical features and trichoscopy. Dermatology 2015;231:171-176. [karger.com]

Pathophysiology

References: [3] [4] Pathophysiology Clinical features Primary syphilis Primary lesion ( chancre ) Typically starts out as a solitary, raised papule (usually on the genitals) Evolves into painle ss, firm ulcer with indurated borde rs and smooth base Resolves [amboss.com]

Commonly Associated Conditions See “Etiology and Pathophysiology.” [unboundmedicine.com]

Prevention

Encyclopedia) RPR test (Medical Encyclopedia) Syphilis (Centers for Disease Control and Prevention) Syphilis - primary (Medical Encyclopedia) Syphilis and MSM (Men Who Have Sex with Men) (Centers for Disease Control and Prevention) VDRL test (Medical [icdlist.com]

Chapter 69 Surrogate Markers of Antiretroviral Efficacy 826 Overcoming Barriers to Providing ARV Therapy in ResourceLimited Settings 831 Chapter 71 Antiretroviral Drugs for HIV Prevention 836 Chapter 72 Acute HIV Infection 843 Chapter 73 Opportunistic [books.google.com]

It is unclear, however, whether repeated doses or larger doses of benzathine penicillin would prevent neurosyphilis [25]. [escholarship.org]

Adequate therapy of the infected mother before the sixteenth week of gestation usually prevents infection of the fetus. [dartmouth.edu]

Asymptomatic ( latent ) syphilis should be treated to prevent occurrence of late complications (tertiary syphilis). [dermnetnz.org]

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