An 8-year-old girl presented with a papillomatous lower eyelid lesion, which had been present since infancy. An incisional biopsy diagnosed syringocystadenoma papilliferum. [ncbi.nlm.nih.gov]

Most patients present a solitary lesion in the head and neck region. Presentation outside the head and neck region is even more uncommon. [scielo.br]

• Soft Tissue Mass

  A gross examination showed two gray brown hairy skin covered soft tissue masses altogether measuring 3 cm × 3 cm, with areas of hemorrhage. [jscisociety.com]

  A mass noted in the left external auditory canal. High resolution computed tomography showed an approximately 0.8 × 0.6 cm soft tissue mass occupying within the left external ear canal near the opnening, without eroding canal wall. [headandneckoncology.biomedcentral.com]

• Constitutional Symptom

  There was no history of itching, fever, weight loss, or other constitutional symptoms. Physical examination revealed a solitary, well circumscribed swelling of 1 cm diameter. The swelling was firm in consistency, mobile and nontender. [jcytol.org]

• Weight Loss

  There was no history of itching, fever, weight loss, or other constitutional symptoms. Physical examination revealed a solitary, well circumscribed swelling of 1 cm diameter. The swelling was firm in consistency, mobile and nontender. [jcytol.org]

• Epilepsy

  Naevus syringocystadenomatosus papilliferus with skull and brain lesions, hemiparesis, epilepsy and mental retardation. Br J Dermatol 1970;82:402–405. 8. Helwig EB, Hackney VC. [synapse.koreamed.org]

• Diplopia

  No history of diplopia was there. Systemic history was unremarkable. On examination, best-corrected visual acuity was 20/20 and 20/120 for oculus dexter and oculus sinister, respectively. [meajo.org]

In such cases, historic features must be combined with complete systemic workup to exclude primary extra cutaneous tumors. Seven such tumors were present in our series. [jpma.org.pk]

Management and treatment Treatment involves complete surgical excision. Carbon dioxide laser treatment can be useful for lesions in anatomic areas not favorable for surgery. [orpha.net]

The treatment of Syringocystadenoma Papilliferum may involve the following: The treatment is a complete surgical excision, which can result in a cure. [dovemed.com]

Treatment is complete excision of the lesion and this has a low recurrence rate. While predominantly benign, there have been cases of basal cell carcinoma development or other malignant transformations. [ncbi.nlm.nih.gov]

Regardless of the type, the histopathology of the lesion is usually the same and renders the same prognosis. [ncbi.nlm.nih.gov]

Etiology The etiology of SCAP has not been elucidated. It is not known whether SCAP derives from eccrine or apocrine glands. The role of pluripotent stem cells has also been suggested. [orpha.net]

TERMINOLOGY Abbreviations Syringocystadenoma papilliferum (SCP) Definitions Benign adnexal tumor with endophytic/exophytic growth pattern ETIOLOGY/PATHOGENESIS Cytogenetics Subset of tumors have loss of heterozygosity for PTCH &/or P16, suggesting a role [basicmedicalkey.com]

Carcinoma, Large Cell/diagnosis, Carcinoma, Neuroendocrine/diagnosis, Keratosis/etiology, Lung Neoplasms/diagnosis, Osteoarthropathy, Secondary Hypertrophic/etiology, Paraneoplastic Syndromes/etiology, Biomarkers, Tumor/analysis, Carcinoma, Large Cell [pesquisa.bvsalud.org]

(Etiology) The cause of development of Syringocystadenoma Papilliferum is unknown Genetic mutations have been suspected by researchers in some cases Some researchers believe that these tumors arise from the eccrine or apocrine sweat gland What are the [dovemed.com]

Benign adnexal tumor with endophytic/exophytic growth pattern ETIOLOGY/PATHOGENESIS Cytogenetics Subset of tumors have loss of heterozygosity for PTCH &/or P16, suggesting a role for loss of these tumor suppressor genes in some cases CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Her main area of interest is cancer epidemiology, with a particular focus on melanoma and other skin cancers. Nagwa M. Elwan is Professor of Dermatology at the Faculty of Medicine, Tanta University, Egypt. [books.google.es]

Summary Epidemiology The prevalence of SCAP is not known. About 300 cases have been reported to date. The condition has been reported in various ethnic groups. [orpha.net]

Breast Neoplasms/epidemiology, Adult, Axilla, Breast Neoplasms/genetics, Breast Neoplasms/pathology, Carcinoma, Ductal, Breast/epidemiology, Carcinoma, Ductal, Breast/pathology, Female, Humans, Lymph Nodes/pathology, Morocco/epidemiology, Neoplasm Staging [pesquisa.bvsalud.org]

Epidemiology of benign eyelid lesions in patients presenting to a teaching hospital. Saudi J Ophthalmol 2012;26:211-6. 6. Rook A, Wilkinson DS, Ebling FJ. Textbook of Dermatology. Pondicherry: Blackwell; 1986. p. 177. 7. Helwig EB, Hackney VC. [ijo.in]

[…] tumors, such as ceruminous adenoma, ceruminous pleomorphic adenoma, and ceruminous syringocystadenoma papilliferum, as well as malignant tumors, such as ceruminous adenocarcinoma, adenoid cystic carcinoma, and, mucoepidermoid carcinoma. [4, 5, 6, 7] Pathophysiology [emedicine.medscape.com]

Natural history of SCAP is yet to be determined, thus prevention is not yet an option. Excision of the lesion is the mainstay of treatment, but wide margins are not necessary. Financial support and sponsorship Nil. [ncbi.nlm.nih.gov]