We describe a case of IgG4-RSD initially presenting as a submandibular mass and subsequently presenting two years later with secondary infiltration of the kidney causing tubulointerstitial nephritis. [ncbi.nlm.nih.gov]

• Weight Gain

  Prednisone has proven very effective in treating this condition but also leads to side effects such as weight gain, osteoporosis, high blood pressure and diabetes. [massgeneral.org]

  The results do provide a clear positive association between weight gain and new cases of periodontitis. [link.springer.com]

  gain, fatigue, moon facies, buffalo hump, mood instability, glucose intolerance, bone fragility, and increased susceptibility to infections. [303] Cutaneous manifestations include striae, acne, hirsutism, and increased skin fragility. [emedicine.medscape.com]

• Eczema

  Cutaneous manifestations of Hodgkin lymphoma include cutaneous Hodgkin disease, eczema, pruritus, and erythema nodosum. [71] Oral manifestations of Hodgkin disease are uncommon, although they may develop secondary to chemotherapeutics. [emedicine.medscape.com]

The authors identified 2 cases of AL amyloidosis confirmed by mass spectrometry localized to the conjunctiva and without evidence of systemic disease as determined by thorough systemic workup. [ncbi.nlm.nih.gov]

Q: When patients present with a chronic, non-healing wound, what workup do you perform to rule out a systemic cause? A: For patients with lower extremity ulcers and non-healing wounds, Dr. Schlanger orders a multi-stage workup. [podiatrytoday.com]

Ideally, early recognition of the characteristic mucocutaneous melanosis would lead to a thorough medical workup and the diagnosis of PJS. [clinicaladvisor.com]

CONCLUSION: Treatment with rituximab led to prompt clinical and serologic improvement in these patients with refractory IgG4-RSD, and is a viable treatment option for this condition. [ncbi.nlm.nih.gov]

Severe extra-articular disease is associated with high levels of rheumatoid factor (RF ) in patients with seropositive rheumatoid arthritis (RA ) and a poor prognosis. [ncbi.nlm.nih.gov]

The prognosis of amyloidosis depends on which organs are involved and the extent of the deposition. For example, protein accumulation in the heart and kidney can result in organ failure. [clinicaladvisor.com]

As you might expect, rheumatoid arthritis patients with systemic complications tend to do worse than those without such complications (i.e. prognosis is worse with systemic involvement). [verywell.com]

In the pediatric population, oral changes can be related to rare cancers, such as Langerhans cell histiocytosis, or infectious etiologies, such as Kawasaki disease. [ncbi.nlm.nih.gov]

The present era of international travel poses a new diagnostic and epidemiologic challenge that demands increased awareness to the possibility of an exotic tropical infectious disease. [ncbi.nlm.nih.gov]

The results of these recent MR studies suggest that the epidemiological association between obesity and periodontitis may be confounded. [link.springer.com]

One mechanism that may explain these epidemiologic observations is the association of hyperhomocysteinemia with increased intake of meats and decreased intake of vitamin B6, vitamin B12, and folate. [humpath.com]

Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects By Susana Coimbra, Hugo Oliveira, Américo Figueiredo, Petronila Rocha-Pereira and Alice Santos-Silva 7226 Open access peer-reviewed [intechopen.com]

In this review, the authors highlight the main clinical features, electrographic abnormalities, histopathological aspects and treatment, as well as the current, but still incomplete understanding of the pathophysiological mechanisms involved. [ncbi.nlm.nih.gov]

System biology will allow in depth understanding of complex diseases like CKD and will set the stage for predictive, preventive and personalized medicine, a long-standing dream of doctors and patients alike. 2014 S. Karger AG, Basel. [ncbi.nlm.nih.gov]