Presentation
We describe a case of IgG4-RSD initially presenting as a submandibular mass and subsequently presenting two years later with secondary infiltration of the kidney causing tubulointerstitial nephritis. [ncbi.nlm.nih.gov]
Entire Body System
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Weight Gain
Prednisone has proven very effective in treating this condition but also leads to side effects such as weight gain, osteoporosis, high blood pressure and diabetes. [massgeneral.org]
The results do provide a clear positive association between weight gain and new cases of periodontitis. [link.springer.com]
gain, fatigue, moon facies, buffalo hump, mood instability, glucose intolerance, bone fragility, and increased susceptibility to infections. [303] Cutaneous manifestations include striae, acne, hirsutism, and increased skin fragility. [emedicine.medscape.com]
Skin
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Eczema
Cutaneous manifestations of Hodgkin lymphoma include cutaneous Hodgkin disease, eczema, pruritus, and erythema nodosum. [71] Oral manifestations of Hodgkin disease are uncommon, although they may develop secondary to chemotherapeutics. [emedicine.medscape.com]
Workup
The authors identified 2 cases of AL amyloidosis confirmed by mass spectrometry localized to the conjunctiva and without evidence of systemic disease as determined by thorough systemic workup. [ncbi.nlm.nih.gov]
Q: When patients present with a chronic, non-healing wound, what workup do you perform to rule out a systemic cause? A: For patients with lower extremity ulcers and non-healing wounds, Dr. Schlanger orders a multi-stage workup. [podiatrytoday.com]
Ideally, early recognition of the characteristic mucocutaneous melanosis would lead to a thorough medical workup and the diagnosis of PJS. [clinicaladvisor.com]
Treatment
CONCLUSION: Treatment with rituximab led to prompt clinical and serologic improvement in these patients with refractory IgG4-RSD, and is a viable treatment option for this condition. [ncbi.nlm.nih.gov]
Prognosis
Severe extra-articular disease is associated with high levels of rheumatoid factor (RF ) in patients with seropositive rheumatoid arthritis (RA ) and a poor prognosis. [ncbi.nlm.nih.gov]
The prognosis of amyloidosis depends on which organs are involved and the extent of the deposition. For example, protein accumulation in the heart and kidney can result in organ failure. [clinicaladvisor.com]
As you might expect, rheumatoid arthritis patients with systemic complications tend to do worse than those without such complications (i.e. prognosis is worse with systemic involvement). [verywell.com]
Etiology
In the pediatric population, oral changes can be related to rare cancers, such as Langerhans cell histiocytosis, or infectious etiologies, such as Kawasaki disease. [ncbi.nlm.nih.gov]
Epidemiology
The present era of international travel poses a new diagnostic and epidemiologic challenge that demands increased awareness to the possibility of an exotic tropical infectious disease. [ncbi.nlm.nih.gov]
The results of these recent MR studies suggest that the epidemiological association between obesity and periodontitis may be confounded. [link.springer.com]
One mechanism that may explain these epidemiologic observations is the association of hyperhomocysteinemia with increased intake of meats and decreased intake of vitamin B6, vitamin B12, and folate. [humpath.com]
Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects By Susana Coimbra, Hugo Oliveira, Américo Figueiredo, Petronila Rocha-Pereira and Alice Santos-Silva 7226 Open access peer-reviewed [intechopen.com]
Pathophysiology
In this review, the authors highlight the main clinical features, electrographic abnormalities, histopathological aspects and treatment, as well as the current, but still incomplete understanding of the pathophysiological mechanisms involved. [ncbi.nlm.nih.gov]
Prevention
System biology will allow in depth understanding of complex diseases like CKD and will set the stage for predictive, preventive and personalized medicine, a long-standing dream of doctors and patients alike. 2014 S. Karger AG, Basel. [ncbi.nlm.nih.gov]