We describe a case of IgG4-RSD initially presenting as a submandibular mass and subsequently presenting two years later with secondary infiltration of the kidney causing tubulointerstitial nephritis. [ncbi.nlm.nih.gov]

Generalised pruritus and cutaneous vasculitis are more common cutaneous presentations where an underlying systemic disease may be present and will influence management. [racgp.org.au]

• Weight Gain

  Prednisone has proven very effective in treating this condition but also leads to side effects such as weight gain, osteoporosis, high blood pressure and diabetes. [massgeneral.org]

  The results do provide a clear positive association between weight gain and new cases of periodontitis. [link.springer.com]

  gain, and lethargy, while cutaneous manifestations include dry skin and hair. [292] On the other hand, common manifestations of hyperthyroid include heat intolerance, abdominal pain, weight loss, and tachycardia, while cutaneous manifestations include [emedicine.medscape.com]

• Disability

  Please enable JS and disable any ad blocker [veterinarycalendar.dvm360.com]

  OBJECTIVE: Epilepsy is one of the most disabling symptoms of tuberous sclerosis complex (TSC) and is a leading cause of morbidity and mortality in affected individuals. [ncbi.nlm.nih.gov]

  Out of these 40% people within 3 years, and 80% in 20 years, become disabled. The real question is, to what extent we could contribute in managing this great problem on the basis of ayurveda. Let's see. [drvasishths.blogspot.com]

• Rigor

  These observations lacked the rigor of modern scientific studies and the theory of focal infection was later discarded. [nature.com]

  If an apical lesion exists, then a surgical procedure is needed to eliminate the lesion followed by rigorous curettage, decontamination, and grafting. [aaosh.org]

• Unconsciousness

  Comes in shock /unconscious state. [3/22, 09:51] Dr Shashi Jindal, Chandigarh: uncontrolled alsak visoochika grahni etc. may get complicate into udar rog, badhgudodar or peforation etc. [3/22, 11:40] Dr Surendra A Soni: Perforation is close to 'aabhyantar-vidradhi [kayachikitsagau.blogspot.com]

• Abdominal Distension

  P: Sorry mam i dont think its Alsak the cardinal sign for alsak is abdominal distension with no vowel sound. [3/22, 13:20] Dr Shashi Jindal, Chandigarh: sir bowel sounds not absent, even more, because vayu is there it is in gati also cause dystonia due [kayachikitsagau.blogspot.com]

• Xerostomia

  CONCLUSION: The severity of xerostomia after treatment with anticholinergics in OAB increases in patients with one systemic disease parallel to its severity before starting treatment. [ncbi.nlm.nih.gov]

  […] deficiency Scurvy, haemorrhage, ulcers, Gingival hyperplasia Iron deficiency Xerostomia, Smooth tongue, burning tongue, Dysphagia, Squamous epithelial metaplasia of oral and/or oesophageal mucosa (Plummer-Vinson syndrome, Precancerous lesion! [med-college.de]

  […] for prevention of tooth decay, xerostomia leads to increased caries risk. [aafp.org]

  […] food debris can form on dentures, which need to be cleaned daily Tonsils – cryptic areas (crevices) in the tonsils can allow food debris to become lodged in the tonsil area Respiratory tract infections – throat, sinus and lung infections Dry mouth (Xerostomia [colgate.com]

  Dry mouth An adverse effect of many medications is dry mouth (hyposalivation or xerostomia). [emedicine.medscape.com]

• Lacrimation

  The diagnosis was confirmed when tissue from the lacrimal gland biopsy was reviewed with special stains for IgG4, performed at the Mayo Clinic. [ncbi.nlm.nih.gov]

• Dry Eyes

  […] on Oxford scale ≥1 in either eye) and patients with dry eye symptomatology but without the clinical findings. [iovs.arvojournals.org]

  On steroid therapy serum IgG4 levels normalized, the eosinophilia resolved, and there was improvement in symptomatic wheeze, dry eyes, serum creatinine, and liver function tests. [ncbi.nlm.nih.gov]

  “She came in for her dry eye assessment, and that ended up becoming a lifesaving visit,” Gupta said. [healio.com]

  […] a commonly prescribed and effective treatment for dry eye syndrome. [uspharmacist.com]

• Morning Stiffness

  She also complains of fatigue but has no difficulty with sleep or morning stiffness. A review of systems is negative for weight loss, fever, rash, paresthesias, weakness, joint swelling, and Raynaud's phenomenon. [rheumatology.org]

  stiffness Serositis Typical pleurisy for more than 1 day OR pleural effusions OR pleural rub Typical pericardial pain (pain with recumbency improved by sitting forward) for more than 1 day OR pericardial effusion OR pericardial rub OR pericarditis by [emedicine.medscape.com]

• Joint Swelling

  There is some tenderness on palpation of the joints and muscles but no joint swelling, warmth, or effusion. There is no rash and the neurologic examination is intact except for a delay in the relaxation phase of the deep tendon reflexes. [rheumatology.org]

  Common symptoms include: severe fatigue joint pain joint swelling headaches a rash on the cheeks and nose, which is called a “butterfly rash” hair loss anemia blood-clotting problems fingers turning white or blue and tingling when cold, which is known [healthline.com]

• Erythema

  Differential diagnosis includes cellulitis, spider bite, erythema multiforme, and erythema annulare centrifugum. Treatment is doxycycline. [clevelandclinicmeded.com]

  Burning, pain, tenderness, and erythema also may be present. Candidiasis may be a concurrent finding or an alternative cause of erythema, burning, and atrophy. [aafp.org]

  Acrodermatitis enteropathica Acrodynia Acute febrile neutrophilic dermatosis Amyloidosis Angioedema Annular erythema Antiphospholipid syndrome Argyria Autoimmune disease Autoinflammatory syndromes Behçet disease Biotin–responsive dermatoses Blau syndrome [dermnetnz.org]

  Often the skin manifestations of systemic disease are vague and nonspecific such as the toxic erythema that might follow a viral infection or a drug eruption. [ncbi.nlm.nih.gov]

  Erythema Multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal Nocrolysis 12. Panniculitis 13. Pruritus 14. Erythroderma 15. Purpura 16. Bullous Diseases 17. Skin Signs of Internal Malignancy 18. Dermatologic Adverse Events of Cancer Therapy 19. [elsevier.com]

• Eczema

  Cutaneous manifestations of Hodgkin lymphoma include cutaneous Hodgkin disease, eczema, pruritus, and erythema nodosum. [71] Oral manifestations of Hodgkin disease are uncommon, although they may develop secondary to chemotherapeutics. [emedicine.medscape.com]

• Stroke

  An ischemic stroke is a type of stroke caused by a blocked blood vessel the gets blood to the brain. [lanap.com]

  Chapter 5 Stroke due to Systemic Diseases First published: 24 January 2013 Summary A wide array of systemic diseases increase stroke risk. [onlinelibrary.wiley.com]

  Autoimmune rheumatic disorders—(1) Systemic lupus erythematosus—neurological manifestations include headache, acute or subacute encephalopathy, fits, myelitis, strokes and movement disorders (including chorea and other extrapyramidal disorders), ataxia [oxfordmedicine.com]

  […] with stroke risk and that “results emphasize the role of oral health personnel in prevention (of stroke).” 7 An earlier review concluded that periodontal disease among older people correlates with increased risk of systemic diseases—including heart attack [lifeextension.com]

  It presents itself clinically solely by its local manifestations, like myocardial infarction or stroke. These local manifestations may be followed by secondary systemic sequelae like congestive heart failure. [ncbi.nlm.nih.gov]

The authors identified 2 cases of AL amyloidosis confirmed by mass spectrometry localized to the conjunctiva and without evidence of systemic disease as determined by thorough systemic workup. [ncbi.nlm.nih.gov]

Q: When patients present with a chronic, non-healing wound, what workup do you perform to rule out a systemic cause? A: For patients with lower extremity ulcers and non-healing wounds, Dr. Schlanger orders a multi-stage workup. [podiatrytoday.com]

Ideally, early recognition of the characteristic mucocutaneous melanosis would lead to a thorough medical workup and the diagnosis of PJS. [clinicaladvisor.com]

[…] associated with nail involvement. [22],[35] Hence, nail findings may not only be window to a plethora of possible systemic associations, but also a window of opportunity as a profound knowledge of the associations may be useful in a complete and targeted workup [idoj.in]

CONCLUSION: Treatment with rituximab led to prompt clinical and serologic improvement in these patients with refractory IgG4-RSD, and is a viable treatment option for this condition. [ncbi.nlm.nih.gov]

Because these extra-pulmonary manifestations of COPD are common and/or may have significant implications for the patient wellbeing and prognosis, they warrant systematic screening and appropriate management in order to provide optimal medical care. [ncbi.nlm.nih.gov]

The prognosis of amyloidosis depends on which organs are involved and the extent of the deposition. For example, protein accumulation in the heart and kidney can result in organ failure. [clinicaladvisor.com]

As you might expect, rheumatoid arthritis patients with systemic complications tend to do worse than those without such complications (i.e. prognosis is worse with systemic involvement). [verywell.com]

In the pediatric population, oral changes can be related to rare cancers, such as Langerhans cell histiocytosis, or infectious etiologies, such as Kawasaki disease. [ncbi.nlm.nih.gov]

The present era of international travel poses a new diagnostic and epidemiologic challenge that demands increased awareness to the possibility of an exotic tropical infectious disease. [ncbi.nlm.nih.gov]

[…] disease and non-celiac gluten sensitivity Clinical Review State of the Art Review BMJ 2015 ; 351 doi: https://doi.org/10.1136/bmj.h4347 (Published 05 October 2015) Cite this as: BMJ 2015;351:h4347 Benjamin Lebwohl, assistant professor of medicine and epidemiology [doi.org]

The results of these recent MR studies suggest that the epidemiological association between obesity and periodontitis may be confounded. [link.springer.com]

One mechanism that may explain these epidemiologic observations is the association of hyperhomocysteinemia with increased intake of meats and decreased intake of vitamin B6, vitamin B12, and folate. [humpath.com]

In this review, the authors highlight the main clinical features, electrographic abnormalities, histopathological aspects and treatment, as well as the current, but still incomplete understanding of the pathophysiological mechanisms involved. [ncbi.nlm.nih.gov]

System biology will allow in depth understanding of complex diseases like CKD and will set the stage for predictive, preventive and personalized medicine, a long-standing dream of doctors and patients alike. © 2014 S. Karger AG, Basel. [ncbi.nlm.nih.gov]

B 33 – 38 Based on one meta-analysis of herpes simplex virus prevention with acyclovir; two meta-analyses of mucositis prevention with chlorhexidine; one RCT and one randomized crossover trial examining mucositis prevention with chlorhexidine and oral [aafp.org]

Dietary fiber, or roughage, resulting in increased fecal bulk, has a preventive effect against diverticulosis of the colon. [humpath.com]

“Although you clean your mouth every day at home, regular checkups to the dentist will prevent additional disease that can likely cause you to be sick.” [padental.org]