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Systemic Disease

Illnesses Systemic


  • We describe a case of IgG4-RSD initially presenting as a submandibular mass and subsequently presenting two years later with secondary infiltration of the kidney causing tubulointerstitial nephritis.[ncbi.nlm.nih.gov]
  • Three patients, all with marked weight loss, who presented with jaundice, abdominal pain, and/or diarrhea were found to have a pancreatic mass at first presentation.[ncbi.nlm.nih.gov]
  • The present era of international travel poses a new diagnostic and epidemiologic challenge that demands increased awareness to the possibility of an exotic tropical infectious disease.[ncbi.nlm.nih.gov]
  • This report presents the case of a 60-year-old female patient with multiple erythematous nodules on the extremities. She had no underlying systemic disease detected to date, although transient, abnormal liver function tests were seen.[ncbi.nlm.nih.gov]
  • PG associated with pregnancy is an extremely rare presentation; only 9 other cases have been reported in the literature. We present PG in a pregnant patient (third trimester) with pathergy. No associated systemic disease was identified.[ncbi.nlm.nih.gov]
Prolonged Bleeding
  • Recent evidence has supported the potential for both hypocoagulable and hypercoagulable states in patients with liver and kidney disease with an even less understood impact on prolonged bleeding in the oral cavity.[ncbi.nlm.nih.gov]
Hemophilia A
  • […] on the gastrointestinal manifestations of systemic diseases, including amyloidosis, angiotensin converter enzyme inhibitor-induced angioedema, celiac sprue, distal intestinal obstruction syndrome, graft-versus-host disease, hemolytic uremic syndrome, hemophilia[ncbi.nlm.nih.gov]
Weight Gain
  • Prednisone has proven very effective in treating this condition but also leads to side effects such as weight gain, osteoporosis, high blood pressure and diabetes.[massgeneral.org]
  • gain or loss, fatigue) Detoxification (for example: fatty liver, acne, poor estrogen clearance) Digestion and absorption (for example: nutrient malabsorption leading to deficiencies, heartburn, bloating, constipation/diarrhea, abdominal pain) Microbiology[vitalhealth.com]
  • […] studies on grading in subarachnoid hemorrhage (SAH) had several limitations such as the unclear grading of Glasgow Coma Scale 15 with neurological deficits in World Federation of Neurosurgical Societies (WFNS), and the inclusion of systemic disease in Hunt[ncbi.nlm.nih.gov]
  • Among these 7 patients with IgG4-related ophthalmic disease, 4 presented with painless eyelid or periorbital swelling, 2 with diplopia and restricted ocular motility, and 1 with proptosis.[ncbi.nlm.nih.gov]
Shagreen Patch
  • patches (OR 1.7, CI 1.0-2.7, p 0.04), and facial angiofibromas (OR 1.7, CI 1.1-2.9, p 0.03) were associated with a higher likelihood of epilepsy.[ncbi.nlm.nih.gov]
Facial Angiofibroma
  • angiofibromas (OR 1.7, CI 1.1-2.9, p 0.03) were associated with a higher likelihood of epilepsy.[ncbi.nlm.nih.gov]
Insect Bite
  • We describe the case of a female who initially presented with localized skin disease associated with an insect bite.[ncbi.nlm.nih.gov]
Preauricular Swelling
  • METHODS AND RESULTS: We report on a 73-year-old male with bilateral preauricular swelling and a remote history of unexplained systemic disease.[ncbi.nlm.nih.gov]


  • The authors identified 2 cases of AL amyloidosis confirmed by mass spectrometry localized to the conjunctiva and without evidence of systemic disease as determined by thorough systemic workup.[ncbi.nlm.nih.gov]
  • Q: When patients present with a chronic, non-healing wound, what workup do you perform to rule out a systemic cause? A: For patients with lower extremity ulcers and non-healing wounds, Dr. Schlanger orders a multi-stage workup.[podiatrytoday.com]
  • Ideally, early recognition of the characteristic mucocutaneous melanosis would lead to a thorough medical workup and the diagnosis of PJS.[clinicaladvisor.com]
  • Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan. norimaki-tky@umin.ac.jp Abstract A 70-year old man with a 14 year history of Sjögren syndrome, interstitial pneumonia, and autoimmune hepatitis (AIH) was admitted to our hospital due to hyponatremia[ncbi.nlm.nih.gov]
  • A 47-year-old woman with psoriatic arthropathy developed high fever with leucocytosis and thrombocytosis and lung infiltrates during exacerbation of her joint disease .[ncbi.nlm.nih.gov]


  • CONCLUSION: Treatment with rituximab led to prompt clinical and serologic improvement in these patients with refractory IgG4-RSD, and is a viable treatment option for this condition.[ncbi.nlm.nih.gov]
  • CONCLUSION: The severity of xerostomia after treatment with anticholinergics in OAB increases in patients with one systemic disease parallel to its severity before starting treatment.[ncbi.nlm.nih.gov]
  • Six months after initiating treatment with rituximab, his disease remained dormant, with improvement in his proptosis and normalization of serum IgG4 levels.[ncbi.nlm.nih.gov]
  • Where appropriate, it also enumerates the treatments involved, both systemic and localized. Copyright 2016 Elsevier Inc. All rights reserved. KEYWORDS: Cutaneous manifestations; Lower extremity; Skin disorders; Systemic disease[ncbi.nlm.nih.gov]
  • KEYWORDS: HCV; Hepatitis C; Treatment[ncbi.nlm.nih.gov]


  • Severe extra-articular disease is associated with high levels of rheumatoid factor (RF ) in patients with seropositive rheumatoid arthritis (RA ) and a poor prognosis.[ncbi.nlm.nih.gov]
  • Because these extra-pulmonary manifestations of COPD are common and/or may have significant implications for the patient wellbeing and prognosis, they warrant systematic screening and appropriate management in order to provide optimal medical care.[ncbi.nlm.nih.gov]
  • The prognosis of amyloidosis depends on which organs are involved and the extent of the deposition. For example, protein accumulation in the heart and kidney can result in organ failure.[clinicaladvisor.com]
  • As you might expect, rheumatoid arthritis patients with systemic complications tend to do worse than those without such complications (i.e. prognosis is worse with systemic involvement).[verywell.com]
  • Patients with CREST syndrome have a better prognosis. Differential diagnosis includes diabetic sclerodema, scleromyxedema, and chronic graft-versus-host disease.[clevelandclinicmeded.com]


  • In the pediatric population, oral changes can be related to rare cancers, such as Langerhans cell histiocytosis, or infectious etiologies, such as Kawasaki disease.[ncbi.nlm.nih.gov]
  • Prevalences of these conditions vary from common to extremely rare, and incidence peaks differ according to etiology.[ncbi.nlm.nih.gov]
  • Herein, a unique case of systemic artery to pulmonary arterial malformation and its endovascular treatment in a patient with no history of the usual etiologies is reported.[ncbi.nlm.nih.gov]
  • Abstract The livedoid vasculopathy is an obstructive vascular process of etiology not yet fully known, being possibly associated with several prothrombotic events.[ncbi.nlm.nih.gov]
  • The diseases discussed are categorized into autoimmune, infiltrative, treatment related, congenital/hereditary, and infectious etiologies.[ncbi.nlm.nih.gov]


  • The present era of international travel poses a new diagnostic and epidemiologic challenge that demands increased awareness to the possibility of an exotic tropical infectious disease.[ncbi.nlm.nih.gov]
  • This is supported also by epidemiological data forwarded in the present paper. In order to clarify the exact meaning of a systemic disease, cancer and its manifestation are compared with arteriosclerosis and its sequelae.[ncbi.nlm.nih.gov]
  • One mechanism that may explain these epidemiologic observations is the association of hyperhomocysteinemia with increased intake of meats and decreased intake of vitamin B6, vitamin B12, and folate.[humpath.com]
  • Psoriasis: Epidemiology, Clinical and Histological Features, Triggering Factors, Assessment of Severity and Psychosocial Aspects By Susana Coimbra, Hugo Oliveira, Américo Figueiredo, Petronila Rocha-Pereira and Alice Santos-Silva 7226 Open access peer-reviewed[intechopen.com]
  • Celiac disease and non-celiac gluten sensitivity Clinical Review State of the Art Review BMJ 2015 ; 351 doi: (Published 05 October 2015) Cite this as: BMJ 2015;351:h4347 Benjamin Lebwohl, assistant professor of medicine and epidemiology 1 2, Jonas F Ludvigsson[doi.org]
Sex distribution
Age distribution


  • In this review, the authors highlight the main clinical features, electrographic abnormalities, histopathological aspects and treatment, as well as the current, but still incomplete understanding of the pathophysiological mechanisms involved.[ncbi.nlm.nih.gov]
  • A mature technology for a system-analysis approach to physiology and pathophysiology of CKD now exists.[ncbi.nlm.nih.gov]
  • This review aims at summarizing clinical features, diagnostic criteria, therapeutic strategies and most recent insights in the pathophysiology of IAC and other organ manifestations of ISD. Copyright 2009 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
  • The University of Texas Southwestern Cutaneous Lupus Erythematosus Registry, of which almost two thirds of participants are those with skin of color, is a part of an ongoing effort to better understand the pathophysiologic mechanisms of CLE and to identify[ncbi.nlm.nih.gov]
  • Plenty remains to be elucidated in this field, identifying even more associated diseases and further exposing pathophysiological mechanisms underlying osteoporotic vertebral fractures.[ncbi.nlm.nih.gov]


  • System biology will allow in depth understanding of complex diseases like CKD and will set the stage for predictive, preventive and personalized medicine, a long-standing dream of doctors and patients alike. 2014 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
  • Early diagnosis and systemic treatment could prevent future complications. A series of three cases is presented in which the initial diagnosis was cutaneous sarcoidosis, but it was actually the first manifestation of a systemic disease.[ncbi.nlm.nih.gov]
  • CLINICAL RELEVANCE: The significance of the oral-systemic disease connection highlights the importance of preventing and treating oral disease which have profound medical implications on general health.[ncbi.nlm.nih.gov]
  • Treatment of the aortitis may prevent progression of the IgG4-related systemic disease to involvement of other organs. IgG4-related systemic disease should be considered in all patients with aortitis judged to be of unknown etiology.[ncbi.nlm.nih.gov]
  • […] manifestations such as cardiac rhabdomyomas that confer a higher risk of epilepsy development in TSC could contribute to disease prognostication and assist in the identification of individuals who may receive maximal benefit from potentially novel, targeted, preventative[ncbi.nlm.nih.gov]

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