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Systemic Mycosis


Presentation

  • Voriconazole is a new antifungal agent that, apart from satisfying this requirement because it has a high oral bioavailability, presents a broad spectrum of antifungal activity that makes its use possible, a priori, in the initial and/or sequential IV[ncbi.nlm.nih.gov]
  • Presentation was variable, consisting of cryptococcal meningitis, cryptococcal pneumonia, aspergillus cerebral vasculitis and disseminated histoplasmosis originating from a histoplasma pneumonia.[ncbi.nlm.nih.gov]
  • Both patients (a four-year-old male and a 57-year-old female) had acute leukemia for which they were receiving chemotherapy, and both presented with fever that was unresponsive to conventional antibiotics.[ncbi.nlm.nih.gov]
  • We present in addition, a summary of the results of our studies concerning the mechanism of action of antifungal agents and detection of in vitro resistance of some important human fungal pathogens.[eurekaselect.com]
Cat Scratch
  • Features up-to-date information on HIV/AIDS, with an emphasis on Africa; malaria; tropical gastroenterological problems; dengue and dengue hemorrhagic fever; tuberculosis; Sexually Transmitted Diseases; SARS; avian flu; bartonellosis, cat-scratch disease[books.google.de]
Meningism
  • Presentation was variable, consisting of cryptococcal meningitis, cryptococcal pneumonia, aspergillus cerebral vasculitis and disseminated histoplasmosis originating from a histoplasma pneumonia.[ncbi.nlm.nih.gov]
  • The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis. ‎ Página 323 - Durand ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis in adults. A review of 493 episodes. ‎[books.google.es]
  • However, in some individuals thedisease may progress to a chronic pulmonarycondition or to a systemic disease involvingthe meninges, bones, joints and subcutaneousand cutaneous tissues.2/10/2011 5Dr.T.V.Rao MD 6.[slideshare.net]
  • Fungal pneumonia Fungal sinusitis Invasive fungal sinusitis Left fungal keratitis Meningitis, fungal Mycosis Mycotic aneurysm Mycotic endocarditis Pneumonia due to fungus Right fungal keratitis Clinical Information An infection caused by a fungus.[icd10data.com]
Headache
  • Systemic mycosis can cause chronic fatigue, pain in the muscles or joints, headaches, and mental fog. Typically, these types of infections only happen to people who already have a weakened immune system.[fibromyalgiatreating.com]
  • Symptoms usually include headache, stiff neck and irritability. Eyes Almost any of the eye structures may be infected by mycoses. Candida and Cryptococcus are the most commonly infecting mycoses.[dermnetnz.org]

Treatment

  • None of 114 patients in the Mayo Clinic trials on conventional treatment for at least six months, but only one of 25 patients (4%) on high dose prednisone, developed systemic mycosis.[ncbi.nlm.nih.gov]
  • He responded completely to treatment with amphotericin B and a prolonged course of ketoconazole. Problems of diagnosis are discussed and all previously reported cases reviewed.[ncbi.nlm.nih.gov]
  • Voriconazole is a new antifungal agent that, apart from satisfying this requirement because it has a high oral bioavailability, presents a broad spectrum of antifungal activity that makes its use possible, a priori, in the initial and/or sequential IV/PO treatment[ncbi.nlm.nih.gov]
  • However, the 57-year-old female died shortly after the begining of similar treatment, and autopsy demonstrated involvement of the left kidney, spleen, bone marrow, and liver.[ncbi.nlm.nih.gov]
  • Slam ThG (1983) Treatment of disseminated and progressive cavitary histoplasmosis with ketoconazole. Am J Med 78:70–73. CrossRef Google Scholar 1.[link.springer.com]

Prognosis

  • PATHOGENESIS ( CONT )Generalized infection inimmune suppressed.Organ transplant recipientsLymphoma patientsAIDSCNS Skin, Joints,Poor prognosis in immunesuppressed and Meningitispatients. 13 2/10/2011 Dr.T.V.Rao MD 14.[slideshare.net]
  • Parfrey NA (1986) Improved diagnosis and prognosis of mucormycosis. Medicine 65:113–123. PubMed CrossRef Google Scholar 26. Berkowitz ID, Robboy SJ, Karchmer AW et al. (1979) Torulopsis glabrata fungemia — a clinicopathologic study.[link.springer.com]
  • Suitable drugs include: Amphotericin B Fluconazole Itraconazole Voriconazole Caspofungin The prognosis depends on the patient’s immune function and the extent of infection when treatment is started.[dermnetnz.org]

Etiology

  • Theonly etiological agent, Paracoccidioidesbrasiliensis is geographically restricted toareas of South and Central America 352/10/2011Dr.T.V.Rao MD 36.[slideshare.net]
  • Incidence of specific etiology and role of methods for specific etiologic diagnosis of primary acute pericarditis. Am J Cardiol 1995; 75:378-382 Chapter 9 SPECIFIC PERICARDIAL DISORDERS Congenital malformations and acquired diseases 1. ‎[books.google.es]
  • All appear to be caused by traumatic inoculation of the etiological fungi into the subcutaneous tissue.[ncbi.nlm.nih.gov]
  • Molecular genetic variation in Emmonsia crescens and Emmonsia parva , etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis ( Ajellomyces dermatitidis ) and other systemic fungal pathogens . J. Clin.[asmscience.org]

Epidemiology

  • Neurology and Neurosurgery Czech and Slovak Ophthalmology Czech and Slovak Psychiatry Czech Geriatric Review Czech Gynaecology Czech Rheumatology Czech Dental Journal Czech Urology Czech-Slovak Dermatology Czecho-Slovak Pathology Czech-Slovak Pediatrics Epidemiology[prolekare.cz]
  • Basic Concepts of Environmental Epidemiology The epidemiology of dimorphic primary pathogens may be contrasted with that of the opportunistic fungal pathogens.[ncbi.nlm.nih.gov]
  • Larsh HW (1970) Ecology and epidemiology of histoplasmosis. Proc Intern Symp Mycoses. Pan Am Health Org 59-63. Google Scholar 11.[link.springer.com]
  • Yapar N ; Epidemiology and risk factors for invasive candidiasis. Ther Clin Risk Manag. 2014 Feb 1310:95-105. doi: 10.2147/TCRM.S40160. eCollection 2014.[patient.info]
  • Molecular epidemiology of Blastomyces dermatitidis . Clin. Infect. Dis. 30 : 328 – 335 . 50. McGinnis , M. R. , , L. Pasarell , , D. A. Sutton , , A. W. Fothergill , , C. R. Cooper , , and M. G. Rinaldi . 1997 .[asmscience.org]
Sex distribution
Age distribution

Prevention

  • Centers for Disease Control and Prevention (November 21, 2015 updated.) Histoplasmosis. Available online at . Accessed August 27, 2016. Centers for Disease Control and Prevention (February 13, 2014 updated.) Pneumocystis Pneumonia.[labtestsonline.it]
  • Página 324 - IDSA Guidelines for the Prevention of Opportunistic Infections in Persons Infected with... ‎ Página 323 - Rotbart HA. Enteroviral infections of the central nervous system. Clin Infect Dis. ‎[books.google.es]
  • Jones PG, Kaufman C, McAuliffe LS et al. (1984) Efficacy of ketoconazole vs nystatin in prevention of fungal infections in neutropenic patients. Arch Int Med 144:549–551. CrossRef Google Scholar 31.[link.springer.com]

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