CASE PRESENTATION: We report the case of a 44 year old man who presented with an ANCA-associated systemic vasculitis and aortic regurgitation of unusual mechanism. [ncbi.nlm.nih.gov]

CASE • A 29yo woman presents with a 4yr h/o skin ulcers on her lower extremities. A previous punch biopsy showed thrombotic lesions in small blood vessels of the dermis. [slideshare.net]

AVR Non specific Present report At initial presentation AR Septal thickening: incomplete closure of Ao valve, thickened leaflets 4 Mo IST AVR Non specific Half the valvular lesions were present at initial presentation and when the diagnosis of vasculitis [bmcmusculoskeletdisord.biomedcentral.com]

• Weight Loss

  CASE REPORT: We present a patient with symptoms suggesting systemic vasculitis (ESR and CRP elevated, weight loss, arthralgia, livedoid rash, and skin ulcerations) who finally was diagnosed having a disseminated epitheloid hemangioendothelioma when PET [ncbi.nlm.nih.gov]

  Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. [orpha.net]

• Weakness

  Weak ANCA which could not be detected in serum was found in IgG. DIAGNOSES: MPO-ANCA-associated AAV developed from ANCA-negative renal-limited AAV. INTERVENTIONS: The patient was treated with glucocorticoid. [ncbi.nlm.nih.gov]

  Symptoms of vasculitis include: Skin rashes Fatigue (tiredness) Weakness Fever Joint pains Abdominal (stomach) pain Kidney problems (including dark or bloody urine) Nerve problems (including numbness, weakness, and pain) Other symptoms can occur, depending [my.clevelandclinic.org]

  It manifests with fever, fatigue, loss of appetite, weakness, skin rash, joint pain, numbness, burning sensation and renal failure. [icd9data.com]

• Malaise

  Signs and symptoms include joint pain, loss of pulse, high blood pressure, night sweats, fever, general malaise, appetite loss, headaches and visual changes. [mayoclinic.org]

  In general terms, some of the symptoms may include: Fever, fatigue, weight loss or malaise (a general sense of discomfort or weakness). These are known as constitutional symptoms. Muscle and joint pain. [disability-benefits-help.org]

  Generally, vasculitis causes fatigue and malaise. Sometimes vasculitis can lead to weakness and weight loss. Vasculitis affecting the skin can cause rashes, skin discoloration, and ulcers. Vasculitis affecting the muscles can cause muscle pain. [medicinenet.com]

• Anorexia

  Noninfectious vasculitis Vascular disease Any of a number of conditions characterized by inflammation of vessels in multiple sites in the body, which share many clinical and lab features Clinical Fever, fatigue, anorexia, weight loss, polymyalgia rheumatica [medical-dictionary.thefreedictionary.com]

  Fever, weight loss, anorexia, and arthralgia. Ocular involvement presents with orbital pseudotumor, scleritis, and uveitis, Renal involvement manifests with proteinuria, hematuria, and renal failure 25. [slideshare.net]

  Symptoms and Signs Regardless of the size of the vessels involved, patients can present with symptoms and signs of systemic inflammation (eg, fever, night sweats, fatigue, anorexia, weight loss, arthralgias, arthritis). [msdmanuals.com]

  Depending on the system involved there may be muscle pain, joint pain, fever, weight loss, loss of appetite (anorexia), headache, or generalized weakness. [rarediseases.org]

  Classification of Vasculitic Disorders Symptoms and Signs Regardless of the size of the vessels involved, patients can present with symptoms and signs of systemic inflammation (eg, fever, night sweats, fatigue, anorexia, weight loss, arthralgias, arthritis [merckmanuals.com]

• Weight Gain

  Possible side effects include weight gain, diabetes and bone thinning (osteoporosis). If a corticosteroid is needed for long-term (maintenance) therapy, you'll likely receive the lowest dose possible. [mayoclinic.org]

  When used long term, corticosteroids are associated with side effects such as weight gain, reduced bone density, and increased risk of diabetes and high blood pressure. [labtestsonline.org]

  Dietary counseling plays an important role in minimizing the risk of weight gain and hyperglycemia in patients receiving glucocorticoids. [renalandurologynews.com]

  Long-term corticosteroid treatment can cause ischemic necrosis of bone, posterior subcapsular cataract, weight gain, glucose intolerance, increased susceptibility to infection, and osteoporosis that may result in a loss of function. [ssa.gov]

• Respiratory Distress

  Abstract Systemic vasculitides represent a heterogeneous group of diseases that share clinical features including respiratory distress, renal dysfunction, and neurologic disorders. [ncbi.nlm.nih.gov]

  In this series, MPA and WG (two patients each) were diagnosed in the ICU among 10 patients admitted for renal insufficiency due to rapidly progressive glomerulonephritis or acute respiratory distress syndrome due to alveolar haemorrhage. [doi.org]

  They share clinical features including fever, arthralgia, respiratory distress, renal dysfunction, and neurologic disorders; but their course and prognosis are heterogeneous. [bmcanesthesiol.biomedcentral.com]

• Abdominal Pain

  Other manifestations may include irritability, arthritis, and abdominal pain. [emedicine.medscape.com]

  / claudication Respiratory Sinusitis / Epistaxis Pulmonary infiltrates Gastrointestinal Abdominal Pain Bloody stools Renal Glomerulo- nephritis Hypertension 11. [slideshare.net]

  A 49-year-old male patient presented to our clinic with abdominal pain and markedly elevated concentrations of C‑reactive protein, creatinine and high-sensitivity cardiac troponin T. [ncbi.nlm.nih.gov]

  For example, a patient with purpura, nephritis, and abdominal pain caused by Henoch–Schönlein purpura usually has a good prognosis. .. [doi.org]

• Loss of Appetite

  It manifests with fever, fatigue, loss of appetite, weakness, skin rash, joint pain, numbness, burning sensation and renal failure. [icd9data.com]

  It can cause: asthma allergic rhinitis ( cold-like symptoms caused by allergies ) a high temperature (fever) muscle and joint pain tiredness loss of appetite and weight loss It can also affect the nerves, causing weakness, pins and needles or numbness [nhs.uk]

  Patients who have MPA may feel generally ill and fatigued, have fever, or have loss of appetite and weight. They usually also have symptoms related to areas of involvement such as rashes, muscle and/or joint pain. [my.clevelandclinic.org]

  Loss of appetite. Weight loss. Fatigue. General aches and pains. [arthritis.org]

• Abdominal Cramps

  Mycophenolate mofetil is associated with nausea, vomiting and loose stools as well as abdominal cramps, anemia and leukopenia. The risks to using rituximab are still being investigated but include progressive multifocal leukoencepholopathy. [renalandurologynews.com]

• Jaw Pain

  Giant cell arteritis can cause headaches, scalp tenderness, jaw pain, blurred or double vision, and even blindness. It is also called temporal arteritis. Granulomatosis with polyangiitis. [mayoclinic.org]

  Symptoms of this condition can include headaches, scalp tenderness, jaw pain, blurred vision, double vision, and acute (sudden) vision loss. Giant cell arteritis is the most common form of vasculitis in adults older than 50. [nhlbi.nih.gov]

  pain, and blurred vision; most common type of vasculitis in adults over age 50; half of those with GCA also develop polymyalgia rheumatica Polymyalgia Rheumatica Large Characterized by pain and stiffness in the shoulders and hips; found mostly in those [labtestsonline.org]

  Jaw pain and claudication and oral mucosa or scalp ulceration can also be presentations of TA. 8. 30% of affected individuals, peripheral neuropathy, transient ischemic attack, and stroke. [slideshare.net]

• Osteoporosis

  Comprehensive health information about cancer, osteoporosis, high blood pressure and more. Comprehensive health information including health news updates and health resources. [web.archive.org]

  Rheumatology System Musculoskeletal, Immune Significant diseases Rheumatoid arthritis, Systemic lupus erythematosus, Osteoarthritis, Psoriatic arthritis, Ankylosing spondylitis, Gout, Osteoporosis Significant tests Joint aspirate, Musculoskeletal exam [en.wikipedia.org]

  Lansoprazole 30 mg PO daily until prednisolone Infection prophylaxis: Cotrimoxazole 480 mg PO daily for at least 3 months (often continued long-term in patients with Wegener’s granulomatosis and in those with ENT/lung disease) Osteoporosis: see Osteoporosis [edren.org]

  Address increased risks of infection and osteoporosis caused by vasculitis treatment with monitoring and/or prophylactic treatments. Click here for Patient Education [msdmanuals.com]

  Address increased risks of infection and osteoporosis caused by vasculitis treatment with monitoring and/or prophylactic treatments. [merckmanuals.com]

• Ulcer

  Characterized by a triple-symptom complex of recurrent oral aphthous ulcers, genital ulcers, and uveitis AUTOIMMUNE DISEASE. [slideshare.net]

  KEYWORDS: Tuberculosis; gangrene; large vessel vasculitis; medium vessel vasculitis; pulse loss; ulcer [ncbi.nlm.nih.gov]

  /eyes □ Adnexal inflammation □ Blepharitis/keratitis □ Blurred vision □ Genital ulcers □ Mouth ulcers/granulomata □ Red eye conjunctivitis/retinal hemorrhages □ Red eye (epi)scleritis □ Retinal vasculitis □ Significant proptosis □ Sudden vision loss □ [aafp.org]

• Skin Lesion

  The other patient developed fever, arthralgia and leukocytoclastic vasculitis of the skin during treatment with PTU for about 2 years. Her symptoms and skin lesions disappeared after discontinuation of PTU. [ncbi.nlm.nih.gov]

  Vasculitis frequently affects the skin and causes different kinds of rashes (lesions). [rarediseasesnetwork.org]

  Systemic polyarteritis nodosa involves all organ systems and the presentation widely varies. [4] Features include vasculitic skin lesions, hypertension, neuropathy, and myalgia. [emedicine.medscape.com]

• Skin Plaque

  The cutaneous changes include firm and thickened, indurate skin plaques and papules on the extremities and trunk. Histopathology typically shows an increase in dermal fibroblast-like cells associated with mucin deposition. [reumatologiaclinica.org]

• Headache

  It may produce a wide range of neurological symptoms, such as headache, skin rashes, feeling very tired, joint pains, difficulty moving or coordinating part of the body, changes in sensation, and alterations in perception, thought or behavior, as well [en.wikipedia.org]

  Signs and symptoms include joint pain, loss of pulse, high blood pressure, night sweats, fever, general malaise, appetite loss, headaches and visual changes. [mayoclinic.org]

  With this immunosuppressive therapy the palatal paralysis subsided, the headaches lessened and the patient, slowly regaining weight and energy, was able to return home. [bmcmusculoskeletdisord.biomedcentral.com]

  Clinical findings included headache, seizure, blurred or loss of vision, confusion, and altered cognition. [ncbi.nlm.nih.gov]

  […] and usually unilateral. development of a new headache or prominent alteration of the pattern of a chronic headache in an elderly patient is the most frequent symptom of TA Diffuse tenderness of the scalp or face is usually present over the temporal or [slideshare.net]

Prompt referral for a complete rheumatologic workup in cases of unexplained hearing loss would allow for a timely diagnosis of a collagen vascular disease and facilitate early initiation of systemic therapy, possibly yielding better audiological results [ncbi.nlm.nih.gov]

Diagnostic workup for MPA reveals the presence of serum ANCA and absence of surface hepatitis B antigen or antibody. [slideshare.net]

Electrocardiograms (ECGs) are a series of leads placed on a person's chest that measure electrical activity associated with contraction of heart muscle.[83] The taking of an ECG is an important part in the workup of an AMI,[24] and ECGs are often not [en.wikipedia.org]

Long-term treatment and disease-related morbidity are major threats. The last decade has seen a collaborative international effort to determine effective treatment. [ncbi.nlm.nih.gov]

TREATMENT: CORTICOSTEROIDS, THALIDOMIDE, IMMUNOSUPPRESSIVE 69. [slideshare.net]

The combination of vasculitis and cardiomyopathy is associated with a poor prognosis. Early treatment with immunosuppressants in conjunction with appropriate cardiac pharmacotherapy is considered important and has dramatically improved prognosis. [ncbi.nlm.nih.gov]

For example, a patient with purpura, nephritis, and abdominal pain caused by Henoch–Schönlein purpura usually has a good prognosis. .. [doi.org]

Over the past three decades, tremendous progress has been made through investigative efforts to understand etiologic, pathogenetic and clinical underpinnings of these disorders. [uncch.pure.elsevier.com]

All patients with a vasculitis of unidentified etiology should be evaluated for HIV infection. [ncbi.nlm.nih.gov]

Homepage Rare diseases Search Search for a rare disease Vasculitis Disease definition Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel [orpha.net]

These protean clinical manifestations, combined with the etiologic nonspecificity of the histologic lesions, complicate the diagnosis of specific forms of vasculitis. [doi.org]

Hoffman in Anti-neutrophil Cytoplasmic Antibody (ANCA), Associated Vasculitis: Granulomatosis with Polyangiitis (GPA, Wegener's) and Microscopic Polyangiitis (MPA) and Primary, Idiopathic Vasculitis: Presumed Autoimmune Etiology. [youtube.com]

Scott, Epidemiology of systemic vasculitis, Current Rheumatology Reports, 10.1007/s11926-005-0036-5, 7, 4, (270-275), (2005). [doi.org]

[…] provide our annual digest of the recent literature on systemic vasculitis in which we reviewed all the articles published during the last 12 months on large-, medium- and small-vessel vasculitis, and selected the most relevant studies regarding the epidemiology [ncbi.nlm.nih.gov]

: Epidemiology of vasculitis in Europe. Ann Rheum Dis 2001, 60 :1156–1157. PubMed CrossRef Google Scholar 6. [link.springer.com]

Subsequently, we review the literature on the combination of myelodysplastic syndromes and systemic vasculitis and discuss the prognostic consequences, considerations for treatment and possible pathophysiological mechanisms. [ncbi.nlm.nih.gov]

Access personal reporting Related Content This Book Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture Edited by Reinhart Grundmann Next chapter Drug-induced aortic aneurysms, ruptures and dissections By Olav Spigset Related [intechopen.com]

Anti-neutrophil cytoplasmic antibodies: current diagnostic and pathophysiological potential. Kidney Int. 1994;46(1):1-15. http://dx.doi.org/10.1038/ki.1994.239. PMid:7933826. Burns JC, Glodé MP. Kawasaki syndrome. [jvascbras.org]

BOSTON— The latest research on the pathophysiology and treatment of small- and large-vessel vasculitides was presented by three international experts at a clinical symposium called “Therapeutic Decisions in Systemic Vasculitis” at the ACR/ARHP Annual [the-rheumatologist.org]

Transthoracic and transesophageal echocardiography disclosed septal hypertrophy preventing a complete closure of the aortic valve and thus responsible for a massive aortic regurgitation. [ncbi.nlm.nih.gov]

Eating well can help prevent potential problems that can result from your medications, such as thinning bones, high blood pressure and diabetes. [mayoclinic.org]