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Tacrolimus


Presentation

  • Pseudopterygium and corneal opacities were present in three of them. All of them experienced an improvement of their itching and ocular surface.[ncbi.nlm.nih.gov]
  • The aim of this case report was to present a successful treatment of an allergic conjunctival granuloma with topical tacrolimus eye drops.[ncbi.nlm.nih.gov]
  • We present the novel use of intravesical tacrolimus for the treatment of refractory radiation cystitis and gross hematuria.[ncbi.nlm.nih.gov]
  • We have observed that some patients admitted for infection presented with increased tacrolimus trough levels (TLs).[ncbi.nlm.nih.gov]
  • We present a 40-year-old woman with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, smooth red to brown nodule was seen at the left malar region.[ncbi.nlm.nih.gov]
Noncompliance
  • […] and uncertainties related to our ability to continue to identify, acquire and develop innovative investigational drug candidates and drugs; risks and uncertainties related to the failure to obtain FDA or foreign authority clearances or approvals and noncompliance[web.archive.org]
Stridor
  • Stridor, facial edema, lip swelling, and skin erythema after consuming tempura udon containing wheat occurred in post-transplant month 39, and she was subsequently diagnosed with anaphylactic shock.[ncbi.nlm.nih.gov]
Regurgitation
  • We report the findings of one such case in which tacrolimus caused acute renal failure with severe tricuspid regurgitation and right ventricular failure documented by echocardiography.[ncbi.nlm.nih.gov]
Blepharitis
  • All four patients had a mixed blepharitis and keratitis. Pseudopterygium and corneal opacities were present in three of them. All of them experienced an improvement of their itching and ocular surface.[ncbi.nlm.nih.gov]
  • […] myasthenia / Delayed / 3.1-14.9 gout / Delayed / 3.1-14.9 jaundice / Delayed / 3.1-14.9 cholangitis / Delayed / 3.1-14.9 hyperbilirubinemia / Delayed / 0.2-14.9 hyperesthesia / Delayed / 0-7.0 migraine / Early / 0.2-0.9 cataracts / Delayed / 0.2-0.9 blepharitis[pdr.net]
Corneal Opacity
  • Pseudopterygium and corneal opacities were present in three of them. All of them experienced an improvement of their itching and ocular surface.[ncbi.nlm.nih.gov]
Foreign Body Sensation
  • The patient had tearing, photophobia, itching, foreign body sensation, and red eye. The patient's signs and symptoms progressed despite the use of topical steroids.[ncbi.nlm.nih.gov]
Anger
  • Department of Pharmacology University Hospital Angers France 6. Department of Nephrology-Transplantation University Hospital Angers France 7. Department of Nephrology-Transplantation University Hospital Brest France 8.[doi.org]
Extrapyramidal Symptoms
  • Hepatic encephalopathy may manifest by a wide spectrum of neuropsychiatric symptoms, including cognitive impairment, seizures or extrapyramidal symptoms.[ncbi.nlm.nih.gov]
Resting Tremor
  • Signs of severe, symmetric Parkinsonism - with resting tremor, bradykinesia, rigidity and severe postural instability were observed. A brain MRI was performed with the presence of T2- hyperintensities in basal ganglia bilaterally.[ncbi.nlm.nih.gov]
Postural Instability
  • Signs of severe, symmetric Parkinsonism - with resting tremor, bradykinesia, rigidity and severe postural instability were observed. A brain MRI was performed with the presence of T2- hyperintensities in basal ganglia bilaterally.[ncbi.nlm.nih.gov]

Treatment

  • We present the novel use of intravesical tacrolimus for the treatment of refractory radiation cystitis and gross hematuria.[ncbi.nlm.nih.gov]
  • The liver transplant can lead to improvement of the signs of encephalopathy but subsequent immunosuppressive treatment might possess pronounced neurotoxicity.[ncbi.nlm.nih.gov]
  • When a high dose was assessed with a need for treatment, the chance of needing treatment increased more than eight times (P .024; odds ratio 8.25; 95% CI 1.33 to 51.26), which was different from results found with high-dose tacrolimus (P 1.0).[ncbi.nlm.nih.gov]
  • She reported feeling better than any of the previously prescribed treatments and without feeling the discomfort of previously administered enemas. After four weeks of treatment, the dose was reduced to 2 mg/week with no relapses.[ncbi.nlm.nih.gov]
  • The drugs used concomitantly at the start of tacrolimus treatment were mesalazine (5 cases) and an immunomodulator drug (1 case).[ncbi.nlm.nih.gov]

Prognosis

  • Lower baseline proteinuria and better renal function were associated with a higher probability of complete remission, while crescent formation was associated with a worse prognosis.[ncbi.nlm.nih.gov]
  • BACKGROUND: Acute moderate-to-severe steroid-refractory ulcerative colitis (UC) has a poor prognosis and requires optimal rescue therapy.[ncbi.nlm.nih.gov]
  • Because prompt intervention with potent medical therapy is crucial in the management of severe UC, top-down therapy with tacrolimus may be useful for avoiding steroid dependency and improving prognosis (*).[intechopen.com]
  • […] transplant recipients, Am J Transplant, 2012 , vol. 12 (pg. 2825 - 2831 ) 11 Stockholm, Sweden Prescribed and Dispensed Drugs in Sweden Apotekens Service AB 12, 2012 Stockholm, Sweden National Board of Health and Welfare Drug Sales in Sweden—Analysis and Prognosis[oxfordjournals.org]

Etiology

  • Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology.[ncbi.nlm.nih.gov]
  • Improvement of clinical symptomatology after tacrolimus discontinuation supports the drug-induced etiology of this neurological condition. Cytostatic treatment after solid organ transplantation often leads to signs of encephalopathy.[ncbi.nlm.nih.gov]
  • Erythema dyschromicum perstans (EDP) is a cosmetically distressing, acquired pigmentary disorder of unknown etiology for which few successful therapies exist.[ncbi.nlm.nih.gov]
  • Keywords Oral lichen planus Squamous cell carcinoma Tacrolimus Lip Introduction Oral lichen planus (OLP) is a chronic mucocutaneous disease, and the etiology of OLP has been reported that stress, systemic medications, dental materials, chronic liver disease[link.springer.com]
  • Schematic representation of the etiology of calcineurin inhibitor nephrotoxicity.[doi.org]

Epidemiology

  • Author information 1 1 Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 2 2 Department of Preventive and Social Medicine, Faculty of Medicine, Srinakharinwirot University[ncbi.nlm.nih.gov]
  • Multiparameter evidence synthesis in epidemiology and medical decision-making. J Health Serv Res Policy. 2008;13 Suppl 3:12–22. View Article PubMed Google Scholar Dias S, Sutton AJ, Ades AE, Welton NJ.[doi.org]
  • Transplantation 63 : 977 –983, 1997 Kasiske BL: Epidemiology of cardiovascular disease after renal Transplantation 72[Suppl] : S5 –S8, 2001 Morales JM, Dominguez-Gil B: Cardiovascular risk profile with the new immunosuppressive combinations after renal[jasn.asnjournals.org]
Sex distribution
Age distribution

Pathophysiology

  • Tacrolimus has been reported to be an offending agent, which potentially plays a role in the pathophysiological process of SOS.[ncbi.nlm.nih.gov]
  • […] concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers Adjusting dose to optimize immunosuppression while minimizing toxicity Evaluating patient compliance Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • Useful For Suggests clinical disorders or settings where the test may be helpful Assessment of postdosing (peak) blood tacrolimus concentrations Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to[mayomedicallaboratories.com]
  • More has been learned over the past few years about the pathophysiology of atopic dermatitis.[aafp.org]

Prevention

  • This literature review will discuss Tac metabolism and its role in preventing tissue and organ transplant rejection.[ncbi.nlm.nih.gov]
  • Long-term toxicities attributed to tacrolimus, such as nephrotoxicity and neurotoxicity, can limit the long-term success of tacrolimus in preventing allograft rejection.[ncbi.nlm.nih.gov]
  • Tacrolimus is superior to cyclosporin in improving survival (patient and graft) and preventing acute rejection after liver transplantation, but it increases the risk of post-transplant diabetes.[ncbi.nlm.nih.gov]
  • Jul 9, 2015 (Started Sep 01, 2010) Effectiveness Major (for Prevent organ rejection) Side effects Mild (fatigue) Burden Not at all hard to take Dosage: 1 mg Twice daily 0 helpful marks Feb 6, 2012 (Started Dec 01, 2009) Effectiveness Major (for Prevent[patientslikeme.com]

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