How does talaromycosis present in the skin? Skin lesions are common in HIV/AIDS-associated talaromycosis (70%) and are often the presenting sign. [dermnetnz.org]

Immunological assays are often not available for the diagnosis of most endemic mycoses and molecular amplification methods for the detection of fungal nucleic acids are not standardized at present. [go.gale.com]

[…] affected more than women.[4] The first natural human case of talaromycosis was reported in 1973 in an American minister with Hodgkin's disease who lived in Southeast Asia.[6] Signs and symptoms[edit] There may be no symptoms,[4] or talaromycosis may present [en.wikipedia.org]

• Weight Loss

  The bumps usually appear on the face and neck but can also appear in other places on the body. 2,3 Other symptoms include: 3,5,6 Fever General discomfort Weight loss Cough Swollen lymph nodes Difficulty breathing Swelling of the liver and spleen Diarrhea [cdc.gov]

  Systemic features of disseminated talaromycosis include: Non-specific symptoms of fever, weight loss, and fatigue Respiratory symptoms such as shortness of breath and cough Enlarged lymph nodes, liver, and/or spleen Gastrointestinal disturbance such as [dermnetnz.org]

  loss, cough, difficulty breathing, diarrhoea, abdominal pain, swelling of the spleen (splenomegaly), liver swelling (hepatomegaly), swollen lymph nodes (lymphadenopathy),[2] and anemia.[2][4] There may be no symptoms.[4] In those without HIV infection [en.wikipedia.org]

• Lymphadenopathy

  Cutaneous manifestations may mimic histoplasmosis, having mucocutaneous papules with central umbilication; ulceration, and lymphadenopathy may also be seen. It may precipitate Sweet's syndrome, erythema nodosum, and exanthematous pustulosis. [ncbi.nlm.nih.gov]

  […] head and neck are most often affected.[2] Other features include: fever, general discomfort, weight loss, cough, difficulty breathing, diarrhoea, abdominal pain, swelling of the spleen (splenomegaly), liver swelling (hepatomegaly), swollen lymph nodes (lymphadenopathy [en.wikipedia.org]

• Splenomegaly

  […] talaromycosis may present with small painless skin lesions.[2] The head and neck are most often affected.[2] Other features include: fever, general discomfort, weight loss, cough, difficulty breathing, diarrhoea, abdominal pain, swelling of the spleen (splenomegaly [en.wikipedia.org]

• Pneumonia

  Pneumocystis pneumonia The PCP caused by the opportunistic fungi Pneumocystis jirovecii remains an important cause of hospitalization and deaths among hospitalized PLHIV. [ncbi.nlm.nih.gov]

• Abdominal Pain

  pain Talaromycosis may affect people living with HIV differently than people who do not have HIV. [cdc.gov]

  pain, swelling of the spleen (splenomegaly), liver swelling (hepatomegaly), swollen lymph nodes (lymphadenopathy),[2] and anemia.[2][4] There may be no symptoms.[4] In those without HIV infection, the lungs, liver, and mouth are usually affected, with [en.wikipedia.org]

• Hepatomegaly

  […] small painless skin lesions.[2] The head and neck are most often affected.[2] Other features include: fever, general discomfort, weight loss, cough, difficulty breathing, diarrhoea, abdominal pain, swelling of the spleen (splenomegaly), liver swelling (hepatomegaly [en.wikipedia.org]

• Skin Disease

  Skin disease: Clinical indicator of immune status in human immunodeficiency virus (HIV) infection. Int J Dermatol. 2005;44:646–9. [PubMed] [Google Scholar] 5. Samson JF, Suja V, Samad KA, Sankar S, Libu GK. [ncbi.nlm.nih.gov]

With antiretroviral treatment (HAART), talaromycosis is now increasingly recognised in HIV-negative patients. [dermnetnz.org]

[…] marneffei[1] Risk factors HIV/AIDS, long-term steroids, organ transplant, old age, malnutrition[4] Diagnostic method Microscopy, culture, biopsy,[2] medical imaging[4] Differential diagnosis Tuberculosis, histoplasmosis[4] Prevention Itraconazole[1] Treatment [en.wikipedia.org]

(Лечение) Talaromyces marneffei shows in vitro susceptibility to multiple antifungal agents including ketoconazole, Itraconazole, Miconazole, flucytosine and Amphotericin B. without treatment patients have a poor prognosis, there will be death from liver [amp.en.google-info.in]

[…] also appear after starting ART, as a manifestation of immune reconstitution inflammatory syndrome.[5] T. marneffei can affect persons with normal immunity also, but it is very rare and quite reasonably it produces mild localized infection.[6] As the prognosis [ncbi.nlm.nih.gov]

[4] Diagnostic method Microscopy, culture, biopsy,[2] medical imaging[4] Differential diagnosis Tuberculosis, histoplasmosis[4] Prevention Itraconazole[1] Treatment Antifungals[1] Medication Amphotericin B followed by itraconazole or voriconazole[1] Prognosis [en.wikipedia.org]

T. marneffei, the etiological fungus of talaromycosis is transmitted to human through inhalation of spores from soil. It then spreads to the reticuloendothelial system, skin and other organ system through the hematogenous route. [ncbi.nlm.nih.gov]

Epidemiology. (Эпидемиология) Once considered rare, its occurrence has increased as a result of AIDS. [amp.en.google-info.in]

Epidemiology of fungal diseases is not completely understood in Africa. [ncbi.nlm.nih.gov]

[…] risk, using the antifungal medication itraconazole, and is treatable with amphotericin B followed by itraconazole or voriconazole.[2] Outcomes[edit] With treatment, less than 25% of those affected die.[2] Without treatment, more than 75% will die.[2] Epidemiology [en.wikipedia.org]

A healthcare provider might prescribe medicine to prevent talaromycosis for people who have a condition that weakens their immune system and who live in places where the fungus is present. 3 Itraconazole is the most commonly used medicine to prevent talaromycosis [cdc.gov]

[…] none.[4] Causes Talaromyces marneffei[1] Risk factors HIV/AIDS, long-term steroids, organ transplant, old age, malnutrition[4] Diagnostic method Microscopy, culture, biopsy,[2] medical imaging[4] Differential diagnosis Tuberculosis, histoplasmosis[4] Prevention [en.wikipedia.org]