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Tauopathy


Presentation

  • However, the morphology of astrocytic inclusions in the present case differed from that in type III.[ncbi.nlm.nih.gov]
Hunting
  • Hunt JB Jr 1 , Nash KR 2 , Placides D 1 , Moran P 3 , Selenica ML 1 , Abuqalbeen F 1 , Ratnasamy K 1 , Slouha N 1 , Rodriguez-Ospina S 3 , Savlia M 3 , Ranaweera Y 1 , Reid P 3 , Dickey CA 3 , Uricia R 1 , Yang CG 4 , Sandusky LA 1 , Gordon MN 2 , Morgan[ncbi.nlm.nih.gov]
  • Gardner M, Paisan-Ruiz C, Band G, Barker RA, Bellenguez C, Bhatia K, Blackburn H, Blackwell JM, Bramon E, Brown MA, Burn D, Casas JP, Chinnery PF, Clarke CE, Corvin A, Craddock N, Deloukas P, Edkins S, Evans J, Freeman C, Gray E, Hardy J, Hudson G, Hunt[dx.doi.org]
Plethora
  • Tau protein undergoes a plethora of intra-molecular modifications and some altered forms promote the production of toxic oligomeric tau and paired helical filaments, and through which further assemble into neurofibrillary tangles, also known as tauopathy[ncbi.nlm.nih.gov]
Hyperkeratosis
  • […] cirrhosis ) KRT10 ( Epidermolytic hyperkeratosis ) KRT12 ( Meesmann juvenile epithelial corneal dystrophy ) KRT13 ( White sponge nevus ) KRT14 ( Epidermolysis bullosa simplex ) KRT17 ( Steatocystoma multiplex ) KRT18 ( Familial cirrhosis ) KRT81 / KRT83[en.wikipedia.org]
Postural Instability
  • Postural instability with early falls, prominent frontal lobe dysfunction and pseudo-bulbar palsy were common and three-quarters of the patients were L-dopa unresponsive.[ncbi.nlm.nih.gov]

Workup

Lymphocytic Infiltrate
  • Interestingly, CD8-positive lymphocyte infiltration was also observed in the cortex of patients exhibiting frontemporal dementia with P301L tau mutation.[ncbi.nlm.nih.gov]

Treatment

  • Author information 1 Department of Diagnosis, Prevention and Treatment of Dementia, Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 116-0013, Japan and. 2 Department of Diagnosis, Prevention and Treatment[ncbi.nlm.nih.gov]
  • This designation is given to novel drugs for the treatment of rare diseases or conditions that affect fewer than 200,000 patients in the United States.[globenewswire.com]

Prognosis

  • The cognitive and non-cognitive or other clinical features of both subtypes are similar and do not serve as indicators for prognosis, but older age ( 80 years), lack of ApoE ε4 allele and less severe cognitive impairment may allow some differentiation[omicsonline.org]
  • The prognosis of the tau positive, tau negative and other pathology groups was the same according to the survival curves ( Fig. 1 ). Fig. 1 Survival curves according to underlying tau-positive and tau-negative pathologies.[dx.doi.org]
  • Prognosis 3.7. Quality of Life 4. Current Treatment Paradigm 4.1. Overview 4.2. Treatment Paradigm 4.3. Anti-Parkinson's Drugs 4.3.1. Amantadine 4.3.2. Dopamine Receptor Agonists 4.3.3. Levodopa 4.4. Antidepressant Drugs 4.4.1.[gii.co.jp]

Etiology

  • Hippocampal sclerosis is defined as selective neuronal loss and gliosis of the hippocampus with heterogeneous etiologies, including neurodegenerative tauopathies.[ncbi.nlm.nih.gov]
  • Etiology and Pathophysiology 3.1.1. Etiology 3.1.2. Pathophysiology 3.2. Classification 3.2.1. Clinical Classification 3.2.2. Pathological Classification 3.2.3. Classification According to 4R:3R Ratio 3.3. Symptoms 3.4. Diagnosis 3.4.1.[gii.co.jp]
  • In these last 25 years, molecular analysis of brain lesions and genetic studies have brought clues on the etiological mechanisms.[folianeuro.termedia.pl]

Epidemiology

  • Although aging is considered to be the most important risk factor for Alzheimer's disease, growing evidence from epidemiological studies suggest that type-2 diabetes (T2DM) increases the risk factor of AD.[cordis.europa.eu]
  • Epidemiology, Neuropathology, Neurochemistry, and Clinics. Key Topics in Brain Research. Springer, Wien, pp 85–91 Google Scholar 9.[dx.doi.org]
  • Epidemiology, Pathology, Diagnosis and Management. CNS Drugs 2012; 26:841-870. PubMed Bigio EH. Making the Diagnosis of Frontotemporal Lobar Degeneration. Arch Pathol Lab Med 2013;137:314-35. PubMed Updated: July, 2013[neuropathology-web.org]
  • Global Director of Therapy Analysis and Epidemiology 9.6. About GlobalData 9.7.[gii.co.jp]
Sex distribution
Age distribution

Pathophysiology

  • Neuroinflammatory changes are thought to be major contributors to Alzheimer's disease pathophysiology, even if their precise role still remains largely debated.[ncbi.nlm.nih.gov]
  • PART pathology appears to correlate with a biomarker profile that has been termed “SNAP,” or “suspected nonamyloid pathology/pathophysiology” ( Jack et al 2012 ; Knopman et al 2013 ; Vos et al 2013 ; Jack 2014 ).[medlink.com]

Prevention

  • Author information 1 Department of Diagnosis, Prevention and Treatment of Dementia, Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 116-0013, Japan and. 2 Department of Diagnosis, Prevention and Treatment[ncbi.nlm.nih.gov]

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