Hunt JB Jr 1, Nash KR 2, Placides D 1, Moran P 3, Selenica ML 1, Abuqalbeen F 1, Ratnasamy K 1, Slouha N 1, Rodriguez-Ospina S 3, Savlia M 3, Ranaweera Y 1, Reid P 3, Dickey CA 3, Uricia R 1, Yang CG 4, Sandusky LA 1, Gordon MN 2, Morgan D 2, Lee DC 5 [ncbi.nlm.nih.gov]

Gardner M, Paisan-Ruiz C, Band G, Barker RA, Bellenguez C, Bhatia K, Blackburn H, Blackwell JM, Bramon E, Brown MA, Burn D, Casas JP, Chinnery PF, Clarke CE, Corvin A, Craddock N, Deloukas P, Edkins S, Evans J, Freeman C, Gray E, Hardy J, Hudson G, Hunt [doi.org]

Tau protein undergoes a plethora of intra-molecular modifications and some altered forms promote the production of toxic oligomeric tau and paired helical filaments, and through which further assemble into neurofibrillary tangles, also known as tauopathy [ncbi.nlm.nih.gov]

[…] cirrhosis ) KRT10 ( Epidermolytic hyperkeratosis ) KRT12 ( Meesmann juvenile epithelial corneal dystrophy ) KRT13 ( White sponge nevus ) KRT14 ( Epidermolysis bullosa simplex ) KRT17 ( Steatocystoma multiplex ) KRT18 ( Familial cirrhosis ) KRT81 / KRT83 [en.wikipedia.org]

Postural instability with early falls, prominent frontal lobe dysfunction and pseudo-bulbar palsy were common and three-quarters of the patients were L-dopa unresponsive. [ncbi.nlm.nih.gov]

We describe a patient with anti-IgLON5 syndrome, who presented with dysautonomia and sleep disorder, followed by subacute dementia. [ncbi.nlm.nih.gov]

Interestingly, CD8-positive lymphocyte infiltration was also observed in the cortex of patients exhibiting frontemporal dementia with P301L tau mutation. [ncbi.nlm.nih.gov]