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Tazarotene

Ethyl 6 (2 (4 4 Dimethylthiochroman 6 Yl)ethynyl)nicotinate


Presentation

  • We present 2 cases of CRP with typical clinical manifestations of scaly, dull, brownish, confluent and reticulate macules and patches.[ncbi.nlm.nih.gov]
Camping
  • GRK5, TIG1A, and TIG1B expression significantly inhibited PGE2-stimulated β-catenin/TCF and cAMP signaling pathway reporters and cAMP.[ncbi.nlm.nih.gov]
Lagophthalmos
  • The two patients with lagophthalmos at the time of tazarotene initiation experienced complete resolution. No adverse effects were reported.[ncbi.nlm.nih.gov]

Workup

Neurofibrillary Tangle
  • Both transglutaminase 1 (TG1) and transglutaminase 2 (TG2) are abundantly expressed in the brain and are associated with fibrillary hyperphosphorylated tau protein inclusions in neurons of AD, so-called neurofibrillary tangles (NFTs).[ncbi.nlm.nih.gov]

Treatment

  • It consisted of a 12-week treatment phase, followed by a 4-week post-treatment observation phase. At the end of the treatment phase, tazarotene-petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment.[ncbi.nlm.nih.gov]

Epidemiology

  • Onychomycosis – epidemiology, diagnosis and management. Indian J Med Microbiol . 2008;26(2):108–116. 3. Chi CC, Wang SH, Chou MC. The causative pathogens of onychomycosis in southern Taiwan. Mycoses . 2005;48(6):413–420. 4.[dovepress.com]
Sex distribution
Age distribution

Pathophysiology

  • Fisher GJWang ZQDatta SCVarani JKang SVoorhees JJ Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;3371419- 1428 Google Scholar Crossref 4. Weinstein GDNigra TPPochi PE et al.[jamanetwork.com]

Prevention

  • PURPOSE: To evaluate the ability of either oral minocycline, topical tazarotene or both, to reduce or prevent cetuximab-related acneiform rash when administered starting on day 1 of cetuximab therapy.[ncbi.nlm.nih.gov]
  • Tazarotene Cream is a topical medication specifically designed to treat acne and plaque psoriasis( an autoimmune disorder that leaves red raised patches and scaly rashes all around the body) as well as to prevent pimples, spots, whiteheads and blackheads[skincareex.com]
  • It does not eliminate or prevent wrinkles, repair sun-damaged skin, reverse photo aging, or restore more youthful or younger skin. This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.[rxwiki.com]

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