Symptoma

Tenecteplase

Although, some patients may present with frank hemodynamic collapse and cardiac arrest, others may present with asymptomatic PE that is discovered incidentally during work up of another condition. [ncbi.nlm.nih.gov]

  • Intravenous Administration

    Tenecteplase is a recombinant tissue plasminogen activator (rt-PA) which has enhanced fibrin specificity, relatively long half-life, and allows single-bolus intravenous administration. [sitsinternational.org]

    However, studies in rabbits have shown that multiple intravenous administrations of tenecteplase cause maternal and embryo toxicity, but no fetal abnormalities have been observed. [drugspedia.net]

    The red and blue bars in the lower left corner represent the duration of tenecteplase or alteplase intravenous administration. Red and blue squares represent ER incidence following tenecteplase and alteplase, espectively. [j-stroke.org]

    Pharmacokinetics and pharmacodynamics of recombinant tissue-type plasminogen activator following intravenous administration in rabbits; comparison of three dosing regimens. Biopharm Drug Dispos 1998; 19: 31–8 PubMed CrossRef Google Scholar 26. [link.springer.com]

    DOSAGE AND ADMINISTRATION Dosage TNKase (Tenecteplase) is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight. [rxlist.com]

  • Collapse

    Although, some patients may present with frank hemodynamic collapse and cardiac arrest, others may present with asymptomatic PE that is discovered incidentally during work up of another condition. [ncbi.nlm.nih.gov]

    […] was little longer (90 days vs 30 days in PEITHO), but the smaller sample size, the composite outcome and the equipoise in short-term safety all make it difficult to recommend systemic tPA in submassive PE unless patients are in impending hemodynamic collapse [pulmccm.org]

  • Recurrent Pulmonary Embolism

    One patient randomized to tenecteplase suffered a clinical event (recurrent pulmonary embolism) in comparison to three patients randomized to placebo (1 recurrent pulmonary embolism; 1 clinical deterioration and 1 non pulmonary embolism-related death) [ncbi.nlm.nih.gov]

  • Hypoxemia

    8 female) with acute PE were included in the study and divided into three groups: (1) Acute PE complicated by shock stage and/or persistent hypotension (12 patients). (2) RV dilatation and/or dysfunction without hypotension (14 patients). (3) Severe hypoxemia [ncbi.nlm.nih.gov]

  • Respiratory Distress

    Two days later, he presented to the same emergency department with a decreased level of consciousness and respiratory distress, requiring mechanical ventilation and transfer to the intensive care unit (ICU). [radcliffecardiology.com]

    Distress Syndrome (ARDS) 1 1, 2 Terminated Treatment Acute Myelogenous Leukaemia (AML) / Myelodysplastic Syndrome 1 2 Active Not Recruiting Treatment Stroke, Ischemic 1 2 Completed Treatment Acute Myocardial Infarction (AMI) 1 2 Completed Treatment Cerebral [drugbank.ca]

  • Pleural Effusion

    Effusions 1 2, 3 Withdrawn Treatment Stroke, Ischemic 1 3 Active Not Recruiting Treatment Pulmonary Embolism (PE) 1 3 Completed Treatment Dysfunctional Central Venous Access Catheters 2 3 Completed Treatment Dysfunctional Hemodialysis Catheters 2 3 Completed [drugbank.ca]

  • Dyspnea at Rest

    The primary composite outcome included: (i) death, circulatory shock, intubation or major bleeding within 5 days or (ii) recurrent PE, poor functional capacity (RV dysfunction with either dyspnea at rest or exercise intolerance) or an SF36( ) Physical [ncbi.nlm.nih.gov]

    […] at rest, and no recurrent PE or DVT. [scholarworks.iupui.edu]

Second, as the participating centers mostly used magnetic resonance imaging for patient workup, the population studied might differ from primarily computed tomography-assessed populations. [j-stroke.org]

  • Pleural Effusion

    Effusions 1 2, 3 Withdrawn Treatment Stroke, Ischemic 1 3 Active Not Recruiting Treatment Pulmonary Embolism (PE) 1 3 Completed Treatment Dysfunctional Central Venous Access Catheters 2 3 Completed Treatment Dysfunctional Hemodialysis Catheters 2 3 Completed [drugbank.ca]

Treatment Cerebral Infarctions / Ischemia, Brain / Strokes 1 2 Completed Treatment Stroke, Ischemic 1 2 Completed Treatment Strokes 1 2 Recruiting Treatment Stroke, Ischemic 1 2 Terminated Treatment Leukemias 1 2 Terminated Treatment Pulmonary Embolism [drugbank.ca]

Results The three treatment groups each comprised 25 patients. The mean ( SD) NIHSS score at baseline for all patients was 14.4 2.6, and the time to treatment was 2.9 0.8 hours. [doi.org]

BACKGROUND: We evaluated the efficacy and safety of the thrombolytic agent tenecteplase for the treatment of dysfunctional hemodialysis (HD) catheters. [ncbi.nlm.nih.gov]

Even with the benefit of cardiopulmonary resuscitation, the prognosis of cardiac arrest remains poor. Multiple case series describe survival with the use of thrombolytic therapy for refractory cardiac arrest. [ncbi.nlm.nih.gov]

[…] number of intravenous and oral antithrombotic agents and new antiplatelet agents Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis [books.google.com]

The carotid atherosclerosis was predominant 63.3% and the cardio embolic etiology 27%. The mean time to the first medical contact after the onset of symptoms was 3h 30 min. [ncbi.nlm.nih.gov]

Stroke epidemiology and stroke care services in India. J Stroke 2013;15:128-34. 9. Durai Pandian J, Padma V, Vijaya P, Sylaja PN, Murthy JM. Stroke and thrombolysis in developing countries. Int J Stroke 2007;2:17-26. 10. [annalsafrmed.org]

FDA Advise-ERR was provided by Tingting Gao, PharmD, BCPS, Safety Evaluator and LT Alice Tu, PharmD, Team Leader of FDA’s Office of Surveillance and Epidemiology, Division of Medication Error Prevention and Analysis. [ismp.org]

A central block randomization was performed by the Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, in blocks of 15 to allow the data and safety monitoring board to review blinded safety data after the recruitment of every [doi.org]

BACKGROUND: Activated Factor XII (XIIa) is believed to participate in a number of pathophysiological processes including inflammation, thrombosis and fibrinolysis. Increasing XIIa levels following thrombolytic therapy have previously been reported. [ncbi.nlm.nih.gov]

TASTE will address crucial clinical and pathophysiologic questions in a much broader group of stroke patients eligible for acute thrombolytic therapy. [heartfoundation.org.au]

The pathophysiology of sepsis is an inflammatory and procoagulant state triggered by infection. Activated protein C (APC) plays an important role by promoting fibrinolysis and inhibiting thrombosis and inflammation. [radcliffecardiology.com]

IM bez elevácie ST Nestabilná AP Infarkt myokardu bez Q More information Pathophysiology of ACS Pathophysiology of ACS 2.0 MM patients admitted to CCU or telemetry annually 0.6 MM ST-segment elevation MI 1.4 MM Non-ST-segment elevation ACS NSTEMI vs STEMI [healthdocbox.com]

BACKGROUND AND PURPOSE: Intravenous tissue- type plasminogen activator (IV tPA) frequently fails to recanalize proximal middle cerebral artery (MCA-M1) obstructions, preventing favorable outcomes. [ncbi.nlm.nih.gov]

Use extra care to prevent bleeding while shaving or brushing your teeth. [everydayhealth.com]

Tenecteplase is used to prevent death in people who have had a heart attack (acute myocardial infarction). Tenecteplase may also be used for purposes not listed in this medication guide. [drugs.com]

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