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Teratogenesis
Teratogenic Effect

Presentation

The present volume is an effort to provide a sampling of concepts currently under active investigation in several of the above fields. [springer.com]

Entire Body System

  • Short Stature

    stature Holoprosencephaly: a developmental field defect in which the forebrain fails to divide into two hemispheres, resulting in fusion of ventricles (leading to the formation of monoventricle) and other bilateral cerebral structures, e.g., basal ganglia [amboss.com]

Cardiovascular

  • Heart Disease

    Maternal illnesses Diabetic embryopathy Onset: first trimester Pathophysiology: hyperglycemia → inhibition of myoinositol uptake → abnormalities in the arachidonic acid-prostaglandin pathway → birth defects and spontaneous abortion Effects Congenital heart [amboss.com]

    Rubella virus was the first infectious disease to be linked to congenital malformations due to an infection in pregnancy, which can include congenital cataracts, microcephaly, hearing impairment and congenital heart disease. [pubmed.ncbi.nlm.nih.gov]

Ears

  • Hearing Impairment

    Rubella virus was the first infectious disease to be linked to congenital malformations due to an infection in pregnancy, which can include congenital cataracts, microcephaly, hearing impairment and congenital heart disease. [pubmed.ncbi.nlm.nih.gov]

Treatment

Fortunately, very few drugs cause… Read More effects of thalidomide In thalidomide: Teratogenic effects Thalidomide went on the market as a treatment for morning sickness in more than 40 countries beginning in 1958. [britannica.com]

A treatment manuel 1976,N/A:133-138 http://www.maps.org/w3pb/new/1976/1976_ ... 3447_1.pdf ---- Strassman RJ Adverse reactions to psychedelic drugs. [psyvault.net]

Prognosis

Prognosis: severe disease in the neonatal period that often results in infant death secondary to cardiac and renal complications Duodenal atresia Small left colon syndrome: self-limiting inability to pass meconium Vertebral anomalies Cleft palate Flexion [amboss.com]

Etiology

Physical agents Metal toxicity Lead [20] Mercury [22] Etiology: methylmercury (can be found in contaminated seafood, esp. tilefish, swordfish, shark, and king mackerel) Effects Cerebellar atrophy Atrophy of the visual brain cortex Polyneuritis Congenital [amboss.com]

Epidemiology

Teratogenesis is a field that requests high epidemiological vigilance and a combination with human and animal findings. [frontiersin.org]

Anatomy, Daniel Baugh Institute, Thomas Jefferson University, Philadelphia, USA 3206 Accesses 69 Citations 3 Altmetric Sections Table of contents About this book Keywords Editors and Affiliations Bibliographic Information Table of contents (17 chapters) Epidemiology [link.springer.com]

[…] provides a fertile field for research in several basic and clinical disciplines; this field also receives input from several disoiplines such as developmental and molecu lar biology, pathology, pharmacology and toxicology, pediatrics and neonatology, and epidemiology [springer.com]

En: Biological markers in epidemiology. B. Hulka, T. Wilcolsky y J. Griffith. New York. Oxford University Press. 1-15 Ivics, Z., Z. Izsvak, A. Minter y P.B. Hackett. (1996). [revistaaquatic.com]

Pathophysiology

[…] toes Ectromelia: collective term for hypoplasia and/or aplasia of one or more long bones, resulting in limb deformity Peromelia/perodactyly: amputation-like stump of a limb, finger, or toe Maternal illnesses Diabetic embryopathy Onset: first trimester Pathophysiology [amboss.com]

Prevention

In this context, animal models are essential for the understanding of teratogenic mechanisms, as they represent a powerful tool for the screening of potential new teratogens and development of preventive measures. [frontiersin.org]

[…] logo Indexado en Citaciones Compartir Publicaciones > Artículo Prevention of teratogenesis in pregnancies of obese rats by vitamin E supplementation Publicado en:Antioxidants. 10 (8): - 2021-08-01 10(8), doi: 10.3390/antiox10081173 Alcalá M.; Sanchez-Vera [investigacionusp.ceu.es]

Diethylstilbestrol [17] Previous use: a synthetic estrogen that is primarily used to prevent miscarriages in expectant mothers Effects Vaginal clear cell adenocarcinoma Congenital anomalies of the Müllerian duct Thalidomide [18] Previous use: a sedative [amboss.com]

This work represents the foundation for development and testing of preventative and therapeutic strategies to inhibit infectious injury of human fetuses and neonates. [pubmed.ncbi.nlm.nih.gov]

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