We present a case of testicular embryonal carcinoma in a boy who had presented 5 years before with features suggestive of gonadotrophin-independent precocious puberty. [ncbi.nlm.nih.gov]

We present a case of 34-year-old man with aggressive clinical course. At the time of presentation, he had left testicular swelling along with supraclavicular mass with extensive metastasis to retroperitoneum, liver, and lung. [scopemed.org]

Embryonal carcinoma presenting as a calcified solitary testicular mass on ultrasound Daniel Gerber 1, Henry Collier Wright 1, Rachael D Sussman 1, Lambros Stamatakis 2 1 Department of Urology, MedStar Georgetown University Hospital, Washington, USA 2 [casereports.bmj.com]

• Halitosis

  No wonder my tongue had a constant milky substance coating it and I suffered halitosis so bad that flies would hang around my face constantly. I looked, felt and smelt like death, inside and out. [mycarcinoma.wordpress.com]

• Hypertension

  […] risk of treatment with a total dose of etoposide of more than 2 g is approximately 2% to 3%. 69,86,87 Testicular cancer survivors are also at risk for multiple other late consequences of therapy, including metabolic syndrome, cardiovascular disease, hypertension [hematologyandoncology.net]

• Testicular Mass

  Calcified testicular masses are typically benign but do carry a differential of spermatic granuloma, large-cell calcifying Sertoli cell tumour, trauma, tuberculosis, filariasis, calcified Leydig cell tumour and burned-out testicular tumour. [casereports.bmj.com]

  […] cancer staging Site testis, ovary, mediastinum Signs testicular mass, pelvic mass Prevalence pure embryonal uncommon Clin. [librepathology.org]

  (solid lesion) and an immature teratoma (cystic lesion) in a patient with microlithiasis Teratomas: Teratoma testis with a calcified testicular mass Mixed germ cell tumor: Testis tumor that proved to be a mixed germ cell tumor Mixed germ cell tumor: [ultrasoundcases.info]

  The most common clinical form of presentation was a painless testicular mass. The a-fetoprotein levels were high in 5 patients (yolk-sac tumors and embryonal carcinomas). [dialnet.unirioja.es]

  At a Glance When a patient discovers a usually painless testicular mass, either unintentionally or by self-examination, or when a testicular mass is discovered by routine physical examination, testicular cancer should be suspected. [clinicaladvisor.com]

• Painless Testicular Mass

  The most common clinical form of presentation was a painless testicular mass. The a-fetoprotein levels were high in 5 patients (yolk-sac tumors and embryonal carcinomas). [dialnet.unirioja.es]

  At a Glance When a patient discovers a usually painless testicular mass, either unintentionally or by self-examination, or when a testicular mass is discovered by routine physical examination, testicular cancer should be suspected. [clinicaladvisor.com]

  […] fails to improve with antibiotic therapy Signs Painless asymmetric, hard, firm testicular mass Transilluminate for reactive Hydrocele Evaluate for Inguinal Lymphadenopathy (as well as Supraclavicular Lymphadenopathy ) Evaluate for Gynecomastia Overall [fpnotebook.com]

  A painless testicular mass is the classic presentation for testicular cancer, although a number of patients present with diffuse pain or swelling. Ultrasonography may be helpful in confirming the presence of a scrotal mass within the testicle. [aafp.org]

• Testicular Pain

  […] age is 30 years, 10 years younger than seminoma Rare in prepubertal children Common as a component of mixed germ cell tumors (GCT) (40% of all mixed GCTs) Rare in pure form, 2% of all GCTs Clinical features Painless swelling of the testis Occasionally testicular [pathologyoutlines.com]

  Indications for Embryonal Carcinoma of the Testis include: Blood in vomit and cough Blood in stool, urine Trouble breathing Headache Low blood pressure Anemia Testicular pain, lump in the testes, feeling of heaviness in the scrotum Abdominal pain and [dovemed.com]

  However, with the extended use of scrotal ultrasound (US) for other indications, such as infertility, scrotal or testicular pain or varicocele, incidental non-palpable testicular tumors have also been unexpectedly discovered. [jjco.oxfordjournals.org]

• Scrotal Mass

  Testicular cancer begins as a scrotal mass, which is usually not painful. Diagnosis is by ultrasonography. [merckmanuals.com]

  A painless testicular mass is the classic presentation for testicular cancer, although a number of patients present with diffuse pain or swelling. Ultrasonography may be helpful in confirming the presence of a scrotal mass within the testicle. [aafp.org]

The patient elected observation after further workup showed no evidence of metastasis. A repeat ultrasound 3 months later showed interval growth and the patient underwent right radical orchiectomy. [casereports.bmj.com]

Review Topic QID: 106375 5 No further workup, instruct patient to return if symptomatic M1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only ARTICLES (4) VIDEOS (1) Topic COMMENTS (12 [medbullets.com]

Testicular Cancer Workup. Available online at http://emedicine.medscape.com/article/279007-overview. Accessed July 2014. Motzer RJ, Agarwal N, Beard C, et al. Testicular Cancer. [labtestsonline.it]

• Trophoblastic Cells

  Abstract Hyperglycosylated human chorionic gonadotropin (hCG-H), a variant of hCG, has been shown to promote the growth and invasion of trophoblast cells in early pregnancy placental implantation, choriocarcinoma and testicular germ cell malignancies. [digitalrepository.unm.edu]

Following treatment with anastrazole, his height velocity slowed down. At the age of 13.7 years, his treatment was stopped. [ncbi.nlm.nih.gov]

Treatment with 0.1 µM RA led to a 13.3-fold increase in cDDP IC 50 to 3.05±0.61 µM, and 4 days of 10 µM RA treatment increased the IC 50 18.6-fold to 4.28±0.28 µM. [journals.plos.org]

In both arms, treatment repeats every 3 weeks for a total of 4 courses in the absence of disease progression or unacceptable toxicity. Quality of life is assessed before treatment randomization and at 1 and 2 years after randomization. [clinicaltrials.gov]

Seminoma late metastasis and excellent prognosis Embryonal worse prognosis than seminoma Choriocarcinoma worst prognosis in contrast to good prognosis in females metastasizes to lungs Please rate topic. [medbullets.com]

The overall prognosis of testicular tumors is excellent; patients can often be cured even in advanced, metastatic stages. [amboss.com]

Germ cell tumors (germinoma, 90643; germ cell tumor, nonseminomatous, 90653) Seminoma (90613, 90623, 90663; most common 40-50%; slow to spread; more likely to occur in older patients; highly radiosensitive; good prognosis) Non-Seminoma (teratoma and embryonal [training.seer.cancer.gov]

[…] tumor masses present within the testes The prognosis for Embryonal Carcinoma of the Testis is poor because of the aggressive nature of the condition. [dovemed.com]

or therapies New developments in treatment As with any cancer, prognosis and long-term survival can vary greatly from individual to individual. [stanfordchildrens.org]

(Etiology) The cause of Embryonal Carcinoma of the Testis is unknown. [dovemed.com]

Testicular dysgenesis syndrome (failure of development of testes) 3 possible etiologies for testis cancer? 1. cryptorchidism 2. scrotal trauma 3. trauma TDS includes 1. sperm = ----- 2. testicular volume less than ----- 3. cryptorchidism 4. [quizlet.com]

Etiology Risk factors Cryptorchidism (increased risk for germ cell tumors ) [4] Contralateral testicular cancer Germ cell neoplasia in situ (GCNIS) Family history of testicular cancer Klinefelter syndrome, Down syndrome (increased risk for germ cell tumors [amboss.com]

About 3-10% of pure germ cell tumors are embryonal carcinomas, and embryonal carcinomas are present in more than 80% of mixed germ cell tumors. [1, 2] Etiology Genetic and environmental factors play a role in the development of germ cell tumors, [3, 4 [emedicine.medscape.com]

The authors concluded that future genetic studies should consider GCTs from all sites to enable a better understanding of their etiology. Oliver RT, Mead GM, Rustin GJ, et al. [cancerindex.org]

[…] more common in Hispanics compared to Asian and black populations in the US References: [1] [2] [3] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Conclusions Testicular and paratesticular tumors in prepubertal children show epidemiological, histological, therapeutical and evolutional characteristics well differentiated from postpubertal or adult subjects. [dialnet.unirioja.es]

Introduction Testicular tumors can be of germ cell or non-germ cell origin germ cell origin are the majority (95%) and are more commonly malignant non-germ cell origin usually benign Epidemiology incidence most common cancer in men between 15-35 years [medbullets.com]

[…] cells recapitulating early stages of embryonic development Essential features Age at presentation: 30's Pure in 2% of the cases; most commonly part of mixed germ cell tumor More than 60% have metastases at presentation Multiple morphologic patterns Epidemiology [pathologyoutlines.com]

These groups are defined by epidemiological characteristics, histological composition and chromosomal constitution (Table 1). [atlasgeneticsoncology.org]

Epidemiology : usually develop after the age of 4 Pathophysiology : produces ↑↑ amounts of testosterone and a small amount of estrogen, progesterone, and corticosteroids → testosterone excess causes precocious puberty in males (and masculinization in [amboss.com]

Testicular Cancer increases risk 6-10 fold Testicular Germ Cell Tumor 1 ( Chromosome Xq27) Tobacco abuse Ongoing Tobacco use with a >12 pack year history confers 2 fold risk Infertility ( Relative Risk 1.6 to 2.8) Testicular atrophy Testicular dysgnesis Pathophysiology [fpnotebook.com]

Removal of the testis Debulking surgery to reduce tumor size, followed by chemotherapy Clotting the vessels in the tumor (embolization) Chemotherapy Radiotherapy Undertaking treatment of underlying conditions How can Embryonal Carcinoma of the Testis be Prevented [dovemed.com]

Available online at https://www.cancer.org/cancer/testicular-cancer/causes-risks-prevention/risk-factors.html. Accessed on 2/13/18. (February 12, 2016) Testicular Cancer Survival Rates. American Cancer Society. [labtestsonline.it]

Treatment may include (alone or in combination): Surgery (to remove the tumor and involved organs) Chemotherapy Radiation Bone marrow transplantation Supportive care (for the effects of treatment) Hormonal replacement (if necessary) Antibiotics (to prevent [stanfordchildrens.org]

[…] months CT Chest may be indicated in symptomatic patients Tumor Marker s (Serum bHCG, AFP levels, Lactate Dehydrogenase ) Obtained at each history and physical Optional in Stage I and IIA Seminoma False negatives in up to 35% of non-seminoma recurrence Prevention [fpnotebook.com]

SIGNS AND SYMPTOMS OF TESTICULAR CANCER Not much can be done to prevent testicular cancer so the best prevention/protection is to be aware of the risks, the signs, the symptoms and early detection by doing self-testicular exams. [testicularcancersociety.org]