This is a rare presentation of seminoma and emphasises the importance of scrotal examination in young men presenting with acute abdomen. [ncbi.nlm.nih.gov]

Back pain, abdominal discomfort or abdominal mass may be a presenting feature in the 25% of patients who have retroperitoneal nodal metastases 3. Presentation with distant or extranodal metastases is rare (~5%). [radiopaedia.org]

Less than 25% of patients have metastatic disease at presentation. [mayoclinicproceedings.org]

• Dry Cough

  At the end of second cycle, he developed a dry cough and fever that was accompanied by newly-identified bilateral infiltrates on chest X-ray. [ncbi.nlm.nih.gov]

• Parotid Mass

  The mass was infiltrating into the parotid gland and into the parapharyngeal space. A primary parotid neoplasm was suspected, and panendoscopy combined with open biopsy was performed. [current-oncology.com]

• Denial

  After going through a period of denial and anger, I decided I was going to do whatever I could to beat it. My doctor said I was fortunate because we had caught it at an early stage. [healthlinkbc.ca]

• Swelling of the Scrotum

  […] mass Negative transillumination test Solid mass with variable echogenicity Hydrocele testis Fluctuant swelling of the scrotum Palpation of an elastic soft swelling Positive transillumination test Hypoechoic mass around the testis Varicocele testis Usually [amboss.com]

In one of them, diagnosis was only achieved after 4 years despite an extensive workup. [frontiersin.org]

Metastatic workup showed no nodal or distant spread, T1N0M0 stage I. After orchiectomy, the patient underwent adjuvant external beam radiotherapy to the para-aortic nodes. [emedicine.com]

• Myocardial Fibrosis

  fibrosis, conduction defects, valvular defects, and coronary artery disease [31,34,35]. [ascopubs.org]

Treatments that may be available through clinical trials are discussed in the section titled Strategies to Improve Treatment. Circumstances unique to each patient’s situation influence which treatment or treatments are utilized. [texasoncology.com]

Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Stage 1 Surgery is the main treatment for stage 1 seminoma. [cancer.ca]

What are the risks of radiation treatment? Radiation treatment has side effects. Most (such as fatigue, nausea, vomiting, and diarrhea) are short-term. That means they go away when treatment is done. [healthy.kaiserpermanente.org]

Therefore, early identification, diagnosis and proper treatment are of great significance for the prognosis of seminoma. The prognosis of seminomas of different pathological types varied. [spandidos-publications.com]

AFP < 1000 ng/mL hCG < 5000 IU/L (1000 ng/mL) LDH < 1.5x ULN Seminoma (90% of cases) All of the following criteria: 5-year PFS 82% 5-year survival 86% Any primary site No non-pulmonary visceral metastases Normal AFP Any hCG Any LDH Intermediate prognosis [esmo.org]

Men's outlook is defined as having good prognosis, intermediate prognosis or poor prognosis. [cancerresearchuk.org]

Etiology Etiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). [orpha.net]

Kataja This Clinical Practice Guideline for Testicular Seminoma and Non-seminoma features epidemiology of these rare malignancies in young men, the diagnosis, management of the primary tumour, post-orchiectomy staging and risk assessment, treatment recommendations [esmo.org]

Epidemiology Most common solid malignant tumor in young men in the US Peak incidence: 20–35 years; (nonseminomas peak in the third decade, seminomas in the fourth decade of life) References:[1][2][3] Epidemiological data refers to the US, unless otherwise [amboss.com]

Links: epidemiology of testicular cancer clinical features/presenting features of testicular cancer investigations in testicular cancer treatment of testicular cancer prognosis of testicular cancer testicular cancer testicular microlithiasis urgent referral [gpnotebook.co.uk]

US National Guidelines Clearinghouse NICE Guidance FDA on Seminoma pathophysiology CDC on Seminoma pathophysiology Seminoma pathophysiology in the news Blogs on Seminoma pathophysiology Directions to Hospitals Treating Seminoma Risk calculators and risk [wikidoc.org]

References:[5][11][14][15] Shock Summary Pathophysiology Stages of shock Multiorgan dysfunction (MODS) Hypovolemic shock Cardiogenic shock Distributive shock Septic shock Neurogenic shock Anaphylactic shock Diagnostics [amboss.com]

The relationship with PTHrP has not been determined or studied.The aim of this study is to describe and discuss the case and the pathophysiological mechanisms involved in a malignant hypercalcemia mediated by 1,25-dihydroxyvitamin D and PTHrP cosecretion [ncbi.nlm.nih.gov]

[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]

Side effects not only cause patients discomfort, but also may prevent the optimal delivery of therapy at its planned dose and schedule. [texasoncology.com]

A wide excision of the left hemiscrotum including the testis was performed in order to prevent severe local and systemic infectious complications. Histological examination revealed an AS. [ncbi.nlm.nih.gov]

Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies Case Studies Case #1 Seminoma pathophysiology On the Web Most recent articles Most cited articles Review articles CME Programs Powerpoint slides Images American Roentgen [wikidoc.org]