Presentation
The incidence of this disease is increasing—the lifetime risk for a man is now about one in 200 in the United Kingdom. 1 Presentation is usually with a painless lump. [bmj.com]
A 50-year-old male presented to us in August 2004 with a history of left-sided testicular swelling. [indianjurol.com]
This book presents a wealth of images of the different diseases and conditions encountered in the field of uroradiology with the aim of enabling the reader to recognize lesions, to interpret them appropriately and to make correct diagnoses. [books.google.com]
Gastrointestinal
- Upper Abdominal Pain
Case report A 22-year-old male patient complaining of right-sided upper abdominal pain. [link.springer.com]
Face, Head & Neck
- Neck Mass
In 2005 a huge left supraclavicular neck mass with extension to anterior mediastinum appeared. Radical surgical resection of the mass was performed and pathologic examination revealed mature teratoma. [ncbi.nlm.nih.gov]
Clinical Presentation • Painless testicular swelling • Dull ache/heaviness in Lower Abdomen • 10% - Acute Scrotal Pain • 10% - Metatstasis • Neck Mass /Cough /Anorexia /Vomiting /Back ache/Lower limb swelling • 5% - Gynecomastia - Estrogen producing tumors [slideshare.net]
Urogenital
- Testicular Mass
Case : The patient was a 29-year-old male with a right testicular mass, measuring 8.5×7.5×8.0 cm in diameter. [jstage.jst.go.jp]
Testicular cancer begins as a scrotal mass, which is usually not painful. Diagnosis is by ultrasonography. [merckmanuals.com]
At a Glance When a patient discovers a usually painless testicular mass, either unintentionally or by self-examination, or when a testicular mass is discovered by routine physical examination, testicular cancer should be suspected. [clinicaladvisor.com]
Non-Seminomatous Germ Cell Tumors • Embryonal Carcinoma • 25 - 35 years • 3 - 6% testicular tumors • small, rounded, irregular mass • invades tunica albuginea • Yolk Sac Tumor/ Endodermal Sinus Tumor • most common testicular tumor in infants & children [slideshare.net]
A painless testicular mass is the classic presentation for testicular cancer, although a number of patients present with diffuse pain or swelling. Ultrasonography may be helpful in confirming the presence of a scrotal mass within the testicle. [aafp.org]
Workup
Metastatic Workup After the diagnosis is confirmed by radical inguinal orchiectomy, further studies should include repeated markers for hCG (wait 1 week) and AFP (wait 4 weeks) and CT of the chest and abdomen. [flylib.com]
X-Ray
- Left Pleural Effusion
Chest x-ray documented left pleural effusion. Cultures from thoracentesis grew out Acremonium strictum and intravenous liposomal amphotericin B was given at a dose of 200 mg daily. On treatment, fever subsided but dyspnea worsened. [bjid.org.br]
Treatment
We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma. A 20-year-old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989. [ncbi.nlm.nih.gov]
Lehman et al. reported a case of retroperitoneal mature teratoma 15 years after initial treatment of testicular germ cell tumor [ 13 ]. Late relapse was observed up to 32 years after initial treatment [ 7 ]. [link.springer.com]
Once the aspects of the treatment fields are satisfactorily set, x-rays representing the treatment fields are taken. [news.cancerconnect.com]
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. [books.google.es]
Prognosis
Germ cell tumors (germinoma, 90643; germ cell tumor, nonseminomatous, 90653) Seminoma (90613, 90623, 90663; most common 40-50%; slow to spread; more likely to occur in older patients; highly radiosensitive; good prognosis) Non-Seminoma (teratoma and embryonal [training.seer.cancer.gov]
Prognosis of Testicular Cancer (Teratoma of the Testicle) As with many malignancies, early diagnosis and intervention are critical to subsequent prognosis in patients with testicular cancer. [myvmc.com]
Adjusting for these and other factors, survival was 60% higher for men treated in a cancer unit that treated the majority of these men, though the unit treated more men with the worst prognosis. [12] Choriocarcinoma of the testicles has the worst prognosis [en.wikipedia.org]
These help in the diagnosis and prognosis of testicular cancers. Alpha-Fetoprotein (AFP) is a tumor marker that helps in diagnosing germ cell (non-seminoma) carcinoma. AFP is also a useful tool for monitoring recurrence and treatment response. [medindia.net]
[…] seminoma and good, intermediate and poor prognosis NSGCT.Table 3: Prognostic-based staging system for metastatic germ cell cancer (iGcccG)Good-prognosis groupNon-seminoma (56% of cases) 5-year PFS 89% 5-year survival 92%All of the following criteria: [dokumen.tips]
Etiology
(Etiology) The cause of Teratoma of the Testis is unknown. [dovemed.com]
Etiology • Cryptorchidism • Intersex disorder • Testicular atrophy • Chromosomal abnormalities - loss of chromosome 11, 13, 18, abnormal chromosome 12p. • Exogenous estrogen administration to mother during pregnancy • Carcinoma-in-situ • Previous testicular [slideshare.net]
Testicular Tumours epidemiologic, etiologic and pathologic features. Cancer 1973; 32:1186. 8. Kalra VB, Ramdeo IN, Kalra R. Testicular tumors clinicopathological study. Indian J Surg 1977; 39:226. 9. Joshi N, Vickers P, Sharma ML, Joshi RI. [jpgmonline.com]
No clear etiologic or genetic factors have been defined; however, 10% of patients have a history of an undescended testis, 50% of which were intraabdominal. Testis cancers will be bilateral in 2% to 3% of cases, either concurrent or in succession. [flylib.com]
While the clinical evidence for the involvement of genetic factors in the etiology of GCT is undisputed, the assumed Testicular GCT 1 gene has so far not been identified [ 41 ]. [bmcurol.biomedcentral.com]
Epidemiology
Keywords: Adolescent, Adult, Carcinoma, Embryonal, epidemiology,Child, Child, Preschool, Endodermal Sinus Tumor, epidemiology,Human, Incidence, India, epidemiology,Infant, Male, Middle Age, Neoplasms, Multiple Primary, epidemiology,Retrospective Studies [jpgmonline.com]
Methods We searched our personal archives of references relating to the epidemiology, diagnosis, and management of testicular germ cell cancers as well as the Cochrane Database for reviews or meta-analyses. [bmj.com]
Rates are lowest in Asia and Africa and intermediate in Central and South America. [6] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. [emedicine.medscape.com]
Br J Cancer 1999 ; 80 : 1859 –63. © International Epidemiological Association 2001 [ije.oxfordjournals.org]
Pathophysiology
Pathophysiology The cause of testicular cancer is not known. The characteristic genetic change found is an isochromosome of the short arm of chromosome 12 [i(12p)], which is often seen in sporadic cancers. [emedicine.medscape.com]
Prevention
Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [jamanetwork.com]
These may be used singly or in combination to kill or prevent the growth and division of cells. [thetcrc.org]
[…] tumors Removal of the testis Debulking surgery to reduce tumor size, followed by chemotherapy Clotting the vessels in the tumor (embolization) Chemotherapy Radiotherapy Undertaking treatment of underlying conditions How can Teratoma of the Testis be Prevented [dovemed.com]
Surveillance is not used as often for seminomas because the morbidity of 2 wk of radiation therapy is so low and the results in preventing late relapse so high that there is less reason to try to avoid treatment. [merckmanuals.com]
So, this case represents an exceptional example showing the low efficacy of chemotherapy to prevent sequential testicular neoplasms. (3) Two brothers of case #2 had suffered from testicular cancer, too, one of whom had even bilateral disease. [bmcurol.biomedcentral.com]