Abstract A case report of father-son testicular cancers, both teratocarcinomas, is presented and genetic considerations discussed. [ncbi.nlm.nih.gov]

In addition, patients with symptomatic disease and patients presenting with visceral metastases carried a poor prognosis [ 2 ]. [wjso.biomedcentral.com]

The incidence of this disease is increasing—the lifetime risk for a man is now about one in 200 in the United Kingdom. 1 Presentation is usually with a painless lump. [bmj.com]

• Upper Abdominal Pain

  Case report A 22-year-old male patient complaining of right-sided upper abdominal pain. [link.springer.com]

• Neck Mass

  In 2005 a huge left supraclavicular neck mass with extension to anterior mediastinum appeared. Radical surgical resection of the mass was performed and pathologic examination revealed mature teratoma. [ncbi.nlm.nih.gov]

  CT scan of the thorax showed a 5 5 8 cm lobulated neck mass with extension to anterior mediastinum. (figure 2 ). The other parts especially paraaortic area were normal in imaging studies. [wjso.biomedcentral.com]

  Clinical Presentation • Painless testicular swelling • Dull ache/heaviness in Lower Abdomen • 10% - Acute Scrotal Pain • 10% - Metatstasis • Neck Mass /Cough /Anorexia /Vomiting /Back ache/Lower limb swelling • 5% - Gynecomastia - Estrogen producing tumors [slideshare.net]

• Meningism

  Invasive infections are exceptional since only a dozen reports exist in the pertinent literature: such conditions usually occur in severely immunocompromised patients with hematologic diseases or solid tumors and include fungemia, meningitis, brain abscess [scielo.br]

• Testicular Mass

  Case : The patient was a 29-year-old male with a right testicular mass, measuring 8.5 7.5 8.0 cm in diameter. [jstage.jst.go.jp]

  If a testicular mass is confirmed, serum tumor markers alpha-fetoprotein and beta-human chorionic gonadotropin should be measured and a chest x-ray taken. [merckmanuals.com]

  At a Glance When a patient discovers a usually painless testicular mass, either unintentionally or by self-examination, or when a testicular mass is discovered by routine physical examination, testicular cancer should be suspected. [clinicaladvisor.com]

  Investigations • All patients with a solid, firm intra-testicular mass that cannot be transilluminated should be regarded as malignant unless otherwise proved. • Scrotal Ultrasound - • rapid, reliable technique • hypoechoic area within the tunica albuginea [slideshare.net]

  Scrotal ultrasonography is nearly 100 percent accurate in distinguishing between intratesticular and extratesticular pathology. 16 All intra-testicular masses are considered cancer until proved otherwise. [aafp.org]

Metastatic Workup After the diagnosis is confirmed by radical inguinal orchiectomy, further studies should include repeated markers for hCG (wait 1 week) and AFP (wait 4 weeks) and CT of the chest and abdomen. [flylib.com]

• Left Pleural Effusion

  Chest x-ray documented left pleural effusion. Cultures from thoracentesis grew out Acremonium strictum and intravenous liposomal amphotericin B was given at a dose of 200 mg daily. On treatment, fever subsided but dyspnea worsened. [scielo.br]

We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma. A 20-year-old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989. [ncbi.nlm.nih.gov]

Lehman et al. reported a case of retroperitoneal mature teratoma 15 years after initial treatment of testicular germ cell tumor [ 13 ]. Late relapse was observed up to 32 years after initial treatment [ 7 ]. [wjso.biomedcentral.com]

Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. ‎ [books.google.es]

On treatment, fever subsided but dyspnea worsened. Whole-body CT scan showed multiple bilateral lung nodules, systemic lymphadenopathies and a mass over the left testis. [scielo.br]

[…] represent the principal predisposing factors. 2 As for the respiratory system, Acremonium strictum has been associated with two types of lesions: multiple bilateral nodules with no halo sign (4 cases) and pleuritis (2 cases including ours). 1-5 The prognosis [scielo.br]

[…] represent the principal predisposing factors. 2 As for the respiratory system, Acremonium strictum has been associated with two types of lesions: multiple bilateral nodules with no halo sign (4 cases) and pleuritis (2 cases including ours). 1–5 The prognosis [bjid.org.br]

In addition, patients with symptomatic disease and patients presenting with visceral metastases carried a poor prognosis [ 2 ]. [wjso.biomedcentral.com]

Germ cell tumors (germinoma, 90643; germ cell tumor, nonseminomatous, 90653) Seminoma (90613, 90623, 90663; most common 40-50%; slow to spread; more likely to occur in older patients; highly radiosensitive; good prognosis) Non-Seminoma (teratoma and embryonal [training.seer.cancer.gov]

(Etiology) The cause of Teratoma of the Testis is unknown. [dovemed.com]

Etiology • Cryptorchidism • Intersex disorder • Testicular atrophy • Chromosomal abnormalities - loss of chromosome 11, 13, 18, abnormal chromosome 12p. • Exogenous estrogen administration to mother during pregnancy • Carcinoma-in-situ • Previous testicular [slideshare.net]

Testicular Tumours epidemiologic, etiologic and pathologic features. Cancer 1973; 32:1186. 8. Kalra VB, Ramdeo IN, Kalra R. Testicular tumors clinicopathological study. Indian J Surg 1977; 39:226. 9. Joshi N, Vickers P, Sharma ML, Joshi RI. [jpgmonline.com]

No clear etiologic or genetic factors have been defined; however, 10% of patients have a history of an undescended testis, 50% of which were intraabdominal. Testis cancers will be bilateral in 2% to 3% of cases, either concurrent or in succession. [flylib.com]

While the clinical evidence for the involvement of genetic factors in the etiology of GCT is undisputed, the assumed Testicular GCT 1 gene has so far not been identified [ 41 ]. [bmcurol.biomedcentral.com]

The epidemiology of testicular cancer. Brit J Urol 1987; 60:285. 12. Young PG, Mount BM, Fools FW, Whitmore WF. Embryonal adenocarcinoma in the prepubertal testis. Cancer 1970; 26:1065. 13. Kimbrough JC, Cook FF. Carcinoma of the testis. [jpgmonline.com]

Methods We searched our personal archives of references relating to the epidemiology, diagnosis, and management of testicular germ cell cancers as well as the Cochrane Database for reviews or meta-analyses. [bmj.com]

Rates are lowest in Asia and Africa and intermediate in Central and South America. [6] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. [emedicine.medscape.com]

International Epidemiological Association 2001 [ije.oxfordjournals.org]

Pathophysiology The cause of testicular cancer is not known. The characteristic genetic change found is an isochromosome of the short arm of chromosome 12 [i(12p)], which is often seen in sporadic cancers. [emedicine.medscape.com]

Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [jamanetwork.com]

These may be used singly or in combination to kill or prevent the growth and division of cells. [thetcrc.org]

[…] tumors Removal of the testis Debulking surgery to reduce tumor size, followed by chemotherapy Clotting the vessels in the tumor (embolization) Chemotherapy Radiotherapy Undertaking treatment of underlying conditions How can Teratoma of the Testis be Prevented [dovemed.com]

Surveillance is not used as often for seminomas because the morbidity of 2 wk of radiation therapy is so low and the results in preventing late relapse so high that there is less reason to try to avoid treatment. [merckmanuals.com]

So, this case represents an exceptional example showing the low efficacy of chemotherapy to prevent sequential testicular neoplasms. (3) Two brothers of case #2 had suffered from testicular cancer, too, one of whom had even bilateral disease. [bmcurol.biomedcentral.com]