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Testicular Teratocarcinoma

Testicular Embryonal Carcinoma and Teratoma


Presentation

  • Abstract A case report of father-son testicular cancers, both teratocarcinomas, is presented and genetic considerations discussed.[ncbi.nlm.nih.gov]
  • The incidence of this disease is increasing—the lifetime risk for a man is now about one in 200 in the United Kingdom. 1 Presentation is usually with a painless lump.[bmj.com]
  • However, it is present as a component of almost ninety percent of mixed nonseminomatous germ cell tumours. The average age at diagnosis is 31 years, and typically presents as a testicular lump which may be painful.[en.wikipedia.org]
  • A 50-year-old male presented to us in August 2004 with a history of left-sided testicular swelling.[indianjurol.com]
Lymphadenopathy
  • Keywords Testicular microlithiasis Ultrasonography Teratocarcinoma of testes Paraortic lymphadenopathy Testicle This is a preview of subscription content, log in to check access. References 1.[link.springer.com]
  • Whole-body CT scan showed multiple bilateral lung nodules, systemic lymphadenopathies and a mass over the left testis. Biopsies from an enlarged supraclavicular lymph node revealed metastatic testicular teratocarcinoma.[bjid.org.br]
  • Chest X-ray was normal and ultrasonography of the abdomen revealed para-aortic lymphadenopathy. He underwent a left high inguinal orchidectomy and left hemiscrotectomy.[indianjurol.com]
Upper Abdominal Pain
  • Case report A 22-year-old male patient complaining of right-sided upper abdominal pain.[link.springer.com]
Hypertension
  • Delivery Models Health Care Economics, Insurance, Payment Health Care Policy Health Care Quality Health Care Reform Health Care Safety Health Care Workforce Health Disparities Health Informatics Health Policy Hematology History of Medicine Humanities Hypertension[jamanetwork.com]
Neck Mass
  • In 2005 a huge left supraclavicular neck mass with extension to anterior mediastinum appeared. Radical surgical resection of the mass was performed and pathologic examination revealed mature teratoma.[ncbi.nlm.nih.gov]
Testicular Mass
  • Case : The patient was a 29-year-old male with a right testicular mass, measuring 8.5 7.5 8.0 cm in diameter.[jstage.jst.go.jp]
  • At a Glance When a patient discovers a usually painless testicular mass, either unintentionally or by self-examination, or when a testicular mass is discovered by routine physical examination, testicular cancer should be suspected.[clinicaladvisor.com]
  • One fifth to two thirds of patients with tumours composed predominantly of embryonal carcinoma have metastases at diagnosis. [1] Signs and symptoms [ edit ] The presenting features may be a palpable testicular mass or asymmetric testicular enlargement[en.wikipedia.org]
  • The most common presentation of pure teratomas is with a painless testicular mass.[radiopaedia.org]

Workup

  • Metastatic Workup After the diagnosis is confirmed by radical inguinal orchiectomy, further studies should include repeated markers for hCG (wait 1 week) and AFP (wait 4 weeks) and CT of the chest and abdomen.[flylib.com]
Left Pleural Effusion
  • Chest x-ray documented left pleural effusion. Cultures from thoracentesis grew out Acremonium strictum and intravenous liposomal amphotericin B was given at a dose of 200 mg daily. On treatment, fever subsided but dyspnea worsened.[bjid.org.br]

Treatment

  • We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma. A 20-year-old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989.[ncbi.nlm.nih.gov]
  • Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. ‎[books.google.es]
  • On treatment, fever subsided but dyspnea worsened. Whole-body CT scan showed multiple bilateral lung nodules, systemic lymphadenopathies and a mass over the left testis.[bjid.org.br]
  • Successful treatment of malignant testicular teratoma with brain metastases . Br Med J, 1979; 1: 233–234. Google Scholar [6] Lester SG, Morphis JG II, Hornback NB, Williams SD, Einhorn LH .[link.springer.com]

Prognosis

  • […] represent the principal predisposing factors. 2 As for the respiratory system, Acremonium strictum has been associated with two types of lesions: multiple bilateral nodules with no halo sign (4 cases) and pleuritis (2 cases including ours). 1–5 The prognosis[bjid.org.br]
  • […] represent the principal predisposing factors. 2 As for the respiratory system, Acremonium strictum has been associated with two types of lesions: multiple bilateral nodules with no halo sign (4 cases) and pleuritis (2 cases including ours). 1-5 The prognosis[scielo.br]
  • Germ cell tumors (germinoma, 90643; germ cell tumor, nonseminomatous, 90653) Seminoma (90613, 90623, 90663; most common 40-50%; slow to spread; more likely to occur in older patients; highly radiosensitive; good prognosis) Non-Seminoma (teratoma and embryonal[training.seer.cancer.gov]
  • Prognosis of Testicular Cancer (Teratoma of the Testicle) As with many malignancies, early diagnosis and intervention are critical to subsequent prognosis in patients with testicular cancer.[myvmc.com]
  • Adjusting for these and other factors, survival was 60% higher for men treated in a cancer unit that treated the majority of these men, though the unit treated more men with the worst prognosis. [12] Choriocarcinoma of the testicles has the worst prognosis[en.wikipedia.org]

Etiology

  • Testicular Tumours epidemiologic, etiologic and pathologic features. Cancer 1973; 32:1186. 8. Kalra VB, Ramdeo IN, Kalra R. Testicular tumors clinicopathological study. Indian J Surg 1977; 39:226. 9. Joshi N, Vickers P, Sharma ML, Joshi RI.[jpgmonline.com]
  • No clear etiologic or genetic factors have been defined; however, 10% of patients have a history of an undescended testis, 50% of which were intraabdominal. Testis cancers will be bilateral in 2% to 3% of cases, either concurrent or in succession.[flylib.com]
  • While the clinical evidence for the involvement of genetic factors in the etiology of GCT is undisputed, the assumed Testicular GCT 1 gene has so far not been identified [ 41 ].[bmcurol.biomedcentral.com]

Epidemiology

  • The epidemiology of testicular cancer. Brit J Urol 1987; 60:285. 12. Young PG, Mount BM, Fools FW, Whitmore WF. Embryonal adenocarcinoma in the prepubertal testis. Cancer 1970; 26:1065. 13. Kimbrough JC, Cook FF. Carcinoma of the testis.[jpgmonline.com]
  • Methods We searched our personal archives of references relating to the epidemiology, diagnosis, and management of testicular germ cell cancers as well as the Cochrane Database for reviews or meta-analyses.[bmj.com]
  • Google Scholar Ruf CG, Isbarn H, Wagner W, Fisch M, Matthies C, Dieckmann KP: Changes in epidemiologic features of testicular germ cell cancer: age at diagnosis and relative frequency of seminoma are constantly and significantly increasing.[bmcurol.biomedcentral.com]
Sex distribution
Age distribution

Prevention

  • Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive[jamanetwork.com]
  • So, this case represents an exceptional example showing the low efficacy of chemotherapy to prevent sequential testicular neoplasms. (3) Two brothers of case #2 had suffered from testicular cancer, too, one of whom had even bilateral disease.[bmcurol.biomedcentral.com]

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