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Testosterone


Presentation

  • Hirsutism is present in up to 25% reproductive aged women and is most often caused by polycystic ovary syndrome.[ncbi.nlm.nih.gov]
Noncompliance
  • […] concentrations, and seemingly unpredictable response requires close monitoring and careful follow up and suggests this modality of therapy may not be appropriate for a substantial number of hypogonadal patients, but this strategy warrants consideration in noncompliant[ncbi.nlm.nih.gov]
  • Bureau of voluntary noncompliance seminar—anabolic steroids. NABP Newsl. 1988; 17:110-1. 119. Thompson PD, Cullinane EM, Sady SP et al. Contrasting effects of testosterone and stanozolol on serum lipoprotein levels. JAMA. 1989; 261:1165-8. 120.[drugs.com]
Euthyroid
  • The study population consisted of 34 euthyroid men with autoimmune thyroiditis and testosterone deficiency.[ncbi.nlm.nih.gov]
  • Methods The study population consisted of 34 euthyroid men with autoimmune thyroiditis and testosterone deficiency.[doi.org]
Deepening of Voice
  • During puberty, testosterone helps build a man's muscles, deepens his voice, and boosts the size of his penis and testes. In adulthood, it keeps a man's muscles and bones strong and maintains his interest in sex.[webmd.com]
  • It deepens the voice, increases muscle growth, promotes facial and body hair, and spurs the sex drive. Testosterone also is associated with personality traits related to power and dominance.[theatlantic.com]
  • Tell female patient to immediately report signs of masculinization, such as excessive body or facial hair, deepening of voice, clitoral enlargement, and menstrual irregularities. • Advise female of childbearing age to use barrier contraceptives.[medical-dictionary.thefreedictionary.com]
Hirsutism
  • To examine the significance of the non-SHBG-bound testosterone (i.e. free plus albumin bound) in hyperandrogenism, we obtained single blood samples from 17 normal women, 20 regularly menstruating but hirsute women, and 20 oligoamenorrheic hirsute women[ncbi.nlm.nih.gov]
  • To examine the significance of the non-SHBG-bound testosterone ( i.e. free plus albumin bound) in hyperandrogenism, we obtained single blood samples from 17 normal women, 20 regularly menstruating but hirsute women, and 20 oligoamenorrheic hirsute women[doi.org]
Alopecia
  • […] resulting from inhibition of 5α-reductases with drugs, such as finasteride and dutasteride, to block transformation of T into 5α-DHT in the course of treatment of benign prostatic hyperplasia (BPH) and male pattern hair loss, also known as androgenetic alopecia[ncbi.nlm.nih.gov]
  • In addition, in 42 of 55 females, testosterone was lower than the upper limit of the ID/GC-MS range (0.50–2.55 nmol/L) as measured in normally menstruating women 19–35 years of age with no evidence of hirsutism, acne, or alopecia and taking no oral contraceptives[doi.org]
  • […] by granulosa-theca cell tumors of the ovary, especially in mares. testosterone cyclopentylpropionate, testosterone cypionate, testosterone propionate esters with a long period of activity. testosterone-responsive dermatosis a bilaterally symmetrical alopecia[medical-dictionary.thefreedictionary.com]
Acne Vulgaris
  • Zouboulis, Acne vulgaris Acne vulgaris, Der Hautarzt, 10.1007/s00105-009-1830-1, 61, 2, (107-114), (2010). Andrew T.[doi.org]
Nipple Discharge
  • Breast cancer was diagnosed in three women in the testosterone groups between 4 and 12 months after treatment initiation ( Table 2 ), one of whom reported in retrospect a bloody nipple discharge before randomization.[dx.doi.org]
Bloody Nipple Discharge
  • Breast cancer was diagnosed in three women in the testosterone groups between 4 and 12 months after treatment initiation ( Table 2 ), one of whom reported in retrospect a bloody nipple discharge before randomization.[dx.doi.org]
Increased Libido
  • Potential benefits of therapy include increased libido, improved sexual function, improved mood and well-being, and increased muscle mass and bone density; however, there is little or mixed evidence confirming clinically significant benefits.[ncbi.nlm.nih.gov]
  • All have seen an increase in physical and mental drive, better moods, increased libido, and a decrease in belly fat.[menstclinic.com]
  • Children exposed to the hormone have experienced enlargement of the penis or clitoris, growth of pubic hair, increased libido, and aggressive behavior.[consumerreports.org]
  • The hormone testosterone stands for typically male attributes – it fosters the forming of the sexual characteristics, increases libido and muscle building. Women also have this sex hormone, but to a much lesser extent.[uni-bonn.de]
  • libido, and the prevention of age-induced testosterone decline.[mercola.com]
Type A Personality
  • Central serous chorioretinopathy (CSR) is a serous detachment of the neurosensory retina commonly associated with male sex, Type-A personality and corticosteroid use.[ncbi.nlm.nih.gov]
Sexual Dysfunction
  • KEYWORDS: hypogonadism; infertility; sexual dysfunction; testicular volume; testosterone[ncbi.nlm.nih.gov]
  • Female sexual dysfunction is a complex problem with multiple overlapping etiologies.[doi.org]
Clitoromegaly
  • We describe an 11.5-year-old girl with a 9-month history of voice deepening, mild hirsutism, minor acne, increased growth velocity, weight gain, and clitoromegaly.[ncbi.nlm.nih.gov]
  • Sartori Sanchez Bachega and Andrea Dardis, The Presence of Clitoromegaly in the Nonclassical Form of 21-Hydroxylase Deficiency Could Be Partially Modulated by the CAG Polymorphic Tract of the Androgen Receptor Gene, PLOS ONE, 11, 2, (e0148548), (2016)[doi.org]
  • ., deepening of the voice, hirsutism, clitoromegaly, menstrual irregularities). 161 If virilization occurs, discontinue therapy. 161 See Virilization in Children and Women from Secondary Exposure to Testosterone under Cautions.[drugs.com]
Oligomenorrhea
  • A 23-year-old nulliparous woman was found to have an ovarian tumor when she visited her primary doctor for virilization and oligomenorrhea. Magnetic resonance imaging revealed a solid left ovarian tumor 40 mm in size.[ncbi.nlm.nih.gov]
Vaginal Bleeding
  • Vital signs, weight, and any vaginal bleeding were recorded at each visit. Blood samples were collected at weeks 24 and 52 for laboratory measurements.[dx.doi.org]

Workup

  • Endocrine workup revealed elevated levels of adrenal androgens and adrenal precursors. Mutation analysis confirmed a non-classical 21-hydroxylase deficiency, that is, a mild form of congenital adrenal hyperplasia (CAH).[ncbi.nlm.nih.gov]
  • Further workup is necessary to determine the causes of precocious puberty -In adult men, testicular or adrenal tumors or androgen abuse might be suspected if testosterone levels exceed the upper limit of the normal range by more than 50%.[mayomedicallaboratories.com]
  • "[The owner] offered me a free workup. I said thank you for your offer, what is it you charge for your first visit? Two thousand dollars? I said I feel fine.[theatlantic.com]
Urine 17 Ketosteroids Increased
Testosterone Increased
  • We hypothesize that testosterone levels in the brain are depleted as a normal consequence of male aging and that low brain levels of testosterone increase the risk of developing Alzheimer disease (AD).[doi.org]
  • In prostate cancer patients, the level of total serum testosterone increased with age. In conclusion, total testosterone is not a statistically significant predictive factor for pathological Gleason score and pathological stage.[ncbi.nlm.nih.gov]
Androgens Increased
  • Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab 87 : 3632–3639, 2002.[dx.doi.org]
  • H. (2001) Posttraining androgens’ enhancement of cognitive performance is temporally distinct from androgensincreases in affective behavior. Cogn Affect Behav Neurosci. 1, 172–82. PubMed CrossRef Google Scholar 32. Frye C. A., Edinger K.[doi.org]
Hyperviscosity
  • Other possible risks include worsening symptoms of benign prostatic hypertrophy, liver toxicity, hyperviscosity, erythrocytosis, worsening untreated sleep apnea or severe heart failure.[ncbi.nlm.nih.gov]
  • […] hematocrit determinations in patients receiving long-term therapy. 117 123 133 135 157 161 162 Perform hematocrit determinations 3–6 months after therapy initiation and annually thereafter. 133 135 157 161 186 187 188 189 190 192 Some clinicians consider hyperviscosity[drugs.com]
Alternaria
  • In vivo, testosterone attenuated Alternaria-extract-induced IL-5 and IL-13 ILC2 numbers and lung eosinophils by intrinsically decreasing lung ILC2 numbers, as well as by decreasing expression of IL-33 and thymic stromal lymphopoietin (TSLP), ILC2-stimulating[ncbi.nlm.nih.gov]

Treatment

  • However, this treatment was not effective, so we changed the treatment to testosterone enanthate because of his symptoms with late-onset hypogonadism.[ncbi.nlm.nih.gov]
  • Treatment Contraception 1 1, 2 Completed Treatment Gender Dysphoria 1 1, 2 Completed Treatment Healthy Males 2 1, 2 Completed Treatment Hypogonadism 1 1, 2 Not Yet Recruiting Treatment Spinal Cord Injuries (SCI) 1 1, 2 Recruiting Treatment Female Infertility[drugbank.ca]

Prognosis

  • When in combination, TS, SHBG and BMI, affected prognosis in different ways depending on menopausal status.[ncbi.nlm.nih.gov]

Etiology

  • Conclusions: The present study demonstrates an association between alcohol drinking and self-reported sober-state aggression, which implies that the etiology of alcohol misuse and aggressive behavior may involve common biological and/or social factors[doi.org]
  • The present study demonstrates an association between alcohol drinking and self-reported sober-state aggression, which implies that the etiology of alcohol misuse and aggressive behavior may involve common biological and/or social factors.[ncbi.nlm.nih.gov]

Epidemiology

  • Author information 1 Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec[ncbi.nlm.nih.gov]
  • Samuli Helle, Women With Long Menstrual Cycles Have More Daughters, Epidemiology, 10.1097/01.ede.0000346251.65625.22, 20, 2, (312-313), (2009). William H.[doi.org]
  • .), the Department of Biostatistics and Epidemiology (A.J.S.-S., J.T.F., X.H., B.Z., J.R.L., S.S.E.), the Center for Clinical Epidemiology and Biostatistics (D.[nejm.org]
Sex distribution
Age distribution

Pathophysiology

  • Obesity, diabetes, hypogonadism, and specific hormone and metabolic profiles have been implicated in the pathophysiology of CVD. The evolving role of androgens in MetS and CVD is of paramount importance.[ncbi.nlm.nih.gov]

Prevention

  • How is low testosterone prevented? Low-T that is caused by genetic factors cannot be prevented, nor can low-T be prevented if the underlying cause is a disease caused by inherited genetic factors or necessary treatments such as chemotherapy.[emedicinehealth.com]

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