Hirsutism is present in up to 25% reproductive aged women and is most often caused by polycystic ovary syndrome. [ncbi.nlm.nih.gov]

• Pain

  One boy suffered from self-limiting priapism and testicular pain (dose 50 mg). Two patients reported testicular pain (each dose 50 mg). The single patient with 250 mg testosterone did not show any adverse effects. [ncbi.nlm.nih.gov]

  Call your doctor at once if you have: chest pain or pressure, pain spreading to your jaw or shoulder; swelling in your ankles or feet, rapid weight gain; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; pain, swelling, warmth, or [drugs.com]

• Virilization

  We believe that the risk-benefit ratio favors abdominal ultrasound to rule out malignancy in all children presenting with virilization. [ncbi.nlm.nih.gov]

• Precocious Puberty

  Long-term exposure to androgens in children, such as in poorly controlled congenital adrenal hyperplasia, is known to promote central precocious puberty. Clinical case report. [ncbi.nlm.nih.gov]

  […] very early (precocious) puberty with obvious secondary sex characteristics. [labtestsonline.org]

  The test may be performed if a young boy seems to be undergoing a very early (precocious) puberty with obvious secondary sex characteristics, such as an enlarged penis, development of muscle mass, deepening voice and growth of body hair. [labtestsonline.org.uk]

• Asymptomatic

  Asymptomatic patients may present with an elevated hormone level due to heterophile antibody interference. [ncbi.nlm.nih.gov]

  “So far, the side effects have been low grade, as long as the treatment is limited to men who are asymptomatic without any pain due to prostate cancer,” he says. [hopkinsmedicine.org]

  Mild-to-moderate testosterone elevations are usually asymptomatic in males, but can cause distressing symptoms in females. The exact causes for mild-to-moderate elevations in testosterone often remain obscure. [mayomedicallaboratories.com]

• Deepening of Voice

  During puberty, testosterone helps build a man's muscles, deepens his voice, and boosts the size of his penis and testes. In adulthood, it keeps a man's muscles and bones strong and maintains his interest in sex. [webmd.com]

  It deepens the voice, increases muscle growth, promotes facial and body hair, and spurs the sex drive. Testosterone also is associated with personality traits related to power and dominance. [theatlantic.com]

  During a boy's puberty, testosterone causes the growth of body hair, muscle development, and deepening of the voice. In adult men, it controls sex drive, maintains muscle mass, and helps make sperm. [medlineplus.gov]

• Myalgia

  […] hormonal effects in males Hematologic: polycythemia, leukopenia, suppressed clotting factors Hepatic: hepatic adenoma (with long-term enanthate use) Metabolic: hyperphosphatemia, hypernatremia, hypercalcemia, hypoglycemia, hyperkalemia Musculoskeletal: myalgia [medical-dictionary.thefreedictionary.com]

• Hirsutism

  To examine the significance of the non-SHBG-bound testosterone (i.e. free plus albumin bound) in hyperandrogenism, we obtained single blood samples from 17 normal women, 20 regularly menstruating but hirsute women, and 20 oligoamenorrheic hirsute women [ncbi.nlm.nih.gov]

  To examine the significance of the non-SHBG-bound testosterone ( i.e. free plus albumin bound) in hyperandrogenism, we obtained single blood samples from 17 normal women, 20 regularly menstruating but hirsute women, and 20 oligoamenorrheic hirsute women [doi.org]

• Alopecia

  Skin cells express all androgen metabolizing enzymes required for the independent cutaneous synthesis of androgens and the development of hyperandrogenism-associated conditions and diseases, such as seborrhea, acne, hirsutism and androgenetic alopecia [ncbi.nlm.nih.gov]

  Finner and Jerry Shapiro, Androgenetic Alopecia, Endocrinology and Metabolism Clinics of North America, 36, 2, (379), (2007). [doi.org]

  […] by granulosa-theca cell tumors of the ovary, especially in mares. testosterone cyclopentylpropionate, testosterone cypionate, testosterone propionate esters with a long period of activity. testosterone-responsive dermatosis a bilaterally symmetrical alopecia [medical-dictionary.thefreedictionary.com]

• Acne Vulgaris

  Zouboulis, Acne vulgaris Acne vulgaris, Der Hautarzt, 10.1007/s00105-009-1830-1, 61, 2, (107-114), (2010). Andrew T. [doi.org]

• Increased Libido

  Potential benefits of therapy include increased libido, improved sexual function, improved mood and well-being, and increased muscle mass and bone density; however, there is little or mixed evidence confirming clinically significant benefits. [ncbi.nlm.nih.gov]

  All have seen an increase in physical and mental drive, better moods, increased libido, and a decrease in belly fat. [menstclinic.com]

  The hormone testosterone stands for typically male attributes – it fosters the forming of the sexual characteristics, increases libido and muscle building. Women also have this sex hormone, but to a much lesser extent. [uni-bonn.de]

  Children exposed to the hormone have experienced enlargement of the penis or clitoris, growth of pubic hair, increased libido, and aggressive behavior. [consumerreports.org]

  Testosterone promotes attention, memory, spatial reasoning, and energy — essentially, it makes you sharper — and, of course, it increases libido and muscle mass. [bigthink.com]

• Insomnia

  Signs you may have low testosterone The symptoms of low testosterone — or hypogonadism — include the following: Decreased energy Loss of muscle mass Decreased sex drive Decreased mental sharpness Increase in body fat Trouble sleeping, including insomnia [ktar.com]

  Oral melatonin may help alleviate insomnia, reduce sleep latency, and improve sleep quality,[64] including in children[65] and the elderly.[66][67] It can also help fight jet lag,[68][69] and so is especially popular among frequent travelers. [examine.com]

  Sometimes low testosterone causes insomnia or other sleep disturbances. Physical changes. Various physical changes are possible, including increased body fat, reduced muscle bulk and strength, and decreased bone density. [mayoclinic.org]

  Signs and symptoms that a person may have low-T include insomnia, increased body fat, weight gain, reduced muscle, infertility, decreased sex drive, depression, and worsening of congestive heart failure or sleep apnea. [medicinenet.com]

  Men with low testosterone can be misdiagnosed as having chronic fatigue, depression, chronic infections, low thyroid, anaemia, liver disease, heart failure, thyroid disease, diabetes, autoimmune disease, insomnia or stress. [theguardian.com]

• Memory Impairment

  Elderly men also experience increased anemia, metabolic syndrome, decreased sexual function and memory impairment. [clinicaltrials.gov]

  Rapp, Volumetric Correlates of Spatiotemporal Working and Recognition Memory Impairment in Aged Rhesus Monkeys, Cerebral Cortex, 10.1093/cercor/bhq210, 21, 7, (1559-1573), (2010). Po H. Lu, Grace J. Lee, Erika P. [doi.org]

  Overall, only one of the trials (N=22) demonstrated a significant improvement in a single measure of verbal memory, with no other changes in cognition noted.225 In the largest RCT, men with subjective or objective memory impairments (severe impairments [auanet.org]

• Amnesia

  Side effects of testosterone include: Acne Abnormal dreams Aggressive behavior Hair loss Anaphylaxis Anger Memory loss (amnesia) Anxiety Bladder irritability Breast soreness Deep venous thrombosis Excessive frequency and duration of erection Fatigue Growth [rxlist.com]

  Other less common adverse reactions, reported in fewer than 1% of patients included: amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation [drugs.com]

  Half life 10-100 minutes Clearance Not Available Toxicity Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation. [drugbank.ca]

• Sexual Dysfunction

  […] treat low libido and sexual dysfunction in women for over 40 y. [ncbi.nlm.nih.gov]

  Sexual dysfunction should be seen as a marker for other health issues. "The penis is the dipstick of the body's health," Fisch said. [nbcnews.com]

  […] treat low libido and sexual dysfunction in women for over 40 y. [doi.org]

  Physicians should discuss whether to initiate testosterone treatment in men with age-related low testosterone with sexual dysfunction who want to improve sexual and erectile function based on the potential benefits, harms, costs, and patient preferences [eurekalert.org]

• Clitoromegaly

  We describe an 11.5-year-old girl with a 9-month history of voice deepening, mild hirsutism, minor acne, increased growth velocity, weight gain, and clitoromegaly. [ncbi.nlm.nih.gov]

  Sartori Sanchez Bachega and Andrea Dardis, The Presence of Clitoromegaly in the Nonclassical Form of 21-Hydroxylase Deficiency Could Be Partially Modulated by the CAG Polymorphic Tract of the Androgen Receptor Gene, PLOS ONE, 11, 2, (e0148548), (2016) [doi.org]

  Abnormally high testosterone levels in women may cause the over-development of typically male sex characteristics and may result in: Hirsutism (excess hair growth, for example on the face or chest); Acne; Male balding pattern; Clitoromegaly (enlargement [healthengine.com.au]

  Systemic testosterone therapy for postmenopausal women, in doses that approximate physiological testosterone concentrations for premenopausal women, is associated with mild increases in acne and body/facial hair growth in some women, but not with alopecia, clitoromegaly [academic.oup.com]

Endocrine workup revealed elevated levels of adrenal androgens and adrenal precursors. Mutation analysis confirmed a non-classical 21-hydroxylase deficiency, that is, a mild form of congenital adrenal hyperplasia (CAH). [ncbi.nlm.nih.gov]

Available online at https://emedicine.medscape.com/article/922038-workup#c6. Accessed March 2018. (Updated 2018 March). Male Hypogonadism. ARUP Laboratories. Available online at https://arupconsult.com/content/hypogonadism-male. Accessed March 2018. [labtestsonline.it]

If an adult male's testosterone levels are below 300 ng/dL, a doctor may do a workup to determine the cause of low testosterone, according to the American Urological Association. Low testosterone levels could be a sign of pituitary gland problems. [healthline.com]

[…] testosterone replacement; evaluate patients who report symptoms of pain, edema, warmth, and erythema in the lower extremity for DVT and those who present with acute shortness of breath for PE; if VTE suspected, discontinue testosterone and initiate appropriate workup [reference.medscape.com]

This is usually part of an infertility workup in men and women. Hormonal Supplementation Testosterone is a potent steroid hormone whose chemical formulation is C19-H28-O2. Testosterone is also known as 17-beta-hydroxy-4-androstene-3-one. [verywellhealth.com]

• Urine 17 Ketosteroids Increased

  thyroxine-binding globulin: decreased levels Urine creatine and creatinine: decreased excretion Urine 17-ketosteroids: increased excretion Drug-herbs. [medical-dictionary.thefreedictionary.com]

• Testosterone Increased

  Muscle morphometry showed no significant increase in muscle fiber diameter. These studies suggest that testosterone increases muscle mass by increasing muscle protein synthesis. [ncbi.nlm.nih.gov]

  We hypothesize that testosterone levels in the brain are depleted as a normal consequence of male aging and that low brain levels of testosterone increase the risk of developing Alzheimer disease (AD). [dx.doi.org]

• Testosterone Decreased

  AD cases had significantly higher LH and FSH and lower free testosterone levels. LH, FSH and SHBG all increased with age, while free testosterone decreased. Low free testosterone was an independent predictor for AD. [ncbi.nlm.nih.gov]

  Men can experience a range of symptoms if testosterone decreases more than it should. Low testosterone, or low T, is diagnosed when levels fall below 300 nanograms per deciliter (ng/dL). [healthline.com]

  Testosterone imbalances can be detected with a blood test and treated accordingly. Testosterone levels naturally decrease as a man ages. [medicalnewstoday.com]

• Androgens Increased

  Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. [ahajournals.org]

  J Clin Endocrinol Metab 85 : 1026 – 1031 35 Hak AE, Witteman JCM, de Jong FH, Geerlings MI, Hofman A, Pols HAP 2002 Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: The Rotterdam Study. [academic.oup.com]

  Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab 87 : 3632–3639, 2002. [dx.doi.org]

  H. (2001) Posttraining androgens’ enhancement of cognitive performance is temporally distinct from androgens’ increases in affective behavior. Cogn Affect Behav Neurosci. 1, 172–82. PubMed CrossRef Google Scholar 32. Frye C. A., Edinger K. [doi.org]

• HDL Cholesterol Decreased

  Plasma concentrations of total and LDL cholesterol and triglycerides did not change in any study group; plasma HDL cholesterol decreased significantly in the placebo-plus-exercise group. [doi.org]

What is the treatment for low testosterone? In males, the treatment for low-T is based on two approaches. [emedicinehealth.com]

However, this treatment was not effective, so we changed the treatment to testosterone enanthate because of his symptoms with late-onset hypogonadism. [ncbi.nlm.nih.gov]

When in combination, TS, SHBG and BMI, affected prognosis in different ways depending on menopausal status. [ncbi.nlm.nih.gov]

Female sexual dysfunction is a complex problem with multiple overlapping etiologies. Androgens play an important role in healthy female sexual function, especially in stimulating sexual interest and in maintaining desire. [ncbi.nlm.nih.gov]

Conclusions: The present study demonstrates an association between alcohol drinking and self-reported sober-state aggression, which implies that the etiology of alcohol misuse and aggressive behavior may involve common biological and/or social factors [doi.org]

Author information 1 Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec [ncbi.nlm.nih.gov]

Samuli Helle, Women With Long Menstrual Cycles Have More Daughters, Epidemiology, 10.1097/01.ede.0000346251.65625.22, 20, 2, (312-313), (2009). William H. [doi.org]

We cannot assume that testosterone replacement will ameliorate the increased risk seen in these epidemiological studies. [ahajournals.org]

Obesity, diabetes, hypogonadism, and specific hormone and metabolic profiles have been implicated in the pathophysiology of CVD. The evolving role of androgens in MetS and CVD is of paramount importance. [ncbi.nlm.nih.gov]

How is low testosterone prevented? Low-T that is caused by genetic factors cannot be prevented, nor can low-T be prevented if the underlying cause is a disease caused by inherited genetic factors or necessary treatments such as chemotherapy. [emedicinehealth.com]

Testosterone: A "male hormone" -- a sex hormone produced by the testes that encourages the development of male sexual characteristics, stimulates the activity of the male secondary sex characteristics, and prevents changes in them following castration [medicinenet.com]

Secondary Prevention, Testosterone, Treatment Outcome, Venous Thrombosis < Back to Listings [acc.org]