Edit concept Question Editor Create issue ticket

Thalassemia Minor

Thallassemia Minor


Presentation

  • To describe very low hemoglobin A1c levels in a patient with type 2 diabetes mellitus and an unusual presentation of beta-thalassemia minor. We present the clinical and laboratory findings of the study patient.[ncbi.nlm.nih.gov]
Anemia
  • Abstract Iron deficiency anemia (IDA) and thalassemia minor are two of the most common causes of microcytic anemias worldwide.[ncbi.nlm.nih.gov]
  • Thalassemia major (Cooley anemia) is characterized by severe anemia, enlargement of the spleen, and body deformities associated with expansion of the bone marrow.[britannica.com]
Fatigue
  • Abstract Beta-thalassemia minor (BTM) patients usually experience fatigue, bone pain complaint, and muscle weakness. Carnitine is an essential protein for transportation of long-chain fatty acids to the matrix for beta-oxidation.[ncbi.nlm.nih.gov]
  • Here are some manifestations of fatigue. Please specify if you have any.[icliniq.com]
  • The entire time I was in college and still today suffer greatly from constipation, severe stomach problems and chronic fatigue. I crave sweets and bread to the point to where I think its ridiculous and realize it's not normal.[easy-immune-health.com]
  • We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: May 13, 2019[patientslikeme.com]
Disturbance of Growth
  • BACKGROUND: Numerous disturbances in growth and development have been observed and demonstrated in homozygote beta-thalassemia patients.[ncbi.nlm.nih.gov]
Muscle Weakness
  • Bone pain complaint and muscle weakness decreased with carnitine. Red blood cell folate level increased after folic acid supplementation.[ncbi.nlm.nih.gov]
  • Query: Hi doctor, I have rashes similar to the rash of SLE, swollen, painful and redness around the eyes, severe fatigue and muscle weakness. These symptoms occurred a few months back after I had an intestinal infection.[icliniq.com]
Severe Osteoporosis
  • A case report of a 53 year old postmenopausal woman with severe osteoporosis occurring in association with beta thalassemia trait is presented.[ncbi.nlm.nih.gov]
Asymmetrical Arthritis
  • Abstract Recurrent episodes of seronegative asymmetrical arthritis usually lasting less than a week have been observed in 4 patients with beta thalassemia minor.[ncbi.nlm.nih.gov]
Sleep Disturbance
  • FM patients without IDA had higher sleep disturbance scores (p 0.012) and longer duration of FM (p 0.045). FM was a common finding in patients with IDA and TM.[ncbi.nlm.nih.gov]
  • Abstract Introduction: Although sleep disturbances, anxiety, and sadness are some of the most common symptoms in patients with chronic anemia, there is little knowledge about sleep structures in patients with chronic anemia such as thalassemia.[bloodjournal.org]
  • Sleep disturbances can cause depression and vice versa I have read your history carefully. You are suffering from insomnia, whic... Read Full »[icliniq.com]
Kidney Failure
  • Chronic kidney failure was already advanced and end-stage was reached after 6 months follow-up. The patient is currently in chronic hemodialysis.Family survey found no similar case.[omicsonline.org]

Workup

  • All parameters indicate that she has TT, and there is no need for a hematologic workup. (2) A 37-year-old woman was seen in the ED for vaginal bleeding associated with uterine fibroids.[web.archive.org]
  • Complications associated with beta thalassemia Complications associated with beta thalassemia, aside from the aforementioned anemia, are as follows (see Prognosis, Presentation, Workup, Treatment, and Medication ): Extramedullary hematopoiesis Asplenia[emedicine.medscape.com]
Glycosuria
  • However, a variety of renal tubular abnormalities including hypercalciuria, hypomagnesemia with renal magnesium wasting, decreased tubular absorption of phosphorus, hypouricemia with renal uric acid wasting, renal glycosuria and tubular proteinuria have[sjkdt.org]
Microcytic Anemia
  • Abstract Iron deficiency anemia (IDA) and thalassemia minor are two of the most common causes of microcytic anemias worldwide.[ncbi.nlm.nih.gov]
  • The peripheral smear showed hypochromic, microcytic anemia with poikilocytes and target cells. Sickling was absent and osmotic fragility was decreased.[jpgmonline.com]
  • A laboratory evaluation revealed a hypochromic microcytic anemia (Hemoglobin 9.8; Hematocrit 28.7; MCV 60; MCH 20.6; Reticulocyte 4.3; Platelets 375; Iron 74 (49-179); TIBC 279 (275-445); Sickle prep, negative).[healio.com]
  • The result is a very hypermetabolic bone marrow with thrombocytosis, leukocytosis and microcytic anemia in the young child prior to the enlargement of their spleen.[thalassemia.com]
  • Microcytic anemia. New England Journal of Medicine. 2014;371:1324. AskMayoExpert. Thalassemia syndrome. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016. Benz EJ. Clinical manifestations and diagnosis of the thalassemia. .[web.archive.org]
Heinz Bodies
  • Six rare mutations, despite being heterozygote, showed hemolytic anemia which is also called, "dominant-type thalassemia", and some of them demonstrated Heinz bodies in the red blood cells.[ci.nii.ac.jp]
  • body anemia Hb-C disease Hb-D disease Hb-E disease Hemoglobinopathy NOS Unstable hemoglobin hemolytic disease Type 1 Excludes familial polycythemia ( D75.0 ) Hb-M disease ( D74.0 ) hemoglobin E-beta thalassemia ( D56.5 ) hereditary persistence of fetal[icd10data.com]
  • These inclusions are termed Heinz bodies, depicted below.[emedicine.com]
  • bodies from HbH β-thalassemia minor target, hypochromic, microcytic cells β-thalassemia major nucleated RBCs target, hypochromic, microcytic cells Hemoglobin gel-electrophoresis α-thalassemia trait normal 3 gene deletion α-thalassemia HbH (β,β,β,β) 4[medbullets.com]
Iron Increased
  • In our patients, serum iron increased significantly with values reaching the normal range. TIBC, which was high prior to iron therapy, normalized indicating good compliance to iron therapy. We used serum ferritin levels 2 – 4 ].[hindawi.com]

Treatment

  • We report this case to emphasize the importance of early diagnosis and treatment of NDI to prevent organic brain damage.[ncbi.nlm.nih.gov]
  • Treatments include blood transfusions and treatment to remove excess iron from the body. If you have mild symptoms or no symptoms, you may not need treatment. In some severe cases, you may need a bone marrow transplant.[icdlist.com]
  • Other Treatments Other treatments for thalassemias have been developed or are being tested, but they're used much less often.[web.archive.org]

Prognosis

  • Because of genetic risk, couples where both partners are carriers of these combinations may require prognosis and prenatal diagnosis. In these cases, recognition of the defect must be done with particular care.[ncbi.nlm.nih.gov]
  • (Outcomes/Resolutions) The prognosis of Beta Thalassemia Minor is good; individuals with the condition are able to lead a normal life.[dovemed.com]
  • Prognosis The prognosis depends on the severity of the disease and adherence to treatment: α thalassaemia The prognosis is excellent for asymptomatic carriers. The overall survival for HbH disease is good overall but variable.[patient.info]
  • Prognosis Individuals with thalassemia minor (thalassemia trait) usually have mild, asymptomatic microcytic anemia. This state does not result in mortality or significant morbidity.[emedicine.medscape.com]

Etiology

  • This report presents the radiographic changes in the hip of a patient with thalassemia minor and discusses the etiology.[ncbi.nlm.nih.gov]
  • This report presents the radiographic changes in the hip of a patient with thalassemia minor and discusses the etiology. Introduction Osteoarthropathy has been well described in thalassemia major, but rarely in thalassemia minor.[healio.com]
  • (See Etiology .) Patients in whom the clinical severity of the disease lies between that of thalassemia major and thalassemia minor are categorized as having thalassemia intermedia.[emedicine.medscape.com]

Epidemiology

  • Chi-Kong Li, New trend in the epidemiology of thalassaemia, Best Practice & Research Clinical Obstetrics & Gynaecology, 39, (16), (2017).[doi.org]
  • Hoorfar, “Thalassemia in Iran: Epidemiology, Prevention, and Management,” Journal of Pediatric Hematol- ogy/Oncology , Vol. 29, No. 4, April 2007, pp. 233-238. [5] A. Samavat and B.[file.scirp.org]
  • Epidemiology United States statistics The frequency of alpha thalassemia is low among whites.[emedicine.medscape.com]
  • We used the results to assess whether there is epidemiological convergence across countries.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • The purpose of this study was to focus on pathophysiological mechanisms linking β-thalassemia intermedia (β-TI) and minor (β-TMI) with cardiovascular risk.[ncbi.nlm.nih.gov]
  • Prchal, MD (Salt Lake City, UT, and Prague, Czech Republic) is Professor of Medicine, Pathology, and Genetics, Hematology Division of the University of Utah, and Department of Pathophysiology, First Faculty of Medicine, Charles University in Prague.[books.google.com]
  • Furthermore, one may speculate as to the pathophysiologic changes that preceded the onset of arthritis, which were probably marrow hyperplasia with secondary weakening of the trabecular bone, fracture, repair, and arthritis. References 1.[healio.com]

Prevention

  • We report this case to emphasize the importance of early diagnosis and treatment of NDI to prevent organic brain damage.[ncbi.nlm.nih.gov]
  • So, it is important that prevention was ensured at the stage of Thalassemia minor with the help of awareness and increased literacy, he opined.[thehindu.com]
  • Increased awareness is the key to prevention.[thalassemia.ca]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!