The aim of this article is to present an alternative therapy for refractory pyoderma gangrenosum, along with a literature review. [ncbi.nlm.nih.gov]

Helen, 31, told the This Morning presenters: “It’s a story that hasn’t been talked about for a while. Hopefully, it will open up a lot of conversations that haven’t been had in a while.” [express.co.uk]

• Disability

  Thousands of their offspring suffered from physical disabilities as a result. Of them, 466 members of the UK’s Thalidomide Trust remain. [web.archive.org]

  Topics: courts-and-trials, health, disabilities, melbourne-3000 First posted February 07, 2014 10:41:35 [abc.net.au]

  By Emma Wilkinson BBC News health reporter Thalidomide caused extensive disabilities The government has awarded £20m of funding for people disabled after their mothers took the drug thalidomide. [news.bbc.co.uk]

  Three individuals were in need of personal assistance and seven had disability-adjusted homes. 28 individuals were working and 24 reported participation in exercises. [ncbi.nlm.nih.gov]

• Fever

  One month later, our patient presented with fever and an important inflammatory syndrome (CRP 150 mg/dL and 16.8 10(9)/L leukocytes), while no infection was found despite a thorough review. [ncbi.nlm.nih.gov]

  His fever resolved and appetite improved one week later. Figure 1: Pulmonary CT. [omicsonline.org]

  Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal. [drugs.com]

  Tell your doctor right away if you have any serious side effects, including: mental/mood changes (e.g., confusion, anxiety ), shaking (tremor), shortness of breath, arm/leg swelling, fast/slow heartbeat, signs of infection (e.g., fever, persistent sore [webmd.com]

• Fatigue

  The rate of drowsiness, fatigue, constipation of the study group was higher than that of the control group, and the rate of anorexia was lower (P CONCLUSIONS: Our results demonstrated that thalidomide combined with capecitabine was mildly effective and [ncbi.nlm.nih.gov]

  These are some of the most common or important side effects: Fatigue Fatigue is very common during cancer treatment and is an overwhelming feeling of exhaustion that is not usually relieved by rest. [oncolink.org]

  Doctors have advised that the rate of deterioration has resulted in fatigue the equivalent of someone 30 years older. She recently was forced to stop the work she loved and the independence it gave her because of the excessive fatigue to her body. [fiftyyearfight.org]

• Short Stature

  Short stature Postnatal growth retardation Heart Ventricular septal defects Ventricular septal defects Ventricular septal defects Atrial septal defects Atrial septal defects Atrial septal defects The remarkable phenotypic overlap of LOF mutations in [doi.org]

• Morning Sickness

  — Sydney Lupkin — Kaiser Health News, STAT, "Drug makers blamed for blocking generics have jacked up prices and cost U.S. billions," 23 May 2018 An example of this is thalidomide, a sedative prescribed in the 1960s for morning sickness; later, it was [merriam-webster.com]

  Between 1958 and 1961, the drug thalidomide was used by expectant mothers to control the symptoms of morning sickness. [web.archive.org]

  She was born with no arms or legs after her mother took the drug to treat morning sickness and anxiety during her pregnancy. [abc.net.au]

  Teratogenic effects Thalidomide went on the market as a treatment for morning sickness in more than 40 countries beginning in 1958. [britannica.com]

• Nausea

  A man of misplaced conviction This pattern was repeated with another anti-nausea drug in pregnancy called Debendox, taken by around 30 million women with no evidence of harm. [abc.net.au]

  Thalidomide had already been sold to pregnant women in Europe and elsewhere as an anti-nausea drug to treat morning sickness, and Merrell wanted a license to do the same in the U.S. As The New York Times reports, Kelsey asked for more information. [npr.org]

  Frances Oldham Kelsey honoured with Order of Canada on Thursday for her vocal opposition to anti-nausea drug thalidomide 1:49 Frances Oldham Kelsey, the Canadian doctor whose vocal opposition to the anti-nausea drug thalidomide helped keep it out of the [cbc.ca]

  Thalidomide or α-(N-phthalimido) glutarimide was first marketed in 1957 for morning sickness and nausea and soon became the ‘drug of choice to help pregnant women’. [who.int]

  America and an Epidemic of Birth Defects," 8 May 2017 The settlement is the most recent chapter in the story of thalidomide, the notorious drug that was developed by a German company and marketed around the world in the 1950s as a sedative and anti-nausea [merriam-webster.com]

• Constipation

  One patient developed constipation, requiring thalidomide to be stopped. Another patient developed symptomatic neuropathy, that resolved with reduction of dosage. [ncbi.nlm.nih.gov]

  Constipation These side effects are less common side effects (occurring in about 10-29%) of patients receiving thalidomide: Low white blood cell count. (This can put you at increased risk for infection). [chemocare.com]

• Vomiting

  An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. sedative A central nervous system depressant used to induce [ebi.ac.uk]

  In this study some 277 patients were given samples of Bendectin to evaluate the drug's ability to reduce symptoms of nausea and vomiting. [web.archive.org]

  […] effects, including: mental/mood changes (e.g., confusion, anxiety ), shaking (tremor), shortness of breath, arm/leg swelling, fast/slow heartbeat, signs of infection (e.g., fever, persistent sore throat ), easy bruising/bleeding, black/ bloody stools, vomit [webmd.com]

  NAUSEA AND VOMITING This is normally mild. Your doctor can prescribe antiemetic drugs to prevent or greatly reduce your nausea and vomiting. [oncohealth.eu]

• Diarrhea

  Thalidomide may be an effective therapy for diarrhea and weight loss from E. bieneusi. [ncbi.nlm.nih.gov]

  Other important side effects include: impotence, diarrhea, constipation, and increased sensitivity. Thalidomide also causes nerve damage ( peripheral neuropathy ), slow heart rate, hypertension, hypotension, and a decrease in white blood cells. [medicinenet.com]

  Among the side effects are erratic heartbeat, swelling (edema), digestive upsets of all sorts, including both constipation and diarrhea, pain in muscles in the back and neck, and skin problems. [encyclopedia.com]

• Tachycardia

  Other side effects are cephalea, dry skin and mouth mucous, pruritus, cutaneous eruption, weight gain, hypothyroidism, neutropenia, bradycardia or tachycardia, and hypotension. [scielo.br]

  […] correction of the bradycardia with temporary pacing, he experienced further episodes of chest pain, during which an ECG (with the pacemaker briefly switched off) showed ST elevation in the inferior leads along with runs of non-sustained ventricular tachycardia [ncbi.nlm.nih.gov]

  Signs and symptoms have included the occurrence of erythematous macular rash, possibly associated with fever, tachycardia, and hypotension, and if severe, may necessitate interruption of therapy. [thalomid.com]

  reported. 1 12 53 54 Measure plasma HIV-1 RNA concentrations in HIV-seropositive patients after first and third months of treatment and every 3 months thereafter. 1 Hypersensitivity reactions (e.g., erythematous macular rash associated with fever, tachycardia [drugs.com]

• Skin Rash

  Skin changes Your skin may become dry and itchy. You may also notice a rash or redness. Tell your doctor or nurse if you have any of these symptoms. They can prescribe creams and drugs to help. [macmillan.org.uk]

  Skin rashes; itching, redness, usually occurring over the trunk, back, arms and legs. It is important that all new rashes be reported to your health care professional immediately. [chemocare.com]

  Skin Changes Some patients may develop a rash, very dry or itchy skin. Some rashes can be a very serious reaction and all skin changes should be reported to your care team. [oncolink.org]

  They include: confusion skin rash and dry skin mood changes, including depression dry mouth weak, faint or unsteady blurred vision changes in your heart including a slow heart rate or heart failure feeling or being sick pain in your chest or difficulty [cancerresearchuk.org]

• Pruritus

  Keywords : erythema nodosum; pruritus; thalidomide; thalidomide [adverse effects]; therapeutics. [scielo.br]

  Epidermolysis bullosa pruriginosa is a rare distinctive variant of dystrophic epidermolysis bullosa characterized by intense pruritus, lichenified plaques in linear distribution, and anonychia. [ncbi.nlm.nih.gov]

  Erythema Nodosum Leprosum Common adverse events, greater than or equal to 8%, reported in THALOMID treated patients in controlled clinical trials in ENL: somnolence (38%), rash (21%), headache (13%), asthenia (8%), malaise (8%), pain (8%), vertigo (8%), pruritus [thalomid.com]

  “Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial”. Nephron 1994; 67: 270-273. George SJ, Hsu S. “Lichen planopilaris treated with thalidomide”. J Am Acad Dermatol 2001; 45: 965-966. Camisa C, Popovsky JL. [medigraphic.com]

• Eruptions

  She presented with a 6-year history of an erythematous papular eruption of the scalp, face, vulva, trunk and axillae. [ncbi.nlm.nih.gov]

  Other side effects are cephalea, dry skin and mouth mucous, pruritus, cutaneous eruption, weight gain, hypothyroidism, neutropenia, bradycardia or tachycardia, and hypotension. [scielo.br]

  When the thalidomide scandal erupted in 1961, the drug was soon banned. Yet pregnant women in Spain continued taking it until the 1980s — and the authorities refuse to accept responsibility. Caroline Scott reports. [thesundaytimes.co.uk]

  (Researchers are also interested in other activities of thalidomide, particularly the ones that make it capable of eliminating skin eruptions, such as sores, or ulcers, in the mouths of patients with AIDS and leprosy.) [encyclopedia.com]

• Muscle Cramp

  Blurry vision Confusion Constipation Cough Depression Diarrhea Dizziness Dysgeusia Dyspepsia Dyspnea Headache Hypocalcemia Hypokalemia Insomnia Leukopenia Lymphopenia Muscle cramps Nausea Neuropathy Paresthesia Peripheral edema Pulmonary embolism Pyrexia [doi.org]

  Call your doctor right away if you have a fast or abnormal heartbeat; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, diarrhea, or not able to eat; or feel sluggish. [drugs.com]

  Other observed side effects include skin eruptions, diarrhea, joint and limb pain, fatigue, anorexia, muscle cramps, electrolyte imbalance, and secondary infections.[ 15 ] But the biggest concern with these drugs is the need to prevent any recurrence [bcmj.org]

• Hand Muscle Weakness

  Tell your doctor right away if you develop any of the following symptoms: numbness/tingling/pain/burning in the feet or hands, muscle weakness/ cramps, feeling of tightness in the feet. [webmd.com]

• Withdrawn

  Definitions of thalidomide 1 n a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis Type of: sedative-hypnotic, sedative-hypnotic drug a sedative that depresses activity of the [vocabulary.com]

  2004 - Thalidomide available on a named patient basis and as part of clinical trials in the UK Thalidomide was withdrawn in 1961 after around 10,000 babies had been born with disabilities, such as the characteristic stunted arms or legs. [news.bbc.co.uk]

  Although Thalidomide has long since been withdrawn for use in pregnant patients, its affects on those exposed pose significant challenges for patients' oral hygiene maintenance. [ncbi.nlm.nih.gov]

• Peripheral Neuropathy

  Among 406 new users of thalidomide, 142 (35%) developed peripheral neuropathy during a mean 499 person-days of follow-up. Among 858 new users of lenalidomide, 244 (29%) developed neuropathy during 587 person-days. [ncbi.nlm.nih.gov]

  If you get symptoms of peripheral neuropathy, tell your doctor promptly. Ongoing use of thalidomide may result in severe peripheral neuropathy, which can be irreversible. [leiomyosarcoma.info]

  […] even clinical peripheral neuropathy. [bloodjournal.org]

• Dizziness

  To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. [webmd.com]

  You may experience drowsiness or dizziness; avoid driving or engaging in tasks that require alertness until your response to the drug is known. Keep your bowels moving. [chemocare.com]

  Thalidomide might cause lightheadedness, dizziness or fainting when you get up too quickly from a lying position. To help with avoiding this issue get out of bed slowly, resting your feet on the floor for a few minutes before you stand up. [disabled-world.com]

  Notify your healthcare provider if you have sudden weight gain, swelling in the ankles or legs, you feel abnormal heart beats or if you feel dizzy or faint. [oncolink.org]

• Confusion

  Tell your doctor right away if you have any serious side effects, including: mental/mood changes (e.g., confusion, anxiety ), shaking (tremor), shortness of breath, arm/leg swelling, fast/slow heartbeat, signs of infection (e.g., fever, persistent sore [webmd.com]

  Many disabled people find it hard to deal with the disgusted, confused, or pitying stares they receive when they're out in public. Society needs to get used to the way we look, and stop seeing us as beings from another planet. [spiritualityandpractice.com]

  Meeting persons who were saying "thalidomide took me out of my wheelchair," when two thalidomide tablets had put me in mine, was confusing. In 1996, FDA invited us to participate in its deliberations about returning thalidomide to the marketplace. [permanent.access.gpo.gov]

  Contact your doctor if any of the following symptoms are severe, or fail to go away: Rash Itching Anxiety Nausea Dry skin Seizures Pale skin Dizziness Confusion Headache Weakness Dry mouth Drowsiness Hoarseness Constipation Weight changes Change in appetite [disabled-world.com]

• Seizure

  It is important to tell your doctor if you have HIV, AIDS, or seizures. Tell your doctor if you are breast feeding. Other things to know prior to taking thalidomide include: Alcoholic beverages can make the side-effects of thalidomide worse. [disabled-world.com]

  If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Keep all appointments with your doctor and the laboratory. [medlineplus.gov]

  […] manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. anticonvulsant A drug used to prevent seizures [ebi.ac.uk]

  […] or at risk for the development of seizures closely for clinical changes that could precipitate acute seizure activity Tumor lysis syndrome may occur; monitor patients at risk (eg, those with high tumor burden prior to treatment) and take appropriate [reference.medscape.com]

• Tremor

  Tell your doctor right away if you have any serious side effects, including: mental/mood changes (e.g., confusion, anxiety ), shaking (tremor), shortness of breath, arm/leg swelling, fast/slow heartbeat, signs of infection (e.g., fever, persistent sore [webmd.com]

  Shaky hands (tremor) You may develop shaky hands (tremor) with this treatment. Dizziness Don’t drive or operate machinery if you have this. Constipation Constipation is easier to sort out if you treat it early. [cancerresearchuk.org]

  42% vs 31%), muscle weakness (40% vs 37%), leukocytes (decreased) (35% vs 29%), neutrophils (decreased) (31% vs 24%), rash/desquamation (30% vs 18%), confusion (28% vs 12%), anorexia (28% vs 24%), nausea (28% vs 22%), anxiety/agitation (26% vs 14%), tremor [thalomid.com]

Researchers found that adding Thalidomide to standard treatment added an average of 18 months to the lives of elderly patients with multiple myeloma. 2008 – The drug is approved for the treatment of multiple myeloma by the European Medicines Agency. 2009 [telegraph.co.uk]

Teratogenic effects Thalidomide went on the market as a treatment for morning sickness in more than 40 countries beginning in 1958. [britannica.com]

Although the prognosis of mucormycosis is generally poor, in the reported case the patient recovered successfully. This case should alert dermatologists to possible opportunistic infections in immunosuppressed patients. [ncbi.nlm.nih.gov]

Since increased bone marrow vascularity imparts a poor prognosis in myeloma, we evaluated the efficacy of thalidomide, which has antiangiogenic properties, in patients with refractory disease. [doi.org]

The etiology of these lesions is poorly understood, and no definitive standard of care has been established for patients with these diagnoses. [ncbi.nlm.nih.gov]

Abstract: Despite the fact that sickle cell anemia was one of the first diseases to have a demonstrated genetic etiology, to date there is still only one approved therapy for this disease. [doi.org]

The epidemiological method is described. Of the 115 children, 74 were alive at the time of reporting, 41 of these being severely handicapped; 8 had been stillborn; 33 had died. [ncbi.nlm.nih.gov]

He conducted a thorough epidemiological investigation, pinpointing the period of pregnancy associated with the greatest risk, and comparing the frequency of the birth defect for mothers who used the drug with the expected frequency in the general population [jameslindlibrary.org]

Allen Mitchell, director of the Slone Epidemiology Unit at the Boston University School of Public Health, which will run the thalidomide monitoring system. [nytimes.com]

Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. [ncbi.nlm.nih.gov]

Recent increases in our understanding of the pathophysiology of the disease should translate into improved and more rapid development of newer therapies. [doi.org]

[…] seizures or reduce their severity. antiemetic A drug used to prevent nausea or vomiting. [ebi.ac.uk]

The Post, in a front-page article published in 1962 described Kelsey as a "heroine" whose "skepticism and stubbornness ... prevented what could have been an appalling American tragedy." Kelsey, a physician and pharmacologist, died on Aug. 7. [npr.org]

The company knew of the side effects in time to have prevented many of the deformities. But it chose to continue selling this very profitable drug using lies and corruption. [web.archive.org]

Thalidomide prevents blood vessel formation and causes stabilisation of the vessels to prevent bleeding. [independent.co.uk]