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Thiabendazole

2 (4' Thiazolyl)benzimidazole


Presentation

  • Although TBZ is a spindle poison that induces aneuploidy, we hypothesize that the photogenotoxicity of TBZ in the present study was produced by a different mechanism, probably by DNA adduct formation.[ncbi.nlm.nih.gov]
  • We present the results of a new combination treatment against M. perstans filariasis. Two cases of M. perstans filariasis were treated with the combination of diethylcarbamazine (DEC) and thiabendazole.[ncbi.nlm.nih.gov]
  • We present a patient with CLM who presumably contacted the disease during a holiday in Singapore. The patient was treated successfully with oral thiabendazole.[ncbi.nlm.nih.gov]
  • Prominent fibrosis and hepatocellular regeneration were also present; however, the lobular architecture was preserved.[ncbi.nlm.nih.gov]
  • Sjögren's syndrome is an autoimmune disease and presents many immune mechanism aberrancies. An association between autoimmune liver disease and sicca complex has been reported.[ncbi.nlm.nih.gov]
Hepatosplenomegaly
  • No association between Strongyloides egg load and nutritional status, hepatosplenomegaly, respiratory ailments, oedema or serum albumin levels was found.[ncbi.nlm.nih.gov]

Workup

Liver Biopsy
  • Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction. The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given.[ncbi.nlm.nih.gov]
  • Two liver biopsy specimens and the hepatectomy specimen were remarkable for almost complete disappearance of interlobular bile ducts.[ncbi.nlm.nih.gov]

Treatment

  • On the fifth treatment day, six patients (40%) in the thiabendazole group and 11 patients (58%) in the albendazole group showed excellent or good drug tolerability. Efficacy of treatment was assessed after 30 weeks (range six to 56 weeks).[ncbi.nlm.nih.gov]
  • AIM: To test the potential effectiveness of thiabendazole, a potent and broad-spectrum antiparasitic and scabicidal agent, for the treatment of pediculosis capitis.[ncbi.nlm.nih.gov]
  • Treatment of human hepatocytes for 72 h with 2-200 microM TB produced concentration-dependent increases in CYP1A2, CYP2B6 and CYP3A4 mRNA levels, whereas treatment with BHT increased CYP2B6 and CYP3A4 mRNA levels.[ncbi.nlm.nih.gov]
  • Side effects of drug treatment were frequent and sometimes severe; nausea was the most common symptom.[ncbi.nlm.nih.gov]
  • Treatment with diethyl-carbamazine or mebendazole is often ineffective. We present a study on the effects of thiabendazole in the treatment of symptomatic M. perstans filariasis.[ncbi.nlm.nih.gov]

Epidemiology

  • The diagnosis was based on epidemiological data and positive antibody tests. In two cases, diagnosis was confirmed by isolation of trichinella larvae from 10 ml blood samples filtered through polycarbonate membranes.[ncbi.nlm.nih.gov]
  • Therefore, massive and simultaneous rather than individual and isolated treatments should be used to achieve the epidemiologic control of this ectoparasitosis.[ncbi.nlm.nih.gov]
  • Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, et al. (2008) Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 113: 1953–1968. View Article Google Scholar 7.[doi.org]
Sex distribution
Age distribution

Prevention

  • In 1973 a field drug trial was conducted to compare effectiveness, cost, and side-effects of thiabendazole and metronidazole in treating active guinea worm disease and preventing latent worms from emerging.[ncbi.nlm.nih.gov]
  • Eleven years later, despite immunosuppressive treatment to prevent graft rejection, he developed mononeuritis multiplex; PAN was diagnosed.[ncbi.nlm.nih.gov]
  • However, the oral administration of tetrachloroethylene and hexylresorcinol were associated with severe anaphylactic reactions which were prevented by prior treatment with antihistamines.[ncbi.nlm.nih.gov]
  • […] with hookworm were still passing ova 2 weeks after treatment although their egg counts were lower or the same as the pre-treatment counts. 26 children experienced some side effects from the drug, vomiting being the most common; in none did side effects prevent[ncbi.nlm.nih.gov]
  • Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis.[emedicinehealth.com]

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