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Thiazide Diuretic

Thiazide Diuretics


Presentation

  • In the present multicenter open trial, we investigated the long-term efficacy and safety of combined antihypertensive therapy with an ACE inhibitor, lisinopril, and a thiazide diuretic, trichlormethiazide.[ncbi.nlm.nih.gov]
  • Thus, we report a case of Gitelman's syndrome presenting with quadriparesis diagnosed by using thiazide clearance test.[ncbi.nlm.nih.gov]
  • : Hyponatremia is an uncommon complication of thiazide diuretic use, which frequently presents with nonspecific symptoms. Identification of TIH is crucial to prevent its potentially life-threatening complications.[ncbi.nlm.nih.gov]
  • Thus, the goal of the present review was to analyse available data to explain the mechanistic actions of the ARB-thiazide diuretic combination.[ncbi.nlm.nih.gov]
  • The aim of the present study was to evaluate and compare salivary flow rate and composition during treatment with the thiazide diuretic bendroflumethiazide in a low dose (2.5 mg o.d.) and placebo.[ncbi.nlm.nih.gov]
Short Stature
  • An excellent response to treatment with thiazide diuretic for twelve years is described in a patient with Gordon's Syndrome, the first to be reported from Scotland, and only the second to manifest the full clinical picture of short stature, hypertension[ncbi.nlm.nih.gov]
Orthostatic Hypotension
  • No patient had symptoms of orthostatic hypotension or cardiac arrhythmias. Thus, thiazide therapy effectively and safely lowers the BP in most patients with systolic hypertension by reducing systemic vascular resistance.[ncbi.nlm.nih.gov]
  • ., orthostatic hypotension), gout flares, a small but measurable increased susceptibility to the development of diabetes mellitus, and rarely causing an allergic reaction to individuals with a severe sulfa allergy.[renalfellow.blogspot.com]
  • Luo F, Wang Y, Wang X, Sun K, Zhou X, Hui R (2009) A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension. Hypertension 54(4):796–801 CrossRef PubMed Google Scholar 38.[link.springer.com]
Withdrawn
  • METHODS: We evaluated predictors of blood pressure response in 363 men and women or 65 years of age with primary hypertension (152 blacks, 211 whites), 86 of whom (24%) were untreated and 277 of whom (76%) were withdrawn from previous antihypertensive[ncbi.nlm.nih.gov]
  • Following a 4-week placebo control period, during which diuretic was not withdrawn, the patients were treated either with 37.5-75 mg/day of captopril (n 133) or with 60-120 mg/day of propranolol (n 137) for 12 weeks, the diuretic being continued in both[ncbi.nlm.nih.gov]

Workup

Increased Bone Density
  • Their use has been associated with increased bone density, but their role in preventing hip fracture has not been established.[ncbi.nlm.nih.gov]
Potassium Decreased
  • While serum potassium decreased significantly in the thiazide group, the total body potassium was unchanged in this group. In the propranolol group, serum potassium rose, while total body potassium decreased significantly.[ncbi.nlm.nih.gov]

Treatment

  • FG increased 6.5 (SD 13.0) mg/dL during short-term thiazide treatment and 3.6 (SD 15.3) mg/dL FG during prolonged thiazide treatment.[ncbi.nlm.nih.gov]
  • ) per QALY gained comparing ACEI-based treatment with diuretic-based treatment (sensitive to the utility value for new-onset diabetes).[ncbi.nlm.nih.gov]
  • The treatment periods were separated by a wash-out period of 2 wk. Resting and stimulated whole saliva was sampled three times daily on scheduled days during the treatment periods.[ncbi.nlm.nih.gov]
  • Ketanserin treatment was associated with significant changes in supine pulse rate (-8 beats min-1, P less than 0.05) and corrected QT interval ( 27 ms, P less than 0.05). Nifedipine treatment had no effect on these variables.[ncbi.nlm.nih.gov]
  • Prazosin is a useful alternative to hydralazine in the treatment of hypertension.[ncbi.nlm.nih.gov]

Epidemiology

  • MATERIALS AND METHODS: We identified and validated incident stone formers in Olmsted County, Minnesota from 1984 to 2011 with manual review of medical records using the Rochester Epidemiology Project.[ncbi.nlm.nih.gov]
  • Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention[ebmconsult.com]
  • Moreover, in addition to prospective randomized trials, some long-term epidemiological studies, such as the ARIC (Atherosclerosis Research in Communities) study, have linked different classes of antihypertensive agents with development of new-onset diabetes[care.diabetesjournals.org]
Sex distribution
Age distribution

Pathophysiology

  • This edition has been thoroughly revised by world-renowned contributors to reflect recent developments in renal pathophysiology.[books.google.com]
  • Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2007:31-48. 10. Masters PA, O’Bryan TA, Zurlo J, et al. Trimethoprim-sulfamethoxazole revisited.[mdedge.com]
  • Magnesium deficiency: pathophysiologic and clinical overview. Am J Kidney Dis 24: 737 - 752, 1994. Dorup I. Magnesium and potassium deficiency.[cancercarewny.com]
  • In: Khullar M (ed) Genetics and pathophysiology of essential hypertension. InTech. ISBN: 978-953-51-0282-3 Google Scholar 30. Kone BC (2013) Epigenetics and the control of the collecting duct epithelial sodium channel.[link.springer.com]

Prevention

  • Thiazides provide a further option in the prevention of postmenopausal bone loss. INTRODUCTION: Thiazide diuretics reduce urinary calcium excretion and therefore might prevent osteoporosis.[ncbi.nlm.nih.gov]
  • In one of these trials, chlortalidone was superior to the ACE inhibitor lisinoprilin preventing stroke. It was also superior to the calcium-channel blocker amlodipine in preventing heart failure.[ncbi.nlm.nih.gov]
  • It is unknown if there is a similar risk with kidney stone prevention.[ncbi.nlm.nih.gov]
  • Identification of TIH is crucial to prevent its potentially life-threatening complications.[ncbi.nlm.nih.gov]
  • The purpose of this study was to evaluate the reasons physicians provided when the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines recommending a thiazide diuretic[ncbi.nlm.nih.gov]

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