A recommended protocol is presented. [ncbi.nlm.nih.gov]

• Chest Discomfort

  Report immediately a rapid heart rate (tachycardia) or signs of other arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness. [fadavispt.mhmedical.com]

• Orthostatic Hypotension

  Low potency phenothiazines such as thioridazine can cause orthostatic hypotension due to their potent alpha-1 receptor blocking effects. [pdr.net]

  Adverse Effect : Pseudoparkinsonism, tardive dyskinesia, dystonia, orthostatic hypotension, cholestatic jaundice, leukopenia, photosensitivity. Interaction : Anticholinergics: Potentiates adverse effects of anticholinergics. [pediatriconcall.com]

  hypotension, hyperpyrexia, paradoxical reaction. [empr.com]

• Motor Restlessness

  Reactions may include dyskinesias such as repetitive, involuntary, and purposeless body or facial movements, Parkinsonism (cogwheel muscle rigidity, pill-rolling tremor and reduced or slowed movements), akathisia (motor restlessness, especially in the [library.neura.edu.au]

  Other signs of the condition include fidgety movements, leg swinging while sitting, rocking from foot to foot or pacing and motor restlessness. [worstpills.org]

  restlessness, hyperreflexia, and convulsions. 6) Hypothermia. 7) Cardiac abnormalities, including arrhythmia, tachycardia. [rxmed.com]

  These disorders include akathisia (motor restlessness), dystonia (abnormal muscle tone), and tardive dyskinesia (involuntary and repetitive movements). [ncbi.nlm.nih.gov]

  Extrapyramidal Symptoms: Akathisia, agitation, motor restlessness, dystonic reactions, trismus, torticollis, opisthotonus, oculogyric crises, tremor, muscular rigidity, akinesia. [rxlist.com]

• Retinal Pigmentation

  Atrophy and disorganization of the photoreceptor outer segments appeared to be the initial degenerative event, followed by loss of the retinal pigment epithelium and choriocapillaris. [ncbi.nlm.nih.gov]

  Fluorescein angiography demonstrated confluent areas of punctate hyperfluorescence consistent with diffuse retinal pigment epithelial alteration secondary to acute thioridazine toxic effects (Figure 2). [jamanetwork.com]

• Skin Rash

  See physician NOW: Low white blood cell count, skin rash or reduced urinary output. Stop taking and see physician NOW: Seizures, chest pain or breathlessness. [psyweb.com]

  […] or eyes Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): difficulty passing urine difficulty sleeping headache sexual dysfunction skin rash, or itching [mychart.geisinger.org]

  SHOW MORE SHOW LESS Side effects Major & minor side effects for Thioridazine Drowsiness Dry mouth Constipation Agitation Weight gain Skin rash Muscle spasm Headache Irregular heartbeat Tremors SEVERE Contact your doctor immediately if any of these symptoms [practo.com]

  Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue low blood counts - this medicine may decrease the number of [fairview.org]

• Seizure

  Four cases on a combination of lithium and thioridazine developed severe neurotoxic symptoms, e.g., delirium, seizures, encephalopathy and grossly abnormal EEG's. [ncbi.nlm.nih.gov]

  Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Many drugs can affect thioridazine, and some drugs should not be used at the same time. [drugs.com]

  Stop taking and see physician NOW: Seizures, chest pain or breathlessness. [psyweb.com]

  Seizures : High doses should be avoided in patients with a history of seizures. [healthyplace.com]

• Agitation

  Because of its strong sedative effect it is well suited for violent and agitated patients. But it can also have a beneficial effect in subjects in whom depressive symptoms are the main problem. [infomed.ch]

  […] of an organic brain syndrome; during alcohol withdrawal for the relief of symptoms such as anxiety, agitation, hostility, or hallucinations; as an adjuvant treatment in agitated depression; in children with severe behavioral disorders such as emotional [rxmed.com]

• Akathisia

  There were no differences between remoxipride and thioridazine on dystonia, hypokinesia, dyskinesia, rigidity and akathisia. The results indicate that remoxipride has similar antipsychotic efficacy to thioridazine but causes fewer side effects. [ncbi.nlm.nih.gov]

  Akathisia (restlessness or desire to keep moving). Other dystonias and dyskinesias (dystonic muscle spasms, twisting motions, twitching, inability to move eyes, weakness of arms or legs). [fadavispt.mhmedical.com]

  ‘In some cases, patients who experience unacceptable rigidity, akathisia, or dystonia with high potency agents may benefit from a lower potency neuroleptic such as thiothixene or thioridazine.’ [oxforddictionaries.com]

  Drug-Induced Acute Akathisia (Restlessness) [ hide all summaries ] (April 2011) The article lists 27 drugs that can cause akathisia, a condition characterized by muscular quivering and the inability to sit still. [worstpills.org]

• Choreoathetoid Movements

  The syndrome is characterized by involuntary choreoathetoid movements which variously involve the tongue, face, mouth, lips, or jaw (e.g., protrusion of the tongue, puffing of cheeks, puckering of the mouth, chewing movements), trunk, and extremities. [rxlist.com]

• Stupor

  14140009 Neuroleptic malignant syndrome contraindication 15244003 DOID:14464 Senile dementia contraindication 15662003 Orthostatic hypotension contraindication 28651003 Hypokalemia contraindication 43339004 Epilepsy contraindication 84757009 DOID:1826 Stupor [drugcentral.org]

  Tobacco smoking: If people taking thioridazine continue to smoke tobacco it may result in lessening stupor caused by this medication. [herbs2000.com]

• Prolonged QT Interval

  Abstract In December 2000, the Committee for Safety of Medicines (CSM) advised that thioridazine may prolong QT intervals risking arrhythmias. [ncbi.nlm.nih.gov]

  Over the Edge NUEDEXTA is contraindicated in patients receiving drugs that both prolong QT interval and are metabolized by CYP2D6 e.g., thioridazine and pimozide and should not be used concomitantly with other drugs containing quinidine, quinine, or mefloquine [wordnik.com]

  Panobinostat is known to significantly prolong QT interval. [reference.medscape.com]

  QT interval contraindication 111975006 Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74 Coma contraindication 371632003 Breastfeeding (mother) contraindication 413712001 Congenital long QT syndrome contraindication 442917000 [drugcentral.org]

  If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. [drugs.com]

• Torsades De Pointes

  CYP2D6 activity associated with Torsades de pointes and/or sudden death.Details [go.drugbank.com]

  Both torsade de pointes-type arrhythmias and sudden death have been reported in association with thioridazine. [rxlist.com]

  ADR Inferred Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death. [drugbank.ca]

  Thioridazine has an established risk of QT prolongation and torsades de pointes (TdP). [pdr.net]

• Electrocardiogram Change

  Electrocardiogram changes were significantly more frequent in the thioridazine group (n=254, 2 RCTs, RR 2.38, CI 1.6 to 3.6, NNH 4 CI 3 to 10). Six RCTs (total n=344) randomised thioridazine against atypical antipsychotics. [ncbi.nlm.nih.gov]

  Electrocardiogram changes were more frequent in the thioridazine (NNH 4) group, confirming its recognised potential to affect heart rhythm ( Psychotropics 2006 ), although we do not know whether these changes were torsades de pointe or other changes. [dx.doi.org]

[…] problems for which specific treatments are available. [rxlist.com]

[…] before treatment with oral thioridazine. [clinicaltrials.gov]

As observed in a single treatment with THIO, the sensitization mechanism induced by the co-treatment also involves both apoptosis and P-gp inhibition. These results suggest that the THIO sensitization mechanism is generally conserved. [ncbi.nlm.nih.gov]

Although thioridazine does produce some serious side-effects, the poor prognosis associated with an XDRTB infection of a patient that presents with AIDS merits that the use of thioridazine for therapy of XDRTB is seriously considered. [ncbi.nlm.nih.gov]

My ophthalmologist said it is so rare there is not much to tell me regarding prognosis. Posted by: Nancy B. at August 27, 2006 05:12 PM [schizophrenia.com]

New Results doi: https://doi.org/10.1101/532788 Abstract Glioblastoma multiforme is a form of cancer with poor survival prognosis and few treatment options. [biorxiv.org]

This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed. [tocris.com]

The etiology of schizophrenia is unknown, but it is thought to result from a combination of complex genetic and environmental factors. [ncbi.nlm.nih.gov]

Increased Mortality in Schizophrenia Due to Cardiovascular Disease – A Non-Systematic Review of Epidemiology, Possible Causes, and Interventions. [bjp.rcpsych.org]

Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusive at this [rxlist.com]

Controlling the data in this way will have important implications for understanding the pathophysiology of psychosis and for evaluating more accurately the effects of so called “atypical” neuroleptics. [ebmh.bmj.com]

The possible risk of combining lithium and neuroleptics (thioridazine) is discussed and repeated EEGs are recommended as a preventive measure. [ncbi.nlm.nih.gov]

Interventions Guard against falls and trauma (hip fractures, head injury, and so forth) caused by drowsiness, blurred vision, or extrapyramidal symptoms; implement fall-prevention strategies (See Appendix E). Because of ... [fadavispt.mhmedical.com]

• health professionals to switch patients from thioridazine to an alternative therapy at the earliest medically feasible point, individualize the switching strategy for each patient, and gradually reduce the thioridazine dosage over several weeks to prevent [apps.who.int]