Orthostatic hypotension could lead to falls with the potential for fractures and other injuries. [pdr.net]

It is also known to possess a relatively high liability for causing orthostatic hypotension compared to other antipsychotics. Similarly to other first-generation antipsychotics it has a relatively high liability for causing prolactin elevation. [en.wikipedia.org]

Adverse Effect : Pseudoparkinsonism, tardive dyskinesia, dystonia, orthostatic hypotension, cholestatic jaundice, leukopenia, photosensitivity. Interaction : Anticholinergics: Potentiates adverse effects of anticholinergics. [pediatriconcall.com]

hypotension, hyperpyrexia, paradoxical reaction. [empr.com]

Reactions may include dyskinesias such as repetitive, involuntary, and purposeless body or facial movements, Parkinsonism (cogwheel muscle rigidity, pill-rolling tremor and reduced or slowed movements), akathisia (motor restlessness, especially in the [library.neura.edu.au]

Other signs of the condition include fidgety movements, leg swinging while sitting, rocking from foot to foot or pacing and motor restlessness. [worstpills.org]

restlessness, hyperreflexia, and convulsions. 6) Hypothermia. 7) Cardiac abnormalities, including arrhythmia, tachycardia. [rxmed.com]

These disorders include akathisia (motor restlessness), dystonia (abnormal muscle tone), and tardive dyskinesia (involuntary and repetitive movements). [ncbi.nlm.nih.gov]

Extrapyramidal Symptoms: Akathisia, agitation, motor restlessness, dystonic reactions, trismus, torticollis, opisthotonus, oculogyric crises, tremor, muscular rigidity, akinesia. [rxlist.com]

Atrophy and disorganization of the photoreceptor outer segments appeared to be the initial degenerative event, followed by loss of the retinal pigment epithelium and choriocapillaris. [ncbi.nlm.nih.gov]

Nevertheless, nine cases of retinal pigmentation following its use have been reported. 1-8 The clinical picture is distinctive and closely resembles that seen following the use of another phenothiazine tranquilizer, NP-207. [jamanetwork.com]

Thioridazine and visual screening procedures are effective in reducing the stereotypic behaviors of individuals with mental retardation. [ncbi.nlm.nih.gov]

delirium, seizures, encephalopathy and grossly abnormal EEG's. All patients had been on lithium without thioridazine prior to and after the neurotoxic episode with no complications or EEG changes. [ncbi.nlm.nih.gov]

Stop taking and see physician NOW: Seizures, chest pain or breathlessness. [psyweb.com]

Seizures : High doses should be avoided in patients with a history of seizures. [healthyplace.com]

[…] approved for the treatment of patients with dementia-related psychosis Contraindications Documented hypersensitivity to phenothiazines Coma, severe hypotension, severe CNS depression, concurrency with large amounts of CNS depressants, poorly controlled seizure [reference.medscape.com]

Neuroleptics have been used to help control agitation, restlessness, and hostility in patients with traumatic brain injury. [ncbi.nlm.nih.gov]

Report of Case A 19-year-old male college student developed symptoms of agitation and was admitted for treatment with a diagnosis of schizophrenia. He was first given chlorpromazine, but this was discontinued after one week when a rash developed. [jamanetwork.com]

Because of its strong sedative effect it is well suited for violent and agitated patients. But it can also have a beneficial effect in subjects in whom depressive symptoms are the main problem. [infomed.ch]

Behavioral deterioration following neuroleptic taper can represent (a) relapse of a mental illness, (b) and anticholinergic rebound reaction, (c) tardive akathisia, and (d) possibly a supersensitivity psychosis. [ncbi.nlm.nih.gov]

‘In some cases, patients who experience unacceptable rigidity, akathisia, or dystonia with high potency agents may benefit from a lower potency neuroleptic such as thiothixene or thioridazine.’ [oxforddictionaries.com]

Drug-Induced Acute Akathisia (Restlessness) [ hide all summaries ] (April 2011) The article lists 27 drugs that can cause akathisia, a condition characterized by muscular quivering and the inability to sit still. [worstpills.org]

There were no differences between remoxipride and thioridazine on dystonia, hypokinesia, dyskinesia, rigidity and akathisia. The results indicate that remoxipride has similar antipsychotic efficacy to thioridazine but causes fewer side effects. [doi.org]

14140009 Neuroleptic malignant syndrome contraindication 15244003 DOID:14464 Senile dementia contraindication 15662003 Orthostatic hypotension contraindication 28651003 Hypokalemia contraindication 43339004 Epilepsy contraindication 84757009 DOID:1826 Stupor [drugcentral.org]

Tobacco smoking: If people taking thioridazine continue to smoke tobacco it may result in lessening stupor caused by this medication. [herbs2000.com]

The syndrome is characterized by involuntary choreoathetoid movements which variously involve the tongue, face, mouth, lips, or jaw (e.g., protrusion of the tongue, puffing of cheeks, puckering of the mouth, chewing movements), trunk, and extremities. [rxlist.com]

Abstract In December 2000, the Committee for Safety of Medicines (CSM) advised that thioridazine may prolong QT intervals risking arrhythmias. [ncbi.nlm.nih.gov]

Over the Edge NUEDEXTA is contraindicated in patients receiving drugs that both prolong QT interval and are metabolized by CYP2D6 e.g., thioridazine and pimozide and should not be used concomitantly with other drugs containing quinidine, quinine, or mefloquine [wordnik.com]

QT interval contraindication 111975006 Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74 Coma contraindication 371632003 Breastfeeding (mother) contraindication 413712001 Congenital long QT syndrome contraindication 442917000 [drugcentral.org]

If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. [drugs.com]

The following occurred in the thioridazine group: sinus bradycardia, premature atrial contractions, first degree atrioventricular block & nonspecific T‐wave abnormality, prlongation of QT interval Figures and Tables - Table 3. [doi.org]

ADR Inferred Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death. [drugbank.ca]

There are several published case reports of Torsades de pointes and sudden death associated with thioridazine treatment. [dailymed.nlm.nih.gov]

Thioridazine has an established risk of QT prolongation and torsades de pointes (TdP). [pdr.net]

Electrocardiogram changes were significantly more frequent in the thioridazine group (n 254, 2 RCTs, RR 2.38, CI 1.6 to 3.6, NNH 4 CI 3 to 10). Six RCTs (total n 344) randomised thioridazine against atypical antipsychotics. [ncbi.nlm.nih.gov]

Electrocardiogram changes were significantly higher in the thioridazine group, which fits with the guidelines of monitoring patients for cardiovascular abnormalities. [dx.doi.org]