Edit concept Question Editor Create issue ticket

Thiotepa

Thio Tepa


Presentation

  • A description of the thiotepa active ingredient of the present invention are described in the aforementioned U.S. Pat. Nos. 2,670,347 and 4,918,199 hereby incorporated by reference into the present application.[google.com]
  • Two cases of severe delayed neurologic toxicity related to the administration of intrathecal (IT) combination chemotherapy including thiotepa (TSPA) are presented.[ncbi.nlm.nih.gov]
  • We present a case of cutaneous toxicity observed in a 4.5-year-old girl patient with medulloblastoma treated with a high-dose thiotepa conditioning regimen before autologous stem cell transplantation.[ncbi.nlm.nih.gov]
  • In the present study, we found that the CD44( )/CD24(-/low) CSCs, isolated from both human breast cell line MCF-7 and MDA-MB-231, were more resistant to thiotepa, paclitaxel and anthracycline, when compared with the non-breast cancer stem cell subset[ncbi.nlm.nih.gov]
Pleural Effusion
  • Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Ovarian cancer.[cancer.gov]
Meningism
  • Metastatic spread of tumors to the meninges is a frequent complication of many malignancies and is difficult to treat. We describe the case of a patient who developed carcinomatous involvement of the meninges from a breast adenocarcinoma.[ncbi.nlm.nih.gov]
  • Carcinomatosis/drug therapy Meningeal Carcinomatosis/mortality* Meningeal Carcinomatosis/secondary Middle Aged Neoplasm Grading Nervous System Diseases/mortality Nervous System Diseases/pathology Prognosis Retrospective Studies Survival Rate Thiotepa[ncbi.nlm.nih.gov]
  • Grade 3 toxicities were thrombocytopenia (N 2), bacterial meningitis (N 2), and pneumonia (N 1).[ncbi.nlm.nih.gov]
  • While IT treatments are generally well tolerated, complications like chemical meningitis, leukoencephalopathy, etc. occur.[ncbi.nlm.nih.gov]
  • Even if meningeal carcinomatosis is not accurately ‘measurable’, as per RECIST criteria, this is one of few reports of a radiological response of meningeal metastases to a medical treatment, associated with the longest survival reported with i.t. trastuzumab[academic.oup.com]

Workup

Pleural Effusion
  • Malignant pleural effusion, malignant pericardial effusion, and malignant peritoneal effusion. Ovarian cancer.[cancer.gov]

Treatment

  • Recruiting Treatment Retinoblastoma 1 2 Recruiting Treatment Sickle Cell Disorders 2 2 Recruiting Treatment Unresectable Localized Soft Tissue Sarcoma 1 2 Recruiting Treatment Very High Risk Neuroblastoma 1 2 Terminated Treatment Acute Lymphoblastic[drugbank.ca]
  • […] agents commonly used in the treatment of LMC.[ncbi.nlm.nih.gov]
  • […] whose disease progresses after a methotrexate-based treatment.[ncbi.nlm.nih.gov]
  • This report is a single-institution experience with salvage treatment in patients with breast cancer (BC) and LM. This retrospective cohort describes 24 consecutive patients with BC selected for a second-line of treatment for LM.[ncbi.nlm.nih.gov]
  • BACKGROUND: Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours.[ncbi.nlm.nih.gov]

Prognosis

  • We report the results of an intensified high-dose chemotherapy (HDC) strategy to improve the prognosis of VHR patients.[ncbi.nlm.nih.gov]
  • Abstract Recurrence of malignant brain tumors results in a poor prognosis with limited treatment options.[ncbi.nlm.nih.gov]
  • CONCLUSION: Thiotepa/topotecan/carboplatin may help consolidate remission of poor prognosis pediatric central nervous system tumors. Diagnosis and extent of disease prior to stem cell rescue may have an impact on outcome.[ncbi.nlm.nih.gov]
  • Follow-Up Studies Humans Injections, Spinal* Meningeal Carcinomatosis/drug therapy Meningeal Carcinomatosis/mortality* Meningeal Carcinomatosis/secondary Middle Aged Neoplasm Grading Nervous System Diseases/mortality Nervous System Diseases/pathology Prognosis[ncbi.nlm.nih.gov]
  • Abstract The prognosis of metastatic malignant mesenchymal tumors (MMT) remains poor.[nature.com]

Etiology

  • PubMed Citation (Review of clinical features, pathology, etiology, prevention and treatment of sinusoidal obstruction syndrome, a better term for this condition than veno-occlusive disease; first described in association with exposure to phytotoxins [[livertox.nih.gov]
  • One patient in the Tt-BuCy group died of encephalitis, the etiological cause of which could not be ascertained. Figure 2. Survival curves.[bloodadvances.org]
  • We investigated the possible etiologic role of chemotherapy, radiotherapy, and other factors, using a case–control study design, with three controls matched to each case of leukemia.[dx.doi.org]

Epidemiology

  • .); Cancer Epidemiology Research Unit, University of Birmingham, United Kingdom (P.P.); Finnish Cancer Registry, Helsinki (S.K.); Weston Park Hospital, Sheffield, United Kingdom (F.N.); Alberta Cancer Registry, Edmonton, Alb., Canada (M.K.); Cancer Control[dx.doi.org]
  • Authors’ Affiliations (1) Department of Clinical Pharmacy, Gustave-Roussy cancer campus, 114 Rue Edouard Vaillant, 94805 Villejuif, France (2) Department of Biostatistics and Epidemiology, Gustave-Roussy, Villejuif, France (3) Department of Pediatric[dx.doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Thiotepa is partly excreted though the skin (as sweat), and therefore thiotepa associated skin toxicity is thought to be caused by concentration of thiotepa in the skin.[eviq.org.au]

Prevention

  • Clear preventive care instructions should be detailed in the Summary of Product Characteristics in order to minimize the cutaneous toxicity of thiotepa.[ncbi.nlm.nih.gov]
  • The drug was used postoperatively to prevent revascularization after removal of a pterygium. By light and electron microscopy, melanocytes were apparently absent in the depigmented area.[ncbi.nlm.nih.gov]
  • Intravesical instillation of thio-tepa and urokinase in prevention of recurrence of bladder carcinoma after resection Wang, R.; Zhang, T.[eurekamag.com]
  • […] at cystoscopic biopsy; as an adjunctive agent at the time of biopsy; or as a therapeutic agent to prevent recurrence after cystoscopic resection of bladder tumor ( transurethral resection of bladder tumor, TURBT).[en.wikipedia.org]
  • For 3 patients who had seizures during the first course, premedication with clonazepam for the second course has prevented recurrence of NAE.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!