The authors present topics related to PSYCHOPHARMACOLOGY ISSUES: Ethical issues, Treatment planning, Side effects, Neural correlates, and Pharmacogenomics. [books.google.com]

The present article aimed to identify those receptor(s) that are most likely to be involved with or mediate antipsychotics-induced diabetes. [doi.org]

If this or any other presentation of the syndrome is observed, the clinician should consider possible discontinuation of antipsychotic medication. (See WARNINGS section.) [rxlist.com]

The present study is primarily concerned with the latter claim. [bjp.rcpsych.org]

In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS [recallguide.org]

• Disability

  Changes in manifest psychosis (symptoms) and social disability were assessed by the use of the Lorr scale (IMPS) and the Nurses' Observation Scale for Inpatient Evaluation (NOSIE) at suitable intervals. [ncbi.nlm.nih.gov]

• Orthostatic Hypotension

  Dental Health: Effects on Dental Treatment Significant hypotension may occur, especially when the drug is administered parenterally; orthostatic hypotension is due to alpha-receptor blockade, the elderly are at greater risk for orthostatic hypotension [syrianclinic.com]

  Cardiac disease, hypotension, orthostatic hypotension, syncope Rarely, thiothixene can cause hypotension or precipitate angina; therefore, it should be used with extreme caution in patients with cardiac disease. [pdr.net]

  hypotension, palpitation, inhibition of ejaculation Anticholinergic effects such as Dry mouth, blurring of vision, constipation, urinary hesitancy in elderly males Extrapyramidal disturbances (extrapyramidal symptoms EPS) such as Parkinsonism, Acute [doctoralerts.com]

  The combination of quinidine with a phenothiazine could lead to additive orthostatic hypotension or, if either agent is used in high doses, prolonged QT syndrome. [iqb.es]

  101 b c u w (see Cardiovascular Effects under Cautions) Hypotensive agents Possible additive hypotensive effect 101 c Observe closely for signs of excessive hypotension 101 c Isoniazid Possible decreased thiothixene clearance l Lithium An acute encephalopathic [drugs.com]

• Formication

  Utilizing a Waters Acquity UPLC HSS T3 1.8μm, 2.1×50mm column at 25ºC, the analytes were separated using a timed, linear gradient of acetonitrile and water, each having 0.1% formic acid added. [ncbi.nlm.nih.gov]

• Motor Restlessness

  Extrapyramidal symptoms are categorized as dystonic reaction, akathisia (subjective and objective motor restlessness), and pseudoparkinsonism. [iqb.es]

• Seizure

  Stop taking and see physician NOW: Seizures. [psyweb.com]

  Contraindications Documented hypersensitivity Blood dyscrasias Coma Circulatory collapse CNS depression (including coma) Neuroleptic malignant syndrome (NMS) Poorly controlled seizure disorder Breastfeeding Cautions Alcohol withdrawal, cardiovascular [reference.medscape.com]

  Thiothixene may increase the tendency to have seizures. People who have had seizures in the past, including alcohol or drug-induced seizures, should take thiothixene only after discussing the risks and benefits with their physician. [minddisorders.com]

  Seizures have been observed in patients without a history of seizures taking amifampridine at recommended doses. Thiothixene may increase the risk of seizures. [pdr.net]

  […] disorders (since it may lower the seizure threshold)or those with an increased risk for seizures, such as withdrawal from alcohol. [doctoralerts.com]

• Agitation

  BACKGROUND: Pharmacologic strategies are often required to help manage agitated patients with delirium. First-and second-generation antipsychotic medications (such as haloperidol, quetiapine, and olanzapine) are commonly used. [ncbi.nlm.nih.gov]

  Risse SC and Barnes R, "Pharmacologic Treatment of Agitation Associated With Dementia," J Am Geriatr Soc, 1986, 34(5):368-76. [syrianclinic.com]

  […] classification: antipsychotic Pregnancy risk category C Available forms Available by prescription only Capsules: 1 mg, 2 mg, 5 mg, 10 mg, 20 mg Injection: 2 mg/ml, 5 mg/ml, 10 mg/ml Oral concentrate: 5 mg/ml (7% alcohol) Indications and dosages Acute agitation [glowm.com]

• Akathisia

  Akathisia with haloperidol could not be suppressed completely in half of the patients. Treatment-resistant akathisia was experienced as anxiety and depression. [ncbi.nlm.nih.gov]

  May cause extrapyramidal reactions, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia (risk of these reactions is high relative to other neuroleptics). [syrianclinic.com]

  Observed side effects include drowsiness/sedation, insomnia/agitation, Parkinsonism, akathisia, and weight gain. See Also References and Readings Janicak, P. G., Davis, J. M., Preskorn, S. H., & Ayd, F. J. (2001). [link.springer.com]

• Stupor

  الصفحة 278 - Serious overdose with hydrocodone is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity [books.google.com]

  Nervous system : Tremor, abnormal dream, hallucinations, euphoria, extrapyramidal symptoms, vertigo, paresthesia, depression, insomnia, nervousness, excessive thirst, dry mouth, abnormal vision, difficult to concentrate, hyperkinesis, stupor. [dexa-medica.com]

• Choreoathetoid Movements

  Tardive dyskinesia (TD) is characterized by involuntary movements of the perioral region (tongue, mouth, jaw, eyelids, or face) or choreoathetoid movements in the extremities. [iqb.es]

Hans-Jürgen Möller, Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: conceptual and treatment issues, The World Journal of Biological Psychiatry, 6, 4, (247), (2005). [doi.org]

Thiothixene did not influence the MOPEG level, but melperone reduced it after 4 weeks of treatment. The 5-HIAA levels were not significantly altered by the drugs. [ncbi.nlm.nih.gov]

Psychopharmacology is a dominant treatment in child and adolescent psychiatry with proven benefits to young patients. [books.google.com]

For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. [books.google.it]

They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity. [books.google.com]

Mesolimbic pathway: Antipsychotic effects As explained earlier, overactivity of this pathway is thought to be involved in the pathophysiology of positive symptoms of schizophrenia. [psychopharmacologyinstitute.com]

Can be used as anti-emetic agent thus, useful in the prevention of nausea and vomiting, particularly treatment of drug-induced nausea. It is effective in morning sickness but not in motion sickness. [doctoralerts.com]

To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. [medicinenet.com]

Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. Dangerous side effects could occur. Avoid becoming overheated or dehydrated during exercise and in hot weather. [everydayhealth.com]

• Tell patient to avoid sun exposure and to wear sunscreen when going outdoors to prevent photosensitivity reactions. [glowm.com]