The authors present topics related to PSYCHOPHARMACOLOGY ISSUES: Ethical issues, Treatment planning, Side effects, Neural correlates, and Pharmacogenomics. [books.google.com]

Two cases of pathological jealousy are presented and their successful treatment with thiothixene is discussed. Evaluation of the projection mechanism is also presented. [ncbi.nlm.nih.gov]

The present article aimed to identify those receptor(s) that are most likely to be involved with or mediate antipsychotics-induced diabetes. [doi.org]

If this or any other presentation of the syndrome is observed, the clinician should consider possible discontinuation of antipsychotic medication. (See WARNINGS section.) [rxlist.com]

• Dentist

  Tell your doctor or dentist that you are taking this medicine if you are having surgery. [psychcentral.com]

  This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you. [mskcc.org]

  This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how thiothixene affects you. [drugs.com]

  Thiothixene. may cause problems in newborns following delivery if it is taken during the last months of pregnancy. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking thiothixene. you should know that this [medlineplus.gov]

• Impaired Balance

  Also if over sixty be careful when standing up because blood pressure may be lowered enough to impair balance. If you smoke blood levels of this drug need to be taken. Smoking drops this drugs level in the blood. [psyweb.com]

• Nasal Congestion

  CNS effects, GI disturbances, nasal congestion, dry mouth, blurred vision, seizures, hypotension, tachycardia, ECG changes, hyperprolactinaemia, amenorrhoea, gynaecomastia, hypoglycaemia or hyperglycaemia, blood dyscrasias, photosensitisation, contact [mims.com]

  Autonomic Effects: Dry mouth, blurred vision, nasal congestion, constipation, increased sweating, increased salivation and impotence have occurred infrequently with Navane (thiothixene hcl) therapy. [rxlist.com]

  EENT: ocular changes, blurred vision, nasal congestion. GI: dry mouth, constipation. GU: urine retention, menstrual irregularities, inhibited ejaculation. Hematologic: transient leukopenia, leukocytosis, agranulocytosis. Hepatic: jaundice. [glowm.com]

  congestion Miscellaneous: Diaphoresis Overdosage/Toxicology Symptoms of overdose include muscle twitching, drowsiness, dizziness, rigidity, tremor, hypotension, cardiac arrhythmias Following initiation of essential overdose management, toxic symptom [syrianclinic.com]

• Rhinitis

  Respiratory : Dyspnea, lung oedema, rhinitis, cough. Five senses : abnormal taste, abnormal vision, blurred vision, tinnitus, deaf. [dexa-medica.com]

• Orthostatic Hypotension

  Cardiac disease, hypotension, orthostatic hypotension, syncope Rarely, thiothixene can cause hypotension or precipitate angina; therefore, it should be used with extreme caution in patients with cardiac disease. [pdr.net]

  Adverse Effect : Constipation, decreased sweating, drowsiness, extrapyramidal symptoms, increased appetite, orthostatic hypotension, photosensitivity, weight gain, xerostomia, agitation, allergic dermatitis, anticholinergic effects, anxiety, depression [pediatriconcall.com]

  Dental Health: Effects on Dental Treatment Significant hypotension may occur, especially when the drug is administered parenterally; orthostatic hypotension is due to alpha-receptor blockade, the elderly are at greater risk for orthostatic hypotension [syrianclinic.com]

  hypotension, palpitation, inhibition of ejaculation Anticholinergic effects such as Dry mouth, blurring of vision, constipation, urinary hesitancy in elderly males Extrapyramidal disturbances (extrapyramidal symptoms EPS) such as Parkinsonism, Acute [doctoralerts.com]

• Dermatitis

  Although not experienced with Navane (thiothixene hcl), exfoliative dermatitis and contact dermatitis (in nursing personnel) have been reported with certain phenothiazines. [rxlist.com]

  Adverse Effect : Constipation, decreased sweating, drowsiness, extrapyramidal symptoms, increased appetite, orthostatic hypotension, photosensitivity, weight gain, xerostomia, agitation, allergic dermatitis, anticholinergic effects, anxiety, depression [pediatriconcall.com]

  […] as Parkinsonism, Acute muscular dystonias, Akathisia, Malignant neuroleptic syndrome, Tardive dyskinesia Blue pigmentation of exposed skin, Corneal and lenticular opacities, retinal degeneration, Cholestatic jaundice Skin rashes, urticaria, contact dermatitis [doctoralerts.com]

  Contact dermatitis has been reported with similar medications. [iqb.es]

• Ulcer

  Severe complications are caused by ketorolac therapy like ulcer, bleeding and gastrointestinal perforation, post operative bleeding, acute renal failure, anaphylactic and anaphylactoid reactions and hepatic failure must be keep on guard. [dexa-medica.com]

  […] antidepressants; antihistamines; atropine (in Motofen, in Lomotil, in Lonox); epinephrine (Epipen); ipratropium (Atrovent); medications for anxiety, high blood pressure, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers [medlineplus.gov]

  […] difficult urination pale skin pinpoint red spots on the skin puffing of the cheeks rapid or worm-like movements of the tongue rapid weight gain restlessness seizures severe muscle stiffness shuffling walk slowed movements slurred speech sore throat sores, ulcers [mayoclinic.org]

• Visual Impairment

  Phenothiazines (and possibly thiothixene) have been associated with deposition of fine particles in the lens and cornea, which can lead to corneal opacification and visual impairment. [iqb.es]

  Renal Impairment Specific data for renal impairment are not available; no dosage adjustments in this population have been noted. [pdr.net]

• Miosis

  Phenothiazines have been associated with miosis, mydriasis, and adynamic ileus. Other Adverse Reactions: Hyperpyrexia, anorexia, nausea, vomiting, diarrhea, increase in appetite and weight, weakness or fatigue, polydipsia, and peripheral edema. [rxlist.com]

• Motor Restlessness

  Extrapyramidal symptoms are categorized as dystonic reaction, akathisia (subjective and objective motor restlessness), and pseudoparkinsonism. [iqb.es]

• Anxiety Disorder

  The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues. Journal of Affective Disorders, Vol. 68, Issue. 1, p. 1. CrossRef Google Scholar Cutler, Janis L. and Siris, Samuel G. 1991. [bjp.rcpsych.org]

• Seizure

  Be alert for new seizures or increased seizure activity, especially at the onset of drug treatment. Document the number, duration, and severity of seizures, and report these findings to the physician immediately. [fadavispt.mhmedical.com]

  Stop taking and see physician NOW: Seizures. [psyweb.com]

  Contraindications Documented hypersensitivity Blood dyscrasias Coma Circulatory collapse CNS depression (including coma) Neuroleptic malignant syndrome (NMS) Poorly controlled seizure disorder Breastfeeding Cautions Alcohol withdrawal, cardiovascular [reference.medscape.com]

  Thiothixene may increase the tendency to have seizures. People who have had seizures in the past, including alcohol or drug-induced seizures, should take thiothixene only after discussing the risks and benefits with their physician. [minddisorders.com]

  Seizures have been observed in patients without a history of seizures taking amifampridine at recommended doses. Thiothixene may increase the risk of seizures. [pdr.net]

• Agitation

  BACKGROUND: Pharmacologic strategies are often required to help manage agitated patients with delirium. First-and second-generation antipsychotic medications (such as haloperidol, quetiapine, and olanzapine) are commonly used. [ncbi.nlm.nih.gov]

  Indication : For the management of schizophrenia Off-Label: Psychosis/agitation associated with dementia. [pediatriconcall.com]

  Risse SC and Barnes R, "Pharmacologic Treatment of Agitation Associated With Dementia," J Am Geriatr Soc, 1986, 34(5):368-76. [syrianclinic.com]

• Akathisia

  Akathisia with haloperidol could not be suppressed completely in half of the patients. Treatment-resistant akathisia was experienced as anxiety and depression. [ncbi.nlm.nih.gov]

  May cause extrapyramidal reactions, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia (risk of these reactions is high relative to other neuroleptics). [syrianclinic.com]

  Observed side effects include drowsiness/sedation, insomnia/agitation, Parkinsonism, akathisia, and weight gain. See Also References and Readings Janicak, P. G., Davis, J. M., Preskorn, S. H., & Ayd, F. J. (2001). [link.springer.com]

• Behavior Problem

  This medicine should not be used to treat behavioral problems in older adult patients who have dementia. This medicine is available only with your doctor's prescription. [mayoclinic.org]

  This medication is not approved for the treatment of dementia-related behavior problems. [webmd.com]

  This medication is not approved for the treatment of dementia -related behavior problems. [medicinenet.com]

  Thiothixene is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. [medlineplus.gov]

• Stupor

  الصفحة 278 - Serious overdose with hydrocodone is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity [books.google.com]

  Nervous system : Tremor, abnormal dream, hallucinations, euphoria, extrapyramidal symptoms, vertigo, paresthesia, depression, insomnia, nervousness, excessive thirst, dry mouth, abnormal vision, difficult to concentrate, hyperkinesis, stupor. [dexa-medica.com]

Hans-Jürgen Möller, Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: conceptual and treatment issues, The World Journal of Biological Psychiatry, 6, 4, (247), (2005). [doi.org]

Thiothixene did not influence the MOPEG level, but melperone reduced it after 4 weeks of treatment. The 5-HIAA levels were not significantly altered by the drugs. [ncbi.nlm.nih.gov]

[…] problems for which specific treatments are available. [recallguide.org]

Psychopharmacology is a dominant treatment in child and adolescent psychiatry with proven benefits to young patients. [books.google.com]

For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. [books.google.it]

They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity. [books.google.com]

Mesolimbic pathway: Antipsychotic effects As explained earlier, overactivity of this pathway is thought to be involved in the pathophysiology of positive symptoms of schizophrenia. [psychopharmacologyinstitute.com]

Interventions Guard against falls and trauma (hip fractures, head injury, and so forth) caused by drowsiness, blurred vision, or extrapyramidal symptoms; implement fall prevention strategies (See Appendix E). [fadavispt.mhmedical.com]

Can be used as anti-emetic agent thus, useful in the prevention of nausea and vomiting, particularly treatment of drug-induced nausea. It is effective in morning sickness but not in motion sickness. [doctoralerts.com]

To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. [medicinenet.com]

• Tell patient to avoid sun exposure and to wear sunscreen when going outdoors to prevent photosensitivity reactions. [glowm.com]

Patients therefore should avoid exposure to extreme temperature variations to prevent hyperthermia or hypothermia. [iqb.es]