Changes in manifest psychosis (symptoms) and social disability were assessed by the use of the Lorr scale (IMPS) and the Nurses' Observation Scale for Inpatient Evaluation (NOSIE) at suitable intervals. [ncbi.nlm.nih.gov]

The case described is of a woman who developed marked leg edema during thiothixene administration, and other cases of neuroleptic induced edema are reviewed. Possible mechanisms for the edema formation and clinical implications are discussed. [ncbi.nlm.nih.gov]

Also if over sixty be careful when standing up because blood pressure may be lowered enough to impair balance. If you smoke blood levels of this drug need to be taken. Smoking drops this drugs level in the blood. [psyweb.com]

الصفحة 278 - Serious overdose with hydrocodone is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity [books.google.com]

Dental Health: Effects on Dental Treatment Significant hypotension may occur, especially when the drug is administered parenterally; orthostatic hypotension is due to alpha-receptor blockade, the elderly are at greater risk for orthostatic hypotension [syrianclinic.com]

Orthostatic hypotension could lead to falls with the potential for fractures and other injuries. [pdr.net]

hypotension, palpitation, inhibition of ejaculation Anticholinergic effects such as Dry mouth, blurring of vision, constipation, urinary hesitancy in elderly males Extrapyramidal disturbances (extrapyramidal symptoms EPS) such as Parkinsonism, Acute [doctoralerts.com]

orthostatic hypotension) effects of antipsychotic agents. 100 101 b h i u w Use with caution. h (See Geriatric Patients under Dosage and Administration and see Special Populations under Pharmacokinetics.) [drugs.com]

The combination of quinidine with a phenothiazine could lead to additive orthostatic hypotension or, if either agent is used in high doses, prolonged QT syndrome. [iqb.es]

Utilizing a Waters Acquity UPLC HSS T3 1.8μm, 2.1 50mm column at 25ºC, the analytes were separated using a timed, linear gradient of acetonitrile and water, each having 0.1% formic acid added. [ncbi.nlm.nih.gov]

Extrapyramidal symptoms are categorized as dystonic reaction, akathisia (subjective and objective motor restlessness), and pseudoparkinsonism. [iqb.es]

While the results are very preliminary, the authors suggest that future studies differentiate the cis and trans isomers, and analyze relative as well as absolute changes in plasma levels as compared to clinical changes. [ncbi.nlm.nih.gov]

Stop taking and see physician NOW: Seizures. [psyweb.com]

Contraindications Documented hypersensitivity Blood dyscrasias Coma Circulatory collapse CNS depression (including coma) Neuroleptic malignant syndrome (NMS) Poorly controlled seizure disorder Breastfeeding Cautions Alcohol withdrawal, cardiovascular [reference.medscape.com]

Thiothixene may increase the tendency to have seizures. People who have had seizures in the past, including alcohol or drug-induced seizures, should take thiothixene only after discussing the risks and benefits with their physician. [minddisorders.com]

Seizures have been observed in patients without a history of seizures taking amifampridine at recommended doses. Thiothixene may increase the risk of seizures. [pdr.net]

Possible risk of seizures; may lower seizure threshold. 101 b c u Use with extreme caution in patients with a history of seizures or during alcohol withdrawal. 101 b c u (See Specific Drugs and Laboratory Tests under Interactions.) [drugs.com]

BACKGROUND: Pharmacologic strategies are often required to help manage agitated patients with delirium. First-and second-generation antipsychotic medications (such as haloperidol, quetiapine, and olanzapine) are commonly used. [ncbi.nlm.nih.gov]

Risse SC and Barnes R, "Pharmacologic Treatment of Agitation Associated With Dementia," J Am Geriatr Soc, 1986, 34(5):368-76. [syrianclinic.com]

[…] classification: antipsychotic Pregnancy risk category C Available forms Available by prescription only Capsules: 1 mg, 2 mg, 5 mg, 10 mg, 20 mg Injection: 2 mg/ml, 5 mg/ml, 10 mg/ml Oral concentrate: 5 mg/ml (7% alcohol) Indications and dosages Acute agitation [glowm.com]

Akathisia with haloperidol could not be suppressed completely in half of the patients. Treatment-resistant akathisia was experienced as anxiety and depression. [ncbi.nlm.nih.gov]

May cause extrapyramidal reactions, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia (risk of these reactions is high relative to other neuroleptics). [syrianclinic.com]

Observed side effects include drowsiness/sedation, insomnia/agitation, Parkinsonism, akathisia, and weight gain. See Also References and Readings Janicak, P. G., Davis, J. M., Preskorn, S. H., & Ayd, F. J. (2001). [link.springer.com]

الصفحة 278 - Serious overdose with hydrocodone is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity [books.google.com]

Nervous system : Tremor, abnormal dream, hallucinations, euphoria, extrapyramidal symptoms, vertigo, paresthesia, depression, insomnia, nervousness, excessive thirst, dry mouth, abnormal vision, difficult to concentrate, hyperkinesis, stupor. [dexa-medica.com]

Tardive dyskinesia (TD) is characterized by involuntary movements of the perioral region (tongue, mouth, jaw, eyelids, or face) or choreoathetoid movements in the extremities. [iqb.es]