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Thiothixene


Presentation

  • Two cases of pathological jealousy are presented and their successful treatment with thiothixene is discussed. Evaluation of the projection mechanism is also presented.[ncbi.nlm.nih.gov]
  • The authors present topics related to PSYCHOPHARMACOLOGY ISSUES: Ethical issues, Treatment planning, Side effects, Neural correlates, and Pharmacogenomics.[books.google.com]
  • An acute thiothixene intoxication is presented. Blood thiothixene concentration of 0.52 mg/L was detected before it declined to 0.047 mg/L in 12 hrs.[ncbi.nlm.nih.gov]
  • The present article aimed to identify those receptor(s) that are most likely to be involved with or mediate antipsychotics-induced diabetes.[doi.org]
  • If this or any other presentation of the syndrome is observed, the clinician should consider possible discontinuation of antipsychotic medication. (See WARNINGS section.)[rxlist.com]
Disability
  • Changes in manifest psychosis (symptoms) and social disability were assessed by the use of the Lorr scale (IMPS) and the Nurses' Observation Scale for Inpatient Evaluation (NOSIE) at suitable intervals.[ncbi.nlm.nih.gov]
Leg Edema
  • The case described is of a woman who developed marked leg edema during thiothixene administration, and other cases of neuroleptic induced edema are reviewed. Possible mechanisms for the edema formation and clinical implications are discussed.[ncbi.nlm.nih.gov]
Orthostatic Hypotension
  • Dental Health: Effects on Dental Treatment Significant hypotension may occur, especially when the drug is administered parenterally; orthostatic hypotension is due to alpha-receptor blockade, the elderly are at greater risk for orthostatic hypotension[syrianclinic.com]
  • )hypotension, palpitation, inhibition of ejaculation Anticholinergic effects such as Dry mouth, blurring of vision, constipation, urinary hesitancy in elderly males Extrapyramidal disturbances (extrapyramidal symptoms EPS) such as Parkinsonism, Acute[doctoralerts.com]
  • ., orthostatic hypotension) effects of antipsychotic agents. 100 101 b h i u w Use with caution. h (See Geriatric Patients under Dosage and Administration and see Special Populations under Pharmacokinetics.)[drugs.com]
Formication
  • Utilizing a Waters Acquity UPLC HSS T3 1.8μm, 2.1 50mm column at 25ºC, the analytes were separated using a timed, linear gradient of acetonitrile and water, each having 0.1% formic acid added.[ncbi.nlm.nih.gov]
Suggestibility
  • While the results are very preliminary, the authors suggest that future studies differentiate the cis and trans isomers, and analyze relative as well as absolute changes in plasma levels as compared to clinical changes.[ncbi.nlm.nih.gov]
  • Experience with thiothixene suggested that it was comparable with control drugs in the activation of withdrawn patients but needs to be used in combination with a more sedative antipsychotic agent in the treatment of some paranoid patients.[ncbi.nlm.nih.gov]
  • Using overall improvement ratings and Gorham's BPRS, zotepine rated higher improvement in motor retardation, suspiciousness, mannerisms and posturing symptoms, suggesting that it has both activating and antipsychotic activities.[ncbi.nlm.nih.gov]
  • Abstract Clinical impressions suggest that thioridazine hydrochloride produces fewer extrapyramidal effects and more sedation than thiothixene.[ncbi.nlm.nih.gov]
  • The results suggest that acute single-dose levels may be useful in predicting clinical response to thiothixene.[ncbi.nlm.nih.gov]
Seizure
  • Contraindications Documented hypersensitivity Blood dyscrasias Coma Circulatory collapse CNS depression (including coma) Neuroleptic malignant syndrome (NMS) Poorly controlled seizure disorder Breastfeeding Cautions Alcohol withdrawal, cardiovascular[reference.medscape.com]
  • Stop taking and see physician NOW: Seizures.[psyweb.com]
  • Thiothixene may increase the tendency to have seizures. People who have had seizures in the past, including alcohol or drug-induced seizures, should take thiothixene only after discussing the risks and benefits with their physician.[minddisorders.com]
  • Possible risk of seizures; may lower seizure threshold. 101 b c u Use with extreme caution in patients with a history of seizures or during alcohol withdrawal. 101 b c u (See Specific Drugs and Laboratory Tests under Interactions.)[drugs.com]
  • Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.[everydayhealth.com]
Agitation
  • BACKGROUND: Pharmacologic strategies are often required to help manage agitated patients with delirium. First-and second-generation antipsychotic medications (such as haloperidol, quetiapine, and olanzapine) are commonly used.[ncbi.nlm.nih.gov]
  • Low potency neuroleptics have also been advocated because their sedative properties might better calm the acutely agitated manic patient.[ncbi.nlm.nih.gov]
  • Abstract In this double-blind study, haloperidol (n 15) and thiothixene (n 15), administered parenterally in emergency rooms and outpatient facilities to 30 acutely excited, agitated psychotic patients in hourly doses of 4 mg. or 8 mg., as needed over[ncbi.nlm.nih.gov]
  • Risse SC and Barnes R, "Pharmacologic Treatment of Agitation Associated With Dementia," J Am Geriatr Soc, 1986, 34(5):368-76.[syrianclinic.com]
  • […] classification: antipsychotic Pregnancy risk category C Available forms Available by prescription only Capsules: 1 mg, 2 mg, 5 mg, 10 mg, 20 mg Injection: 2 mg/ml, 5 mg/ml, 10 mg/ml Oral concentrate: 5 mg/ml (7% alcohol) Indications and dosages Acute agitation[glowm.com]
Akathisia
  • Akathisia with haloperidol could not be suppressed completely in half of the patients. Treatment-resistant akathisia was experienced as anxiety and depression.[ncbi.nlm.nih.gov]
  • Side effects on high dose included several instances of EPS: akathisia and tremor, and transient CNS stimulation. Low dose produced persistent CNS stimulation: excitement and insomnia.[ncbi.nlm.nih.gov]
  • A high incidence of akathisia in the thiothixene group was responsible for a statistically significant difference between groups in the number of central nervous system symptoms.[ncbi.nlm.nih.gov]
  • May cause extrapyramidal reactions, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia (risk of these reactions is high relative to other neuroleptics).[syrianclinic.com]
  • Observed side effects include drowsiness/sedation, insomnia/agitation, Parkinsonism, akathisia, and weight gain. See Also References and Readings Janicak, P. G., Davis, J. M., Preskorn, S. H., & Ayd, F. J. (2001).[link.springer.com]
Stupor
  • الصفحة 278 - Serious overdose with hydrocodone is characterized by respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity[books.google.com]
  • Nervous system : Tremor, abnormal dream, hallucinations, euphoria, extrapyramidal symptoms, vertigo, paresthesia, depression, insomnia, nervousness, excessive thirst, dry mouth, abnormal vision, difficult to concentrate, hyperkinesis, stupor.[dexa-medica.com]

Treatment

  • Hans-Jürgen Möller, Occurrence and treatment of depressive comorbidity/cosyndromality in schizophrenic psychoses: conceptual and treatment issues, The World Journal of Biological Psychiatry, 6, 4, (247), (2005).[doi.org]
  • Thiothixene did not influence the MOPEG level, but melperone reduced it after 4 weeks of treatment. The 5-HIAA levels were not significantly altered by the drugs.[ncbi.nlm.nih.gov]
  • The results encourage the use and further evaluation of melpherone in the treatment of psychotic patients.[ncbi.nlm.nih.gov]
  • On one occasion thiothixene was given concurrently, and following 3 days of pre-treatment with oral paroxetine (20 mg/day). On the other occasion thiothixene was given without paroxetine pre-treatment.[ncbi.nlm.nih.gov]
  • There was no significant relationship between diagnosis and outcome of treatment.[ncbi.nlm.nih.gov]

Epidemiology

  • For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions.[books.google.it]
Sex distribution
Age distribution

Pathophysiology

  • They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity.[books.google.com]
  • الصفحة 660 - Corticotropin releasing hormone in the pathophysiology of melancholic and atypical depression and in the mechanism of action of antidepressant drugs. ‏[books.google.com]
  • Mesolimbic pathway: Antipsychotic effects As explained earlier, overactivity of this pathway is thought to be involved in the pathophysiology of positive symptoms of schizophrenia.[psychopharmacologyinstitute.com]

Prevention

  • To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details.[medicinenet.com]
  • Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. Dangerous side effects could occur. Avoid becoming overheated or dehydrated during exercise and in hot weather.[everydayhealth.com]
  • . • Tell patient to avoid sun exposure and to wear sunscreen when going outdoors to prevent photosensitivity reactions.[glowm.com]

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