Sixteen percent of the cases presented with neurological symptoms and 14% of the patients presented with acute respiratory distress. Urinary catecholamines were elevated in 76% of the cases. [ncbi.nlm.nih.gov]

The characteristic presentation of a thoracic neuroblastoma however, is with tracheal / mediastinal / or cord compression. [indianjcancer.com]

METHODS Twenty-six children with primary thoracic neuroblastoma presented over the last 14 years were analysed for age, mode of presentation, tumour histopathology, biology and outcome. [academic.oup.com]

• Pain

  Stay current with coverage of hot topics including MRSA, neonatal pain, cardiovascular fetal interventions, care of the late preterm infant, and the developing intestinal microbiome. [books.google.com]

  Chest radiograph Bone or muscle pain Pain is prolonged (> 2 weeks) and has no identifiable cause. [aafp.org]

  Patient commonly present with chest pain, cough and respiratory distress due to airway obstruction. Chest radiograph is the initial radiological investigation to be done in such patients. [radrounds.com]

  Metastatic spread to the bones and bone marrow can cause pain (especially with ambulation), blood count abnormalities, and fever. In young children, who cannot complain of pain, bone pain may manifest as a limp or unexplained irritability. [telemedicina.med.muni.cz]

  They may be associated with palpable mass, digestive problems, discomfort and pain. Thoracic neuroblastomas (≈ 20%) are often diagnosed coincidentally by chest X-rays. [ispub.com]

• Fever

  Fever lasts longer than 14 days with no identifiable cause. [aafp.org]

  Usually further systemic symptoms are present – weight loss, fever. [intechopen.com]

  Metastatic spread to the bones and bone marrow can cause pain (especially with ambulation), blood count abnormalities, and fever. In young children, who cannot complain of pain, bone pain may manifest as a limp or unexplained irritability. [telemedicina.med.muni.cz]

  Signs Mild fever. Abdominal distension due to enlarged liver. Hypertension - due to pressure on the renal artery. Horner's syndrome due to thoracic lesion. Primary cervical neuroblastoma is rare but may result in a mass in the neck. [patient.info]

  Bone marrow—blood cunt abnormalities and fever Liver—hepatomegaly Skin—nontender papules and subcutaneous nodules Diagnosis Most often, neuroblastoma is discovered as a mass on an ultrasound, radiograph, CT, MRI, or during a physical exam. [pedclerk.bsd.uchicago.edu]

• Swelling

  Local examination revealed a hard swelling of size 7 x 8 x 8 cm over the right parietal region, with fixity to the underlying bone. There was no tenderness or signs of inflammation over the swelling. [indianjcancer.com]

  Orbital signs with lid swelling, ecchymosis, proptosis, and orbital inflammation may herald occult primary lesions. Thoracic and cervical neuroblastomas are quite rare. [healio.com]

  Signs and symptoms of metastatic neuroblastoma include: Pain and limping, sphenoid bone and retrobulbar tissue involvement causes orbital ecchymoses swelling and proptosis (raccoon face), infants present as irritable and fussy. [intechopen.com]

  Less common clinical findings include proptosis, [24] periorbital swelling, [25] periorbital hemorrhage, [26] strabismus, restricted ocular motility, [27] ipsilateral Horner syndrome, ptosis, [28] iris heterochromia, opsoclonus/ myoclonus syndrome, [29 [eyewiki.aao.org]

• Asymptomatic

  Five cases of neonatal thoracic neuroblastoma were either clinically asymptomatic or presented as uncharacteristic respiratory distress. [ncbi.nlm.nih.gov]

  Most symptomatic patients were diagnosed in the 2 first months after onset, and asymptomatic cases were common. [analesdepediatria.org]

  Patients with localized disease can be asymptomatic, whereas children with advanced disease appear ill at presentation, usually with systemic symptoms. [telemedicina.med.muni.cz]

  In these circumstances, patients can present with an asymptomatic abdominal mass that usually is discovered by the parents or a caregiver. [emedicine.medscape.com]

• Constitutional Symptom

  Constitutional symptoms include failure to thrive, fever, hypertension, bouts of sweating and pallor. 7,8 The major clinical staging systems (International Neuroblastoma Staging System (INSS)) based on the Evans staging system is shown in Table 1. 7 Figure [ispub.com]

  Constitutional symptoms associated with disseminated disease may include failure to thrive and fever, the latter observed most often in the presence of extensive bone metastases [ 7 ] Regional lymph node metastases are noted in up to 35% of patients with [intechopen.com]

  Approximately 30 percent of children with Hodgkin's disease present with constitutional symptoms, the so-called “B” symptoms. [aafp.org]

  Pain is the most common presenting symptom. This frequently is caused by bone, liver, or bone marrow metastases or local visceral invasion by the primary tumor. Other constitutional symptoms may include weight loss, anorexia, malaise, and fever. [oncohemakey.com]

• Abdominal Pain

  Abdominal tumors can present with abdominal pain or fullness, abdominal mass, or rarely intestinal obstruction. An abdominal mass may be detected in an asymptomatic child by the primary care physician during a routine examination. [telemedicina.med.muni.cz]

  This malignancy can also present with abdominal pain, gross hematuria, fever and hypertension. [aafp.org]

  Abdominal pain or distention may occur from abdominal tumor and difficulty breathing may occur from respiratory tumor spread. [eyewiki.aao.org]

  Generally, symptoms include abdominal pain, emesis, weight loss, anorexia, fatigue, and bone pain. Hypertension is an uncommon sign of the disease and is generally caused by renal artery compression, not catecholamine excess. [emedicine.medscape.com]

  Symptoms: abdominal pain or fullness, abdominal mass, or rarely intestinal obstruction, enlarged and/or displaced liver and spleen. [intechopen.com]

• Vomiting

  CBC with differential Vomiting Vomiting lasts longer than 7 days with no identifiable cause. Abdominal and head CT scans Vomiting is associated with headache during sleep. [aafp.org]

  There was no history of trauma, convulsions, vomiting, limb weakness, abnormal bleeding or bladder / bowel disturbances. On examination the child was pale, had an average build, there was no lymphadenopathy or organomegaly. [indianjcancer.com]

  Vomiting. Weight loss. Fatigue. Bruising due to pancytopenia as a result of marrow infiltration. Periorbital bruising - 'racoon eyes' (due to metastatic disease in the orbits). [patient.info]

• Hepatomegaly

  Other accompanying syndromes include: H utchinson syndrome : bony metastases may present with skeletal pain or a palpable lump or limping and irritability due to skeletal metastases 2 Pepper syndrome : hepatomegaly due to extensive liver metastasis blueberry [radiopaedia.org]

  Bone marrow—blood cunt abnormalities and fever Liver—hepatomegaly Skin—nontender papules and subcutaneous nodules Diagnosis Most often, neuroblastoma is discovered as a mass on an ultrasound, radiograph, CT, MRI, or during a physical exam. [pedclerk.bsd.uchicago.edu]

  Respiratory distress may accompany massive hepatomegaly, especially in infants with stage IV-S disease. 8 Horner’s syndrome can accompany a primary tumor originating in the neck. [oncohemakey.com]

• Hypertension

  Apply new evidence-based management options to treat genetic and constitutional factors leading to a high-risk pregnancy (such as diabetes, obesity, hypertension, and cardiac disease) through new and expanded coverage of these increasingly common presentations [books.google.com]

  Hypertension - due to pressure on the renal artery. Horner's syndrome due to thoracic lesion. Primary cervical neuroblastoma is rare but may result in a mass in the neck. [patient.info]

  Hypertension – as neuroblastoma is derived from neural crest cells that are destined to form components of the peripheral sympathetic nervous system, that frequently produce catecholamines. [telemedicina.med.muni.cz]

  Rarely, patients will experience renin-mediated hypertension because of compromise of renal vasculature. [intechopen.com]

  […] presentation of abdominal tumors include: Abdominal mass (detected by PCP during routine WCC in 11% of cases) Abdominal discomfort or pain Intestinal obstruction and compression of bowel or bladder (esp. when arising from organ of Zuckerkandl) Systemic hypertension [pedclerk.bsd.uchicago.edu]

• Tachycardia

  Hypertension, tachycardia, flushing, and sweating are uncommon symptoms because epinephrine is rarely released from most neuroblastomas, since they lack the enzyme necessary for synthesis. [intechopen.com]

• Aggressive Behavior

  Some tumors undergo spontaneous regression, some are cured by surgery alone or after chemo-reduction, while other exhibit extremely aggressive behavior. [journals.plos.org]

• Hematuria

  Head CT scan Hematuria Evaluate immediately if hematuria has no identifiable cause. Abdominal ultrasound examination Voiding difficulty Evaluate immediately if voiding difficulty has no identifiable cause. [aafp.org]

  Specific surgical complications include nephrectomies (intraoperatively from organ extension), Horner syndrome, pleural effusions, abscess, hematuria, ileus, and tumor rupture. [54] Follow up Urine catecholamines are used as sensitive and specific tumor [eyewiki.aao.org]

The tumor should be assessed by CT or MRI, and a metastatic workup including bone scan should be done as well. If possible, the tumor should be biopsied and assessed for cytogenic and molecular markers. [pedclerk.bsd.uchicago.edu]

Staging workup The minimum requirements for staging include: Bilateral iliac crest bone marrow aspirate and biopsy. Bone radiographs and either technetium radionuclide scan or I123-MIBG scan (Figure 2). [telemedicina.med.muni.cz]

Examination of the abdomen may reveal an abdominal mass, leading to the appropriate workup. Neurologic examination may reveal Horner syndrome. [emedicine.medscape.com]

It also provides guidelines for treatment with surgery, radiotherapy and chemotherapy. [books.google.de]

No further treatment was given. The residual primary tumor regressed spontaneously. Four years after diagnosis, both twins are healthy and normally developed. [ncbi.nlm.nih.gov]

Prepare for clinical challenges and save time in addressing them thanks to expert advice on treatment options from international contributors. [books.google.com]

One child died during treatment. Two have completed treatment and are under follow-up. [nature.com]

Prognosis was related to the age at diagnosis, stage of disease and the histological type. [ncbi.nlm.nih.gov]

etiology and causative factors of neuroblastoma are not well understood at this point. [eyewiki.aao.org]

Case reports, literature review, and etiologic considerations. Cancer 57(9): 1887–93 CrossRef CAS PubMed Google Scholar Shahar E, Shinawi M (2003) Neurocristopathies presenting with neurologic abnormalities associated with Hirschsprung’’s disease. [link.springer.com]

PMID 10519894 Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. [atlasgeneticsoncology.org]

In the thorax, neurogenic tumors are found most commonly in the posterior mediastinum (63%–96%). 1 – 6 In fact, neurogenic tumors account for 75% of all posterior mediastinal neoplasms. 3 The epidemiology of neurogenic tumors depends primarily on whether [accesssurgery.mhmedical.com]

"The epidemiology of neuroblastoma: a review". Paediatric and Perinatal Epidemiology. 23 (2): 125–43. doi : 10.1111/j.1365-3016.2008.00983.x. PMID 19159399. ^ Esthesioneuroblastoma at eMedicine ^ Cheung, Nai-Kong (2005). Neuroblastoma. [en.wikipedia.org]

Epidemiology Fewer than 100 children are diagnosed with neuroblastoma each year in the UK. However, neuroblastomas are the most common extracranial solid tumour of childhood. [ 3 ] Neuroblastoma is the third most common paediatric cancer. [patient.info]

El síntoma más frecuente es la tos y la primera prueba diagnóstica es la radiografía torácica en la mayor parte de los casos Palabras clave: Neuroblastoma torácico Niños Síntomas Objectives To analyze clinical onset and other epidemiological findings [analesdepediatria.org]

Pathophysiology Neuroblastoma is derived from precursor cells of the sympathetic nervous system, which require a cohort of transcription factors to properly differentiate into mature sympathetic neurons. [eyewiki.aao.org]

November 8, 2012 Update on Mesothelioma Intro incidence and nomenclature Update on Classification Diagnostic specimens Morphologic features Epithelioid Histology Biphasic Histology Immunohistochemical More information LIFE EXPECTANCY IN ROMÂNIA JOURNAL OF PREVENTIVE [docplayer.net]

Other postulated theories include toxic metabolites from cancer or from chemotherapy causing axoplasmic transport stasis. [21] Primary prevention As most of neuroblastoma is sporadic or genetic, there are no primary prevention measures. [eyewiki.aao.org]

NIH: National Cancer Institute Cancer (Medical Encyclopedia) Cancer and lymph nodes (Medical Encyclopedia) Cancer treatment -- early menopause (Medical Encyclopedia) Cancer treatment: preventing infection (Medical Encyclopedia) Cancer treatments (Medical [icdlist.com]

^ Darshak Sanghavi, "Screen Alert: How an Ounce of RX Prevention can Cause a Pound of Hurt" Archived 2006-12-01 at the Wayback Machine, Slate magazine, November 28, 2006 ^ Johnson, Erik; Dean, Shannon M.; Sondel, Paul M. (2007). [en.wikipedia.org]