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Thost-Unna Palmoplantar Keratoderma

Nonepidermolytic Palmoplantar Keratoderma


  • Definition A dermatological disorder characterized by well-demarcated hyperkeratosis is present over the palms and soles. A red band is frequently present at the periphery of the keratosis.[uniprot.org]
  • There exist reports on the involvement being present in up to six generations.[scielo.br]
  • Subsequently, a thick yellowish hyperkeratosis appeared and expanded to attain the present status.[indianpediatrics.net]
  • We present a case of Unna-Thost keratoderma in a 9 year old male child who presented with waxy, thick, yellow palms and soles with fissures and contractures in hands.[scopemed.org]
  • ., certified Specialist by Brazilian Society of Dermatology (SBD) IV Medical pathologist, Head of clinic, Adjunct Professor of Pathological Anatomy, Santa Casa de Sao Paulo Medical Faculty V Student-physician, CHPBG VI Head Physician, Padre Bento Hospital[scielo.br]
Localized Pain
  • The damage brought about to the palms and soles can lead to not only local pain and mobility difficulties, but also infections and discomfort caused by hyperhidrosis.[revistasrd.ro]
  • Radiological examinations were carried out of the dental arch and hands, which did not exhibit any abnormalities; of the right foot, which showed bone resorption of the proximal phalange of the fifth toe; of the left foot, which showed a fracture of the[scielo.br]
Localized Scleroderma
  • A case of atypical localized scleroderma presenting with pseudoainhum: treatment with tranilast an anti-fibrotic agent [letter]. Acta Derm Venereol 1996; 76(2): 162. [ Links ] 9. McLaurin CI. Psoriasis presenting with peudoainhum.[scielo.br]
Abnormal Dermatoglyphic Pattern
  • dermatoglyphic pattern Abnormal dermatoglyphic pattern (disorder) Abnormal palmar creases Abnormal palmar creases (disorder) Abnormal plantar creases Abnormal plantar creases (disorder) Accessory skin tags Acne vermoulante Acquired perforating pseudoxanthoma[averbis.com]
Cutis Laxa
  • laxa Localised palmoplantar keratoderma Localized congenital cutis laxa Localized congenital cutis laxa (disorder) Localized palmoplantar keratoderma Lumpy scalp syndrome Lumpy scalp syndrome (disorder) Mal de Meleda Melanism Mendes da Costa syndrome[averbis.com]
  • Angiomatosis (disorder) Atrophoderma vermiculatum Atrophoderma vermiculatum (disorder) Autosomal dominant dyskeratosis congenita Autosomal dominant dyskeratosis congenita (disorder) Autosomal dominant mutilating keratoderma Autosomal dominant mutilating[averbis.com]


  • In Conclusion Overall, palmoplantar keratodermas are rare entities that require a thorough clinical history, workup and discussion of treatment options with little chance of topical agents meeting patient expectations.[podiatrytoday.com]
  • Many melanin granules in basal cells HID syndrome, CIE Sepsis workup none Meleda type Mal de Meleda, MDM, Meleda Disease, Keratosis Palmoplantaris Transgradiens of Siemens 757.4 Inhabitants of the island of Mljet off the Dalmation Coast SLURP-1, Ly-6[dermatologyadvisor.com]


  • More Symptoms of Unna-Thost palmoplantar keratoderma » Treatments: Unna-Thost palmoplantar keratoderma Treatment : The following treatments can help to soften the thickened skin and make it less noticeable: [1, 3] Emollients Keratolytics (such as salicylic[familydiagnosis.com]
  • We started a treatment with acitretin 20 mg/day and a local treatment consisting of tretinoin and urea twice a day.[casereports.bmj.com]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[resourcerepository.org]
  • I have tried topical treatments as well as oral retinoids with no improvement. I'm looking at more aggressive treatments if at all possible. The only problem is this is pretty uncommon.[medhelp.org]


  • Prognosis - Thost-Unna palmoplantar keratoderma Not supplied.[checkorphan.org]
  • Prognosis Prognosis of squamous cell cancer of oesophagus: In general is poor with 5 year survival of 75% in Stage 0 (intraepithelial cancer) to Note The tylosis oesophageal cancer gene (RHBDF2) is localized to a small region on band 17q25, a region frequently[atlasgeneticsoncology.org]
  • The prognosis of tylosis with oesophageal cancer is difficult to determine due to the limited number of affected individuals.[cancerindex.org]
  • We assessed the influence of cytokeratin -positive micrometastases in the bone marrow on the prognosis of women with breast cancer [11] .[wikigenes.org]


  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • The exact etiology and pathogenesis of this syndrome are still not fully understood. Several factors were attributed to the etiology of PLS-periodontitis including microbiologic, immunologic, and genetic.[omicsonline.org]
  • London : The Society, Clinical and etiological researches in psoriasis.The Unna-Thost form of PPK is clinically [windowTitleOverride Hereditary Palmoplantar (Epidermolytic) Keratoderma Advances in Psoriasis Research.Hair loss can be an isolated problem[dakifigisa.xpg.uol.com.br]
  • The exact etiology of this disorder is not known, but a dual influence of genetic and environmental factors may trigger the disease.[intechopen.com]


  • Tay YK, Kong KH, Khoo SW, Goh CL, Giam YC Theprevalence and descriptive epidemiology of atopic derma-titis in Singapore school children. Br J Dermatol2002;146:101106.8.[documents.tips]
  • Epidemiologic surveys in young individuals have been performed in many parts of the world and among individuals with a widely varied background.[omicsonline.org]
  • Disorder Synonyms PPK Column* ICD-9 Selected Epidemiologic Features Genetic Cause Syndromic Associations Distinguishing features Age of onset (for disorder manifistation) Erythema Transgrediens Other Epidermal Features** Systemic Features*** Relevant[dermatologyadvisor.com]
Sex distribution
Age distribution


  • Molecular and Systemic Pathophysiology Keratin intermediate filaments belong to the cytoskeletal system within the cytoplasm of epithelial cells. They consist of type I and II proteins, which assembly into 10-nm intermediate filaments.[link.springer.com]
  • The recent identification of genetic skin dis-h mutations in the genes encoding some ofuctural proteins has disclosed that abnormalcell envelope synthesis is significantly in-the pathophysiology of certain inheritedrmas (Christiano and Uitto, 1996; Ruhrbergt[docslide.com.br]


  • Prevention - Thost-Unna palmoplantar keratoderma Not supplied. Diagnosis - Thost-Unna palmoplantar keratoderma Not supplied. Prognosis - Thost-Unna palmoplantar keratoderma Not supplied.[checkorphan.org]
  • PDF PD F PDF Download Next Article: Vinegar As a Disarming Agent to Prevent Further Discharge of the Nematocysts of the Stinging Hydromedusa Olindias sambaquiensis[mdedge.com]
  • To learn more or modify/prevent the use of cookies, see our Cookie Policy and Privacy Policy . This research hasn't been cited in any other publications.[researchgate.net]
  • For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.[avivasysbio.com]
  • Treatment and Prevention Hardened areas on the sole are often treated with lotions that can soften them.[feetfirstinc.com]

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