Abstract A new type of congenital platelet dysfunction was found in a young woman presenting a life-long bleeding disorder. The known types of thrombopathia and von Willebrand's disease were excluded by appropriate investigations. [ncbi.nlm.nih.gov]

The parents and a sister of our propositus presented a normal coagulation pattern © 1973 S. Karger AG, Basel Article / Publication Details First-Page Preview [karger.com]

• Weakness

  In addition, prolonged and frequent bleeding, although of a minor nature, however, affect a person’s well-being, causing him anemic syndrome, which is characterized by: dizziness; weakness; pallor of the skin and mucous membranes fatigue; falling blood [brulanta.com]

• Hemophilia A

  Consequently, the proband was defined as a hemophilia A carrier manifesting also hereditary thrombocytopathy. [ncbi.nlm.nih.gov]

  In hemophilia used transfusions of blood or plasma. Anemia involves the appointment of iron supplementation, diet. [noillen.bitballoon.com]

  It can be used with uremic induced platelet dysfunction and it is not effective in the treatment of hemophilia B or severe hemophilia A. [wikivisually.com]

  Hemorrhages with a pathology such as thrombocytopathy, differ from those that occur with hemophilia. And most importantly their difference lies in the absence of hemorrhages in the intermuscular and interarticulate spaces. [brulanta.com]

  In disorders of secondary hemostasis (eg, hemophilia A and B), bleeding time is almost invariably normal. [emedicine.medscape.com]

• Easy Bruising

  bruising, bleeding into the skin, and excessive bleeding following injury and surgery. [medigest.uk]

  In Gaucher disease type I bleeding is a common presenting symptom, that may manifest itself as frequent nose bleeds, easy bruising but can also cause substantial bleeding after surgical or dental procedures and may occur in association with pregnancy [clinicaltrials.gov]

  Physical exam may show areas of easy bruising, purpuric spots, petechiae, ecchymosis, hemarthrosis, and enlarged spleen due to sequestering of platelets. [mhmedical.com]

  She has some easy bruising and gum bleeding, but admits to not flossing. She has no PMHx, and is on no medications. She works as gym instructor in a fitness center. She is started on 1 mg/kg of prednisone. [slideplayer.com]

  The bleeding manifestations are predominantly skin-related and mucocutaneous (ie, easy bruising, epistaxis, GI hemorrhage). Most bleeding episodes occur following trauma or surgery. [emedicine.medscape.com]

• Diarrhea

  Common side effects include headaches, diarrhea, and low blood sodium, the low blood sodium that results may cause seizures. [wikivisually.com]

  Diarrhea and abdominal cramps are very prominent symptoms. [12] Disorders of Platelet Function Functional disorders of platelets are relatively rare, and most of these disorders are mild. [emedicine.medscape.com]

• Bleeding Gums

  Symptoms and Signs Symptoms of thrombocytopahy include: abnormal blood clotting, prolonged bleeding time, hemorrhage, excessive bleeding, abnormal blood platelet function, excessive menstrual bleeding, bleeding gums, gastrointestinal bleeding, blood in [medigest.uk]

  Primary disorders will commonly have epistaxis, bleeding gums, and metromenorrhagia. Physical exam may show areas of easy bruising, purpuric spots, petechiae, ecchymosis, hemarthrosis, and enlarged spleen due to sequestering of platelets. [mhmedical.com]

  These are: bleeding gums; spontaneous bleeding from the nasal passages; prolonged healing of even minor wounds umbilical cord bleeding in newborns bleeding from the genital tract in adolescent girls who are not related to menstruation There are fewer [brulanta.com]

  Bleeding gums or bleeding from tooth extractions. [patient.info]

  Bleeding gums is a common symptom in persons with primary disorders of hemostasis. The bleeding could be spontaneous or it could be associated with brushing or flossing. Bleeding from tooth extractions is possible. [emedicine.medscape.com]

• Purpura

  Thrombocytopenic purpura thrombocytopenic purpura n. See idiopathic thrombocytopenic purpura. Thrombocytopoiesis thrombocytopoiesis throm·bo·cy·to·poi·e·sis (thrŏm’bō-sī’tə-poi-ē’sĭs) n. [definithing.com]

  […] antibodies Primary thrombocythemia Purpura Thrombocytopenia Thrombotic thrombocytopenic purpura Thromobocytopenia - drug-induced Von Willebrand disease [ Read More ] [icdlist.com]

  […] and other haemorrhagic conditions Excludes: benign hypergammaglobulinaemic purpura ( D89.0 ) cryoglobulinaemic purpura ( D89.1 ) essential (haemorrhagic) thrombocythaemia ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1 [apps.who.int]

  ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1 ) Waldenström hypergammaglobulinemic purpura ( D89.0 ) Purpura and other hemorrhagic conditions Approximate Synonyms Platelet disorder Platelet disorder, qualitative Platelet [icd10data.com]

  These include hemorrhagic purpura, hereditary and disaggregation thrombocytopathy, hemorrhagic vasculitis, vascular lesions in the liver, poisoning, drugs, infections. [noillen.bitballoon.com]

• Epistaxis

  INTRODUCTION Nasal hemorrhage or epistaxis is one of the most frequent of the hemorrhages. [arquivosdeorl.org.br]

  Primary disorders will commonly have epistaxis, bleeding gums, and metromenorrhagia. Physical exam may show areas of easy bruising, purpuric spots, petechiae, ecchymosis, hemarthrosis, and enlarged spleen due to sequestering of platelets. [mhmedical.com]

  Physical examination is remarkable only for epistaxis and scattered petechiae. [slideplayer.com]

  […] peripheral blood smear on a freshly taken specimen should be performed. [ 9 ] Presentation Careful and thorough history and examination, including any features associated with platelet dysfunction and any indication of the underlying cause. [ 10 ] History Epistaxis [patient.info]

  Details about the frequency, duration, packing requirement, and previous treatment (cautery or transfusion) are helpful for assessing the severity of bleeding (see also the Medscape Reference articles Anterior Epistaxis Nasal Pack and Posterior Epistaxis [emedicine.medscape.com]

• Hematuria

  Bleeding in gums, epitaxis, hematuria, melena 2. Small puppies bleeding exxcessively following injection/venipuncture What are the clinical pathology abnormalaities in vWD? 1. Coagulation tests are WRI 2. Throbocrit is 3. Platelet count is WRI 4. [quizlet.com]

  Hemoptysis, hematemesis, hematuria, hematochezia, and melena are rarely the initial symptoms of a bleeding disorder. However, these may be exacerbated by an underlying bleeding disorder. Menstrual history is important. [emedicine.medscape.com]

• Intracranial Hemorrhage

  The presence of hemorrhagic bullae in the buccal mucosa and retinal hemorrhages are harbingers of internal and intracranial bleeding. [emedicine.medscape.com]

  Intracranial hemorrhages were few in number (GpIIb-IIIa plus aspirin, 0.2% vs. aspirin alone, 0.1% [NS]). [care.diabetesjournals.org]

  hemorrhage Laboratory Data Other blood counts should be normal. [slideplayer.com]

In patients who have functional defects in factor VIII, the use of desmopressin is moot and it is also used in the diagnostic workup for diabetes insipidus, in order to distinguish central from DI due to the kidneys. [wikivisually.com]

Evaluating the impact of Imiglucerase treatment duration and Gaucher disease severity on platelet function [clinicaltrials.gov]

Treatment Treatment depends on the underlying disease. [medigest.uk]

This exam is extremely important to find bleeding point and to chose a suitable treatment for each case (3). [arquivosdeorl.org.br]

These are: alcohol use treatment with blood thinning drugs prolonged and frequent exposure to the sun some physiotherapy procedures; eating a large amount of vinegar and food on its basis. [brulanta.com]

We describe how treatment with recombinant factor VIIa (Novoseven) during a surgical procedure in a boy with SPD leads to an immediate rise in PF-4, thereby activating factor Xa on the platelet surface, leading to active thrombin generation. [ncbi.nlm.nih.gov]

Beginning with history taking, clinical examination, terminology and imaging, each of the following chapters examines a different oral disease, providing step by step analysis of its aetiology, clinical features, histopathology, diagnosis, treatment and prognosis [books.google.com]

Prognosis - Thrombocytopathy Not supplied. Treatment - Thrombocytopathy Not supplied. Resources - Thrombocytopathy Not supplied. [checkorphan.org]

In particular, in cases of cerebral hemorrhage, the prognosis of the disease becomes unfavorable, although in the usual course of the pathology pathology, doctors can significantly alleviate the child’s life and improve its quality. [brulanta.com]

Prognosis The prognosis is very variable and will depend on the underlying condition. [patient.info]

More abdominal pain in symptoms Usually precipitated by diarrheal illness, especially E. coli O157:H7 („Shigatoxin“) or Shigella Seen more in pediatric patients, usually has better prognosis. [slideplayer.com]

However, In other cases the etiology is an abnormality of platelet function. [clinicaltrials.gov]

This practical text covers disorders of thrombosis and hemostasis in a logical and sequential manner: etiology, pathophysiology, clinical and laboratory diagnosis, and management. [books.google.com]

They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]

Different types of treatment have been suggested with the purpose of controlling epistaxis, based on its location, etiology and current doctor experience. [arquivosdeorl.org.br]

Epidemiology of Platelet Disorders Inherited hemostatic disorders are relatively rare. The prevalence of von Willebrand disease has been estimated at 1 case per 1000-5000 population. [emedicine.medscape.com]

This practical text covers disorders of thrombosis and hemostasis in a logical and sequential manner: etiology, pathophysiology, clinical and laboratory diagnosis, and management. [books.google.com]

Clinical spectrum, pathophysiology and treatment of the Wiskott-Aldrich syndrome. Curr Opin Hematol. 2011; 18: 42-48. -MINELLI A, et al. [revistaseletronicas.fmu.br]

Thus, the knowledge of these platelet-related phenomena from the pathophysiological point of view, and of their eventual normalization, has been of great interest; in fact, the clinical practice guidelines on DM 5 have incorporated, to a greater or lesser [revespcardiol.org]

Thus, the pathophysiology of this disease is similar to that of the hemolytic disease of newborns. Unlike hemolytic disease, however, thrombocytopenia occurs during the first pregnancy in 50% of cases. [emedicine.medscape.com]

These findings have recently been confirmed [ 137 ] and have ignited an interesting debate about whether this decrease in plasmatic fibrinogen levels plays a pathophysiological role in the development of severe PPH or if it is instead an epiphenomenon [aneskey.com]

Preventive Services Task Force ( 46 ). [care.diabetesjournals.org]

Platelets help wounds heal and prevent bleeding by forming blood clots. Your bone marrow makes platelets. Problems can result from having too few or too many platelets, or from platelets that do not work properly. [xpertdox.com]

Aspirin for Primary Prevention of Cardiovascular Events in People With Diabetes. [revespcardiol.org]

Symptoms - Thrombocytopathy - Abnormal blood clotting - Prolonged bleeding time - Hemorrhage - Excessive bleeding - Abnormal blood platelet function Causes - Thrombocytopathy - Clopidogrel - Aspirin - Triflusal - Anagrelide - Bernard-Soulier syndrome Prevention [checkorphan.org]