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Thrombocytopathy

Thrombocytopathia


Presentation

  • Abstract A new type of congenital platelet dysfunction was found in a young woman presenting a life-long bleeding disorder. The known types of thrombopathia and von Willebrand's disease were excluded by appropriate investigations.[ncbi.nlm.nih.gov]
  • The relationship of excessive bleeding during orthopaedic surgery secondary to thrombocytopathy and low levels of serotonin caused by drugs that inhibit the reuptake of serotonin is presented.[ncbi.nlm.nih.gov]
  • Unique findings were, however, present in the hepatocytes, another inclusion containing dense fine granuloreticular structures was found electron microscopically.[ncbi.nlm.nih.gov]
  • Abstract A patient is described who presented a thrombocytopenia with thrombocytopathy followed by the development of a leukaemia.[ncbi.nlm.nih.gov]
  • Electron microscopic evaluation showed giant platelets with dense and alpha bodies present.[ncbi.nlm.nih.gov]
Camping
  • Platelet cAMP content was increased.[ncbi.nlm.nih.gov]
  • Alterations of platelet adhesion and aggregation are caused by uremic toxins, increased platelet production of NO, PGI(2), calcium and cAMP as well as renal anemia.[ncbi.nlm.nih.gov]
  • PLT cAMP: dipyridamol, theofylin, phospohodiesterase inhibitors, Clopidogrel (Plavix, Thrombex) ADP receptor blocade GPIIb/IIIa inactivation aggregation Other: penicillin, cephalosporins, dextran, tricyclic antidepressants, antihistamins, betablockers[slideplayer.com]
Gaucher Disease
  • Understanding the etiology for platelets dysfunction in Gaucher disease. Evaluating the impact of Imiglucerase treatment duration and Gaucher disease severity on platelet function[clinicaltrials.gov]
Bleeding Gums
  • Symptoms and Signs Symptoms of thrombocytopahy include: abnormal blood clotting, prolonged bleeding time, hemorrhage, excessive bleeding, abnormal blood platelet function, excessive menstrual bleeding, bleeding gums, gastrointestinal bleeding, blood in[medigest.uk]
  • Pediatricians usually do not attach due importance to hemorrhagic manifestations and guide children to specialists: child LORu - when nosebleeds; children's gynecologist - with heavy menstruation; pediatric dentist - with bleeding gums, etc.[medicalformat.com]
  • Primary disorders will commonly have epistaxis, bleeding gums, and metromenorrhagia. Physical exam may show areas of easy bruising, purpuric spots, petechiae, ecchymosis, hemarthrosis, and enlarged spleen due to sequestering of platelets.[mhmedical.com]
  • These are: bleeding gums; spontaneous bleeding from the nasal passages; prolonged healing of even minor wounds umbilical cord bleeding in newborns bleeding from the genital tract in adolescent girls who are not related to menstruation There are fewer[brulanta.com]
  • Bleeding gums or bleeding from tooth extractions.[patient.info]
Purpura
  • Thrombocytopenic purpura thrombocytopenic purpura n. See idiopathic thrombocytopenic purpura. Thrombocytopoiesis thrombocytopoiesis throm·bo·cy·to·poi·e·sis (thrŏm’bō-sī’tə-poi-ē’sĭs) n.[definithing.com]
  • […] antibodies Primary thrombocythemia Purpura Thrombocytopenia Thrombotic thrombocytopenic purpura Thromobocytopenia - drug-induced Von Willebrand disease [ Read More ][icdlist.com]
  • […] plaquettes plasma plastic plate platelet concentrates platelet count platelet factor platelet level platelet material platelet transfusions platelet-poor platelet-rich plasma preparations preserved platelets protein prothrombin consumption purified purpura[books.google.com]
  • […] and other haemorrhagic conditions Excludes: benign hypergammaglobulinaemic purpura ( D89.0 ) cryoglobulinaemic purpura ( D89.1 ) essential (haemorrhagic) thrombocythaemia ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1[apps.who.int]
  • ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1 ) Waldenström hypergammaglobulinemic purpura ( D89.0 ) Purpura and other hemorrhagic conditions Approximate Synonyms Platelet disorder Platelet disorder, qualitative Platelet[icd10data.com]

Treatment

  • We describe how treatment with recombinant factor VIIa (Novoseven) during a surgical procedure in a boy with SPD leads to an immediate rise in PF-4, thereby activating factor Xa on the platelet surface, leading to active thrombin generation.[ncbi.nlm.nih.gov]
  • Evaluating the impact of Imiglucerase treatment duration and Gaucher disease severity on platelet function[clinicaltrials.gov]
  • Treatment Treatment depends on the underlying disease.[medigest.uk]
  • These are: alcohol use treatment with blood thinning drugs prolonged and frequent exposure to the sun some physiotherapy procedures; eating a large amount of vinegar and food on its basis.[brulanta.com]
  • […] laboratory examination, receive preventive treatment, eliminate classes traumatic sports.[medicalformat.com]

Prognosis

  • Prognosis - Thrombocytopathy Not supplied. Treatment - Thrombocytopathy Not supplied. Resources - Thrombocytopathy Not supplied.[checkorphan.org]
  • In particular, in cases of cerebral hemorrhage, the prognosis of the disease becomes unfavorable, although in the usual course of the pathology pathology, doctors can significantly alleviate the child’s life and improve its quality.[brulanta.com]
  • Prognosis The prognosis is very variable and will depend on the underlying condition.[patient.info]
  • More abdominal pain in symptoms Usually precipitated by diarrheal illness, especially E. coli O157:H7 („Shigatoxin“) or Shigella Seen more in pediatric patients, usually has better prognosis.[slideplayer.com]
  • […] control, or the best possible control in a given patient, including both the glycemic and nonglycemic aspects, together with the use of compounds that help to effectively modulate platelet hyperreactivity, will undoubtedly contribute to improve the prognosis[revespcardiol.org]

Etiology

  • However, In other cases the etiology is an abnormality of platelet function.[clinicaltrials.gov]
  • This practical text covers disorders of thrombosis and hemostasis in a logical and sequential manner: etiology, pathophysiology, clinical and laboratory diagnosis, and management.[books.google.com]
  • Different types of treatment have been suggested with the purpose of controlling epistaxis, based on its location, etiology and current doctor experience.[arquivosdeorl.org.br]
  • They are organised into groups, and further divided into clinical, etiological or histopathological sub-types.[orpha.net]
  • Hemorrhagic diathesis have different etiologies and mechanisms of development. Types of bleeding diathesis Hemorrhagic diathesis may occur as an independent disease, and to develop other diseases.[noillen.bitballoon.com]

Pathophysiology

  • This practical text covers disorders of thrombosis and hemostasis in a logical and sequential manner: etiology, pathophysiology, clinical and laboratory diagnosis, and management.[books.google.com]
  • Clinical spectrum, pathophysiology and treatment of the Wiskott-Aldrich syndrome. Curr Opin Hematol. 2011; 18: 42-48. -MINELLI A, et al.[revistaseletronicas.fmu.br]
  • Thus, the knowledge of these platelet-related phenomena from the pathophysiological point of view, and of their eventual normalization, has been of great interest; in fact, the clinical practice guidelines on DM 5 have incorporated, to a greater or lesser[revespcardiol.org]
  • These findings have recently been confirmed [ 137 ] and have ignited an interesting debate about whether this decrease in plasmatic fibrinogen levels plays a pathophysiological role in the development of severe PPH or if it is instead an epiphenomenon[aneskey.com]

Prevention

  • The issue of preventive vaccination of children is decided on an individual basis.[medicalformat.com]
  • Platelets help wounds heal and prevent bleeding by forming blood clots . Your bone marrow makes platelets. Problems can result from having too few or too many platelets, or from platelets that do not work properly.[xpertdox.com]
  • Platelets help wounds heal and prevent bleeding by forming blood clots. Your bone marrow makes platelets. Problems can result from having too few or too many platelets, or from platelets that do not work properly.[icdlist.com]
  • Symptoms - Thrombocytopathy - Abnormal blood clotting - Prolonged bleeding time - Hemorrhage - Excessive bleeding - Abnormal blood platelet function Causes - Thrombocytopathy - Clopidogrel - Aspirin - Triflusal - Anagrelide - Bernard-Soulier syndrome Prevention[checkorphan.org]
  • Therefore it is very important in the planning of pregnancy to visit the hematologist to find out about possible problems with the blood of a future child and be ready to prevent them.[brulanta.com]

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