BACKGROUND: The present study reports a case of piperacillin-induced thrombocytopenia in a dual heart and kidney transplant patient on January 28, 2016 (taking mycophenolate mofetil and tacrolimus). [ncbi.nlm.nih.gov]

• Gaucher Disease

  disease Platelets become diluted Massive red blood cell replacement or exchange transfusion; stored red blood cells do not contain very many platelets Use or destruction of platelets increases Immune thrombocytopenia HIV infection and other viral infections [msdmanuals.com]

  The most common causes of splenomegaly (enlarged spleen) are portal hypertension secondary to liver disease and splenic infiltration with tumor cells, or with macrophages in storage disorders (like Gaucher's disease). [healthcentral.com]

  Platelets get trapped in enlarged spleen in splenomegaly, portal hypertension, Gaucher disease, etc., and cause low platelet count. 1.10. [intechopen.com]

  disease Zika virus Medication-induced[edit] The following medications can induce thrombocytopenia through direct myelosuppression.[14] Valproic acid Methotrexate Carboplatin Interferon Isotretinoin Panobinostat H2 blockers and proton-pump inhibitors [en.wikipedia.org]

• Easy Bruising

  It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues A condition in which there is an abnormally small number of platelets in the circulating blood A decrease in the number of platelets in [icd9data.com]

  Other symptoms include nosebleeds and easy bruising; sometimes gastrointestinal bleeding, excess menstrual bleeding, or other hemorrhage is observed. Hemorrhage in the brain can have serious consequences. [britannica.com]

  Thrombocytopenia is characterized by easy bruising and increased bleeding. [rxlist.com]

  bruising, petechiae, bleeding, hematuria, melena Acute ITP (typically in children): following a viral infection Chronic ITP (typically women of childbearing age): insidious onset or incidental finding Diagnosis CBC: normal except for decreased platelet [amboss.com]

• Hematemesis

  Hemoptysis, hematemesis, hematuria, hematochezia, and melena are rarely the initial symptoms of a bleeding disorder. However, these may be exacerbated by an underlying bleeding disorder. Menstrual history is important. [emedicine.medscape.com]

• Bleeding Gums

  bleeding gums, epistaxis) at lower platelet counts. Other patients with thrombocytopenia are clinically ill and have multisystem findings (e.g., acute infection, liver disease, TTP/HUS, DIC). [amboss.com]

  Key points about ITP in children ITP is a blood disorder with decreased blood platelets, which may result in easy bruising, bleeding gums, and internal bleeding. [stanfordchildrens.org]

  People with thrombocytopenia can: bruise easily have nose bleeds or bleeding gums have pinpoint bleeding in the skin that looks like a rash (known as petechiae) have cuts that keep bleeding feel tired In rare cases, dangerous internal bleeding may occur [healthdirect.gov.au]

  But if the count drops low enough, a child might have one or more of these problems: easy bruising bleeding gums bleeding from minor wounds or nosebleeds that's hard to stop small red or purple spots on the skin called petechiae (peh-TEE-kee-eye) purple [kidshealth.org]

  Possible symptoms include: Severe bruising or bleeding Small red or purple spots (petechiae) on the skin Bleeding gums Nosebleeds Bleeding from a wound that stops and starts again Bloody urine or stool Heavy menstrual flow (women only) How is thrombocytopenia [fairview.org]

• Purpura

  At presentation, acquired thrombotic thrombocytopenia purpura in a very young child is commonly misdiagnosed as other conditions like idiopathic thrombocytopenic purpura, Evans syndrome, atypical hemolytic-uremic syndrome, or malignancy. [ncbi.nlm.nih.gov]

  "How Is Thrombotic Thrombocytopenic Purpura Treated? - NHLBI, NIH". www.nhlbi.nih.gov. Retrieved 2015-05-20. Thrombocytopenic Purpura: New Insights for the Healthcare Professional: 2013 Edition: ScholarlyPaper. ScholarlyEditions. 2013-07-22. [en.wikipedia.org]

• Petechiae

  Larger than petechiae, ecchymoses are purple, blue or yellow-green areas of skin that vary in size and shape. [en.wikipedia.org]

  Suspect ITP in a child with thrombocytopenia and petechiae following a viral illness! [amboss.com]

  A 20-month-old boy presented with a 2-day history of fever and systemic petechiae. There were no abnormal findings except for an extremely low platelet count (8000/μl) on blood examinations. [ncbi.nlm.nih.gov]

  […] thrombocytes Artificial heart valves Use of heart-lung machine Dialysis with extracorporeal circulation Diffusion disorders Splenomegaly Hypothermal anesthesia Laboratory artifact Pseudothrombocytopenia 3 Symptoms In thrombocyte counts below 30,000/µl, petechiae [flexikon.doccheck.com]

• Epistaxis

  The patient was admitted to hematology service with epistaxis, ecchymoses, fever, thrombocytopenia (0.6 x 103/μL) and anemia. His initial diagnosis was idiopathic thrombocytopenic purpura. [ncbi.nlm.nih.gov]

  bleeding gums, epistaxis) at lower platelet counts. Other patients with thrombocytopenia are clinically ill and have multisystem findings (e.g., acute infection, liver disease, TTP/HUS, DIC). [amboss.com]

  It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae, ecchymoses, or splenomegaly. [enerca.org]

• Somnolence

  Findings suggestive of intracranial hemorrhage include the following: Headache, blurred vision, somnolence, or loss of consciousness Hypertension and bradycardia, which may be signs of increased intracranial pressure On neurologic examination, any asymmetrical [emedicine.medscape.com]

Other laboratory tests should be obtained based on the initial workup and history. [clinicaladvisor.com]

Disseminated Intravascular Coagulation (DIC) Liver disease induced coagulopathy Uremic bleeding syndrome Genetic Hemophilia Factor VIII inhibitor Lupus anticoagulant Evaluation Algorithm for the Evaluation of Thrombocytopenia Platelet count (CBC) Additional workup [wikem.org]

It is not still clear if detection of H. pylori infection should be routinely included in the initial workup of chronic thrombocytopenia. Key words. H. pylori. Thrombocytopenia. Purpura. Mexico. [scielo.org.mx]

Evaluation begins with risk-stratification using the 4T score.2 interpretation of the 4T score: 0-3 points: Low probability ( 1%) No further workup of HITT is indicated (avoid checking heparin-PF4 antibodies). 4-5 points: Intermediate probability ( 10% [emcrit.org]

• Decreased Platelet Count

  PGRN deficiency further decreased platelet count in a passive-transfer ITP murine model. By contrast, administration of recombinant PGRN increased platelet count in SCID mice with chronic ITP. [ncbi.nlm.nih.gov]

  In addition to a complete medical history and physical examination, laboratory testing of the blood can show decreased platelet counts. [chop.edu]

  Thrombocytopenia is a decreased platelet count. Normal platelet count should range from 150,000 to 400,000 per microliter. [youtube.com]

• Toxoplasma Gondii

  Candida sp.[33]), and Toxoplasma gondii.[32] The severity of thrombocytopenia may be correlated with pathogen type; some research indicates that the most severe cases are related to fungal or gram-negative bacterial infection.[33] The pathogen may be [en.wikipedia.org]

Therefore, warfarin treatment was replaced with dabigatran (300 mg/day). Her platelet count decreased (41,000/μL) significantly and dabigatran treatment was discontinued. [ncbi.nlm.nih.gov]

Early confirmation and treatment may improve the prognosis. [ncbi.nlm.nih.gov]

On further work up we found a coexistent autoimmune etiology. Thrombocytopenia promptly responded to steroids, a cost effective option. [ncbi.nlm.nih.gov]

Additional etiologies include hereditary syndromes, such as Wiskott-Aldrich syndrome and Alport syndrome. [amboss.com]

34/2, 8036, Graz, Austria. 3 Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria. [ncbi.nlm.nih.gov]

However, a decrease in AIPC after admission was independently associated with the development of severe thrombocytopenia and mortality, suggesting the importance of suppressed thrombopoiesis in the pathophysiology of sepsis-induced thrombocytopenia. [ncbi.nlm.nih.gov]

Electronic address: [email protected] 5 Daishan County Center for Disease Control and Prevention, Zhoushan, Zhejiang, China. [ncbi.nlm.nih.gov]

The National Heart, Lung, and Blood Institute (NHLBI) leads or sponsors many studies aimed at preventing, diagnosing, and treating heart, lung, blood, and sleep disorders. [nhlbi.nih.gov]