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Thrombocytopenia 2

THC2


Presentation

  • Snapshot A 42-year-old man presents to his primary care physician's office for easy bruising and gingival bleeding. He reports his symptoms began one day prior to presentation and has never occurred before.[medbullets.com]
  • In this installment, we present the case...[ascopost.com]
  • A monitoring plan for the early detection of ITP, implemented after presentation of the index case, identified all 5 subsequent cases before serious hemorrhagic morbidity or mortality occurred.[ncbi.nlm.nih.gov]
  • The current pregnancy had a breech presentation, for which the patient was scheduled for a cesarean delivery.[anesthesiology.pubs.asahq.org]
  • While ACOG makes every effort to present accurate and reliable information, this publication is provided “as is” without any warranty of accuracy, reliability, or otherwise, either express or implied.[journals.lww.com]
Rales
  • Blood pressure: 180/100mmHg, tachypnoea, no fever, jugular vein engorgement or cyanosis, with a heart rate of 90 beats per minute, with systolic ejection murmur II/VI, without ectopic beats or pericardial rubs, bronchospasms without crepitant rales, no[revistanefrologia.com]
Abdominal Mass
  • Moreover, if anamnesis or physical assessment shows elements indicative for secondary IT (abdominal masses and adenopathies), the algorithm becomes not necessary, and the laboratory and radiological approach must start with investigations directed to[frontiersin.org]
Ejection Murmur
  • Blood pressure: 180/100mmHg, tachypnoea, no fever, jugular vein engorgement or cyanosis, with a heart rate of 90 beats per minute, with systolic ejection murmur II/VI, without ectopic beats or pericardial rubs, bronchospasms without crepitant rales, no[revistanefrologia.com]

Workup

  • Other laboratory tests should be obtained based on the initial workup and history.[clinicaladvisor.com]
  • Figure 1 shows our algorithm for workup of thrombocytopenia based on the observation of the peripheral blood film.[bloodjournal.org]
  • See Workup. Treatment of HIT begins with discontinuation of all heparin products (including heparin flushes of intravenous catheters). The patient should then be started on an alternative anticoagulant. See Treatment and Medication.[emedicine.medscape.com]
Immunoglobulin A Increased
  • Immunoglobulin injections increase the platelet count (10). Transfusion, where the platelet mass is transfused. But it is rarely done. Rinsing with aminocaproic acid when there is excessive bleeding from the mucus membrane of the mouth.[momjunction.com]

Treatment

  • When treatment is needed, the two most common forms of treatment are steroids and immune globulin: Corticos teroids. Brief treatment with steroid medication helps prevent bleeding by decreasing platelet destruction.[stanfordchildrens.org]
  • Treatment For Low Platelet Count During Pregnancy The treatment depends on the severity of the condition and focuses on addressing the cause. Mild cases do not need any medical treatment but need regular monitoring.[momjunction.com]
  • […] initial treatment for patients with a platelet count 30,000/μL intravenous immunoglobulins (IVIG) indication for patients with a platelet count 30,000/μL who have contraindications to corticosteroids, are refractory to corticosteroid treatment, or are[medbullets.com]
  • Once-daily treatment with lusutrombopag 3 mg or placebo is to commence on Day 1 and continue for up to 7 days.[clinicaltrials.gov]

Prognosis

  • Overall, prevention of serious bleeding, such as head injuries, is the most significant factor in prognosis. Providing a safe environment, prompt medical attention, and continued medical care are all necessary for a long-term, healthy prognosis.[stanfordchildrens.org]
  • Treatment and Prognosis Treatment Women, diagnosed with gestational thrombocytopenia, will have their complete blood test conducted during each pre-natal visit and monitored by the doctor. [7] Having diagnosed gestational thrombocytopenia, women should[ipfs.io]
  • A more than 30% drop in PC should probably be considered to be associated with a poor prognosis (weak agreement). 5.[annalsofintensivecare.springeropen.com]
  • Prognosis HIT-II is a potentially very serious condition.[myvmc.com]
  • Many cases of thrombocytopenia may be reversible (medication-induced, infectious), thus carrying a favorable prognosis. The function of platelets (clotting and prevention of bleeding) remains undisturbed in most cases, despite a low platelet count.[emedicinehealth.com]

Etiology

  • ., HIV infection) Epidemiology demographics 1-7 years of age commonly in children Etiology primary ITP unknown secondary ITP autoimmune disorders systemic lupus erythematosus antiphospholipid syndrome infection HIV hepatitis C virus malignancy chronic[medbullets.com]
  • Etiology of ITP Etiologic classification divides two categories of ITP: primary ITP and secondary IT.[frontiersin.org]
  • The clinical context should suggest the etiology of thrombocytopenia in most cases in intensive care (strong agreement). 10.[annalsofintensivecare.springeropen.com]
  • Common Etiologies of Thrombocytopenia with Clinical Findings and Suggested Treatment Etiology Severity Clinical presentation Evaluation Treatment Comments Bone marrow suppression by irradiation, chemotherapy, or neoplasia Moderate to severe History of[aafp.org]

Epidemiology

  • ., HIV infection) Epidemiology demographics 1-7 years of age commonly in children Etiology primary ITP unknown secondary ITP autoimmune disorders systemic lupus erythematosus antiphospholipid syndrome infection HIV hepatitis C virus malignancy chronic[medbullets.com]
  • Epidemiologic and clinical characteristics of severe fever with thrombocytopenia syndrome in the Republic of Korea. Public Health Weekly Report, KCDC. 2014 ; 7 : 493 – 8.[wwwnc.cdc.gov]
  • Field 1: Definition – epidemiology – prognosis 1. Thrombocytopenia is defined by a platelet count (PC) 150   10 9 /L (strong agreement). 2.[annalsofintensivecare.springeropen.com]
  • Kurata Y, Fujimura K, Kuwana M, Tomiyama Y, Murata M (2011) Epidemiology of primary immune thrombocytopenia in children and adults in Japan: a population-based study and literature review. Int J Hematol 93: 329-335.[omicsonline.org]
  • Chronic immune thrombocytopenia in adults: epidemiology and clinical presentation. Hematol Oncol Clin North Am. 2009;23(6):1213-21. Cines DB, Liebman HA.[rarediseases.org]
Sex distribution
Age distribution

Pathophysiology

  • Figure 1 illustrates the pathophysiology of HIT. Figure 1 Pathophysiology of heparin induced thrombocytopenia. Clinical features and diagnosis The onset of heparin-induced thrombocytopenia may be rapid or delayed.[thrombosisjournal.biomedcentral.com]
  • The exact reason for thrombocytopenia during pregnancy might be difficult to diagnose because of the overlapping pathophysiology.[momjunction.com]
  • Platelet kinetic studies have been performed to determine the pathophysiologic mechanisms in various thrombocytopenic states, particularly in complicated clinical situations.[accessmedicine.mhmedical.com]
  • […] complications of HIT can be severe Two types HIT type I, a benign non-immune condition HIT type II, an immune-mediated syndrome caused by an antibody to the PF4/heparin complex — what we mean when we say “HIT” Incidence of HIT type II 1-5% with UFH 1% with LMWH PATHOPHYSIOLOGY[lifeinthefastlane.com]

Prevention

  • Some patients may require a platelet transfusion to prevent acute bleeding or in preparation for surgery. Preventing bleeding The parents of a child with the disorder need to be aware of how to prevent injuries and bleeding.[stanfordchildrens.org]
  • Policy statement recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine, and antibiotic prophylaxis. Pediatrics. 2000;! 06:362-366. 3.[books.google.com]
  • Can thrombocytopenia (low platelet count) be prevented? Thrombocytopenia may be preventable only if its underlying cause is known and preventable. For example, in patients with alcohol-induced thrombocytopenia, alcohol avoidance is recommended.[emedicinehealth.com]
  • There is no known information regarding the prevention of this disorder.[ipfs.io]

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