Presentation
A comprehensive textbook of adult emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department. [books.google.com]
In patients with normal hepatic function, splenectomy corrects the thrombocytopenia; however, splenectomy is not indicated unless severe thrombocytopenia due to simultaneous bone marrow failure is present. [univadis.co.uk]
Abstract A case of giant hemangioma with thrombocytopenia has been presented. Isotopic studies with Cr-51 tagged platelets indicated that the basic mechanism of thrombocytopenia in this patient involved platelet sequestration in the tumor. [ashpublications.org]
Entire Body System
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Hypothermia
Thrombocytopenia caused by hypothermia (disorder) Thrombocytopenia due to blood loss Thrombocytopenia due to blood loss (disorder) Thrombocytopenia due to cold Thrombocytopenia due to extracorporeal circulation Thrombocytopenia due to extracorporeal [averbis.com]
(see Hypothermia, [[Hypothermia]]) Massive Transfusion Epidemiology : particularly in the trauma setting (see Trauma-General, [[Trauma-General]]) Physiology : due to dilution of platelets Transfusion of Fresh Frozen Plasma (FFP) (see Fresh Frozen Plasma [mdnxs.com]
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Coronary Atherosclerosis
atherosclerosis, (ii) cerebral infarction and type II diabetes. [onlinelibrary.wiley.com]
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Pediatric Disease
Succinct, targeted coverage of normal childhood growth and development, as well as the diagnosis, management, and prevention of common pediatric diseases and disorders, make this an ideal medical reference book for students, pediatric residents, nurse [books.google.com]
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Refractory Anemia
Seven of the nine patients had refractory anemia (RA), one had refractory anemia with excess of blasts (RAEB) and one had chronic myelomonocytic leukemia (CMML). [nature.com]
Gastrointestinal
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Early Satiety
[Review] Cancer Treat Rev 2017; 53:47-52Zaorsky NG, Williams GR, … Meyer JECT Splenic irradiation (SI) is a palliative treatment option for symptomatic splenomegaly (i.e. for pain, early satiety, pancytopenia from sequestration) secondary to hematologic [unboundmedicine.com]
Even massive splenomegaly can be well tolerated, but the patients may complain of abdominal discomfort, early satiety, and trouble sleeping on one or the other side. [medtextfree.wordpress.com]
Cardiovascular
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Palpitations
This edition's highlights include new chapters on palpitations, cystic fibrosis, travel related emergencies, and ultrasound and a new appendix on practice pathways. [books.google.com]
Palpitations — Throbbing or pulsation. Heart palpitations usually infer an irregular or rapid rhythm. Polycythemia vera — A chronic disorder characterized by increased red blood cell mass and other malfunctions of the blood system. [medical-dictionary.thefreedictionary.com]
Psychiatrical
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Withdrawn
Briefly, whole blood (50 ml) was withdrawn from the patient into acid citrate glucose (ACG, 6:1) as anticoagulant and centrifuged at 90–100 g for 10 min. [onlinelibrary.wiley.com]
They are given for a minimum duration and are withdrawn as soon as remission is achieved. Blood counts must be monitored during therapy. [askhematologist.com]
Workup
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. [mcwhealthcare.com]
Direct or circulating antiplatelet antibodies has no value in the workup of thrombocytopenia in pregnancy because they usually are nonspecific and will not distinguish GT from ITP. [emedicine.medscape.com]
Serum
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Decreased Platelet Count
A decreased platelet count can result from a variety of mechanisms: Impaired Platelet Production: This is the major mechanism underlying neonatal thrombocytopenia. [learn.pediatrics.ubc.ca]
Additional laboratory evaluation should be performed as clinically indicated, and a trial of discontinuing agents known to decrease platelet counts is recommended. [aafp.org]
Microbiology
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Candida
Albicans (see Candida, [[Candida]]) Chlamydia (see Chlamydia, [[Chlamydia]]) Clostridium Difficile (see Clostridium Difficile, [[Clostridium Difficile]]) Coxsackie Virus (see Coxsackie Virus, [[Coxsackie Virus]]) Cryptococcosis (see Cryptococcosis, [ [mdnxs.com]
"Transmission rate of Ureaplasma urealyticum, Mycoplasma spp., Gardnerella vaginalis, B-streptococci, Candida spp. and Chlamydia trachomatis from the mother to the newborn". [en.wikipedia.org]
Treatment
This outcome can interrupt treatment or force dosage reduction, decreasing efficiency of cancer therapy. [unboundmedicine.com]
or unspecified remission; (iv) a well‐controlled patient on a first‐line treatment; (v) physician, parent, or patient choice (vi) a non‐first‐line treatment‐based remission; (vii) a well‐controlled patient on a non‐first‐line treatment; (viii) platelet [onlinelibrary.wiley.com]
Median lung "survival" was significantly longer ( 240 vs. 162 min reference, p 0.016), and platelet activation (as CD62P and βTG) were significantly inhibited, when pigs were pre-treated with DDAVP, with or without αGPIb Fab treatment. [ncbi.nlm.nih.gov]
Also has boxes featuring controversial areas of treatment. Practical and clinically orientated. Major changes to resuscitation guidelines. Complete rewriting of ENT section. [books.google.com]
Treatment-induced thrombocytopenia often complicates interferon-based antiviral treatment for chronic hepatitis B virus (HBV) or HCV infection [ 38, 39, 40 ]. [link.springer.com]
Prognosis
In addition to being an indicator of advanced disease and poor prognosis, it frequently prevents crucial interventions. [unboundmedicine.com]
What is the prognosis for a person with thrombocytopenia (low platelet count)? The prognosis for someone with thrombocytopenia depends on the cause and the severity of the disease. [rxlist.com]
Prognosis Prognosis depends on the underlying cause and progression of the disease. Left untreated, spleen enlargement can lead to serious complications. Hypersplenism can also lead to complications due to decreased blood cell counts. [medical-dictionary.thefreedictionary.com]
Describe the usual presentation and laboratory tests in the child who has acute idiopathic thrombocytopenic purpura, review the treatments, and know the usual prognosis. [pedsinreview.aappublications.org]
Etiology
Sulfisoxazole : suspected etiology Sulfamerazine : suspected etiology Sulfamethazine : suspected etiology Sulfamethoxypyridazine : suspected etiology Sulfamethoxazole (see Sulfamethoxazole-Trimethoprim, [[Sulfamethoxazole-Trimethoprim]]): suspected etiology [mdnxs.com]
Common Etiologies of Thrombocytopenia with Clinical Findings and Suggested Treatment Etiology Severity Clinical presentation Evaluation Treatment Comments Bone marrow suppression by irradiation, chemotherapy, or neoplasia Moderate to severe History of [aafp.org]
The most common cause is chronic alcohol abuse; however, other etiologies include infectious hepatitis, drug-induced liver disease, nonalcoholic liver disease, and metabolic disorders. [mcwhealthcare.com]
Etiology of thrombocytopenia in HIV patients. Primary HIV associated thrombocytopenia Hypersplenism Opportunistic infections Malignancy (Lymphoma, etc.) Medications TTP/HUS* Bone marrow problems (e.g. [antimicrobe.org]
TABLE 14-1 Overview of Platelet Disorders View Table Favorite Table Download (.pdf) TABLE 14-1 Overview of Platelet Disorders Disorder Etiology Occurrence Examples Bleeding Thrombocytopenia Acquired Common ITP, DIC, marrow aplasia or malignancy Qualitative [accessmedicine.mhmedical.com]
Epidemiology
[…] a low incidence, a high rate of recurence, no mortality, a high comorbidity in particular concerning vaso-occlusive crisis and acute chest syndrom, a frequent infectious factor associated (70%) more often respiratory,with yearly fluctuations (virus epidemiology [theses.fr]
[…] sequestration Lymphoma (see Lymphoma, [[Lymphoma]]): however, many patients with lymphoma have both marrow infiltration and splenic sequestration Abnormal Platelet Distribution/Pooling Hypothermia (see Hypothermia, [[Hypothermia]]) Massive Transfusion Epidemiology [mdnxs.com]
An epidemiologic study from Europe and the United States showed an annual incidence of 10 cases per 1 mil lion persons, but numbers could be higher in older persons and in hospitalized patients. 29 Drug-induced thrombo cytopenia should be suspected in [mcwhealthcare.com]
About this article Publication history Received 25 September 2000 DOI Further reading Thrombocytopenia in MDS: epidemiology, mechanisms, clinical consequences and novel therapeutic strategies W Li, K Morrone, S Kambhampati, B Will, U Steidl & A Verma [nature.com]
EDTA-dependent pseudothrombocytopaenia: a 12-month epidemiological study. Scand J Clin Lab Invest. 1988;48(6):537–542. 18. Sane DC, Damaraju LV, Topol EJ, et al. [aafp.org]
Pathophysiology
We conducted a prospective phase II study for the … FREE Publisher Full TextPMC Free Full TextPMC Free PDF The pathophysiology of thrombocytopenia in chronic liver disease. [unboundmedicine.com]
Pathophysiology The pathophysiology involves antibody formation against the heparin-platelet factor 4 complex, with resultant thrombosis. [askhematologist.com]
Pathophysiology Etiology is unknown, but endothelial damage is suspected as the initiator. [emedicine.medscape.com]
An in-depth understanding of the complex pathophysiology of the thrombocytopenia of CLD is crucial when considering treatment strategies. This review outlines the recent advances in our understanding of thrombocytopenia in cirrhosis and CLD. [dovepress.com]
Therefore, a review of the pathophysiology, differential diagnosis, and management of thrombocytopenia is in order. [pedsinreview.aappublications.org]
Prevention
Policy statement recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine, and antibiotic prophylaxis. Pediatrics. 2000;! 06:362-366. 3. [books.google.com]
In addition to being an indicator of advanced disease and poor prognosis, it frequently prevents crucial interventions. [unboundmedicine.com]
Prevention Some of the underlying causes of hypersplenism or enlarged spleen can be prevented, such as certain forms of anemia and cirrhosis of the liver due to alcohol. [medical-dictionary.thefreedictionary.com]
Can thrombocytopenia (low platelet count) be prevented? Thrombocytopenia may be preventable only if its underlying cause is known and preventable. For example, in patients with alcohol-induced thrombocytopenia, alcohol avoidance is recommended. [emedicinehealth.com]