A comprehensive textbook of adult emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department. [books.google.com]

Click for pdf: neonatal thrombocytopenia General presentation Thrombocytopenia is one of the most common haematological problems encountered in the neonatal period presenting in 1-5% of newborns at birth. [learn.pediatrics.ubc.ca]

In patients with normal hepatic function, splenectomy corrects the thrombocytopenia; however, splenectomy is not indicated unless severe thrombocytopenia due to simultaneous bone marrow failure is present. [univadis.co.uk]

C 2, 21 Patients with myelodysplastic syndrome usually will present with anemia and lymphoma with lymphadenopathy. [aafp.org]

• Massive Splenomegaly

  […] haemorrhage (consumption of platelets in clot formation) Increased aggregation early sign of MODS sepsis (e.g. bacterial and fungal infections) massive PE thrombotic storm (widespread thrombosis in multiple organs) Dilution post resuscitation massive [lifeinthefastlane.com]

  Even massive splenomegaly can be well tolerated, but the patients may complain of abdominal discomfort, early satiety, and trouble sleeping on one or the other side. [medtextfree.wordpress.com]

Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. [mcwhealthcare.com]

Direct or circulating antiplatelet antibodies has no value in the workup of thrombocytopenia in pregnancy because they usually are nonspecific and will not distinguish GT from ITP. [emedicine.medscape.com]

• Enlargement of the Liver

  Causes of thrombocytopenia resulting from splenic enlargement include advanced liver diseases with portal hypertension, and some blood cancers. 6. [thrombocyte.com]

• Thrombocytosis

  Occurrence Examples Bleeding Thrombocytopenia Acquired Common ITP, DIC, marrow aplasia or malignancy Qualitative defect Acquired Common Drugs, uremia, bone marrow disorders Hereditary Rare Bernard-Soulier syndrome, Glanzmann thrombasthenia Thrombosis Thrombocytosis [accessmedicine.mhmedical.com]

  Furthermore, a platelet count of less than 150,000 is referred to as thrombocytopenia while an amount greater than 450,000 is termed as thrombocytosis. [thrombocyte.com]

  A platelet count greater than 400,000 is called thrombocytosis. Platelets participate in coagulation. Platelets initiate a sequence of reactions that eventually lead to the formation of a blood clot. [rxlist.com]

  Impaired filtering function usually causes a mild thrombocytosis and an increased risk of severe bloodstream infections.8 The filtering and immunogenic functions of the spleen are reduced to a varying degree in a number of illnesses (Table 60-3) and of [medtextfree.wordpress.com]

• Decreased Platelet Count

  A decreased platelet count can result from a variety of mechanisms: Impaired Platelet Production: This is the major mechanism underlying neonatal thrombocytopenia. [learn.pediatrics.ubc.ca]

  Additional laboratory evaluation should be performed as clinically indicated, and a trial of discontinuing agents known to decrease platelet counts is recommended. [aafp.org]

This outcome can interrupt treatment or force dosage reduction, decreasing efficiency of cancer therapy. [unboundmedicine.com]

or unspecified remission; (iv) a well‐controlled patient on a first‐line treatment; (v) physician, parent, or patient choice (vi) a non‐first‐line treatment‐based remission; (vii) a well‐controlled patient on a non‐first‐line treatment; (viii) platelet [onlinelibrary.wiley.com]

Treatment-induced thrombocytopenia often complicates interferon-based antiviral treatment for chronic hepatitis B virus (HBV) or HCV infection [ 38, 39, 40 ]. [link.springer.com]

Treatment Special treatment is not usually required. Adequate treatment of underlying disease is necessary. [iliveok.com]

What is the prognosis for a person with thrombocytopenia (low platelet count)? The prognosis for someone with thrombocytopenia depends on the cause and the severity of the disease. [rxlist.com]

In addition to being an indicator of advanced disease and poor prognosis, it frequently prevents crucial interventions. [unboundmedicine.com]

Prognosis Prognosis depends on the underlying cause and progression of the disease. Left untreated, spleen enlargement can lead to serious complications. Hypersplenism can also lead to complications due to decreased blood cell counts. [medical-dictionary.thefreedictionary.com]

Describe the usual presentation and laboratory tests in the child who has acute idiopathic thrombocytopenic purpura, review the treatments, and know the usual prognosis. [pedsinreview.aappublications.org]

Sulfisoxazole : suspected etiology Sulfamerazine : suspected etiology Sulfamethazine : suspected etiology Sulfamethoxypyridazine : suspected etiology Sulfamethoxazole (see Sulfamethoxazole-Trimethoprim, [[Sulfamethoxazole-Trimethoprim]]): suspected etiology [mdnxs.com]

Common Etiologies of Thrombocytopenia with Clinical Findings and Suggested Treatment Etiology Severity Clinical presentation Evaluation Treatment Comments Bone marrow suppression by irradiation, chemotherapy, or neoplasia Moderate to severe History of [aafp.org]

Etiology of thrombocytopenia in HIV patients. Primary HIV associated thrombocytopenia Hypersplenism Opportunistic infections Malignancy (Lymphoma, etc.) Medications TTP/HUS* Bone marrow problems (e.g. [antimicrobe.org]

The most common cause is chronic alcohol abuse; however, other etiologies include infectious hepatitis, drug-induced liver disease, nonalcoholic liver disease, and metabolic disorders. [mcwhealthcare.com]

TABLE 14-1 Overview of Platelet Disorders View Table | Favorite Table | Download (.pdf) TABLE 14-1 Overview of Platelet Disorders Disorder Etiology Occurrence Examples Bleeding Thrombocytopenia Acquired Common ITP, DIC, marrow aplasia or malignancy Qualitative [accessmedicine.mhmedical.com]

[…] a low incidence, a high rate of recurence, no mortality, a high comorbidity in particular concerning vaso-occlusive crisis and acute chest syndrom, a frequent infectious factor associated (70%) more often respiratory,with yearly fluctuations (virus epidemiology [theses.fr]

[…] etiology -> usually mild (50-100k), but may persist for several months after discontinuation of drug Ibuprofen (see Ibuprofen, [[Ibuprofen]]) IIb/IIIa Inhibitors (see IIb IIIa Inhibitors, [[IIb IIIa Inhibitors]]): abciximab, eptifibatide, tirofiban Epidemiology [mdnxs.com]

An epidemiologic study from Europe and the United States showed an annual incidence of 10 cases per 1 mil¬lion persons, but numbers could be higher in older persons and in hospitalized patients. 29 Drug-induced thrombo¬cytopenia should be suspected in [mcwhealthcare.com]

About this article Publication history Received 25 September 2000 DOI https://doi.org/10.1038/sj.leu.2402129 Further reading Thrombocytopenia in MDS: epidemiology, mechanisms, clinical consequences and novel therapeutic strategies W Li, K Morrone, S Kambhampati [nature.com]

We conducted a prospective phase II study for the … FREE Publisher Full TextPMC Free Full TextPMC Free PDF The pathophysiology of thrombocytopenia in chronic liver disease. [unboundmedicine.com]

Pathophysiology The pathophysiology involves antibody formation against the heparin-platelet factor 4 complex, with resultant thrombosis. [askhematologist.com]

Pathophysiology Etiology is unknown, but endothelial damage is suspected as the initiator. [emedicine.medscape.com]

An in-depth understanding of the complex pathophysiology of the thrombocytopenia of CLD is crucial when considering treatment strategies. This review outlines the recent advances in our understanding of thrombocytopenia in cirrhosis and CLD. [dovepress.com]

Therefore, a review of the pathophysiology, differential diagnosis, and management of thrombocytopenia is in order. [pedsinreview.aappublications.org]

Policy statement recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine, and antibiotic prophylaxis. Pediatrics. 2000;! 06:362-366. 3. [books.google.com]

Prevention Some of the underlying causes of hypersplenism or enlarged spleen can be prevented, such as certain forms of anemia and cirrhosis of the liver due to alcohol. [medical-dictionary.thefreedictionary.com]

Can thrombocytopenia (low platelet count) be prevented? Thrombocytopenia may be preventable only if its underlying cause is known and preventable. For example, in patients with alcohol-induced thrombocytopenia, alcohol avoidance is recommended. [emedicinehealth.com]

Can thrombocytopenia be prevented? In general, thrombocytopenia can be prevented if the cause is known and it is preventable. [rxlist.com]