Twenty patients who received eculizumab with SLE and/or APS have been published to date: 11 were female and mean age at presentation was 31 years. Seven out of the 20 patients presented only SLE, 5 patients only APS and 8 patients both SLE and APS. [ncbi.nlm.nih.gov]

• Epigastric Pain

  Here, we present a case of a 61-year-old woman with a history of alcohol misuse who presented with epigastric pain, nausea and vomiting after binge drinking. Elevated serum lipase and imaging were suggestive of acute-on-chronic pancreatitis. [ncbi.nlm.nih.gov]

• Severe Abdominal Pain

  abdominal pain and gastrointestinal bleeding, requiring heavy narcotic use and frequent transfusion support. [ncbi.nlm.nih.gov]

• Mental Deterioration

  Abstract A 49-year-old man with malignant hypertension, acute kidney injury and mental deterioration was referred to our hospital. [ncbi.nlm.nih.gov]

Interestingly, further workup was diagnostic for the presence of thrombotic microangiopathy (TMA): haemoglobin 12.7 g/dL, indirect bilirubin 2.0 mg/dL, haptoglobin 6 mg/dL, platelet count 121 000/μL and schistocytes on peripheral smear. [ncbi.nlm.nih.gov]

[…] of patients differs in inherited and acquired forms, and as the persistence of autoantibodies during clinical remission is of prognostic value, the determination of the activity of VWF-CP and of antibodies against VWF-CP is an important part of the workup [degruyter.com]

See Workup for more detail. Management The therapy of choice for TTP is plasma exchange with fresh frozen plasma. [emedicine.medscape.com]

• Unconjugated Bilirubin Increased

  CBC and blood film: decreased platelets and schistocytes PT, aPTT, fibrinogen: normal markers of hemolysis: increased unconjugated bilirubin, increased LDH, decreased haptoglobin negative Coombs test. [en.wikipedia.org]

• ST Elevation

  On day 10 she developed: a non-ST elevation myocardial infarction complicated with acute left ventricular failure evidenced by acute shortness of breath with desaturation despite adequate ultrafiltration; new onset lateral lead T inversions in electrocardiogram [ncbi.nlm.nih.gov]

• Haemophilus Parainfluenzae

  His early transplant course was complicated by Haemophilus parainfluenzae paronychia and a Pseudomonas aeruginosa catheter-associated urinary tract infection. [ncbi.nlm.nih.gov]

• Pseudomonas

  His early transplant course was complicated by Haemophilus parainfluenzae paronychia and a Pseudomonas aeruginosa catheter-associated urinary tract infection. [ncbi.nlm.nih.gov]

• Capnocytophaga Canimorsus

  The Gram-negative bacillus Capnocytophaga canimorsus may cause a severe illness resembling thrombotic thrombocytopenic purpura (TTP). The pathogenesis and optimal therapy of this secondary thrombotic microangiopathy (TMA) remain uncertain. [ncbi.nlm.nih.gov]

• Capnocytophaga

  The Gram-negative bacillus Capnocytophaga canimorsus may cause a severe illness resembling thrombotic thrombocytopenic purpura (TTP). The pathogenesis and optimal therapy of this secondary thrombotic microangiopathy (TMA) remain uncertain. [ncbi.nlm.nih.gov]

She underwent treatment with plasmapheresis; however, her response to treatment was poor and died on day 16 of hospitalization. The autopsy performed revealed microthrombi in the glomeruli and tubulonecrosis in the kidneys. [ncbi.nlm.nih.gov]

Almost all patients with pulmonary tumor thrombotic microangiopathy die within 1 week of the onset of dyspnea; however, the prognosis in this case was better, with 10 weeks of survival from presentation. [ncbi.nlm.nih.gov]

Its etiology is related to endothelial injury accompanied by complement activation. [ncbi.nlm.nih.gov]

Multiple etiological factors include vascular endothelial cell damage due to shiga toxin; factor h deficiency; and aberrant von willebrand factor formation The syndromes of microangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organ [icd9data.com]

In the following study new aspects and insights into the epidemiology, pathogenesis and typical morphology of kidney involvement in thrombotic microangiopathy (TMA) are discussed. [ncbi.nlm.nih.gov]

Hypertension. 19(3):242–247, MAY 2010 DOI: 10.1097/MNH.0b013e3283378f25, PMID: 20186056 Issn Print: 1062-4821 Publication Date: 2010/05/01 Checking for direct PDF access through Ovid Abstract In the following study new aspects and insights into the epidemiology [oadoi.org]

Post-operative TMA mostly occurs in adult patients with cardiovascular surgery, with the distinct pathophysiology from classical thrombotic thrombocytopenic purpura (TTP) although the exact pathophysiology remains unclear. [ncbi.nlm.nih.gov]

Author information 1 Center for HUS Control, Prevention and Management, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy. [ncbi.nlm.nih.gov]