The PE tests were compared between the hyperthyroid and euthyroid states in five of the TPP and three of the Tw/oPP patients. [ncbi.nlm.nih.gov]

A 23-year-old Vietnamese male presented with a 2-h history of complete flaccid quadriplegia and chest tightness. Electrolyte studies revealed a critical potassium level of 1.4 mmol/L. [ncbi.nlm.nih.gov]

It occurs predominantly in males of Chinese, Japanese, Vietnamese, Filipino, and Korean descent. TPP is one of several conditions that can cause periodic paralysis. An attack often begins with muscle pain, cramping, and stiffness. [en.wikipedia.org]

[…] disorder with three characteristics which occur at the same time: too much thyroid hormone low levels of potassium in the blood (hypokalemia) muscle weakness or paralysis TPP occurs most often in males of Asian descent, including Japanese, Chinese, Vietnamese [hkpp.org]

It is most commonly seen in Asian men (Chinese, Vietnamese, Filipino and Koreans). In North America the incidence is 0.1% to 0.2%. [omicsonline.org]

In this case, a 43-year-old African American woman with thyrotoxic periodic paralysis had recurrent lower extremity myopathy and acute respiratory failure precipitated by noncompliance with treatment for Graves disease. [ncbi.nlm.nih.gov]

Given that there is much racial variation in the prevalence of TPP, and the suggestion that non-thyrotoxic periodic paralysis may be more prevalent in Maori, the case highlights the need for more research into the prevalence and pathogenesis of TPP in [ncbi.nlm.nih.gov]

Clinicians should include this disease process in their differential diagnoses along with other paralyzing disorders such as Guillain-Barré, multiple sclerosis, transverse myelitis, tick paralysis, conversion disorder or hysteria. [westjem.com]

[…] patients already exhibit signs of hyperthyroidism due to Graves’ disease (goiter and exophthalmia) or thyrotoxicosis symptoms at the time of the paralysis crisis, but often the thyroid alteration is not recognized at the time and may be confused with hysteria [intechopen.com]

Although patients can present with tetraparesis that resembles other conditions such as Gullain-Barré syndrome, transverse myelitis, and acute spinal cord compression or hysteria, bowel and bladder function are never affected. [dx.doi.org]

Hypokalemia leads to hyperpolarization of muscle cells, making the neuromuscular junction less responsive to normal nerve impulses and leading to decreased contractility of the muscles.It is not clear how the described genetic defects increase the Na [en.wikipedia.org]

Low potassium levels in the serum lead to hyperpolarization of skeletal muscle cells, making the neuromuscular junction less responsive to normal nerve impulses, which in turn decreases the contractility of the muscles [7]. [cureus.com]

Cardiovascular examination during this time showed apical impulse at left 6 th intercostal space 0.5 cm lateral to the mid-clavicular line with forceful ill-sustained character. [jnsbm.org]

Or, there may be signs of hyperthyroidism, such as an enlarged thyroid changes in the eyes, tremor, hair and nail changes. [nlm.nih.gov]

Case 3 A 32-year-old male presented with acute onset flaccid paraparesis, tremors of both hands and palpitations. He had a history of transient proximal weakness 6 weeks back which recovered spontaneously. [ijem.in]

They include: Weight loss Palpitations Heat intolerance Increased appetite Agitation Insomnia Hand tremors A fast heart rate Excessive sweating The attack itself normally begins with muscle pain, cramps or muscle stiffness followed by weakness which begins [markvanderpump.co.uk]

Exercise-related attacks tend to occur during a period of rest immediately after exercise; exercise may therefore be recommended to abort an attack.There may be symptoms of thyroid overactivity, such as weight loss, a fast heart rate, tremor, and perspiration [en.wikipedia.org]

We herein report a 25-yr-old Korean man who suffered from flaccid paralysis of the lower extremities and numbness of hands. The patient was subsequently diagnosed as having TPP associated with transient thyrotoxicosis due to painless thyroiditis. [ncbi.nlm.nih.gov]

He had tachycardia, fine tremors of both hands, and grade1 diffuse goiter. His serum potassium was 1.8 mmol/l, ESR 30 mm/h, TSH 0.03 μU/l, free T4:3.2 ng/dl, TPO antibody 117 IU/ml (nl 35), and there was decreased uptake (0.21%) on 99m Tc scan. [ijem.in]

Studies suggest that restoration of potassium levels leads to resolution of paralysis, with potassium decreasing the time to resolution from 13 hours to six hours. 5 However, the physiology of TTP suggests that patients are not truly deficient in potassium [westjem.com]

Our patient was found to have an extremely low serum potassium concentration, as well as an electrocardiogram that revealed a prolonged QT interval and right bundle branch block. [ncbi.nlm.nih.gov]

The human leukocyte antigen (HLA) B46, DR9, and DQB1*0303 have been reported to be present at a higher prevalence among Hong Kong Chinese TPP patients, whereas HLA A2, Bw22, AW19, B17, and DRW8 are reported to be associated in Singapore Chinese and Japanese [dx.doi.org]