Thyroid storm may present with normal serum triiodothyronine, thyroxine, and hepatic failure. Such presentation is rare. [ncbi.nlm.nih.gov]

• Weight Loss

  Excessive use of L-thyroxine can speed your metabolism and lead to weight loss -- and serious health problems, including an irregular heartbeat, angina, heart attack and a loss of bone mass -- in severe cases it can lead to osteoporosis. [livestrong.com]

  If there is one thing most doctors think they know it’s that weight gain can be caused by an underactive thyroid and having an overactive thyroid leads to weight loss. So the thyroid hormone, thyroxine, will lead to weight loss. [rxisk.org]

  If the thyroid gland produces too much T4, the rate of the patient's body functions will increase and cause symptoms associated with hyperthyroidism such as increased heart rate, anxiety, weight loss, difficulty sleeping, tremors in the hands, and puffiness [healthcheckusa.com]

  loss, but I'm not noticing that. [patientslikeme.com]

• Fever

  A 63-year-old male presented with productive cough, fever, palpitation, shortness of breath, and mental confusion. Fulminant hepatic failure occurred with high aminotransferase and severe jaundice. [ncbi.nlm.nih.gov]

  These reactions have included urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms ( abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. [drugs.com]

  A physiological change in body temperature does, however, occur in humans with the fevers that are induced by inflammation and infection. [rspb.royalsocietypublishing.org]

  If you have diabetes, see your doctor if you suspect you have athlete's foot, especially if you notice any signs of a possible secondary bacterial infection such as excessive redness, swelling, drainage or fever. [mayoclinic.org]

  3 times a day Blood levels of thyroid hormone do not drop until the stores of thyroid hormone in the thyroid are depleted, typically after 2-4 weeks Thyroid hormone levels may take 1 to 4 months to normalize Mild side effects include rash, low grade fevers [emedicinehealth.com]

• Increased Energy

  Alternatively, the increase in RQ could have been a consequence of a positive energy balance in some individuals. [journals.plos.org]

• Rigor

  In summary, pregnancy rates higher than those reported previously were observed based on a rigorous diagnostic work‐up with frequent TRH testing. [academic.oup.com]

• Underweight

  Cortisol upon awakening was highest in the stunted and lowest in the underweight groups: control=5·05 (95% CI 3·71, 6·89) nmol/l, stunted=6·62 (95% CI 3·97, 11·02) nmol/l, underweight=2·51 (95% CI 1·75, 3·63) nmol/l and recovered=3·46 (95% CI 2·46, 4· [ncbi.nlm.nih.gov]

• Diarrhea

  These reactions have included urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms ( abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. [drugs.com]

  Inform your doctor if you have diarrhea, nervousness, irritability, sleep disturbances, shaking hands, or chest pain. Your doctor may adjust your dose. [1mg.com]

  Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and [drugbank.ca]

  [PubMed:17468187 ] Diabetes Mellitus, Congenital Insulin-dependent, With Fatal Secretory Diarrhea; Immunodeficiency, Polyendocrinopathy, and Enteropathy, X-linked, Formerly Levy-Lahad E, Wildin RS: Neonatal diabetes mellitus, enteropathy, thrombocytopenia [hmdb.ca]

• Constipation

  […] of hair High blood sugar Shortness of breath More urination Symptoms of hypothyroidism, or less than normal thyroid activity, include: Extreme tiredness Low tolerance for cold Weight gain Hair loss Eye swelling Slower heart rate Shortness of breath Constipation [urmc.rochester.edu]

  […] underactive thyroid gland, and the symptoms usually are: Dry, cool skin Loss of concentration White patches in the skin Brittle hair Weak nails Heavy menstruation Slow pulse Tiredness Ringing of ears Joint pain Weakness Muscle pain Slow speech Slow reflexes Constipation [progressivehealth.com]

  Diagnosis In general, your doctor may test for an underactive thyroid if you are feeling increasingly tired, have dry skin, constipation and weight gain, or have had previous thyroid problems or a goiter. [mayoclinic.org]

  Symptoms of low thyroid hormone levels include tiredness, muscle aches, constipation, dry skin, weight gain, slow heartbeat, or sensitivity to cold. [webmd.com]

• Tachycardia

  At this time, the common clinical signs and symptoms include nervousness, insomnia, mild tremor of hands, tachycardia, mild elevation of body temperature, blood pressure elevation, and loose stools. [ncbi.nlm.nih.gov]

  […] effects require changes in gene expression) symptoms (when present) may last up to 3 weeks. clinical manifestations of thyroxine overdose are largely sympathomimetic in nature and result from adrenergic stimulation – they include: agitation, sweating, tachycardia [lifeinthefastlane.com]

  […] cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients. [ Ref ] Frequency not reported : Palpitations, tachycardia [drugs.com]

• Hypertension

  Hypertension, dysrhythmias, and delusions did not appear in our patient. Only distal tremor and diaphoresis appeared on day 1 after ingestion. [ncbi.nlm.nih.gov]

  A 65-year-old female with a past medical history significant for hypothyroidism, hypertension and obesity was brought into the emergency room after experiencing a syncopal episode. [go.gale.com]

• Brittle Hair

  Low levels of thyroid hormones are caused by the underactive thyroid gland, and the symptoms usually are: Dry, cool skin Loss of concentration White patches in the skin Brittle hair Weak nails Heavy menstruation Slow pulse Tiredness Ringing of ears Joint [progressivehealth.com]

• Irregular Menstruation

  If the thyroid gland does not produce sufficient T4, due to thyroid dysfunction or to insufficient TSH, then the affected patient experiences symptoms of hypothyroidism such as weight gain, dry skin, cold intolerance, irregular menstruation, and fatigue [healthcheckusa.com]

• Tremor

  Only distal tremor and diaphoresis appeared on day 1 after ingestion. [ncbi.nlm.nih.gov]

  […] intolerance hives or welts, skin itching, rash, or redness irregular breathing irritability menstrual changes nausea pain or discomfort in the arms, jaw, back, or neck sweating swelling of the eyes, face, lips, throat, or tongue tightness in the chest tremors [drugs.com]

  If the thyroid gland produces too much T4, the rate of the patient's body functions will increase and cause symptoms associated with hyperthyroidism such as increased heart rate, anxiety, weight loss, difficulty sleeping, tremors in the hands, and puffiness [healthcheckusa.com]

  Other symptoms of thyrotoxicosis include intolerance to heat, weight loss, increased appetite, increased bowel movements, irregular menstrual cycle, rapid or irregular heartbeat, palpitations, tiredness, irritability, tremor, hair thinning/loss and retraction [yourhormones.info]

• Agitation

  A week into the increase I began to feel ill with nausea, diarrhoea, agitation, nervousness. At first I didn't realise it was my meds and thought I had some sort of virus. [endocrineweb.com]

  and its clinical effects require changes in gene expression) symptoms (when present) may last up to 3 weeks. clinical manifestations of thyroxine overdose are largely sympathomimetic in nature and result from adrenergic stimulation – they include: agitation [lifeinthefastlane.com]

  Mihran Damadian, who never mentions a Torossian in his recollections, and Mushegh Seropian were veterans of Armenian agitation. [dailysabah.com]

  Beta-blockers (propranolol, Inderal, Inderal LA, InnoPran XL) This medicine can help block the body's reaction to hyperthyroidism It can control heart-related symptoms, such as palpitations, tremors, and agitation Iodide solutions (Lugol's solution, Strong [emedicinehealth.com]

• Hand Tremor

  Symptoms of hyperthyroidism, or too much thyroid activity, include: Anxiety and mood swings Irritability Weakness in the arms and legs Sleeping problems Hand tremors Sweating Low tolerance for heat Irregular heartbeat Extreme tiredness Unexplained weight [urmc.rochester.edu]

  tremors changes in heart rate changes in blood pressure You may also experience more general symptoms, such as: weight changes difficulty sleeping or insomnia anxiety fatigue and weakness intolerance to cold sensitivity to light menstrual irregularity [healthline.com]

• Hyperactivity

  The common side effects that you should watch out for when taking synthetic thyroxine drugs are as follows: Hyperactivity Insomnia Headache Fatigue Excessive sweating Anxiety Appetite changes Weakness These side effects are usually experienced when one [progressivehealth.com]

  Nature volume 157, pages771–772(1946)Cite this article 5 Accesses 0 Altmetric Metrics details Abstract THIOUREA and derivatives1–3 and sulphonamide compounds4,5 inhibit the formation of the catabolic hormone both in normal and in hyperactive thyroids. [nature.com]

  […] pressure, heart failure, angina, myocardial infarction, cardiac arrest [ Ref ] Endocrine Frequency not reported : Changes in symptom presentation for diabetes and adrenal cortical insufficiency [ Ref ] Nervous system Frequency not reported : Headache, hyperactivity [drugs.com]

  Consequently, tissue concentrations of thyroxine are precisely defined: too much leads to hyperactivity and too little to dormancy. The storage and transport of thyroxine in blood has been well documented in humans [ 2, 3 ]. [rspb.royalsocietypublishing.org]

Laboratory workup showed hypokalaemia, low thyroid-stimulating hormone and thyroxine (T4) but normal T3 and thyroglobulin levels. The radioiodine uptake scan also showed reduced uptake. [ncbi.nlm.nih.gov]

• Increased Basal Metabolic Rate

  […] cardiac output Increases heart rate Increases ventilation rate Increases basal metabolic rate Potentiates the effects of catecholamines (i.e. increases sympathetic activity) Potentiates brain development Thickens endometrium in females Increases catabolism [en.wikipedia.org]

  All the patients had symptoms and signs of hyperthyroidism, diffuse goiter, an increased basal metabolic rate, increased thyroidal uptake of 123I, and increased serum levels of thyroxine, triiodothyronine, and antibodies to TSH receptors. [nejm.org]

The patient was started on D-T4 treatment since she exhibited clinical symptoms of hyperthyroidism. After 1.5 years, D-T4 treatment was switched to TRIAC which lasted 5.5 years. [ncbi.nlm.nih.gov]

Patients with lower FT4 (Q1) showed poorer baseline attention; therefore, lower baseline FT4 levels predicted a poorer prognosis in terms of attention performance. [ncbi.nlm.nih.gov]

Prognosis The type of tinea pedis infection and underlying conditions (eg, immunosuppression, diabetes) affect the prognosis; however, with appropriate treatment, the prognosis is generally good. [emedicine.medscape.com]

[…] and low TSH T4 thyrotoxicosis: high T4, low / normal T3; due to iodine, beta blockers, amiodarone, steroids or nonthyroidal illness T3 thyrotoxicosis: low / normal T4, high T3, low TSH Severe nonthyroidal illness: low T3, low T4, associated with poor prognosis [pathologyoutlines.com]

For a considerable time, CU has been considered a disease of unknown etiology, but in recent years, a wide variety of causes and mechanisms have been suggested. [ncbi.nlm.nih.gov]

Patients were classifed according to underlying etiology and disease severity; and the time it took for different initial Na-L thyroxine doses to bring serum thyroid hormone levels to target levels was evaluated. 71 patients diagnosed with CH in the Pediatric [openaccess.hacettepe.edu.tr]

Cutaneous id reactions: A comprehensive review of clinical manifestations, epidemiology, etiology, and management. Crit Rev Microbiol 2012;38:191–202. DermNet NZ. Palmoplantar psoriasis. DermNet NZ, 2014. [bpac.org.nz]

METHODS: We first conducted an epidemiological study, examining the prevalence of TGD among patients with KC. [ncbi.nlm.nih.gov]

He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]

Cutaneous id reactions: A comprehensive review of clinical manifestations, epidemiology, etiology, and management. Crit Rev Microbiol 2012;38:191–202. DermNet NZ. Palmoplantar psoriasis. DermNet NZ, 2014. [bpac.org.nz]

CONCLUSIONS: Our data implicate a crucial role of T4 in KC pathophysiology, which is most likely mediated by T4Rs. [ncbi.nlm.nih.gov]

Interpretation Provides information to assist in interpretation of the test results A change in thyroxine-binding globulin (TBG) concentration may be of hereditary, pathophysiologic, or pharmacologic origin. [mayomedicallaboratories.com]

VIVO Pathophysiology Thyroid hormones are derivatives of the the amino acid tyrosine bound covalently to iodine. [vivo.colostate.edu]

Clinical awareness and early recognition of these conditions are important to prevent unnecessary therapy with possible untoward effects. [ncbi.nlm.nih.gov]

Congenital hypothyroidism is probably the single most commom preventable case of mental retardation. [tosohindia.com]

Centers for Disease Control and Prevention [medlineplus.gov]